JOURNAL OF MOLECULAR LIQUIDS
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2018
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IF 4.513
Huanxin Li,Xiaoqiang Gao,Yonghui Dou,Li Xu,Guoji Liu
The ternary systems of {(1-butanol or 1-pentanol) + (−)-trans-Cyclohexane-1,2-diamine + water} at (298.2–318.2) K under 100.02 kPa in terms of liquid-liquid equilibrium were investigated. The solubility data of each system were obtained by using cloud point method. For evaluation of extraction ability of the solvents used in this work, the distribution coefficients and separation factors were calculated and 1-pentanol was demonstrated to be very suitable. Besides, Othmer-Tobias and Hand correlation equations were applied to check the consistency of the tie-line data. Furthermore, NRTL and UNIQUAC models were used to correlate the experimental data with all the RMSD values less than 2.57%.
研究领域:
化学工程
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物理化学
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DOI
高影响因子
JOURNAL OF CATALYSIS
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2024
·
IF 6.5
Gongcheng Sun,Subing Fan,Junmin Lv,Tiansheng Zhao
A hollow zeolite encapsulated Rh catalyst Rh@H-S-1 with an “eggshell” structure was prepared using the method of organic alkali treatment and recrystallization. Compared with catalysts with directly encapsulated Rh@S-1 and surface impregnated Rh/S-1, this catalyst exhibited both superior activity and a higher TOF value in hydroformylation of 1-hexene due to the high dispersion of Rh and high diffusion. The Rh element did not need to be reduced in the preparation, and it was in situ reduced by the syngas. The content of lower valence Rh δ+ gradually increased with the reaction procedure and played as an active center. The low oxidized state Rh + or Rh δ+ in the form of Rh(CO) 2 are proposed as active sites in hydroformylation, which were generated under the synergistic effect between CO and H 2 . Importantly, the hollow encapsulated catalyst effectively decreased Rh leaching to 0.1 ppm and showed better stability compared with the impregnated Rh/S-1 catalyst.
研究领域:
催化
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化学工程
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材料科学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
·
IF 3.119
Lingxiao Cai,Jiajia Yin,Xiaopo Wang
The density and viscosity of binary mixtures of polyoxymethylene dimethyl ethers (PODEn) with three 1-alcohols (1-propanol, 1-butanol, and 1-pentanol) were investigated in this work from 303.15 to 333.15 K and at atmospheric pressure. The measurements were conducted by a vibrating-tube method for density and a capillary-tube method for viscosity. The densities and viscosities of the mixtures were correlated by the Jouyban–Acree model and McAllister four-body model, respectively. In addition, the excess molar volumes and the viscosity deviations of the mixtures were computed and correlated by the Redlich–Kister equation, and the discussion about the excess molar volumes and viscosity deviations was carried out.
研究领域:
物理化学
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材料科学
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DOI
高影响因子
EMBO JOURNAL
·
2024
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IF 9.4
GengShan,YangShan,TangXuejiao,XueShiyao,LiKe,LiuDongfang,ChenChen,ZhuZhiming,ZhengHongting,WangYuanqiang,YangGangyi,LiLing,YangMengliu
Communication of gut hormones with the central nervous system is important to regulate systemic glucose homeostasis, but the precise underlying mechanism involved remain little understood. Nesfatin-1, encoded by nucleobindin-2 (NUCB2), a potent anorexigenic peptide hormone, was found to be released from the gastrointestinal tract, but its specific function in this context remains unclear. Herein, we found that gut nesfatin-1 can sense nutrients such as glucose and lipids and subsequently decreases hepatic glucose production. Nesfatin-1 infusion in the small intestine of NUCB2-knockout rats reduced hepatic glucose production via a gut – brain – liver circuit. Mechanistically, NUCB2/nesfatin-1 interacted directly with melanocortin 4 receptor (MC4R) through its H-F-R domain and increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion in the intestinal epithelium, thus inhibiting hepatic glucose production. The intestinal nesfatin-1 -MC4R-cAMP-GLP-1 pathway and systemic gut-brain communication are required for nesfatin-1 - mediated regulation of liver energy metabolism. These findings reveal a novel mechanism of hepatic glucose production control by gut hormones through the central nervous system.
