JOURNAL OF MOLECULAR LIQUIDS
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2024
·
IF 5.3
Bolun Mei,Yueru Wang,Jianhua Zhou,Xingchuan Yang,Yi Yu,Li Xu,Guoji Liu
To meet the demand of separating and purifying 1-naphthylamine from the reaction production and filling the solubility data gap, the solubility of 1-naphthylamine in twelve pure solvents (acetone, acetonitrile, ethyl acetate, n-butyl acetate, cyclohexane, n-heptane, methanol, ethanol, n-propanol, iso-propanol, n-butanol, and iso-butanol) was experimentally investigated in the range from 273.15 K to 308.15 K. It was found that the solubility of 1-naphthylamine increases markedly with increasing temperature in all solvent systems. The maximum solubility was 0.8978 (in the solvent of acetone, T = 308.15 K) and the minimum solubility was 0.005485 (in the solvent of n-heptane, T = 273.15 K). Then the experimental solubility data was correlated by the modified Apelblat model, Van't Hoff model, NRTL model, Wilson model, and Margules model. ARD% was calculated to assess the accuracy of the five equations and the results indicated that the modified Apelblat model fits optimally with an average ARD% value of 1.62 %. The effects of various physicochemical properties such as solvent polarity, hydrogen bond donor, hydrogen bond acceptor, and cohesive energy density on solute dissolution behavior were explored. In addition, the apparent thermodynamic properties of 1-naphthylamine in different solvents were analyzed based on modified Van’t Hoff model, which indicated the dissolution process of 1-naphthylamine in selected solvents is endothermic and entropy-driving. Finally, the effect of intermolecular interactions on the dissolution behavior was investigated at the molecular scale through molecular dynamics simulation studies, including molecular electrostatic potential surface, solvation free energy and radial distribution function analysis. This work will provide a fundamental guidance for the crystallization, separation, and purification of 1-naphthylamine.
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ACS Sensors
·
2024
·
IF 8.2
Chunning Chen,Jiaqi Liu,Jiaxin Lu,Yalei Wang,Jingtong Zhai,Hongkun Zhao,Nan Lu
As one of the common carriers of biological information, along with human urine specimens and blood, exhaled breath condensate (EBC) carries reliable and rich information about the body’s metabolism to track human physiological normal/abnormal states and environmental exposures. What is more, EBC has gained extensive attention because of the convenient and nondestructive sampling. Facemasks, which act as a physical filter barrier between human exhaled breath and inhaled substances from the external environment, are safe, noninvasive, and economic devices for direct sampling of human exhaled breath and inhaled substances. Inspired by the ability of fog collection of Namib desert beetle, a strategy for in situ collecting and detecting EBC with surface-enhanced Raman scattering is illustrated. Based on the intrinsic and unique wettability differences between the squares and the surrounding area of the pattern on facemasks, the hydrophilic squares can capture exhaled droplets and spontaneously enrich the analytes and silver nanocubes (AgNCs), resulting in good repeatability in situ detection. Using R6G as the probe molecule, the minimal detectable concentration can reach as low as 10–16 M, and the relative standard deviation is less than 7%. This proves that this strategy can achieve high detection sensitivity and high detection repeatability. Meanwhile, this strategy is applicable for portable nitrite analysis in EBC and may provide an inspiration for monitoring other biomarkers in EBC.
