MOLECULES
·
2018
·Vol. 23
·期 10
·2663
·
IF 3.098
Tian Chai,Xiao-Bo Zhao,Wei-Feng Wang,Yin Qiang,Xiao-Yun Zhang,Jun-Li Yang
Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis, as well as comparison with literature data. Compounds1–20were evaluated for their anti-AD potential by using DPPH radical scavenging assay for considering their anti-oxidant activity, thioflavin T (ThT) fluorescence assay for considering the inhibitory or disaggregate potency of Aβ, and transgenicDrosophilamodel assay for evaluating their rescue effect on memory loss. Finally, compound13was determined as a promising anti-AD candidate.Keywords:Alzheimer’s disease;gx-50;DPPH assay;ThT assay;transgenicDrosophilamodel assay
研究领域:
药理学
·
神经科学
·
化学
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产品关联
DOI
PubMed
高影响因子
Separations
·
2021
·Vol. 8
·期 6
·72
·
IF 2.777
Xiqiang Liu,Hui Zhang,Yunlong Liu
Apatite is an important carrier of rare earth elements (REEs) and phosphorite is a potential REEs resource. However, the influence of hydrothermal fluids on the migration and enrichment of REE in apatite remains controversial. The experimental study of the interaction between REE-bearing fluid and apatite is one of the essential ways to understand the chemical behavior of rare earth elements in apatite. In this study, we conducted the fluid–mineral reaction experimental study (at 400 °C, 50 MPa and 4–16 wt %) between high lanthanum (La) content hydrothermal solution and low REE content to reveal the influence of different salinities on the diffusion of rare earth elements in fluorapatite. Based on in situ geochemical analyses of experimental products, we show that the diffusion coefficients of La in fluorapatite are between 3.24 × 10−15and 5.88 × 10−15m2/s. The salinity of the fluid has a great influence on the diffusion coefficient, with the increase of salinity, the diffusion coefficient increase.Keywords:water–mineral reaction;fluorapatite;lanthanum;diffusion
研究领域:
地质学
·
地球化学
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Haiyan Zhu,Bing Liu
Porphyrin is an excellent photosensitizer for generating singlet oxygen (SO) in photodynamic therapy, but the aggregation issue has long been reported to weaken its therapeutic efficacy in practical applications. To address this challenge, we here report the design and synthesis of a series of amphiphilic porphyrin-terminated poly(N-isopropylacrylamide), which can self-assemble into sub-50 nm porphyrin nanoparticles via the nanoprecipitation route. We demonstrated that the NP size could be easily tuned by adjusting the self-assembly conditions. Furthermore, compared with pure hydrophobic porphyrin NPs prepared using a similar method, the resulting NPs exhibited an enhanced SO generation rate. Notably, the SO generation rate showed an intriguing temperature dependence, highlighting the potential of these NPs to serve as photosensitizers in photodynamic therapy applications.
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xunjian Zhang,Shuping Zhang,Yige Wu,Xiao Xu,Liqian Song,Zhenbiao Liu,Xu Jia
This study aims to improve the mechanical sensitivity of TKX-50 by adding various thermal conductive materials. The results showed that the synergistic addition of one-dimensional (1D) and two-dimensional (2D) thermal conductive materials significantly improves thermal conductivity and mechanical sensitivity. Among them, PBX@AgNWs-Graphene demonstrated superior performance compared to the raw TKX-50, with 44.44 % increase in thermal conductivity, 120.00 % decrease in impact sensitivity, and 153.13 % decrease in friction sensitivity. Research revealed a positive correlation between thermal conductivity and impact sensitivity at low levels, but high thermal conductivity had limited impact on further reducing sensitivity. Absolutely, the research highlights the existence of an optimal range for the content of thermal conductive materials in the formula. Adding more than the optimal amount may not significantly boost impact sensitivity and may also degrade the detonation performance. These discoveries are pivotal for guiding the formulation design of TKX-50, ensuring the balance between impact sensitivity and detonation performance.