研究领域:
内分泌学
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代谢学
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胃肠病学
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神经科学
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产品关联
DOI
PubMed
高影响因子
Discover Oncology
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2024
·Vol. 15
·期 1
·1-12
·
IF 2.8
Liu Yueli,Li Fan,Wang Qiongyu,Zhang Yunfei,Tian Shuhong,Li Biao
Anlotinib is effective in treatment of many kinds of malignant cancer, but its antineoplastic effects on esophageal cancer remains unclear. This study aims to investigate its impact on esophageal cancer and the underlying mechanisms. Anlotiniband 5-fluorouracil + cisplatin (5-FU + DDP) was administered separately to human esophageal cancer TE- 1 cells tumor xenograft mouse models every 3 days. Tumor size and body weight were measured before each treatment and at the end of the experiment. In vitro studies were conducted using TE- 1 cells to examine the effects of Anlotinib. Cell viability, migration, proliferation, apoptosis, cell cycle, their regulatory proteins and the transcriptomic changes were analyzed. Anlotinib reduced tumor size, tumor weight, and the ratio of tumor weight to body weight in vivo. It decreased the viability of TE- 1 cells, with a 50% growth-inhibitory concentration of 9.454 μM for 24 h, induced apoptosis, and arrested TE- 1 cell cycle in the S phase. It inhibited migration and proliferation while negatively regulating the PI3K/Akt signaling pathway. Enhanced expressions of P21, Bax, and lowered expressions of cyclin A1, cyclin B1, CDK1, PI3K, Akt, p-Akt, and Bcl-2 were observed after Anlotinib treatment. Anlotinib exhibits antineoplastic activity against human esophageal cancer TE- 1 cells by negatively regulating the PI3K/Akt signaling pathway, consequently altering the expressions of proteins related to proliferation, apoptosis, and the cell cycle.
研究领域:
肿瘤学
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药理学
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细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2025
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IF 3.9
Liuxing She,Lei Peng,Hang Yuan,Tianrong Zhu,Qiang Fu,Zaikun Wu
The absorption kinetics of CO2 into a novel nonaqueous mixture of 2-amino-2-methyl-1-propanol (AMP) and piperazine (PZ) was studied at atmospheric pressure. The effects of AMP/PZ molar ratio, total concentration, absorption temperature, and inlet flow rate were discussed. The results showed that the composite absorbent with an AMP/PZ ratio of 6:4 had a good effect on the CO2 absorption at 293 K. Unlike relevant reports at home and abroad, the solubility of CO2 in the 1-pentanol solution of AMP and PZ (AMP-PZ-Pentanol) was calculated based on a solution rule model and relevant data from Aspen Plus. The absorption kinetics of CO2 into nonaqueous composite absorbent was analyzed by a double stirred-cell absorber. It shows the enhancement factor increases with the increasing of total concentration but decreases with the increasing of absorption temperature. The absorption mechanism of CO2 in AMP-PZ-Pentanol was determined to be the formation of carbamate by FT-IR, 13C NMR, and XRD analysis. Based on the vapor–liquid equilibrium theory, the reaction heat of CO2 into the phase change absorbent was calculated to be 9.30 KJ mol–1. The results show that the composite absorbent has a lower reaction heat than any single component in it. The desorption experiment of saturated solution shows that the composite absorbent can be completely regenerated in a short period of time, which meets the industrial requirements for CO2 absorbents and will provide a theoretical basis for further industrial applications of this type of absorbent.