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JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Yiran Xia,Lushuai Wang,Yang Liu,Jiawei Liu,Quan Bai
Covalent organic frameworks (COFs) show promise as a stationary phase in high performance liquid chromatography (HPLC). However, there are only a few COFs-based stationary phases developed for HPLC separation so far. Therefore, it is crucial to not only develop more varieties of COFs-type stationary phases for HPLC separation, but also to explore the retention mechanism of solutes on these stationary phases. In this paper, a new in-situ growth method was developed to prepare β -ketoenamine COF-TpPa-1@SiO 2 composite microspheres, using spherical silica as the core material and COF-TpPa-1 fabricated by covalent conjugation of 1,3,5-triformylphloroglucinol (Tp) and p -phenylenediamine (Pa-1) as the COF shells. The resulting microspheres exhibit uniform morphology, good monodispersity, large specific surface area, narrow size distribution, and high stability. Due to diverse functional groups in the structure of COF-TpPa-1, the microspheres can offer multiple interactions, such as hydrophobic, π-π stacking and electron-donor–acceptor (EDA) between COFs and analytes. As a result, the COF-TpPa-1@SiO 2 composite microspheres can be used as a mixed-mode stationary phase for HPLC separation. The chromatographic performance and retention mechanism of the COF-TpPa-1@SiO 2 packed column were investigated by separating polar and non-polar solutes, as well as isomers, in various HPLC modes, including reversed-phase liquid chromatography (RPLC), hydrophilic interaction chromatography (HILIC), and RPLC/HILIC mixed-mode chromatography. The results showed successful separation of non-polar alkylbenzene homologues, polycyclic aromatic hydrocarbons (PAHs), and polar amines and phenols in RPLC mode. The “U-shaped” curves of retention factor with the ACN concentration in mobile phase for four nucleobases indicated that the solute retention on the column followed a mixed mode mechanism of RPLC/HILIC. Compared to a traditional C18 column, the COF-TpPa-1@SiO 2 column exhibited superior separation efficiency, stability, repeatability and reproducibility in the separation of analytes with different polarities. The column enhanced the aromatic, shape and planar selectivity for PAHs and isomers through π-π interaction and improved the separation efficiency for electron-deficient compounds due to EDA effect. At last, the column was successfully used to separate and detect the residues of 5 phenylurea herbicides (PUHs) in soil. All these results indicate the potential of COFs for chromatography applications.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2024
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IF 6
Xianqing Huang,Wenxin Li,Jing Wang,Qian Li,Yue Shen,Yongxia Cheng,Tiange Li,Tianlin Wang,Yinping Wang,Lianjun Song,Yan Ma
In this paper, the effects of NaCl stress on physiological and biochemical changes, phenolic compounds and antioxidant system of pea sprouts were studied. Results showed that NaCl stress inhibited the bud length, root length and respiration rate of pea sprouts, and resulted in oxidative damage. However, NaCl promoted the accumulation of total phenolics in pea sprouts, which reached a peak under 60 mmol L −1 NaCl stress. At the same time, the key enzymes activities of PAL, C4H, and 4CL were enhanced. In addition, NaCl stress increased the activity of POD, CAT, SOD and APX, enhancing the antioxidant capacity of pea sprouts. The enrichment of phenolic compounds and the increase of antioxidant enzyme activity together promoted the enhancement of antioxidant capacity. This results provided a scientific basis for further improving the functional components of pea.
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Science China-Chemistry
·
2018
·Vol. 61
·期 5
·569-575
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IF 4.448
Xiao Jiangang,Hu Yu,Du Jianzhong
It is an important challenge to make disk-like polymeric nanostructures. Herein we report a facile method for preparing polymer nanodisks by self-collapse of nanocapsules self-assembled from a statistical copolymer after partial hydrolysis. We find that partial hydrolysis of the statistical copolymer is crucial for the formation of nanodisks as it affords a suitable rigidity for the membrane of nanocapsules. The nanodisk structure has been confirmed by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and atomic force microscopy (AFM) studies with a thickness of 6.3±0.2 nm. Overall, our results demonstrated a new method for making disk-like nano-objects.
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EUROPEAN JOURNAL OF PHARMACOLOGY
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2024
·
IF 4.2
Xuening Chen,Changkun Chen,Chengmiao Luo,Jianyong Liu,Zhonghui Lin
The emergence of chemoresistance poses a significant challenge to the efficacy of DNA-damaging agents in cancer treatment, in part due to the inherent DNA repair capabilities of cancer cells. The Ku70/80 protein complex (Ku) plays a central role in double-strand breaks (DSBs) repair through the classical non-homologous end joining (c-NHEJ) pathway, and has proven to be one of the most promising drug target for cancer treatment when combined with radiotherapy or chemotherapy. In this study, we conducted a high-throughput screening of small-molecule inhibitors targeting the Ku complex by using a fluorescence polarization-based DNA binding assay. From a library of 11,745 small molecules, UMI-77 was identified as a potent Ku inhibitor, with an IC 50 value of 2.3 μM. Surface plasmon resonance and molecular docking analyses revealed that UMI-77 directly bound the inner side of Ku ring, thereby disrupting Ku binding with DNA. In addition, UMI-77 also displayed potent inhibition against MUS81-EME1, a key player in homologous recombination (HR), demonstrating its potential for blocking both NHEJ- and HR-mediated DSB repair pathways. Further cell-based studies showed that UMI-77 could impair bleomycin-induced DNA damage repair, and significantly sensitized multiple cancer cell lines to the DNA-damaging agents. Finally, in a mouse xenograft tumor model, UMI-77 significantly enhanced the chemotherapeutic efficacy of etoposide with little adverse physiological effects. Our work offers a new avenue to combat chemoresistance in cancer treatment, and suggests that UMI-77 could be further developed as a promising candidate in cancer treatment.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Yanyan Chen,Hao Deng,Pengliang Liang,Heng Yang,Long Jiang,Jing Yin,Jia Liu,Shuying Shi,Huiqiang Liu,Yuxiang Li,Ying Xiong
