CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Junjun Liu,Naibo Feng,Xinyu Jiang,Xirui Xin,Yubo Hou,Zhende Jiang,Laijin Lu,Weixian Yu,Bai Yang
Periodontitis is a common chronic inflammatory disease and the local accumulation of excessive reactive oxygen species (ROS) could cause oxidative damage to periodontal tissues. Thus, antioxidative therapy is considered to be the promising strategy for treating periodontitis. However, highly efficient antioxidant activity of biomaterials with low cost, ease of synthesis, and good biocompatibility are still highly desired. Here amylopectin from maize (AFM)-derived carbonized polymer dots (AFM-CPDs-240) with excellent antioxidant activity, good water solubility and biosafty is parepared. Detailed characterizations identify that the antioxidant properties and formation mechanism of AFM-CPDs, and antioxidant activity of AFM-CPDs-240 is much higher than Trolox (a hydrophilic derivative of vitamin E) due to the large contents of conjugated C=C and C=O. Besides, in vitro and in vivo experiments suggest AFM-CPDs-240 could effectively alleviate inflammatory response, inhibit alveolar bone resorption and promote bone formation, showing excellent therapeutic effects on periodontitis. Moreover, the label-free proteomics and western blot results demonstrate AFM-CPDs-240 could accelerate the recovery of periodontitis by blocking TLR4/NF-κB (Toll-like receptor 4/ nuclear factor-kappa B) signaling pathway. This study will develop a simple approach to design highly efficient antioxidant carbon dots with good biocompatibility, and also provide a new promising nanoplatform for treating diseases associated with ROS.
研究领域:
牙医学
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材料科学
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生物化学
·
药理学
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产品关联
DOI
高影响因子
MINERALS ENGINEERING
·
2026
·
IF 6
Qi Cheng,Shiyong Zhang,Sheng Liu,Guangyi Liu
DDA + SDS with molar ratio of 3:7 could efficiently separate lepidolite from albite and quartz at pH ∼ 8.0. • The adsorption mechanisms of DDA + SDS on lepidolite, albite and quartz were unraveled by AFM force measurement. • DDA + SDS adsorbed on lepidolite surface by the hydrophobic and electrostatic attractions. • DDA + SDS adsorbed on albite and quartz surfaces by the electrostatic attraction. This study investigated the underlying flotation mechanism for separating lepidolite from lepidolite-albite-quartz mixture via the combined collectors of dodecylamine (DDA) and sodium dodecyl sulfate (SDS). The micro-flotation results exhibited that DDA + SDS could efficiently separate lepidolite from their mixture without depressant. At pH ∼ 8.0 and the molar ratio of DDA: SDS = 3:7, DDA + SDS with the total dose of 2.0 × 10 -4 mol/L achieved 85.05% Li 2 O recovery with Li 2 O grade of 4.07% from the artificial mixture of the three minerals with the mass ratio of 1:1:1. The results of contact angle, adsorption capacity, zeta potential, optical microscope image, FTIR, in-situ AFM image demonstrated that DDA could adsorb on lepidolite, albite and quartz surfaces and render them hydrophobic. The presence of SDS slightly affected DDA’s adsorption onto the lepidolite surface, while significantly inhibited DDA’s adsorption on the albite and quartz surfaces. AFM force measurements implied that the hydrophobic attraction existed between lepidolite’s Si-O tetrahedra and the carbon chain of DDA + SDS, while that was absent in albite and quartz surfaces. Thus, DDA + SDS could adsorb on lepidolite surface via hydrophobic and electrostatic attraction. While, it only exhibited the weakly electrostatic attraction to albite and quartz surfaces, thereby hardly adsorbing on their surfaces and rendering them hydrophobic. The different adsorption configurations of DDA + SDS on lepidolite, albite and quartz caused the different wettability and floatability, promoting the selective separation of lepidolite from their mixture. The adsorption mechanism of DDA+SDS on lepidolite, albite and quartz surfaces. Download: Download high-res image (183KB) Download: Download full-size image
