Materials
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2022
·Vol. 15
·期 23
·8398-8398
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IF 3.748
Ze Wang,Zhiqiang He,Bohua Duan,Xinli Liu,Dezhi Wang
Porous NiTi alloys are widely applied in the field of medical implant materials due to their excellent properties. In this paper, porous NiTi alloys were prepared by non-aqueous gel-casting. The influence of solid loading on the process characteristics of slurries and the microstructure and mechanical properties of sintered samples were investigated. The viscosity and the stability of slurry significantly increased with the growth of solid loading, and the slurry had better process characteristics in the solid loading range of 40-52 vol.%. Meanwhile, the porosity and average pore diameter of the sintered NiTi alloys decreased with a rise in the solid loading, while the compressive strength increased. Porous NiTi alloys with porosities of 43.3-48.6%, average pore sizes of 53-145 µm, and compressive strengths of 87-167 MPa were fabricated by gel-casting. These properties meet the requirements of cortical bone. The results suggest that the pore structure and mechanical properties of porous NiTi products produced by gel-casting can be adjusted by controlling the solid loading.
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Metabolic Engineering Communications
·
2022
·
IF 0
Yushi Liu,Wan-Qiu Liu,Shuhui Huang,Huiling Xu,Haofan Lu,Changzhu Wu,Jian Li
Fatty acid-derived products such as alkanes, fatty aldehydes, and fatty alcohols have many applications in the chemical industry. These products are predominately produced from fossil resources, but their production processes are often not environmentally friendly. While microbes like Escherichia coli have been engineered to convert fatty acids to corresponding products, the design and optimization of metabolic pathways in cells for high productivity is challenging due to low mass transfer, heavy metabolic burden, and intermediate/product toxicity. Here, we describe an E. coli -based cell-free protein synthesis (CFPS) platform for in vitro conversion of long-chain fatty acids to value-added chemicals with product selectivity, which can also avoid the above issues when using microbial production systems. We achieve the selective biotransformation by cell-free expression of different enzymes and the use of different conditions (e.g., light and heating) to drive the biocatalysis toward different final products. Specifically, in response to blue light, cell-free expressed fatty acid photodecarboxylase (CvFAP, a photoenzyme) was able to convert fatty acids to alkanes with approximately 90% conversion. When the expressed enzyme was switched to carboxylic acid reductase (CAR), fatty acids were reduced to corresponding fatty aldehydes, which, however, could be further reduced to fatty alcohols by endogenous reductases in the cell-free system. By using a thermostable CAR and a heating treatment, the endogenous reductases were deactivated and fatty aldehydes could be selectively accumulated (>97% in the product mixture) without over-reduction to alcohols. Overall, our cell-free platform provides a new strategy to convert fatty acids to valuable chemicals with notable properties of operation flexibility, reaction controllability, and product selectivity.