Sustainable photocatalysis can effectively reduce the radioactive 99TcO4– to less soluble TcO2·nH2O(s), but the reduction efficiency is highly susceptible to coexisting nitrate (NO3–). Here, we quantitatively investigate photocatalytic remediation conditions for Tc-contaminated water stimulated by the analogue perrhenate (ReO4–) in the presence of NO3–, and we elucidate the influence mechanism of NO3– by in situ characterizations. The interfering NO3– can compete with Re(VII) for the carbonyl radical (·CO2–) produced by formic acid (HCOOH) oxidation to generate nitrogen-containing products such as NH4+, NO2–, and NOx, resulting in the decrease in the Re(VII) reduction ratio. Under the conditions of 4% (volume ratio) HCOOH and pH = 3, the yield of NOx is the lowest, and the selectivity of N2 reaches 93%, which makes the overall reaction more in line with the pollution-free concept. The X-ray absorption fine structure reveals that the redox product Re(IV) mainly exists in the form of ReO2·nH2O(s) and is accompanied by a decrease with the increase in NO3– concentration. Re(VII)/Tc(VII) reduction suffers from a serious interferential effect of NO3–, whereas the higher the concentration of NO3–, the more conducive to slowing down the reoxidation of the reduction products, which is advantageous for the subsequent sequestration or separation.
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JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Yali Yang,Jia Chen,Xiaojing Liang,Bei Liu,Kaijun Quan,Xiuhui Liu,Hongdeng Qiu
In this paper, three imidazole- and C18- bifunctional silica stationary phases (Sil-Im-C18) were prepared by adjusting introduction interval of octadecyltrichlorosilane (ODS) and 3-imidazol-1-ylpropyl(trimethoxy)silane (TMPImS), which can be used for reversed-phase liquid chromatography (RPLC) and ion exchange chromatography (IEC) with adjustable performance. The successful preparation of Sil-Im-C18 were confirmed by the characterizations of elemental analysis, infrared spectroscopy (FTIR) and contact angle (CA). Chromatographic performance of Sil-Im-C18 were evaluated by the separation of Tanaka test mixture, alkylbenzenes, linear PAHs and a set of analytes with different properties (uracil, phenol, 1,2-dinitrobenzene and naphthalene), and compared with commonly used C18 column. It was found that the chromatographic performance of Sil-Im-C18 changed significantly with the difference in bonding amount of imidazole and C18. Sil-Im-C18 demonstrated the excellent separation performance towards polycyclic aromatic hydrocarbons (PAHs), phenylesters, phenylamines , phenols and inorganic anions, and notably, nucleobases and nucleosides can be separated using pure water as mobile phases . The van Deemter plot showed that the column efficiency of Sil-Im-C18-3 was 64,933 plate· m − 1 for naphthalene, indicated that Sil-Im-C18 was reasonably chromatographic columns. The RSD values of retention time were 0.22 %-0.61 % for 10 needles alkylbenzenes injected continuously at 50 °C to investigate thermal stability and repeatability, all the fluctuations of k of naphthalene were less than 2.3 % for Sil-Im-C18-1 during flushing 24 h with the mobile phase at different pH values (pH = 3 and 8), the retention time of alkylbenzenes were almost same for Sil-Im-C18-1 at different time, the RSD values of retention time of alkylbenzenes were 0.45 %-2.28 % for two batches Sil-Im-C18-1, revealing the excellent repeatability, thermal stability, durability and reproducibility of Sil-Im-C18, and implying a commercial prospect.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Zhaofen Xu,Lingfang Tang,Yuanyi Zhou,Gang Lu,Haojie Dong,Mingshan Zhu
Utilizing the immanent salt (Cl – ) in wastewater to generate reactive chlorine species (RCS) satisfies the future needs for sustainable, on-demand, and decentralized ammonia nitrogen (NH 4 + -N) removal. The microstructural evolution of bismuth oxychloride (BiOCl) photocatalyst under irradiation benefits for overcoming the competition between Cl – and H 2 O oxidation and achieving high N 2 selectivity. Herein, internal electric field (IEF) engineering by carbon doping is applied to promote photocatalytic RCS generation rate over BiOCl. The carbon dopant not only enhances the IEF intensity of BiOCl by a factor of 2.1 times for carrier dynamics promotion, but also improves Cl – oxidation against H 2 O oxidation. An RCS production rate of 0.23 mg/L min −1 is realized over carbon-doped BiOCl (C-BiOCl) through the accelerated interaction between lattice and environmental Cl – , which is twice that of the undoped BiOCl (0.11 mg/L min −1 ). The relation between IEF intensity and RCS generation rate over C-BiOCl manifests a correlation coefficient of 0.96. Effective NH 4 + -N degradation with N 2 selectivity of >99% is validated. The system is competent in dealing with saline NH 4 + -N wastewater with a wide range of NH 4 + -N (20∼200 mg N/L) and NaCl (6∼10 g/L) concentrations. In the treatment of realistic landfill leachate (884 mg N/L NH 4 + -N), C-BiOCl displays a photocatalytic NH 4 + -N removal efficiency of up to 95.6% while maintaining the NO 2 − -N (∼2 mg N/L) and NO 3 − -N (∼40 mg N/L) levels. This system provided an interesting and innovative idea for wastewater self-purification.
