RSC Advances
·
2016
·Vol. 6
·期 103
·101313-101317
·
IF 3.289
Jing Cao,Wanghui Yan,Yiling Huang
A novel fluorescent chemosensor, a thieno[2,3-b]thiophene derivative carrying two oxazoline groups (DTTO) was designed and synthesized, which was discovered to exhibit good selectivity to dichromate anions (Cr2O72−). We also found that if the oxazoline group was replaced with a chiral one, for example, (S)-DTTO acted as a chiral fluorescent chemosensor, which exhibited a distinguishing fluorescent response to the enantiomers of mandelic acid.
研究领域:
分析化学
·
材料科学
·
有机化学
✓ 已验证
DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2017
·Vol. 33
·期 2
·187-193
·
IF 1.024
Li Hongshuang,Wu Xiaming,Zhang Ruize,Hao Liqiang,Duan Guiyun,Xiao Yuliang,Xia Chengcai,Li Furong,You Guirong,Han Junfen
Based on the hit 5-hydroxy-2-methyl-10-propyl-2,3-dihydro-4 H ,8 H -pyrano[2,3- f ]chromene-4,8-dione( 1 ), a series of pyrano[2,3- f ]chromene-4,8-dione derivatives was designed and synthesized using phloroglucinol as starting material. Meanwhile, a regioselective synthetic route was developed for 5-methoxy-2,3-dihydro-4 H ,8 H -pyrano-[2,3- f ]chromene-4,8-dione products( 11 a― 11 f), and their structures were further confirmed by nuclear Overhauser effect(NOE). The evaluation of anticancer activities of these compounds against four human cancer cell lines, including human glioma cell line (SHG-44), human lung cancer cell line(H1299), breast cancer cell line(MCF7) and human colon carcinoma cell line(HCT-116) in vitro shows that 5-methoxy-2,2-dimethyl-9-chloro-10-trifluormethyl-2,3-dihydro-4 H ,8 H -pyrano-[2,3- f ]chromene-4,8-dione( 11 e) possesses the best anticancer activities with IC 50 values of 6.68, 7.90, 5.16 and 4.82 μmol/L, respectively. Finally, the preliminary structure-activity relationships(SARs) were summarized, which could pave the way for generating more potent anticancer agents with drug-like properties.
研究领域:
药物化学
·
肿瘤学
✓ 已验证
DOI
高影响因子
MATERIALS SCIENCE-POLAND
·
2024
·Vol. 42
·期 2
·70-80
·
IF 1.3
Yanling Yu,Biwu Huang,Yafen Qu,Junshan Qiu,Yong Lai
[2-(3,4-epoxycyclohexyl) ethyl] triphenylsilane was synthesized, using triphenylsilane and 1,2-epoxy-4-vinylcyclohexane as the main raw materials. When the molar ratio of triphenylsilane to 1,2-epoxy-4-vinylcyclohexane was 1.0:1.2, the content of Wilkinson catalyst was 0.4%, the reaction temperature was 90°C, and the reaction time was 6 hours, the yield of [2-(3,4-epoxycyclohexyl) ethyl] triphenylsilane could reach 95.21%. The structure of the synthesized product was analyzed and characterized using FT-IR and 1H-NMR. The synthesized product was added to a bisphenol A-type epoxy resin (E-51) and a modified amine (593 amine) to prepare an adhesive. Then, the adhesive was poured into the mold and cured at 35°C for 8 hours. The cured sample exhibited the best performance when the ECETPS: E-51:593 amine molar ratio was 0.8:7.2:2. Thermal gravimetric analysis (TG) showed that the thermal stability of the cured samples increased relative to pure E-51 amine-cured samples with the synthesized product added. The mechanical properties of the samples were tested using a universal material testing machine, and the results showed a tensile strength of 37.95 MPa and a bending strength of 39.10 MPa.
