JOURNAL OF RARE EARTHS
·
2024
·
IF 5.2
Aoyang Sha,Huifang Yang,Meiling Jiang,Zhengyan He,Zhenhu Liu,Zhigao Xu,Yaguang Du,Wu Ming,Ru'an Chi
Weathered crust elution-deposited rare earth ores (WREOs) are rich in medium and heavy rare earth. In order to improve the in-situ leaching process, which is prone to landslides and poor permeability, cationic hydroxyethyl cellulose (PQ-10) was used as a novel green swelling inhibitor and percolation promoter and was mixed with conventional leaching agent ammonium sulfate ((NH 4 ) 2 SO 4 ) to form a composite leaching agent to study the performance and mechanism of swelling inhibition and percolation promotion. Adding PQ-10 can inhibit the hydration swelling of WREOs, promote the percolation effect of the leaching agent, improve the rare earth (RE) leaching efficiency, and reduce the impurity aluminum (Al) leaching efficiency. Compared with the conventional leaching agent 2 wt% (NH 4 ) 2 SO 4 , the percolation time is reduced by 50% by using the composite leaching agent (0.02 wt% PQ-10+2 wt% (NH 4 ) 2 SO 4 ). PQ-10 has positively charged quaternary ammonium groups and hydrophilic group hydroxyl groups, which makes it easy to adsorb on WREOs multiple sites through electrostatic interaction and hydrogen bonding, weakening the electrostatic repulsion between mineral particles, reducing the WREOs interlayer spacing, compressing the double electric layer thickness at the solid-liquid interface, weakening the mineral hydration swelling and increasing the percolation rate. The long carbon chains of the polymer entangle and link the fine mineral particles to agglomerate them, increasing their particle size and reducing their hydration dispersion, and preventing blockage of the percolation pores caused by migration of the fine particles through the ore body with the solution. PQ-10 molecules also insert the mineral interlayer and expulsion of the internal water, further inhibiting the swelling of WREOs. Adding PQ-10 reduces the surface tension of (NH 4 ) 2 SO 4 solution, improving the spreading and spreading ability of the solution, reducing the adhesion work between molecules in the solid-liquid phase and the adhesion work reduction factor. It proves that PQ-10 promotes the percolation effect of the leaching process of WREOs. In addition, PQ-10 expands the leaching pore size and seepage channels, further improving the percolation rate.
研究领域:
矿物学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
APPLIED RADIATION AND ISOTOPES
·
2012
·
IF 1.172
Zhen-feng Liu,Guo-lin Wang,Meng-jie Dong,Qian Zhang,Jia-jun Li,Kui Zhao,Shu-ye Yang,Xiang-tong Lin
10-[ 11 C]methoxy-20(S)-camptothecin was synthesized automatically. The radiochemical yield was 30%–50% (all calculated at EOB, n =20) with [ 11 C]methyl triflate as a methylating agent. The radiochemical purity was greater than 96%, and the specific activity was 8.72±2.18 GBq/μmoL at EOS . Biodistribution showed that 10-[ 11 C]methoxy-20(S)-camptothecin is characterized by quick clearance from the blood and by significant uptake in the liver (5.72±1.92% ID/g at 15 min), intestines (2.43±0.38% ID/g at 15 min), and kidney (1.57±0.85% ID/g at 15 min). Micro-PET imaging clearly showed high radioactivity accumulation in liver, intestines and bladder, indicating that the primary modes of excretion of the radiotracer are through the hepatobiliary system and, to a lesser extent, through the renal system.
研究领域:
药理学
·
核医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2023
·Vol. 19
·期 34
·2300801
·
IF 13.3
Chen Chen,Quan-Wei Cai,Cai-Zhen Zhan,Bi-Cong Wang,Ping-Fan Li,Rui Xie,Xiao-Jie Ju,Zhuang Liu,Wei Wang,Liang-Yin Chu
Sub-10 nm nanoparticles are known to exhibit extraordinary size-dependent properties for wide applications. Many approaches have been developed for synthesizing sub-10 nm inorganic nanoparticles, but the fabrication of sub-10 nm polymeric nanoparticles is still challenging. Here, a scalable, spontaneous confined nanoemulsification strategy that produces uniform sub-10 nm nanodroplets for template synthesis of sub-10 nm polymeric nanoparticles is proposed. This strategy introduces a high-concentration interfacial reaction to create overpopulated surfactants that are insoluble at the droplet surface. These overpopulated surfactants act as barriers, resulting in highly accumulated surfactants inside the droplet via a confined reaction. These surfactants exhibit significantly changed packing geometry, solubility, and interfacial activity to enhance the molecular-level impact on interfacial instability for creating sub-10 nm nanoemulsions via self-burst nanoemulsification. Using the nanodroplets as templates, the fabrication of uniform sub-10 nm polymeric nanoparticles, as small as 3.5 nm, made from biocompatible polymers and capable of efficient drug encapsulation is demonstrated. This work opens up brand-new opportunities to easily create sub-10 nm nanoemulsions and advanced ultrasmall functional nanoparticles.
