AIP Advances
·
2023
·Vol. 13
·期 6
·
IF 1.6
Tu Peng,Cai Xiangcheng,Ai Yansong,He Hongshen,Shen Peng,Zhou Yuanming,Mei Fei
Perovskite light-emitting diodes (PeLEDs) have attracted much attention due to their excellent performance. In this work, phenylethylamine bromide (PEABr) was employed to modify perovskite phases, while Poly(9-vinylcarbazole) (PVK) was added as a hole transport layer between perovskite and PEDOT:PSS to engineer the device structure, which is predicted to improve the optoelectronic performance of PeLEDs synergistically. The doping of PEABr in MAPbBr 3 can improve the radiative recombination of the emission layer through the formation of two-dimensional perovskite phases and modified film morphology. When the ratio of MAPbBr 3 :PEABr is 1:0.25, the maximum luminance of the optimal device increased from 80 to 9000 cd/m 2 and the maximum external quantum efficiency increased from 0.02% to 1.63% compared with the control device without PEABr doping. In addition, the hole injection ability of the device is further improved by adding PVK as the hole transport layer. The introduction of PVK can also facilitate the interface modification via surface defect passivation. When the PVK concentration is 10 mg/ml, the maximum current efficiency and external quantum efficiency of the optimal device are increased to 13.70 cd/A and 2.70%, respectively. These findings can provide a basis for the enhanced performance of PeLEDs.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 52
·30398-30405
·
IF 3.049
Yanting Wu,Zewu Xiao,Lihong He,Xiaoli Yang,Yajun Lian,Guoqing Li,Xiaohui Yang
In this paper, a cross-linked poly(9-vinylcarbazole) (PVK):phosphomolybdic acid (PMA) layer is used as the hole transport layer in perovskite light-emitting devices, and the morphology, crystal structure, and photophysical properties of perovskite films on the PVK:PMA layer are studied. The addition of PMA into the PVK layer improves the perovskite morphology integrity and promotes hole transport. As a result, perovskite light-emitting devices using a PVK:PMA hole transport layer exhibit an improved maximum luminous efficiency of 22.1 cd A−1 and power efficiency of 18.2 lm W−1 when compared with those of the counterparts with a PVK hole transport layer. Efficient perovskite light-emitting devices can be accessed by using various antisolvents due to the good solvent resistance of PVK:PMA networks. Moreover, the luminous efficiencies of perovskite light-emitting devices with a PVK:PMA hole transport layer are almost invariant irrespective of the presence of a hole injection layer, illustrating wide applicability of the PVK:PMA hole transport layer in perovskite light-emitting devices.
研究领域:
材料科学
·
光电学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2019
·
IF 4.084
Jiaqin Liu,Chuanyao Liu,Aisheng Huang
Hydrogen has been regarded as the most promising clean and renewable energy. Beside the production of the hydrogen, the separation of hydrogen is also an import issue before it can be used in fuel cells. Membrane-based separation technologies have gained considerable attentions due to its high efficiency and low energy consumption. Zeolite imidazolate framework (ZIF) membranes have drawn intense interest due to their zeolite-like properties such as permanent porosity, uniform pore size and exceptional thermal and chemical stability. It is rather challenged to prepare well-intergrown Co-based zeolitic imidazolate frameworks (ZIFs) membranes on porous α-Al 2 O 3 tubes since Co-based ZIFs prefer to form crystals in the synthesis solution rather than grow as membrane layer on the support surface. In this work, we report the preparation of high-quality ZIF-9 membrane with high H 2 /CO 2 selectivity and excellent thermal stability by using 3-aminopropyltriethoxysilane (APTES) as a covalent linker to modify the α-Al 2 O 3 tube. Due to the formation of covalent bonds between APTES and ZIF-9, ZIF-9 nutrients are bound to the support surface, thus promoting the growth of dense and phase-pure ZIF-9 membrane with a thin thickness of about 4.0 μm. The gas separation performances of the ZIF-9 membrane were evaluated by single gas permeation and mixture gas separation of H 2 /CO 2 , H 2 /N 2 and H 2 /CH 4 , respectively. The mixture separation factors of H 2 /CO 2 , H 2 /CH 4 , and H 2 /N 2 of the ZIF-9 membrane are 21.5, 8.2 and 14.7, respectively, which by far exceeds corresponding Knudsen coefficients. Moreover, the as-prepared ZIF-9 membrane exhibits excellent stability at a relatively broad range of operating temperature, which is beneficial for the industrial application of hydrogen separation or further membrane reactor .