研究领域:
有机化学
·
材料科学
✓ 已验证
DOI
高影响因子
TETRAHEDRON
·
2015
·
IF 2.641
Xiong-Li Liu,Wen-Hui Zhang,Zhen Yao,Xiong-Wei Liu,Li-Jun Peng,Zhi Zhao,Yi Lu,Ying Zhou,Wei-Cheng Yuan
A new methodology was developed for the synthesis of hexahydro-1 H -pyrido[2,3- b ]indol-2-one scaffolds via a sequential Michael addition/amidation/reductive cyclization process. A wide variety of products bearing a hexahydro-1 H -pyrido[2,3- b ]indol-2-one core with varying degrees of substitution around it, which is a key structural skeleton found in a large number of biologically active natural products and pharmaceutical compounds, were obtained smoothly with high efficiency (up to overall yield of 67%). Furthermore, their biological activities have been preliminarily demonstrated by in vitro evaluation against human prostate cancer cells PC-3, human lung cancer cells A549 and human leukemia cells K562 by the MTT-based assays, using the commercially available standard drug Cisplatin as a positive control. These results suggested there is a trend that lipophilic groups improve the potency, and also suggested a carbonyl moiety located in the hexahydro-1 H -pyrido[2,3- b ]indol-2-one scaffolds is beneficial for the activity. The results also demonstrated that most of the compounds showed considerable cytotoxicities to these three cell lines K562, A549 and PC-3, and that hexahydro-1 H -pyrido[2,3- b ]indol-2-one scaffolds may be potential leads for further antitumor activity screenings.
研究领域:
有机化学
·
药物化学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Probiotics and Antimicrobial Proteins
·
2025
·
IF 4.4
Huang Xi,Gao Zhangshan,Gao Peichao,Ji Helong,Xu Laizhi,Fan Wentao,Song Suquan
Intensive poultry farming has significantly increased the incidence of lipid metabolic disorders, severely compromising the economic benefits of poultry industry. Currently, gamma-aminobutyric acid (GABA) is primarily used to mitigate adverse effects of heat stress in poultry, while the effects and mechanisms of GABA on lipid metabolism disorders remain underexplored. Lactobacillus plantarum ( L. plantarum ) serves as a significant source of GABA and is widely used in the livestock industry. This study therefore examines the effects of postbiotic GABA and the GABA-producing probiotic L. plantarum 1-2-3 on abdominal adipose tissue of laying hens following corticosterone-induced stress. To this end, hens subjected to corticosterone subcutaneous injections (4 mg/kg of body weight) were respectively received GABA (100 mg/kg BW) or L. plantarum 1-2-3 (1 × 10⁹ CFU/day). Results demonstrated that both GABA and L. plantarum 1-2-3 alleviated corticosterone-induced lipid metabolism disorders and reduced adipocyte size in abdominal fat. Additionally, expression analyses of genes and proteins related to lipid metabolism (PPARγ, C/EBPα, CD36, LPL, ATGL, and HSL) further showed that GABA and L. plantarum 1-2-3 inhibited excessive deposition of abdominal lipids in laying hens by suppressing adipogenesis and lipogenesis, while promoting lipolysis. Moreover, GABA and L. plantarum 1-2-3 both mitigated lipid deposition-induced inflammation and oxidative damage by normalizing macrophage infiltration and improving antioxidative enzyme activities (GSH-Px, T-SOD, CAT). These findings demonstrate the efficacy of GABA and L. plantarum 1-2-3 in alleviating lipid metabolism disorders in the abdominal adipose tissue of laying hens, suggesting their promise as nutritional supplements for counteracting stress-induced metabolic dysfunction.
研究领域:
家禽科学
·
动物营养学
·
微生物学
·
代谢紊乱
·
益生菌与后生元
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Shuai Wang,Jiayang Li,Cong Xie,Wanhui Chen,Huajie Feng,Wenying He
Our previous study found that 1-(4-bromophenyl)-5-phenyl-1H-1,2,3-triazole (BPT) exhibited very low toxicity and higher biology activity. In the present study, BPT was used to investigate its mechanism against Colletotrichum gloeosporioides in mango by chemical proteomics and chemicobiological methods. The experimental results of some phenotypic traits and cytotoxicity indicated that there are some changes in permeability of the cell membranes and BPT has fungistatic activity with lower cytotoxicity. Next, a biotin probe named BPTN with a higher activity (EC 50 value of 11.08 mg/L) than that of BPT(EC 50 value of 14.13 mg/L) was designed and synthesized by the chemical proteomics approach. The major differentially expressed proteins between BPT or BPTN and Colletotrichum gloeosporioides were identified and analyzed by Matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF-MS) and bioinformatics. The results indicated that there are 25 differentially expressed proteins in Colletotrichum gloeosporioides under BPT intervention, and 29 target proteins in Colletotrichum gloeosporioides captured by BPTN. For BPTN-anthracnose system, the protein No. 8 belonged to cytochrome P450 proteins (CYP) family can be taken as a target protein of BPTN, which confirmed by bioinformatics analysis. Further, a classic fungal target protein of triazoles, sterol 14α-demethylase (CYP51) was used to verify the interaction in the presence of BPT by various spectroscopic and molecular docking methods. The results showed that BPT exhibited strong interactions with CYP51 and it was predominantly driven by hydrophobic forces and hydrogen bonds. The present study has significant theoretical and practical implications for the development of novel 1,2,3-triazole antifungal agents.