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TALANTA
·
2020
·
IF 5.339
Xin-Qiao He,Yuan-Yuan Cui,Cheng-Xiong Yang
Development of efficient adsorbents for the enrichment of trace contaminants from complex matrix still remains great challenge and interest. Here we report the decoration of amino microporous organic network on zeolitic imidazolate framework (ZIF)-67 derived nitrogen-doped carbon (Co@NC-MON-2NH 2 ) for efficient magnetic solid phase extraction (MSPE) of plant growth regulators (PGRs) from vegetables. The ZIF-67 was calcined to produce Co and N co-doped porous carbon (Co@NC), serving as the magnetic separation module and the core for in-situ growth of MON-2NH 2 shell. The Co@NC-MON-2NH 2 owned large surface area, good magnetic property and stability, giving high affinity to PGRs via multiple extraction mechanisms such as hydrogen bonding , π-π and hydrophobic interactions. Under optimal conditions, the Co@NC-MON-2NH 2 based MSPE-HPLC-UV method gave wide linear range, good precisions, large enrichment factors, less adsorbent consumption and low limit of detections for the studied PGRs. The proposed MSPE-HPLC-UV method was also successfully applied to monitor the trace PGRs in diverse vegetables. These results not only revealed the promise of Co@NC-MON-2NH 2 in extraction and adsorption of environmental contaminants from complex matrix, but also provided a new way to fabricate magnetic functionalized MONs in environmental science.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Pengpeng Lu,Jincheng Cheng,Yifan Li,Li Li,Qiang Wang,Chiyang He
A novel porous β ‐cyclodextrin/pillar[5]arene copolymer was prepared using tetrafluoroterephthalonitrile as cross-linker for rapid removal of variety of organic pollutants. The copolymer was characterized by water contact angle, scanning electron microscope, FT-IR spectrum, solid-state 13 C NMR spectrum, thermo-gravimetric analysis, nitrogen adsorption-desorption isotherms, and elemental analysis. Results showed that the co-polymer had good water immersibility, co-existing micro-/meso-pores, and a large specific surface area (BET) of 479 m 2 /g. The copolymer presented high adsorption capacity with the maximum adsorption capacity of 258 mg/g for bisphenol A and good reusability and reproducibility. It also showed fast binding kinetics with the apparent second-order rate constants of 0.109−0.179 g/mg·min and simultaneously rapid removal ability with removal efficiencies of 74–90% within 30 s for variety of organic pollutants. The new copolymer can be potentially used as adsorbent for rapidly removing a wide range of organic pollutants in wastewater.
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JOURNAL OF CHROMATOGRAPHY A
·
2016
·
IF 3.926
Li-Hua Liu,Cheng-Xiong Yang,Xiu-Ping Yan
Covalent-organic frameworks (COFs) are a newfangled class of intriguing microporous materials. Considering their unique properties, COFs should be promising as packing materials for high performance liquid chromatography (HPLC). However, the irregular shape and sub-micrometer size of COFs synthesized via the traditional methods render the main obstacles for the application of COFs in HPLC. Herein, we report the preparation of methacrylate-bonded COF monolithic columns for HPLC to overcome the above obstacles. The prepared COF bonded monolithic columns not only show good homogeneity and permeability, but also give high column efficiency, good resolution and precision for HPLC separation of small molecules including polycyclic aromatic hydrocarbons, phenols, anilines, nonsteroidal anti-inflammatory drugs and benzothiophenes. Compared with the bare polymer monolithic column, the COF bonded monolithic columns show enhanced hydrophobic, π-π and hydrogen bond interactions in reverse phase HPLC. The results reveal the great potential of COF bonded monoliths for HPLC and COFs in separation sciences.
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