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Di Meng,Haipeng Xie,Bin Yan,Weixuan Zhao,Yiming Fu,Wenjihao Hu,Yongli Gao
Quartz is a key raw material in high-tech fields (such as photovoltaics and semiconductor microelectronics), and the most efficient extraction method of quartz is mineral flotation. Quartz activation plays a crucial role in mineral flotation. However, the mechanism underlying the process remains unclear, and the role of additional metal ions is controversial. In this study, the interaction forces between the quartz surface, the dodecylamine (DDA) cation/sodium oleate (NaOL) anion mixed collectors, and Ca2+ were analyzed using atomic force microscopy in order to systematically explore the activation process of quartz flotation. The results confirmed that the activation process was initialized from NaOL, which was adsorbed on the surface of a calcium-covered quartz surface. The existence of DDA inhibited the binding of Ca2+ to NaOL so that more Ca2+ was adsorbed on the quartz surface to provide the adsorption site for NaOL. Moreover, the best adsorption condition of Ca2+ + NaOL + DDA mixed solution was analyzed by quartz crystal microbalance with dissipation, and it demonstrated that the most stable chemisorption environment on the quartz surface was at pH 11.0. In these circumstances, Ca2+ could first adsorb in a point-like manner on the quartz surface, which was then adsorbed with a mixture of NaOL and DDA. This result showed that, at a specific pH, Ca2+ could encourage the coadsorption of cationic/anionic mixed collectors on quartz. This work provides an important new understanding of the intermolecular interactions that take place during complex mineral flotation processes between chemical additives and mineral surfaces. The methodology used in this study can be easily adapted to different interfacial processes, including water treatment, membrane technology, bioengineering, and oil production.
研究领域:
矿物浮选
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界面化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2020
·
IF 3.557
Wenjihao Hu,Mengjie Tian,Jian Cao,Lei Xie,Lu Gong,Wei Sun,Zhiyong Gao,Hongbo Zeng
Probing the interaction mechanism between organic molecules and material surfaces in the presence of metal ions is of great importance in many fields, such as mineral flotation. The collectability of benzohydroxamic acid (BHA) to a spodumene (LiAl(SiO3)2) mineral surface during mineral flotation could be enhanced with the addition of metal ion activators—Pb2+ ions. Pb2+ ions could be added as either Pb–BHA complex formed by premixing Pb2+ ions and BHA molecules at a given ratio or sequential addition of Pb2+ ions and BHA molecules. However, the complete understanding of the interaction mechanisms (e.g., adhesion) between BHA and the spodumene mineral surface in the presence of Pb2+ ions remains very limited. In this study, atomic force microscopy (AFM) was used to measure the intermolecular forces between BHA and the spodumene mineral surface in aqueous solutions. A BHA model molecule, that is, N-hydroxy-4-mercaptobenzamide (MBHA), was synthesized to prepare a BHA-functionalized AFM probe for force measurements. Two model systems (i.e., a Pb–BHA complex interacting with the spodumene mineral surface (model I) and BHA with a Pb2+-activated spodumene surface (model II)) were investigated for comparing the role of Pb2+ in BHA–mineral adhesion. The adhesion measured for model I (23.7 mN/m) is much higher than that of model II (12.5 mN/m), as further supported by the adsorption energies obtained from density functional theory (DFT) calculations. The calculation results showed a higher adsorption energy for model I (∼188.58 kJ/mol) than model II (∼128.16 kJ/mol), which is due to the better spodumene flotation recovery for the Pb–BHA complex as a collector than the sequential addition of Pb2+ and BHA. This work provides useful information on the intermolecular interactions between chemical additives and mineral surfaces in complex mineral flotation processes, and the methodology can be readily extended to other related interfacial processes such as membrane technology, water treatment, oil production, and bioengineering processes.