研究领域:
植物病理学
·
药理学
·
分子生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF HETEROCYCLIC CHEMISTRY
·
2013
·Vol. 51
·期 4
·1210-1214
·
IF 1.224
Pei Chen,Yan Li,Xinbing Chen,Zhongwei An,Yiwei Xu,Xiaojun He
A convenient one-pot microwave-assisted synthesis of Benzopyrano[2,3- c ]pyrazol-3-one derivatives was developed, where Knoevenagel condensation and hydrazinolysis reactions were continuously performed under microwave irradiation without separation and purification of the intermediates until the last cyclocondensation reaction except the substrates addition. The one-pot procedure exhibited shorter reaction times and higher yields (25–55%) of the objects than the conventional heating method.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
ANIMAL REPRODUCTION SCIENCE
·
2025
·
IF 3.3
Xi Huang,Zhangshan Gao,Peichao Gao,Helong Ji,Laizhi Xu,Dengfei Feng,Wentao Fan,Suquan Song
Stress is a well-established disruptor of reproductive function in poultry. Gamma-aminobutyric acid (GABA), a notable postbiotic derived from Lactobacillus plantarum ( L. plantarum ), has attracted increasing attention as a dietary supplement. While existing research predominantly focuses on GABA applications in broilers and other species, its effects on laying hens remain underexplored. This study investigated whether GABA and L. plantarum 1-2-3 supplementation mitigated corticosterone (CORT)-induced chronic stress in laying hens. Results demonstrated that both GABA and L. plantarum 1-2-3 effectively mitigated CORT-induced declines in laying performance and ovarian damage. They reduced ovarian oxidative stress, inflammation, and atretic follicles by enhancing antioxidant capacity and normalizing expression of inflammatory factors ( IL18 , LITAF , IL6 , IL1B) , and apoptosis-related factors ( BCL2 , BAX , CASP9 , CASP3 ). Furthermore, GABA and L. plantarum 1-2-3 markedly increased the serum reproductive hormone levels, as well as the transcription level of ovarian steroidogenic genes ( LHCGR, FSHR, StAR, CYP11A1 ), while modulated ovarian cholesterol metabolism via PPARα-mediated pathways. These findings elucidate the mechanisms by which GABA and L. plantarum 1-2-3 alleviate stress in laying hens, providing a theoretical and practical basis for their use as functional feed additives in stress-exposed flocks.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2023
·Vol. 10
·期 10
·3121-3130
·
IF 7
Qian-Qian Chen,Chun-Li Hu,Bing-Xuan Li,Jiang-Gao Mao
Exploration of new iodates is crucial due to their splendid applications in the nonlinear optical (NLO) field. Two new IIIA metal iodate–selenates, namely, [M(OH)2]3(IO3)(SeO4)·H2O (M = Ga and In), have been successfully synthesized using the hexagonal tungsten oxide (HTO) framework as an ideal structural template. Isostructural [M(OH)2]3(IO3)(SeO4)·H2O (M = Ga and In) crystallize in the polar space group P63mc. Their structures feature ∞[MO2(OH)2]3− (M = Ga, In) layers composed of corner-shared circular M3O6(OH)9 trimeric units based on MO2(OH)4 octahedra. The SeO4 groups are capped above half of the trimeric units of the layers while the IO3 groups are capped below the remaining trimeric units of the layers. Both compounds exhibit moderate phase-matchable second-harmonic generation (SHG) responses (2.9× and 3.8× KH2PO4) under 1064 nm laser radiation and the same band gap of 3.38 eV. Results of theoretical calculations revealed that their SHG effects originated from the synergistic effect of MO6, IO3 and SeO4 groups. So far reports on iodate–selenates are scarce and this work provides a new perspective to design new NLO materials through polar HTO-type topologies and a mixed-anionic strategy.