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FUEL
·
2023
·
IF 7.4
Yibo Zhang,Wei Wang,Chunlai Liu,Peihang Shen,Zelong Liu,Jianglei Hu,Fengwei Shi
In this work, we successfully synthesized a novel composite (HPW@MOF-199/SBA-15C, PMS-15C) in which MOF-199 encapsulated HPW catalyst (named HPW@MOF-199) was confined in SBA-15C, which is the carboxy-functionalized SBA-15. Physicochemical properties of the composites PMS-15C were systemically characterized by N 2 adsorption–desorption isotherms, wide-angle and low-angle XRD, XPS, FT-IR, SEM, and TEM. The results exhibited that HPW@MOF-199 had been successfully synthesized and embedded into the SBA-15C pores by COOH on the surface of SBA-15C. Meanwhile, the composites PMS-15C exhibited high activity and excellent reuse properties in the esterification reaction of acetic acid and ethanol, and no evidence of aggregation, leaching, or inactivation of HPW@MOF-199 during repeated use. The good dispersion of HPW within the MOF-199 cage and the interaction between HPW@MOF-199 and SBA-15C may be responsible for the good catalytic activity as well as the high stability of PMS-15C.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
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IF 4.2
Si-Ke Chen,Da-Wei Pan,Zhuang Liu,Wei Wang,Rui Xie,Xiao-Ting Mu,Xiao-Jie Ju,Liang-Yin Chu
A simple microfluidic strategy is proposed for the controllable preparation of calcium alginate/chitosan (CaA/CS) microcapsules with ultrathin shells for peroxidase immobilization. In this study, the composite microcapsules are composed of CaA and CS, which are beneficial to improve the stability of CaA microcapsules, and are generated using a two-stage capillary microfluidic device. The inner layer of the composite capsule shells is ionically cross-linked CaA, and the outer layer is covalently cross-linked CS. Moreover, the Fe3O4 magnetic nanoparticles are added to facilitate the recovery and reuse of the composite microcapsules. The morphology, permeability, encapsulation efficiency, enzyme activity, and reusability of CaA/CS microcapsules are investigated. The overall thickness of the double-layered shell is about 346 nm. Meanwhile, the microcapsules have good molecular selective permeability, excellent encapsulation performance, stable enzyme activity, and good stability for reusability. The composite microcapsules retained above 80% of residual activity after six recycle uses. The developed novel strategy for fabricating peroxidase-immobilized CaA/CS microcapsules with ultrathin shells is of great potential value for enzyme immobilization applications.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2022
·
IF 3.269
Mai Han,Mingyi Xu,Yufan Pang,Jingwei Cao,Anle Zhang,Yuxin Wang,Jiajun Wei,Yujian Song,Qingsong Li
Ethyl acrylate (EA) has a wide range of uses, providing convenience for industrial production and daily life. The production process often produces water by-products, so this work selects four commonly used alcohols (1-pentanol, 1-hexanol, 1-heptanol, and 1-octanol) as extractants to explore the liquid–liquid equilibrium (LLE) of water + EA + extractants. Through the analysis of partition coefficient (D), and separation factor (S), it is found that the data of all systems are>1. At the same time, the RMSD% and AAD% calculated by the regression of thermodynamic models (NRTL and UNIQUAC) are both less than 1, indicating that all four alkyl alcohols can separate EA from aqueous solutions well, and 1-octanol has the best effect. Furthermore, the consistency of the LLE data is demonstrated using MATLAB tools.
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CHEMICAL ENGINEERING SCIENCE
·
2022
·
IF 4.889
Chenghao Gao,Sida Ling,Zhuo Chen,Yundong Wang,Jianhong Xu
Droplet microfluidic technology refers to the technique of preparing and controlling microscale monodisperse droplets by shear force and interfacial tension of two immiscible phases accurately, which has a wide range of applications in biomedicine, chemical reaction enhancement, nanoparticle preparation, and other fields due to its efficient mass and heat transfer, easy manipulation, rapid response, and high throughput. In the application of droplet microfluidic technology, coalescence often occurs due to the structural complexity of microchannels, which limits the practical application performance. The mechanism of droplet coalescence has been widely studied in conventional reactors, among which the liquid film drainage theory is the most widely accepted. To achieve accurate control of the droplet coalescence process, there have been many studies on droplet coalescence in microchannels. A variety of microchannel structures have been proposed and the mechanism and influencing factors of double droplets coalescence have been explored. However, most of the existing studies on coalescence are based on cross structures, mainly studying the coalescence of double droplets in confined systems. There is still a lack of research on the coalescence process of droplet swarms, which is more widespread in practical applications. Therefore, this work used the rectangular expansion structure to realize the droplet coalescence and explored the effects of two-phase flow rate, continuous phase viscosity, surfactant concentration, and the size of expanding channel on the droplet coalescence behavior. The coalescence types, probabilities, and size distributions of microdroplet swarms under different factors were summarized. The time distribution of liquid film drainage in the droplet coalescence process and the influence of various factors on it were further analyzed based on the liquid film drainage theory.