研究领域:
材料科学
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化学工程
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矿物加工工程
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DOI
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 2
·1134-1140
·
IF 3.9
Fangxiu Li,Yue Sun,Xiaoxia Sun,Yu Hu
Fluorescence recognition for the antimalarial cinchonidine could be achieved efficiently and rapidly through bamboo-like carbon nanotubes based on chiral conjugated H8BINOL derivatives. Herein, it was proved that the chiral fluorescence probe H8BINOL exhibited excellent fluorescence identification ability for cinchonidine. The structure and size of the S-1 (S-(3,3′-phenyl)-5,5′6,6′,7′,8,8′-octahydro-[1,1′-dinaphthalene]-2,2′-diol) and R-1 (R-(3,3′-phenyl)-5,5′6,6′,7′,8,8′-octahydro-[1,1′-dinaphthalene]-2,2′-diol) were studied by using the DLS, TEM, and SEM spectra, which exhibited a self-assembled bamboo-like carbon nanotube structure. In the CD (circular dichroism) test, cinchonidine was added to a pair of enantiomers of H8BINOL derivatives. The different configurations of H8BINOL derivatives showed significantly different Cotton effects for cinchonidine, indicating that cinchonidine formed diastereoisomer π–π complexes with different configurations of H8BINOL derivatives. From the AFM tests, it was revealed that cinchonidine could effectively quench the fluorescent spot of the probes quickly. The fluorescence titration tests demonstrated that 6.4 × 10−7 mol of cinchonidine could completely quench the fluorescence sensor of S-1 (2 × 10−5 M, 2 mL) through the formation of a 1 : 1 complex. The limit of detection (LOD) of S-1 was calculated to be 6.08 × 10−10, which indicates that S-1 has a high sensitivity and can be applied effectively to the practice of identifying cinchonidine. Meanwhile, the fluorescence sensor R-1 also exhibited the same sensibility with a low limit of detection (7.60 × 10−10).
研究领域:
分析化学
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材料科学
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药物化学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
·
2024
·
IF 14.3
Yuan Su,Si Li,Xin Li,Jing-Ying Zhou,Vraj P. Chauhan,Meng Li,Ya-Hui Su,Chun-Mei Liu,Yi-Fei Ren,Wu Yin,Jeffrey D. Rimer,Ting Cai
Kidney stones are a pervasive disease with notoriously high recurrence rates that require more effective treatment strategies. Herein, tartronic acid is introduced as an efficient inhibitor of calcium oxalate monohydrate (COM) crystallization, which is the most prevalent constituent of human kidney stones. A combination of in situ experimental techniques and simulations are employed to compare the inhibitory effects of tartronic acid with those of its molecular analogs. Tartronic acid exhibits an affinity for binding to rapidly growing apical surfaces of COM crystals, thus setting it apart from other inhibitors such as citric acid, the current preventative treatment for kidney stones. Bulk crystallization and in situ atomic force microscopy (AFM) measurements confirm the mechanism by which tartronic acid interacts with COM crystal surfaces and inhibits growth. These findings are consistent with in vivo studies that reveal the efficacy of tartronic acid is similar to that of citric acid in mouse models of hyperoxaluria regarding their inhibitory effect on stone formation and alleviating stone-related physical harm. In summary, these findings highlight the potential of tartronic acid as a promising alternative to citric acid for the management of calcium oxalate nephropathies, offering a new option for clinical intervention in cases of kidney stones.
研究领域:
泌尿学
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材料科学
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生物物理学
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药理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Cheng Cheng,Lijun Liu
In order to solve the problems of weak interface interaction and limited control effect of traditional profile control and water plugging materials, which lead to severe fracture flow in tight reservoir and ultra-tight reservoir reservoirs, weak interface effects of traditional profile control and water plugging materials, and limited control effects, this study designed and synthesized a biomimetic polymer (CTPAM) with strong cohesion and adhesion properties based on the principle of mussel biomimetics. The molecular weight distribution of the polymer is relatively narrow. CTPAM exhibits significant advantages under high temperature aging of 110°C for 150 days and high salt mineralization of 29,000 mg L −1 , with a viscosity retention rate of 64.6% significantly higher than traditional polyacrylamide (HPAM), and a viscosity recovery rate of 71.5% after high shear of 3000 s −1 , which is 1.7 times that of HPAM. Atomic force microscopy (AFM) analysis shows that the adsorption thickness of CTPAM on mica surface is 576 ± 10 nm, which is 2.3 times that of HPAM, attributed to its multiple supramolecular interactions. Application evaluation shows that the dynamic adsorption capacity of CTPAM based self-grown gel dispersion in formation water environment, Δ f = −36 Hz, is significantly higher than that of ordinary systems.