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Huihui Gao,Xiankun Wu,Yaowen Hu,Mang Wu,Wei Liu,Zhongkai Wang
Although tremendous efforts have been made to convert woody oils into valuable chemicals, most of the known protocols still require multi-step procedures and rigorous conditions. Herein, a highly efficient method for converting woody oils into long-chain unsaturated dicarboxylic acid was reported. Such a strategy holds promises for opening new routes for utilizing woody oils. Firstly, self-metathesis of fatty acids from Rubber seed oil (RSO), Sapium sebiferum oil (SSO) and High oleic Canola oil (HOCO) were optimized. Pure E -octadec-9-enedioic acid monomer (C18) was obtained, and confirmed by 1 H NMR and FTIR spectra. The prepared dicarboxylic acid was then experienced condensation polymerization with 1,6-hexamethylenediamine. The chemical structures of the obtained polyamides were investigated by FTIR and 13 C NMR spectra. DSC , TGA, DMA, and tensile testing was used to explored their thermal and mechanical properties. Interestingly, due to the existence of broad melting and glass transition, the prepared polyamides possess multiple-shape memory properties.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FITOTERAPIA
·
2025
·
IF 2.6
Zhong He,Hui Long,Hongyue Ma,Wanrong Ran,Yinhong Song,Wenjuan Shang,Junhui Wang,Ye Qin,Zhangshuang Deng
Triple-negative breast cancer (TNBC) is the most aggressive and malignant breast cancer. Ferroptosis is an oxidative, iron-dependent form of regulated cell death. Ferroptosis-targeted therapies is a promising approach to improving treatment outcomes of TNBC. Combining death pathway inhibitors with relevant indices for ferroptosis and LipROS, this study uncovered that a natural product of 4, 9-dihydroxy- α -lapachone (DLN) from Catalpa bungei “jinsi” exhibited in vitro and in vivo inhibitory activity against TNBC via ferroptosis. The molecular mechanism is an activation of the FTH1 led to iron overload, and then inhibition of cysteine-glutamate antiporter (system Xc − ) and GPX4, which further sensitized TNBC cells to ferroptosis. This study clarified the pathway of DLN-induced cell death in TNBC treatment and exhibited its potential as therapeutic agent for TNBC.
研究领域:
肿瘤学
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分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL GENETICS
·
2022
·Vol. 61
·期 3
·916-930
·
IF 2.22
Wang Pengwei,Mao Senlin,Yi Tingting,Wang Lihua
Vascular dementia (VaD) is the second most common subtype of dementia, but the precise mechanism underlying VaD is not fully understood. Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) can act as a key regulator in physiological and pathological processes, including neurological disorders, but whether it is correlated with VaD has not been elucidated. In this study, we established a mouse model of VaD by the transient bilateral common carotid artery occlusion surgery. As expected, the Morris water maze showed that VaD mice had significant deficits in spatial learning and memory. MALAT1 was elevated in the hippocampus of VaD mice. Additionally, we found that microRNA (miR)-9-3p was downregulated in the VaD hippocampus. By performing a dual-luciferase report assay, we verified the binding relationship between MALAT1 and miR-9-3p. Interestingly, synapse-associated protein-97 (SAP97), a well-known gene related to synaptic functions, was found upregulated in the hippocampus of VaD mice. In vitro experiments performed on hippocampal neurons demonstrated that miR-9-3p negatively regulated SAP97 expression. The downregulation of MALAT1 in hippocampal neurons increased miR-9-3p and reduced SAP97, whereas miR-9-3p inhibition rescued the MALAT1 downregulation-mediated SAP97 reduction. In conclusion, the present study reported the alterations in the expression levels of MALAT1, miR-9-3p, and SAP97 in the hippocampus of VaD mice, suggesting that MALAT1 targets miR-9-3p to upregulate SAP97 in the hippocampus of mice with VaD. This work will be helpful for understanding the molecular mechanisms of VaD.