研究领域:
材料科学
·
纳米技术
·
制药工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Zhizhen Qin,Siyuan Gong,Xiangwen Zhang,Qincheng Bi,Zhaohui Liu,Guozhu Liu
Density is one of the most important thermophysical properties of aviation fuel for the advanced fuel-cooled thermal management. The density of a hydrocarbon fuel JP-10 was measured using a gamma-ray radial method calibrated with deionized water, cyclohexane, and a mixture of n-heptane and n-octane. The average absolute deviation (AAD) of deionized water is 0.22% under 3.0 MPa and 0.43% under 5.0 MPa, that of cyclohexane is 0.80% under 5.0 MPa, and that of the mixture of n-heptane and n-octane is 0.33% under 5.1 MPa. The experimental density of JP-10 was reported at 267 to 873 K under the pressure of 0.70 to 6.00 MPa. Two empirical correlations were used to fit the liquid and gas density data separately. The results are that the AAD for all the liquid data is 0.46%, and that for all the gas data is 6.12%. Finally, the isobaric thermal expansion was calculated.
研究领域:
热力学
·
能源工程
✓ 已验证
DOI
高影响因子
PHYTOMEDICINE
·
2025
·
IF 8.3
Feng Jia,Yongqing Wang,Zhiqiang Chen,Jingxian Jin,Lei Zeng,Li Zhang,Huaijian Tang,Yanyan Wang,Pei Fan
Background 10-Hydroxydec-2-enoic acid (10-HDA), a unique and marker compound in royal jelly, has a wide range of bio-activities. However, its role in regulating inflammation of vascular smooth muscle cell (VSMC), which is essential to a set of vascular diseases, is still unknown. Purpose Our study aimed to investigate whether 10-HDA exerts effect on VSMC inflammation via interacting with toll-like receptor 4 (TLR4), a pivotal inflammatory initiator. Methods A package of proteins, which might participate in TLR4-mediated signaling, influenced by 10-HDA were analyzed in mouse VSMCs with Angiotensin Ⅱ(Ang Ⅱ) or lipopolysaccharide (LPS) stimulation. Accordingly, pro- or anti-inflammatory cytokines, reactive oxygen species (ROS), and anti-oxidants that are closely relevant to inflammatory process were determined. The possible mode for 10-HDA interacting with TLR4 was also characterized. Moreover, involvement of a key miRNA in 10-HDA regulating VSMC inflammation was identified. Results In the presence of Ang Ⅱ, 10-HDA inhibited the TLR4 expression in a dose-dependent manner. In such occasion, 10-HDA hindered the up-regulation of specificity protein 1 (SP1) and serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C), the phosphorylation of extracellular signal-regulated kinase 1/2, TGF-β-activated kinase 1, and nuclear factor-κB p56, as well as the enhancement of myeloid differentiation primary response gene 88. Apart from SP1 and PPP6C, the level change of these proteins by 10-HDA was similar with LPS stimulation. The effect might be resulted from 10-HDA blocking TLR4 through multiple atomic interactions. 10-HDA mitigated the increase of pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-2 (IL-2), and IL-6, as well as increased the anti-inflammatory cytokine IL-10, in the Ang Ⅱ- or LPS-induced VSMCs. Correspondingly, the level of ROS was attenuated and the anti-oxidants such as glutathione and superoxide dismutase were fortified. The data indicated the anti-inflammatory potential of 10-HDA in VSMCs, which was associated with 10-HDA's capability of relieving oxidative stress. Additionally, the expression of miR-17–5p was saved by 10-HDA from Ang Ⅱ- or LPS-treated VSMCs, which might be relevant to SP1 and PPP6C targeting. Conclusion The present work of 10-HDA, for the first time, revealed its ability to alleviate VSMC inflammation by targeting TLR4 and therefore modulate the downstream inflammatory participants. Our data will cast light on the utilization of 10-HDA in VSMC inflammation-related vascular disorders.