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Guoshen Yang,Xianqi Xu,Gangrui Qu,Jie Deng,Yachao Zhu,Chi Fang,Olivier Fontaine,Pritesh Hiralal,Jiaxin Zheng,Hang Zhou
The earth-abundant magnesium resource and aqueous electrolyte make aqueous magnesium-ion batteries (AMIBs) a promising post-lithium-ion battery technology to synchronously address cost and safety concerns. Nonetheless, the freeze issue of aqueous electrolytes is curbing the development of AMIBs working at low-temperature conditions. Here, we report an MgCl 2 solution having a great low-temperature property via anion and concentration adjustment, which roots in the variation of the pristine hydrogen bond reticulation. Consequently, a 4 M MgCl 2 aqueous electrolyte endows a low freezing point (−62 °C) as well as ultra-high ionic conductivity (2.77 mS/cm at −50 °C). By using 4 M MgCl 2 as an electrolyte, the MnO 2 //VO 2 battery is capable of working in a wide temperature range from +25 to −50 °C, achieving a high discharge capacity of 97.9 mAh/g (0.1 A/g) and a high cycling capability of 1000 cycles (∼90 % capacity retention at −20 °C). Furthermore, MgCl 2 can be well compatible with polyacrylamide into an outstanding hydrogel electrolyte (in terms of mechanical property, anti-freeze performance, and high ionic conductivity) for a flexible quasi-solid-state MIBs application. The assembled flexible device attains appealing electrochemical properties across a broad temperature region, while the constructed pouch cell demonstrates superior flexibility and reliable safety. Our current exploration depicts an expeditious but productive paradigm for devising the high-performing AMIBs for low-temperature energy storage sectors.
研究领域:
电化学
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材料科学
·
能量存储
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2022
·Vol. 97
·期 7
·1781-1791
·
IF 3.709
Yuying Ma,Haixia Zhao,Dongze Ma,Junmei Zhang
(Synthesis, characterization, and catalytic behaviour of nano-bimetallic nickel oxide on the thermal decomposition of dihydroxylammonium-5,5′-bistetrazole-1,1′-diolate) Bimetal combustion catalyst has become an emerging field in recent years, which is still in its infancy. When the combustion catalyst is used in double-base propellants, it can produce effects that conventional catalysts cannot achieve. In this study, nano-bimetallic nickel oxides (nanospheres of NiFe 2 O 4 and the sub-nanometre flower NiCo 2 O 4 ) were prepared by hydrothermal method and characterized using X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and N2 adsorption–desorption test (BET). Moreover, its thermal catalytic action on dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50) was studied. The thermal analysis of composite TKX-50/NiFe 2 O 4 and TKX-50/NiCo 2 O 4 was carried out by thermogravimetric differential scanning calorimetry (TG-DSC). The results show that when the addition amount of NiFe2O4 is 10%, the heating rate is 5.0 K min −1 , the NiFe 2 O 4 has the best catalytic activity for TKX-50 thermal decomposition, and the high thermal decomposition peak temperature (Tpeak1) is decreased by 29 °C. More interestingly, the apparent activation energies of the two composites were calculated by Kissinger, Ozawa, and Starink methods. The advanced thermal analysis kinetics software (AKTS) was used to perform kinetic calculations on the DSC experimental curves of the above-mentioned composite energetic materials, and reaction rate curves obtained by the simulation are in good agreement with the experimental curves of the thermal decomposition reaction process, further proving that the accuracy of the experiment is high. Therefore, the addition of NiFe 2 O 4 shows high catalytic efficiency on the thermal decomposition of TKX-50 components, and this would be beneficial to promote the burning rate of propellants containing TKX-50 components. © 2022 Society of Chemical Industry (SCI).
研究领域:
材料科学
·
推进剂化学
✓ 已验证
产品关联
DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Zhenzhen Cui,Baoying Wang,Ruirui Li,Zihao Wang,Weicheng Fu,Junying Yan,Liang Wu,Yaoming Wang,Tongwen Xu
Rapid and highly effective enrichment of nuclides containing liquid effluent is crucial for online monitoring of radioactive trace elements from nuclear power plants (NPPs). In this study, auxiliary electrodialysis (AED) was proposed for high enrichment of trace ions in the liquid effluents of NPPs. The effects of the auxiliary ion type and concentration and the operating voltage on the AED concentration performance were investigated. When the volume ratio of the solution was 140: 1 with 0.03 mol/L HNO 3 as the auxiliary electrolyte, most of the nuclide ions were concentrated more than 50 times after the two-stage electrodialysis experiment. In the first-stage electrodialysis, the concentration of most ions, with the exception of the higher valence ions (Ru 3+ and Zr 4+ ), tends to increase with increasing operating voltage. The diluate stream volume could be minimized to 98.8% with a total energy consumption of 9.5 kWh/m 3 . By considering the impact of boron in the liquid effluents, more than 52 times concentrations could still be achieved by extending the running time of the first-stage ED (increasing the ion removal rate). The transmembrane fluxes of various cations decreased in the order of Cs + > Sr 2+ > Zn 2+ > Co 2+ ≈ Ni 2+ ≈ Mn 2+ > Fe 3+ > Cr 3+ > Ru 3+ > Zr 4+ , which is attributed to the experimental operating parameters and ionic properties. This research provided a viable technique for rapid and highly effective enrichment of nuclides containing liquid effluents for both radioactive element monitoring and wastewater volume reduction.