研究领域:
神经科学
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分子生物学
·
病理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Jegatheeswaran Sonamuthu,Yurong Cai,Han Liu,Mohamed Subarkhan Mohamed Kasim,Vasantha Ruban Vasanthakumar,Boomi Pandi,Hangxiang Wang,Juming Yao
The infected diabetic wound ulcer is a significant problem for the diabetic patients, which leads to removal of affected foot site due to its delayed/non-healing tissues. The poly-microbial infections and active matrix metalloproteinases (MMP) are the significant influencing factors to delayed healing in diabetic mice. The main purposes of present investigation are to evaluation the targeted inactivation of MMP and avoid polymicrobial infections by using a combined therapeutic effect of metal chelating dipeptide (L-carnosine) and curcumin with the biocompatible silk protein hydrogel (L-car@cur/SF) dressing in the infected diabetic wound ulcer. The in vitro biological assay methods, such as, cell viability, anti-oxidant activity, anti-inflammatory macrophage cells and inhibition collagenase exhibited that the designed hydrogel matrix to be human cell compatible and could be accelerate for significant diabetic healing potential. The activation of cur/SF matrix by the L-carnosine was persuading the inactivation of matrix metalloproteinase-9 (MMP-9) through its potent chelating effects of Zn 2+ ions from the MMP-9 active center. The L-car@cur/SF hydrogel was demonstrated for the effective MMP-9 inactivation and bacterial inhibition via in vivo mice wound site, which indorsed the diabetic wound healing efficiency in streptozotocin-tempted diabetic mice.
研究领域:
生物材料学
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医学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Yaming Gu,Yizhen Guo,Changyong Wang,Jiake Xu,Jianping Wu,Thomas Brett Kirk,Dong Ma,Wei Xue
It is a promising way to treat the multi drug resistance (MDR) of tumor cells in both of drug and gene methods. A polyamidoamne dendrimer functionalized graphene oxide (GO-PAMAM) was designed, which could load doxorubicin (DOX) and MMP-9 shRNA plasmid at the same time in order to achieve effective treatment to breast cancer. GO-PAMAM has a high loading capacity to DOX and pH-controlled DOX release. Besides, it has efficient gene transfer ability, the transfection efficiency is significantly better than PEI-25k in the presence of serum, and it can significantly inhibit the expression of MMP-9 protein in MCF-7 cells. The effect of DOX and MMP-9 shRNA plasmid co-delivery was more significant than that of the single drug. Moreover, GO-PAMAM exhibited lower cytotoxicity compared to PEI-25k in CCK-8 assays, and also showed a good biocompatibility in vivo . Therefore, GO-PAMAM will have broad prospects for drug and gene co-delivery.
研究领域:
生物医学工程
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肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Danni Jiang,Yang Yang,Xiaojuan Han,Qianni Li,Yingxiu Ma,Jun Jiao,Lan Chao
Fluorene-9-bisphenol (BHPF), a widely recognized alternative to bisphenol A (BPA), has been increasingly used in a wide range of industries. However, despite numerous studies, the direct mechanism underlying its male reproductive toxicity remains poorly understood. Here, a BHPF-exposed mouse model was established to evaluate the effect of BHPF on male fertility. The results showed that BHPF exposure induced reproductive dysfunction, including testis damage, spermatogenesis impairment, steroid hormone disruption and sperm quality degradation. Mechanistically, over 90,000 differentially methylated regions were identified and increased global testicular methylation levels indicated that DNA methylation may be associated with BHPF-induced testicular damage. Transcriptome analysis revealed 221 up-regulated genes and 227 down-regulated genes in BHPF-exposed mice, mainly enriched in the steroid biosynthetic pathway. Further combined methylome and transcriptome analysis revealed the critical methylated genes potentially involved in lipid metabolism. The differentially expressed genes (Cyp4a10 and Rdh1) were further confirmed to correlate with impaired male mouse fertility. Taken together, the results of this study provide a better understanding of the molecular mechanisms of toxicity effects induced by BHPF exposure from the perspective of methylome and transcriptome.