研究领域:
药理学
·
分子生物学
·
心血管疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Daoan Sun,Chunying Li,Yuan Li,Yongmei Du,Chuyi Zhang,Jiangwei Li,Jian Lu
JP-10 as a representative polycyoalkane has high energy density and volumetric hydrogen storage capacity, which makes it very suitable for hydrogen production onboard by catalytic reforming. Monometallic Ni and bimetallic Ni-M (M = Fe, Co, and Cu) catalysts supported on γ-Al 2 O 3 were prepared by incipient-wetness co-impregnation method. Effects of the second metal M on the catalytic performance of Ni/γ-Al 2 O 3 for hydrogen production by steam reforming of JP-10 were investigated in a coated microchannel reactor. The catalysts were characterized by N 2 adsorption–desorption, XRD, XPS, TEM, NH 3 -TPD, TG, H 2 -TPR, and Raman techniques. The results showed that the catalytic performance of Ni-M/γ-Al 2 O 3 deeply depended on the second metal M, in which Ni-Fe/γ-Al 2 O 3 was the best in terms of JP-10 conversion (82.9 %), H 2 selectivity (63.9 %), and coke amount (0.091 g coke/g cat. · h) under reaction conditions of 750 °C, 1.0 bar, steam to carbon of 2.4, weigh hourly space velocity of 472 h −1 . The doping of Fe formed highly dispersed Ni 3 Fe alloy crystallite for NFeA catalyst, and the average particle size is about 12.2 nm. Fe facilitated surface migration of Ni 0 species resulting in higher surface concentrations of Ni 0 species, thus enhanced the catalytic activity. In addition, Fe moderated the interaction between the support and nickel oxide particles, and promoted the reducing property of calcined catalysts overall, which ensured excellent resistance to sintering and high activity. The amount of weak and medium acid in the reduced NA catalyst were increased due to the presence of Fe, which improved activity and simultaneously avoided severe carbon formation. After reaction, NFeA catalyst produced much whisker graphite carbon, while the spent NA catalyst mainly generated amorphous carbon. NFeA catalyst maintained good stability over time on stream of 50 h, and severe carbon deposition, rather than the sintering of the active components, was the main cause of the catalyst deactivation. This work may provide important guidance for catalyst design applied to steam reforming of polycyoalkanes.
研究领域:
催化化学
·
能源材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AEROSOL SCIENCE
·
2021
·
IF 3.433
Yiliang Liu,Michel Attoui,Yueyang Li,Jianmin Chen,Qing Li,Lin Wang
A butanol-based fast condensation particle counter (Fast CPC, Model 3650, Kanomax Inc., Japan) was characterized in this study with three different types of monodisperse particles, including positively and negatively charged nickel-chromium (Ni/Cr) particles, positively charged tetraheptyl ammonium bromide (THABr) and tetrabutyl ammonium bromide (TBABr) particles, and positively charged polyethylene glycol (PEG) particles. The PEG particles were characterized with varied numbers of charges, whereby the charge number effect on particle activation was investigated. The performance of the Fast CPC was compared with a TSI® 3775 CPC and a TSI® 3776 CPC, respectively, under both factory temperature settings and boosted temperature settings, the latter of which corresponded to the brink of butanol homogeneous nucleation. Our results show that size-resolved Ni/Cr particles were detected by the Fast CPC with comparable detection efficiencies regardless of the charge polarity. When the charge number on a PEG particle increased from 1 to 3, an increasing tendency of the detection efficiency was observed, hinting that multiple charges on a particle will facilitate its activation. Particle activation was affected by the particle chemical composition as well, which is suggested by the higher activation efficiencies of PEG particles than those of Ni/Cr particles. The effects of multiple charges and chemical composition on particle activation were both more significant under factory temperature settings, but became less pronounced under boosted temperature settings. In addition to a quicker response time, the Fast CPC was capable of detecting sub-3 nm particles under boosted temperature settings, with the detection efficiency higher than that of the 3775 CPC but lower than that of the 3776 CPC, and can be used as a good candidate for the measurement of rapidly varying concentrations of small particles.