研究领域:
化学工程
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环境科学
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材料科学
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产品关联
DOI
高影响因子
Journal of Analysis and Testing
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2024
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IF 5.5
Xiao Qi,Liu Shuai,Wang Yali,Li Huihao,Yang Mingli,Fang Yi,Chen Sijing,Huang Shan
Human T-cell lymphophilic virus type 1 (HTLV-1), the known retrovirus causing cancer in humans, is closely associated with adult T-cell leukemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. Due to its ability to evade the host's defense mechanisms, early tracking of HTLV-1 becomes crucial. In this study, we integrate λ-Exonuclease (λ-Exo)-assisted target recycling with a terminal deoxynucleotidyl transferase (TdT)-mediated template-free DNA extension process to develop an electrochemical analysis platform for the specific and sensitive detection of HTLV-1 DNA. During the λ-Exo-assisted target recycling, HTLV-1 DNA is recognized by hairpin DNA (Hp-DNA), forming double-stranded DNA (dsDNA) through DNA hybridization. The dsDNA, featuring blunt 5' terminal phosphorylation, is cleaved by λ-Exo, generating abundant short output sequence (sDNA). HTLV-1 DNA is released, initiating a cyclic hybridization-cleavage process. Subsequently, thiol-labelled capture DNA (CP-DNA) assembled on gold electrode surface captures a substantial amount of the generated sDNA, forming CP-DNA-sDNA nanostructures. When TdT and dNTPs are present on the electrode surface, the 3'-OH terminal of sDNA extends to generate long single-stranded DNA (ssDNA) structure. Methylene blue (MB) is selected as the electrochemical signal molecule. MB not only binds with ssDNA but also interacts specifically with dsDNA, resulting in a significantly enhanced electrochemical signal on modified electrode surface. The detection limit of HTLV-1 DNA is as low as 19 amol/L ( S / N = 3) when the two signal amplification strategies are combined. The analysis platform exhibits excellent analytical performance and holds promise as a novel tool for the early tracing and diagnosis of HTLV-1 DNA.
研究领域:
分子生物学
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医学诊断
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生物化学
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DOI
高影响因子
MATERIALS RESEARCH BULLETIN
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2024
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IF 5.3
Lei Cai,Xiu Gao,Peihang He,Beining Luo,Xianzai Yan,Zedong Zhang,Wenjun Wang,Guoqiang Wu
To improve the catalytic epoxidation activity of conventional TS-1 zeolite under acid-free conditions, a series of TS-1-supported zinc ( x Zn/TS-1) catalysts were prepared and evaluated in the epoxidation of 1-hexene and methyl oleate (MO) with H 2 O 2 oxidant. The microstructure of x Zn/TS-1 was investigated using various characterization techniques, and the results showed that the introduction of Zn species was not only well dispersed on the surface of TS-1 but also did not disrupt the crystal structure of TS-1 and tetrahedral framework titanium. Furthermore, the Ti-O-Zn structure can be formed between Zn and Ti species through O-atomic coordination, which improves the vulnerability of the Ti-O bond to attack the H 2 O 2 molecule, and ultimately facilitates the epoxidation reaction between 1-hexene and MO. In addition, the 2% Zn/TS-1 catalysts showed optimal conversions of 45.7 % and 75.41 % for 1-hexene and MO, respectively, and exhibited good catalytic stability and regeneration during the epoxidation process.
研究领域:
催化化学
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材料科学
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产品关联
DOI
高影响因子
AICHE JOURNAL
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2024
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IF 3.5
Ze Zong,Xuliang Deng,Dong Lin,Yang Xu,Qiuming He,Zhe Ma,De Chen,Chaohe Yang,Xiang Feng
Titanosilicate with H 2 O 2 stands out as a highly consequential oxidized catalytic system, prized for its user-friendly operation, mild conditions, and eco-friendly attributes. However, a synthesis strategy for large surface area titanosilicalites approaching the theoretical lowest Si/Ti ratio without extra-framework Ti species remains an ongoing challenge. In this study, we successfully synthesized single-crystalline Ti-rich nanosized aggregated TS-1 by shielding effect with a Si/Ti polymer. This polymer demonstrated effectiveness in restraining TiO 2 species by regulating the proximity of Si/Ti species in Ti-Diol-Si polymers. The polymer not only facilitated the synthesis of single-crystalline Ti-rich TS-1 but also exploited the chain length of PEG, functioning as a shielding cage by hydrogen bonds, to synthesize nanosized aggregated TS-1 (TS-1-PEG400). This TS-1-PEG400 exhibited superior conversion (~60%), selectivity (~90%), and stability in 1-hexene epoxidation. This study not only establishes a synthesis pathway for Ti-rich TS-1 but also holds the potential to enhance related industrial oxidation reactions involving titanosilicates and H 2 O 2 .