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Materials
·
2022
·Vol. 15
·期 20
·7331
·
IF 3.748
Zhiqiang He,Ze Wang,Dezhi Wang,Xinli Liu,Bohua Duan
Porous NiTi alloys were manufactured by integration of gel-casting and microwave sintering. The effects of sintering temperature on porosity, compressive strength, pore morphology and phase composition of sintered samples were researched. The results show that the porosity and the mean pore diameter of porous NiTi alloys decrease with increasing sintering temperature, whereas the content of the NiTi phase, the elastic modulus and compressive strength of sintered samples increase. When the gel body with the solid loading of 50 vol.% is microwave sintered at 1000 °C for 30 min, porous NiTi alloys are obtained with the porosity of 38.9%, the compressive strength of 254 MPa, elastic modulus of 4 GPa, and predominant phase of NiTi. The results suggest that the method is suitable for rapid preparation of large-size and complex-shape personalized products similar to human bones at a low cost.Keywords:gel-casting;porous NiTi alloy;microwave sintering;microstructure;mechanical properties
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Wenxia Sima,Kaisen Fan,Potao Sun,Tao Yuan,Ming Yang,Zhaoping Li,Fengqi Liu,Yao Yuan
Repairing the micro-scale damage of insulating materials under a strong electric field has long been a highly desired but challenging task. Among all kinds of damage, water tree damage in the insulating materials of electrical equipment and electronic devices working in humid environments has long been considered irreparable. The main challenge is that residual water prevents the healing agent from filling the water tree branch channel. To solve this problem, this work reports a magnetically targeted, water-triggered, self-healing microcapsule (MTWTSH-MC) that makes a breakthrough against water tree damage based on microfluidic techniques. Targeted microcapsules driven by a directional magnetic field are concentrated to the vulnerable area of the insulating materials, exerting very limited effects on the dielectric. When damage breaks the microcapsules, the healing agent releases and quickly fills the damage channel and then reacts with water in the air or in the branch channel of the water tree, achieving solidification of the healing agent and self-healing of the damage channels. In this way, we can realize self-perception, self-triggering, and self-healing for both mechanical damage and water tree damage in insulation materials without any external stimulation.
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Nanoscale
·
2022
·Vol. 14
·期 46
·17222-17229
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IF 8.307
Heng Lu,Xiaohong Tan,Guobin Huang,Shaoru Wu,Yanmei Zhou,Junying Zhang,Qiaowen Zheng,Tianju Chen,Feiming Li,Zhixiong Cai,Jingbin Zeng,Maosheng Zhang
Perovskite nanocrystals (PNCs) have attracted widespread attention as promising materials for the optoelectronic field due to their remarkable photophysical properties and structural tunability. However, their poor stability and the use of toxic organic solvents in the preparation process have severely restricted their practical applications. Herein, a facile, rapid and toxic organic solvent-free synthesis strategy of CsPbBr3 PNCs was developed for the first time via the ligand-assisted reprecipitation (LARP) method using natural deep eutectic solvents (NADESs) as solvents and surface ligands. In this method, the NADESs not only functioned as solvents for green synthesis, but also served simultaneously as surface ligands of CsPbBr3 PNCs to significantly improve their optical properties and stability. The as-synthesized CsPbBr3 PNCs exhibited high photoluminescence quantum yield (PLQY, ∼96.8%), narrow full width at half-maximum (FWHM, ∼18.8 nm) and a high stability that retained 82.9% of PL intensity after 70 days. This work provides a new strategy for the green synthesis of PNCs, which promises feasibility for the industrial large-scale synthesis of high-quality PNCs.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2022
·
IF 6.364
Haidong Wu,Wei Liu,Lifu Lin,Yong Chen,Yuerui Xu,Shanghua Wu,Zhenzhong Sun,Di An,Sai Wei,Zhipeng Xie
It is still a challenge to prepare high-performance ceramics due to the inherent problems of poor compatibility between ceramic powder and photosensitive resin in Vat photopolymerization . Herein, we used two types of coupling agents, aluminic acid ester and silane coupling agent, to modify Al 2 O 3 ceramic powder based on transesterification reactions. In addition, after pressureless sintering, hot isostatic pressing sintering was followed to further improve the mechanical performance of the Al 2 O 3 ceramic. Furthermore, Al 2 O 3 ceramic cutting tools with chip breaker grooves were prepared based on vat photopolymerization and adopted for cutting for the first time. Simulation and experimental results showed that the as-prepared ceramic cutting tool with grooves has the best surface processing quality and the medium flank wear amount compared with that without grooves and even Kyocera commercial ceramic cutting tool. The results open a new avenue for the preparation of high-performance and complex-shaped ceramic cutting tools in the future.