研究领域:
高分子科学
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石油工程
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材料科学
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仿生学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2019
·
IF 2.923
Yao Wang,Baohuan Jia,Min You,Haoran Fan,Siyu Cao,Hui Li,Wenkai Zhang,Gang Ma
Amyloid fibrillation by hen egg white lysozyme (HEWL) under the influences of two common surfactants, sodium dodecyl sulfate (SDS) and Triton X-100 (TX-100), was investigated with atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy. Detailed AFM investigations indicated that both SDS and TX-100 were able to induce some significant morphological changes of HEWL amyloid fibrils. Both SDS and TX-100 could induce a morphological change which was characterized with alternating fibril regions with increased thicknesses along the fibril axis. In addition, TX-100 was also able to induce a morphological change which was characterized with fibril branching. In contrast, the positively charged cetyltrimethylammonium bromide displayed no such effect as compared with the negatively charged SDS and the nonionic TX-100. These intriguing modulation effects of SDS and TX-100 on amyloid fibrillation were hypothesized to be due to surfactant-induced surface-catalyzed secondary nucleation owing to the noncovalent interaction between the surfactants and HEWL. The proposed hypothesis was further supported by FTIR spectroscopic investigation, which demonstrated the formation of a SDS–amyloid fibril complex and TX-100–amyloid fibril complex. Detailed FTIR analysis suggested that the tail group of SDS associated with amyloid fibrils is more disordered similar to that of SDS in aqueous solution, while the headgroup of SDS appears to interact with amyloid fibrils strongly similar to that of SDS in the solid state, and the ether groups of TX-100 associated with amyloid fibrils experienced a different microenvironment as compared with that of neat TX-100. Additional control experiments with FTIR spectroscopy revealed that the interactions of SDS/TX-100 with HEWL amyloid fibrils were different from those of SDS/TX-100 with HEWL amorphous aggregates. In addition, the β-sheet structures of the HEWL amyloid fibrils were found to be increased due to the influences of SDS and TX-100. Our work provides new insight into the modulation effects of surfactants on amyloid fibrillation.
研究领域:
生物化学
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分子生物学
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蛋白质科学
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产品关联
DOI
PubMed
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2023
·
IF 7.4
Chenchen Xiong,Yulin Wang,Yang Zhou,Xingyu Liu,JinHui Tang,Pan Feng
An ordered structure and high mechanical property of calcium silicate hydrate (C-S-H) gel has been always pursued in the field of cementitious materials. In this paper, compacted and layer-by-layer stacking C-S-H plates were fabricated based on Layer-by-Layer (LBL) method and H-cell penetration (HCP) method through cation exchange membrane templating. This new way changed the randomly packing structure of traditional C-S-H, and synthesized a high-orderly C-S-H platelets with denser structure. Based on molecular dynamics simulations, it can be attributed to the strong adsorption and nucleation sites contributed by sulfonic acid groups on the cation exchange membrane. Besides, AFM indentation experiments indicate this C-S-H owns significantly higher elastic modulus than traditional C-S-H, while the mechanical properties can be further increased by the addition of PVA and the regulation of reaction time. This new type C-S-H may pave the way to the preparation of high-performance concrete in the future.