研究领域:
毒理学
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表观遗传学
·
生殖生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2018
·
IF 3.794
Y.H. Zhang,J.J. Sun,N. Dai,Z.C. Wu,H.T. Wu,C.H. Yang
A new kind of low-temperature fired Eu 2 Zr 3 (MoO 4 ) 9 ceramic was fabricated by conventional solid-state reaction method. The mixed powders was calcined at 600 ℃ and the samples were sintered at 500 ℃ –700 ℃ for 4 h. X-ray diffraction analysis and Rietveld refinement indicated that Eu 2 Zr 3 (MoO 4 ) 9 belonged to a trigonal system with space group R-3c. Bond ionicity, lattice energy and bond energy of the ceramic were calculated by the complex chemical bond theory. Microwave dielectric properties were determined at microwave frequencies of 9.7–14.7 GHz by a network analyzer. Far infrared spectra indicated the main contribution to polarization for Eu 2 Zr 3 (MoO 4 ) 9 ceramics was the absorption of structural phonon oscillation. The ceramic sintered at 600 ℃ for 4 h exhibited the best dielectric properties with a relative permittivity ( ε r ) of 10.75, a quality factor ( Q·f ) of 74,900 GHz and a temperature coefficient of resonance frequency ( τ f ) of -8.88 ppm/℃.
研究领域:
材料科学
·
无机化学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Xiaomin Chen,Hui Wang,Xiaojun Huang,Shengkun Xia,Chunhua Chen,Qixing Nie,Shaoping Nie
This work established an effective method for kale flavonoids enrichment by resins. Resin screening, adsorption kinetics and isotherms, dynamic adsorption and desorption tests were conducted to optimize the appropriate resins and enrichment conditions. The results showed that NKA-9 was the optimum resin. The best adsorption conditions were 0.2 mg/mL flavonoids concentration, 12.5 bed volume (BV) sample volume and 2 BV/h adsorption rate. The desorption conditions were 3 BV of 80% ethanol at 2 BV/h elution rate. Under these conditions, the product purity was 31.16%. The purified flavonoids extract was mainly comprised of Kaempferol-3-O-sophoroside-7-O-diglucoside, Kaempferol-3,7,4′-O- d -triglucoside, Kaempferol-3-O-feruloyl-sophoroside-7-O- d -glucoside, and Kaempferol-3-O-sinapoyl-sophoroside. Moreover, it presented higher scavenging ability against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and hydroxyl ( OH) radical than crude extract. In conclusion, kale flavonoids can be well concentrated by NKA-9 resin and the purified flavonoids extract has good antioxidant activity which can be potentially applied in food, cosmetic or pharmacy industries.
研究领域:
食品科学
·
植物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Jiankai Zhang,Wujian Mao,Jiaji Duan,Sumei Huang,Zhejuan Zhang,Wei Ou-Yang,Xuehua Zhang,Zhuo Sun,Xiaohong Chen
Poly(9-vinylcarbazole) (PVK) was introduced to modify the interface of perovskite/PCBM. The modified PVK material can induce the formation of the quasi-continuous sheet-shaped perovskite film at the surface of 3D perovskite layer, which may reduce the exposed grain boundaries. Besides, the PVK modified perovskite layer can reduce carrier recombination and accumulation at the interface of perovskite/PCBM and improve the crystallinity of perovskite layer and the interface contact properties. The PVK modification can greatly improve the PCEs and thermal and moisture stability and suppress the J-V hysteresis of perovskite solar cells (PSCs). PSCs with PVK modification achieved champion PCE of 19.03% (average PCE of 18.40%), maintained 80% of the original PCE value aging for 50 days under ambient conduction without encapsulation. Furthermore, PSCs with PVK modification can maintain 87% of the origin PCEs aging for 3 h under 85 °C thermal stress, which are greatly higher than that (26%) of PSCs without PVK modification.
研究领域:
材料科学
·
能源技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）