研究领域:
材料科学
·
晶体学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 30
·期 1
·647-657
·
IF 2.324
Xiao Tai,Huang Zu-Sheng,Wang Lingyun,Cao Derong
Three novel dithieno[3,2- f :2′,3′- h ]quinoxaline-based organic dyes ( IQ-C, IQ-D and IQ-F ) with three π-spacers were synthesized and developed for dye sensitized solar cells, where dithieno[3,2- f :2′,3′- h ]quinoxaline was used as electron-withdrawing π-spacers, and 2,3-diphenylquinoxaline or dibenzo[ a,c ]phenazine as auxiliary electron-withdrawing π-spacers. The dye IQ-D with 2,3-diphenylquinoxaline as auxiliary electron-withdrawing π-spacer exhibited higher photocurrent ( J sc ) and photovoltage ( V oc ) than that of the dye IQ-C with 2,3-bis(4-(octyloxy)phenyl)quinoxaline as the additional electron-withdrawing π-spacer, due to the larger adsorption amount of IQ-D . The dye IQ-F with a rigid conjugated dibenzo[ a,c ]phenazine as additional electron-withdrawing π-spacer showed the highest efficiency of 6.54% under AM 1.5 G irradiation. It was demonstrated that the π-spacers influence the photovoltaic performance of the dithieno[3,2- f :2′,3′- h ]quinoxaline-based organic dyes significantly. The results indicated that the dyes with three π-spacers are promising candidates for efficient dye-sensitized solar cells.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2013
·Vol. 160
·期 3
·H173
·
IF 2.588
Bin Hu,Xiaojing Lv,Jingwei Sun,Mi Ouyang,Zhiyan Fu,Cheng Zhang
In this study, a novel material, Z-2, 3-bis(4-(thiophen-3-yl)-phenyl) –acrylonitrile (Z-TPA), was synthesized and characterized. Optical and electrochromic properties of its homopolymer and copolymer with 3, 4-Ethylenedioxythiophene (EDOT) were investigated in details. UV–vis absorption and fluorescence spectra showed that this material possessed the properties of aggregation-induced emission (AIE) due to the introduction of acrylonitrile, which could show sky-blue emitting at the aggregation state and almost no emitting at the solution state. Both its polymer and copolymer displayed better redox activity. Spectroelectrochemical analysis displayed that the copolymer film exhibited multicolor showing, with a claret red in the fully reduced form and a blue-green color in the fully oxidized. Spectrochronoamperometry data revealed that the copolymer films had fast switching time and high chromatic contrast as compared to the homopolymer P(Z-TPA). What's more, the copolymer film was used to construct a dual type polymer electrochromic device (ECDs) with PEDOT. The performance of ECDs were also investigated.
研究领域:
材料科学
·
光学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2017
·
IF 3.615
Bo Xu,Xuejiao Li,Zhiming Chen,Tao Zhang,Cuncheng Li
Pd@MIL-100(Fe) composite nanoparticles were synthesized and characterized by high-resolution transmission electron microscopy (HRTEM), powder X-ray diffraction analysis, nitrogen adsorption-desorption analysis, X-ray photoelectron spectroscopic (XPS) analysis, energy-dispersive X-ray spectroscopy (EDS) and element mapping. Due to the local restriction or confinement effect of the unique pore/surface structure within the MIL-100(Fe) nanospheres , small Pd nanoparticle (4–6 nm) were obtained with high stability without using any surfactant as stabilizer . The as-synthesized Pd@MIL-100(Fe) composite nanoparticles were then employed for the catalytic reduction of 2/3/4-nitrophenol, which exhibiting high catalytic activity and recyclability attributed to the synergistic effect between Pd nanoparticles and MIL-100(Fe) nanospheres.
研究领域:
材料科学
·
环境化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）