研究领域:
材料科学
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土木工程
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化学工程
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产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2024
·Vol. 26
·期 9
·7855-7864
·
IF 2.9
Yao Wang,Ziqi Wang,Lujuan Yang,Wenkai Zhang,Gang Ma
Understanding the amyloid nucleation mechanism is fundamentally important for the development of diagnostics and therapeutics of amyloid-related diseases and for the design and application of amyloid-based materials. To this end, we here explore the use of atomic force microscopy (AFM) and a side-chain-based infrared (IR) probe technique to investigate the amyloid nanosheet formation mechanism of an Aβ16–22 variant, KLVFXAK, where X is p-cyanophenylalanine with its side-chain cyano group being an infrared probe. Using AFM, we reveal that the formation of KLVFXAK amyloid nanosheets follows a two-step non-classical nucleation mechanism. The first step is the rapid formation of a metastable fibrillar intermediate and the second step is slow transformation to the final nanosheet. Using the side-chain-based IR probe technique, we obtain spectroscopic evidence for the proposed nucleation mechanism of the amyloid nanosheet as well as the structural details for the intermediate and amyloid nanosheet. By using the structural constraints set by the two techniques, we propose the structural models for both the fibrillar intermediate and the amyloid nanosheet. In addition, we further investigated the amyloid nanosheet formation mechanism of a similar Aβ16–22 variant, KLVFXAE, and showed the impact of mutation on the amyloid nucleation mechanism. Our work also provides a nice example of how to use the combined approach of AFM and a side-chain-based IR probe technique to unravel the complex nucleation mechanism of amyloid formation.
研究领域:
生物物理学
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结构生物学
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材料科学
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蛋白质化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Yuxuan Ma,Dan He,Xiaojing Wang,Yuan Fu
Focused on energy and environment issues, in present investigation, an economical and eco-friendly photocatalyst for hydrogen evolution in water splitting reaction has been designed and fabricated. The characteristics by XRD, TEM, XPS and AFM confirmed that an octahedral H 2 Ta 2 O 6 is uniformly capsuled by ZnIn 2 S 4 thin clothes to form a package ZnIn 2 S 4 /H 2 Ta 2 O 6 heterojunction . The assembled ZnIn 2 S 4 /H 2 Ta 2 O 6 exhibits superior hydrogen generated performance with a value of 3217.31 μmol g −1 •h −1 under simulated sunlight irradiation, without obvious deactivation in five consecutive cycles. The enhanced activity and reusability are mainly attributed to ultrathin clothe-like shell, the well-matched band structure and a large tight contact interface in the package type construction, which can promote redox ability, extend light harvesting range and boost charge separation efficiency. The present study proposes a new design idea to assemble a highly efficient and durable photocatalyst for solar hydrogen generation by splitting water.
研究领域:
能源与环境
·
材料科学
·
光催化
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Jianfang Yang,Xiaoyun Hu,Tianshi Zhang,Juhui Liu,Haonan Zhang,Xiaoyang Liang,Qingqing Guan
Filtration is a pivotal industrial technology that enables the efficient separation and purification of multiphase systems while optimizing resource utilization, improving operational efficiency, and addressing environmental sustainability challenges. However, developing filtration systems that deliver high clarity and rapid filtration rates, while resisting surface cracks in multiphase unstable polysilicon slurry remains a significant challenge. In this work, a cellulose-modified diatomite-based dipole-interaction-enhanced (CE@D-IE) strategy, characterized by its straightforward yet highly effective, was proposed as a solution to the issue. The CE@D-IE filtration system prevented filter cake from surface cracking at 10-40 °C, attributed to diatomite's capillary resistance, cellulose-enhanced dipole interactions, and chain entanglement. Atomic force microscopy (AFM) and molecular dynamics (MD) simulations further revealed stronger interaction within the filter cake formed by the CE@D-IE strategy, providing critical molecular-level evidence for its improved resistance to surface cracking. Furthermore, the CE@D-IE strategy achieved excellent filtrate clarity and demonstrated a 50% improvement in filtration rate compared to the BF strategy, resulting in a comprehensive enhancement of polysilicon slurry filtration performance . This work provides a viable and practical solution to address filtration challenges in polysilicon slurry under complex and dynamic conditions, while also demonstrating significant potential to enhance filtration performance in other complex systems.
研究领域:
化学工程
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材料科学
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环境工程
·
纳米技术
·
分离技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）