研究领域:
催化
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材料科学
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化学工程
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DOI
高影响因子
Brazilian Journal of Pharmaceutical Sciences
·
2023
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IF 1.3
Mei Xuejiao,Lu Dingqiang,Yan Xiangping
L-Malic acid is the Active Pharmaceutical Ingredient of the latest generation of compound electrolyte injection (STEROFUNDIN ISO, Germany) and plays a very important role in the rescue of critically ill patients. The optical purity of L-malic acid is a Critical Quality Attributes. A new reversed-phase high performance liquid chromatography (RP-HPLC) method for pre-column derivatization of D-malic acid enantiomer impurity in L-malic acid bulk drug was established. The derivatization reaction was carried out using (R)-1-(1-naphthyl)ethylamine ((R)-NEA) as a chiral derivatization reagent. The Kromasil C18 column was used with a detection wavelength of 225 nm, a flow rate of 1.0 mL·min-1, and a column temperature of 30 °C. The mobile phase was acetonitrile-0.01 mol·L-1 potassium dihydrogen phosphate solution (containing 20 mmol·L-1 sodium heptanesulfonate, adjusted to pH 2.80 with phosphoric acid) (at a ratio of 45:55) and the resolution of D-malic acid and L-malic acid derivatization products reached 1.7. The proposed method possesses the advantages of simple operation, mild conditions, stable derivatization products and low cost. Also it gave better separation and was more accurate than previous methods.
研究领域:
药物分析
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分析化学
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DOI
高影响因子
Antioxidants
·
2021
·Vol. 10
·期 11
·1697
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IF 6.313
Shiling Feng,Chunyan Zhang,Tao Chen,Lijun Zhou,Yan Huang,Ming Yuan,Tian Li,Chunbang Ding
Oleuropein (OLE) is a secoiridoid glycoside that mainly exists in olives with multifaceted health benefits. The present study aimed to investigate the stress resistance and lifespan extension effects of OLE inCaenorhabditis elegans. The results showed that OLE could significantly prolong the lifespan ofC. elegansby 22.29%. Treatment with OLE also significantly increased the survival rates of worms against lethal heat shock and oxidative stress. Meanwhile, OLE supplementation increased the expression and activity of antioxidant enzymes and suppressed the generation of malondialdehyde in nematodes. In addition, the results from mutants implied that OLE might mediate longevity and stress resistance via DAF-16/FoxO, which played a vital role in the insulin/IGF-1 signaling (IIS) pathway. To further identify the molecular targets of OLE, mRNA level and loss-of-function mutants of IIS-associated genes were investigated. The data revealed that OLE activated IIS by down-regulating the upstream components,daf-2andage-1. Furthermore, another stress response and longevity pathway in parallel to DAF-16, SKN-1/Nrf2, was also shown to involve in OLE-induced beneficial effects. Collectively, these results provide the theoretical basis that OLE could enhance the stress resistance and increase the lifespan ofC. elegansthrough the IIS and SKN-1/Nrf2 signaling pathways.Keywords:oleuropein;Caenorhabditis elegans;longevity;stress resistance
研究领域:
分子生物学
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老年学
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药理学
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遗传学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 28
·13800-13813
·
IF 4.682
Sun Menghui,Yan Cheng,Wu Yue,Li Mei,Chen Shiwei,Yang Zhizhou
A series of new hyper-cross-linked porous polymers (HCP-TTDs) were successfully prepared by the Friedel–Crafts alkylation reaction of 1, 1, 1-trimethyl-3, 3, 3-triphenyldisiloxane and formaldehyde dimethyl acetal (FDA). Nitrogen adsorption–desorption test showed that the BET specific surface areas of them were between 989 and 1285 m 2 g −1 . Furthermore, the prepared HCP-TTDs exhibited excellent adsorption capacities of organic dyes in aqueous solution (Malachite green: 2346 mg g −1 , Congo red: 2052 mg g −1 , and Rhodamine B: 1938 mg g −1 ). The adsorption behavior was well agreed with the pseudo-second-order model and Langmuir model. Additionally, the functionalization of HCP-TTDs could be realized by the condensation reaction of 3-(2-aminoethylamino)propyl-dimethoxymethylsilane (AAMD) and the alkali-treated porous polymer. The functionalized HCP-TTD displayed high adsorption performance for chromium ion, and the adsorption capacity was up to 76.9 mg g −1 , which is higher than many reported adsorbents. Therefore, HCP-TTDs are promising candidates for the removal of dyes and chromium ion from wastewater. Graphical abstract
研究领域:
材料科学
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环境工程
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化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）