研究领域:
大气科学
·
仪器科学与技术
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Yumeng Zhao,Guoshu Gao,Peng Zhu,Haiou Liu,Yu Guo,Xiongfu Zhang
The preparation of stable metal–organic framework tubular membranes for liquid mixture separation has always been a tough problem. Herein, a flexibly prepared, continuous, and stable Al-based CAU-10 membrane with ceramic tubes as support was developed by a thin γ-Al2O3 layer induction method and employed for the first time in the separation of MeOH/MTBE azeotropic mixtures through pervaporation. The γ-Al2O3 layer introduced on the tube by the dip-coating technique not only facilitated the crystal nucleation and continuous growth of CAU-10 membranes but also reinforced the membrane stability by acting as anchoring sites between the membrane and the substrate. The as-prepared CAU-10 tubular membrane exhibited excellent separation performance for MeOH/MTBE mixtures owing to its suitable pore size and good hydrophilicity. For the separation of 14.3 wt % MeOH/MTBE azeotropic mixtures, the membrane displayed a permeation flux of 1.76 kg/(m2 h) and a high separation factor of 2041 at 50 °C, which is better than most of the membranes reported for the pervaporation separation of MeOH/MTBE mixtures. More excitedly, the CAU-10 tubular membrane continued to be tested for more than 7 days without any obvious change in pervaporation performance, demonstrating its outstanding operational and hydrothermal stability. Accordingly, the CAU-10 tubular membrane would be a promising alternative to separate the MeOH/MTBE azeotropic mixtures due to its easy preparation, high performance, and excellent stability.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 6
·1597-1603
·
IF 6.641
Ming Liu,Meixiang Yang,Yuqing Yao,Yingjie Zhang,Yunqian Zhang,Zhu Tao,Qianjiang Zhu,Gang Wei,Bing Bian,Xin Xiao
We report herein a cucurbit[10]uril-based porous supramolecular assembly (A) that is readily obtained in the presence of [ZnCl4]2− as a structure-directing agent in HCl solution. Loading the Q[10]-based porous supramolecular assembly A with various fluorophore guests, including various dyes and fused-ring compounds, yielded solid luminescent materials showing fluorescence enhancement or quenching or emission color change. Moreover, these solid luminescent materials could respond to certain volatile organic compounds. In particular, the assembly obtained by loading A with 1,8-diaminonaphthalene exhibited a distinct response to formaldehyde and could be used as a solid sensor.
研究领域:
化学
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2022
·Vol. 32
·期 8
·2986-2993
·
IF 3.518
Hao Bei-bei,Deng Xiu-zhen,Yang Jia-ke,Jia Ying-dong,Shang Xiao-jun,Shi Yong-li,Yan Xi-qing
A novel folate-decorated and magnetic mediated drug delivery system was fabricated by combining folate and magnetic nanoparticles to the surface of silica mesoporous nanoparticles (FMMSNs) via chemical reaction. The 10-hydroxycamptothecin (10-HPCT), an analogue of camptothecin, was sealed in the mesoporous to evaluate the system’s pharmaceutics performance. The diameter of the FMMSMs was about 100 nm and the in vitro release result showed that the applied magnetic field could influence the release process. The result of the inhibition rate of the 10-HPCT loaded FMMSNs to HepG-2 cells revealed that they could be influenced by the applied magnetic field or the folic acid bonded on the surface of the mesoporous nanoparticles.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Oxidative Medicine and Cellular Longevity
·
2023
·
IF 7.31
Hongwei Shi,Liang Duan,Ying Lan,Quan He,Peng Pu,Heng Tang
Pirarubicin (THP) is one of the classic chemotherapy drugs for cancer treatment. It is often clinically limited because of its cardiotoxicity. The occurrence and development of THP-mediated chemotherapy-related cardiotoxicity (CRC) may be reversed by RING finger protein 10 (RNF10). This study was performed with the aim of evaluating the inhibitory effect of RNF10 on THP-mediated CRC and its molecular mechanism. In vivo, we found that the expression of RNF10 decreased in THP-induced CRC rats, accompanied by Meox2 inhibition and AP-1 activation, resulting in increased cardiomyocyte apoptosis. After small interfering RNA (siRNA) and lentivirus transfection (Lv) of RNF10 in vitro, the expression of RNF10, Meox2, and AP-1 proteins and the degree of cardiomyocyte apoptosis were detected. We found that overexpression of RNF10 in H9C2 cardiomyocytes significantly promoted Meox2 and inhibited AP-1, alleviated apoptosis, and showed further inhibitory activity on THP-induced cardiomyocyte toxicity. Silencing RNF10 showed the opposite result. Our study showed that RNF10 inhibited THP-induced CRC through the activity of Meox2 and AP-1 proteins. RNF10 may be the next drug target for the treatment of CRC and other related cardiovascular diseases.
研究领域:
肿瘤学
·
心脏病学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2024
·
IF 5.4
Cuicui Li,Tongtong Gao,Wanzhen Wu,Xinpu Zhou,Shuyu Zhang,Guangpeng Ma,Xianfeng Guan,Shuang Wang
A series of composite membranes (sPBIp3-CAUX) are prepared by using modified sulfonated polybenzimidazole with an optimal side link grafting degree of 30% as a polymer matrix and then doping with CAU-10-H. The hydrophobic alkyl side chains and hydrophilic sulfonic acid groups easily form microphase separated structures due to the polarity difference, which is conducive to the enhancement of proton conductivity. The introduction of CAU-10-H into the polymer effectively prevents the passage of vanadium ions because the vanadium ion transport path becomes more tortuous. The sPBIp3-CAU2 membrane has low vanadium permeability (3.1 × 10–9 cm2 min–1) and excellent ion selectivity (9.16 × 106 S min cm–3). In addition, the sPBIp3-CAU2 membrane shows good cell performance at 60 mA cm–2 with CE of 93.32% and EE of 83.03% compared with those of Nafion 117.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）