研究领域:
环境科学
·
核技术应用
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DOI
高影响因子
ACS Omega
·
2025
·
IF 4.3
Shuai Li,Kanghui Jia,Xiu Liu
Polymer-bonded explosives (PBX), as a classical representative of energetic composite materials, have poor mechanical properties due to weak interface interaction, which limits their wide application. Inspired by the strong adhesion of mussels, coating polydopamine (PDA) on the surface of energetic materials is considered an effective method to enhance the interaction. In this study, the self-polymerization of dopamine was accelerated by the addition of potassium permanganate, which was successfully coated on the surface of dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate (TKX-50), a high-energy and insensitive energetic material. After PDA coating, TKX-50 had excellent thermal stability and mechanical properties. The spontaneous decomposition temperature and thermal explosion critical temperature of TKX-50 after PDA coating increased from 204.300 and 217.604 °C to 210.700 and 223.839 °C, respectively, and the compressive strength increased from 6.38 to 7.65 MPa. This novel method improves the thermal stability and mechanical properties of energetic materials to ensure their large-scale industrial production and application.
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产品关联
DOI
PubMed
高影响因子
Advanced Energy Materials
·
2021
·Vol. 11
·期 39
·2101855
·
IF 29.368
Liang Tan,Xuexia Lan,Jinwei Chen,Hanyin Zhang,Renzong Hu,Min Zhu
Lithium-ion batteries (LIBs) suffer dramatic energy reduction, and are even unable to safely charge below -10 °C, due to sluggish Li + transport kinetics in the anode, electrolyte and solid electrolyte interphase (SEI), as well as large overpotential which causes Li plating on the anode surface. Herein, a SnO 2 -LiF-graphite (SLG) composite anode is developed for wide temperature application. The SLG with a propylene carbonate electrolyte delivers a stable capacity of more than 900 mA h g −1 at 60 °C with 100 mA g −1 , maintaining 823.9 mA h g −1 at -10 °C. When matched with a tetrahydrofuran-based electrolyte, the SLG delivers stable capacities of 780.4 mA h g −1 at -40 °C and 637.2 mA h g −1 at -50 °C, respectively. It is demonstrated that the LiF-induced inorganic-rich SEI maintains the nanostructure of the active Sn, and that their interfaces with the electrolyte are highly stable. Furthermore, the formation of α-Sn with higher Li + diffusion kinetics results in a very small overpotential (≈0.18 V) of lithiation for SLG from 30 °C to -50 °C. This work shows that LiF-modified SnO 2 anodes matched with suitable electrolytes can qualify the LIBs for a safe and long-life at wide temperature, which is helpful to further promote these batteries for low-temperature applications.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 4
·1437-1447
·
IF 5.251
Mengxue Ma,Xiangmei Liu,Lei Tan,Zhenduo Cui,Xianjin Yang,Yanqin Liang,Zhaoyang Li,Yufeng Zheng,Kelvin Wai Kwok Yeung,Shuilin Wu
Implant materials are prone to bacterial infections and cause serious consequences, while traditional antibiotic therapy has a long treatment cycle and even causes bacterial resistance. In this work, a photothermal therapy (PTT) assisted drug release system has been developed on the implant surface for in situ rapid disinfection under 808 nm light irradiation within a short time, in which gentamicin (Gent) is loaded by polyethylene glycol (PEG) modified molybdenum disulfide (MoS2) on Ti surface, and then encapsulated with chitosan (CS) (CS/Gent/PEG/MoS2-Ti). The hyperthermia produced by the coatings irradiated by 808 nm near-infrared (NIR) light can not only accelerate the local release of Gent, but also reduce the activity of bacteria, which makes it easy for these locally released drugs to enter the interior of the bacteria to inhibit the protein synthesis and destroy the cell membrane. When maintained at 50 °C for 5 min under NIR irradiation, this system can achieve an antibacterial efficacy of 99.93% and 99.19% against Escherichia coli and Staphylococcus aureus, respectively. By contrast, even after treatment for 120 min, only a 93.79% antibacterial ratio can be obtained for Gent alone. This is because hyperthermia produced from the coatings during irradiation can assist antibiotics in killing bacteria in a short time. Even under a low dose of 2 μg mL−1, the photothermal effect assisted gentamicin can achieve an antibacterial efficacy of 96.86% within 5 min. In vitro cell culture shows that the modified surface can facilitate cell adhesion, spreading and proliferation. The 7 day subcutaneous infection model confirms that the prepared surface system can exhibit a much faster sterilization and tissue reconstruction than the control group with light assistance. Compared with the traditional drug release system, this photothermy controlled drug-loaded implant surface system can not only provide rapid and high-efficiency in situ sterilization, but also offer long-term prevention of local bacterial infection.