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MICROCHEMICAL JOURNAL
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2022
·
IF 5.304
Meichao Liao,Lin Yang,Xiaoyue Yang,Erxu Wang,Bin Lu,Jiye Wang,Li Duan
A novel green vortex-assisted liquid–liquid microextraction based on hydrophobic deep eutectic solvents (VALLME-HDES) technique was developed and applied to the urinary excretion study of Taraxacum mongolicum (TM) extract in rats. Deep eutectic solvent (DES), a less toxic extraction phase, was formed by camphor and 1-hexanol at a molar ratio of 1:2. The key factors affecting the extraction efficiency of the VALLME-HDES method, such as DES volume, vortex time, molar rations of camphor and 1-hexanol, and amount of salts, were systematically examined through one-factor-at-a-time strategy. Under optimum conditions, the developed method exhibited a good linearity (r ≥ 0.9994). The acceptable precision and repeatability were less than 1.10 % and 4.78 %, respectively. Recoveries from urine samples spiked at different concentration levels were 80.0–89.5 % (RSD ≤ 4.78 %). To further investigate the applicability and effectiveness of hydrophobic DES, the validated method was applied to the urinary excretion study of two flavone aglycones in rats after oral administration of the TM extract. The average 48 h cumulative urinary excretion of luteolin and diosmetin accounted for 0.12 % and 1.71 % of the respective administered dose. In addition, the greenness of the proposed method was assessed using the Analytical GREEnness (AGREE) tool. All these results indicated that the proposed method was feasible and efficient, which had great development potential for pharmacokinetic studies and clinical sample analysis.
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BIOCATALYSIS AND BIOTRANSFORMATION
·
2022
·
IF 2.325
Mingxin Zhu,Shuyi Guo,Rongchen Mang,Hua Zhou
Sebacic esters have excellent lubricity, thermal stability, and biodegradability and therefore are widely used as aerospace lubricants, metal working oil, or engine oil. They are mainly produced by chemical synthesis which, however, may cause environmental pollution, its enzymatic synthesis represents a more environmentally friendly alternative. A few reports have described the synthesis of sebacic esters employing immobilised lipases, but these biocatalytic reactions were exclusively carried out in solvent-free systems and thus, could have been limited by slow reaction rates and high reaction temperatures due to poor enzyme dispersion, low substrate solubility, and high viscosity of the reaction mixture. The current study investigated the biosynthesis of dioctyl sebacate in toluene by Novozym 435, a commercial immobilised lipase. The reaction parameters were investigated using the single factor approach and an orthogonal array design. The optimal conditions obtained were as follows: 10 mL toluene, sebacic acid,1 mmol (202.25 mg); molar ratio of sebacic acid to 1-octanol, 1:3; Novozym 435, 0.03 g; 4 Å molecular sieves, 1.5 g; reaction temperature, 40 °C; reaction time, 30 h. A dioctyl sebacate conversion rate of 93% was achieved under these optimal conditions. In particular, the addition of molecular sieves to the reaction mixture markedly improved the product yield. The reaction temperature was low enough to make the operation easy and energy-efficient and therefore, well suited for large-scale production.
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