研究领域:
生物材料
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生物医学工程
·
药学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
·
2014
·
IF 3.043
Chenxi Ning,Erzheng Su,Dongzhi Wei
Lodderomyces elongisporus LH703 isolated from soil samples contained three novel aldo–keto reductases (AKRs) (LEAKR 48, LEAKR 49, and LEAKR 50). The three enzymes were cloned, expressed, and purified to homogeneity for characterization. These three AKRs shared <40% amino acid identity with each other. LEAKR 50 was identified as a member of AKR3 family, whereas the other two LEAKRs were identified as members of two novel AKR families, respectively. All the three AKRs required nicotinamide adenine dinucleotide phosphate as a cofactor. However, they showed diverse characteristics, including optimum catalyzing conditions, resistance to adverse reaction conditions, and substrate specificity. LEAKR 50 was estimated to be a promising biocatalyst that could reduce ethyl 4-chloroacetoacetate with high enantiomeric excess (98% e. e.) and high activity residue under adverse conditions.
研究领域:
生物化学
·
酶学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
Food Science & Nutrition
·
2025
·Vol. 13
·期 7
·e70666
·
IF 3.8
Yanxia Tao,Xingkai Zhang,Zhuangyu Li,Shouzheng Tian,Li Li,Xuhong Zhou
Edible flowers are widely consumed for their potential health benefits. This study assessed the active components and in vitro antioxidant properties of 50 edible flowers from Yunnan to explore their potential uses. A 70% ethanol extract was prepared, and the total polyphenol content (TPC), total flavonoid content (TFC), and total anthocyanin content (TAC) were analyzed. Antioxidant capacity was evaluated using the ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) assays. Additionally, tyrosinase inhibition and antimicrobial activities were determined, and the correlation between active components and antioxidant capacity was investigated. The results showed that Prunus mume had high polyphenol content, Osmanthus fragrans Lour. had high flavonoid content, and Rosa rugosa Thunb. (Dianhong) had high anthocyanin content. Rosa rugosa Thunb. (Mohong) exhibited the strongest DPPH and ABTS radical scavenging activities. Clerodendranthus spicatus (Thunb.) C. Y. Wu demonstrated the highest FRAP activity, whereas Punica granatum L. showed the highest tyrosinase inhibition activity. Nymphaea coerulea exhibited significant antimicrobial effects against Escherichia coli and Staphylococcus aureus . Extracts from Hibiscus rosa-sinensis and Platycodon grandiflorus (Jacq.) A. DC. demonstrated excellent antimicrobial effects against Pseudomonas aeruginosa . Correlation analysis indicated a positive relationship between TPC and antioxidant activities, suggesting that polyphenols are closely linked to antioxidant capacity. This study highlights the potential of these edible flowers as antimicrobial agents and natural antioxidants. Analysis using the membership function identified N. coerulea , R. rugosa , P. granatum , and Lagerstroemia indica L. as having the highest comprehensive scores, indicating their superior quality as sources of bioactive compounds.
研究领域:
食品科学
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植物化学
·
抗菌研究
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天然产物
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）