TALANTA
·
2019
·
IF 4.916
Xiaoli Wu,Pengsi Wang,Shaoyan Hou,Peiling Wu,Jian Xue
Organophosphorus pesticides (OPs) are frequently for pest control in the agriculture industry. Accumulation of OPs is harmful to the environment and human health. Thus, facile and portable detection of organophosphorus pesticides is of great importance. Among these methods, the fluorescence assay holds the advantages of high sensitivity, simplicity, nondestructive properties. Conventional fluorophores have the drawbacks of poor photostability and low signal-to-noise ratio due to their aggregation-caused quenching drawbacks at high concentration or in the aggregate state. Aggregation-induced emission fluorogens (AIEgens) are one key to develop next-generation fluorescence sensor due to their high emission efficiency in the aggregated state. 1,2-bis[4-(3-sulfonatopropoxyl) phenyl]-1,2-diphenylethene (BSPOTPE) is a typical AIE molecule containing two hydroxyl group . In this study, a fluorescence sensor based on BSPOTPE-SiO 2 –MnO 2 sandwich nanocomposites was fabricated. Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can “turn on” the fluorescence sensor. Based on the inhibition effect of OPs on AChE activity and the corresponding “turn off” effect on the fluorescence sensor, an AIE-based assay for OPs determination was developed. The fabricated sensor for paraoxon determination has a good linear relationship in the range of 1–100 μg/L and the LOD of 1 μg/L. Moreover, a simple, convenient fluorescence strip for visual semi-quantitative of OPs was fabricated, indicating this “on-off” fluorescent sensor is promising for on-site and infield detection.
研究领域:
环境科学
·
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Shujing Wang,Ying Lin,Chengkai Zhang,Tong Zhu,Xiaohe Tian,Dandan Li,Wen Ma,Qiong Zhang,Jieying Wu,Yupeng Tian
In this work, a series of multiphoton terpyridine agents (ZA, ZA-Mex, and ZA-Hex) for fluorescence lifetime imaging microscopy (FLIM) are designed and synthesized. The results from photophysical property research reveal that ZA-Hex, as an N-hexylated terpyridine salt, has stronger three-photon aggregation-induced emission (AIE) properties compared to ZA-Mex due to enhanced intramolecular charge transfer (ICT) performance. All three terpyridine derivatives possess suitable fluorescence intensities and stable fluorescence lifetimes under different pH conditions (pH = 4.0–8.0), thereby performing multiphoton fluorescence lifetime imaging. For biological imaging applications, it is found that ZA shows good lipid droplet (LD) turn-on fluorescence performance, and ZA-Hex could easily accumulate in mitochondria with high specificity. This is the first report of terpyridine salts as three-photon AIE probes used for multiphoton FLIM imaging.
研究领域:
化学
·
生物成像
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Xiang Gao,Peng Nie,Peiran Li,Zhi Zheng,Jieshun Cheng,Ying Gu,Yizhong Shen
To combat food freshness fraud, it is urgent to develop a method which could realize the detection of biogenic amines (BAs) present in food. In our study, we developed a colorimetric and ratiometric fluorescence dual-mode sensor which integrated with silver metallization-based response system of AIE liposome + OPD + RSM + Ag + toward BAs in foods for fighting freshness fraud. With the hydrolysis from the alkaline of BAs to resorcinol monoacetate (RSM), the production resorcinol (RS) could metallize silver ion (Ag + ) to silver atoms (Ag 0 ) which could lead to a BAs concentration-dependent decrease of the oxidation product 2,3-diaminophenothiazine (DAP) of Ag + to o -phenylenediamine (OPD). As a result, the dual-mode sensor has a low detection limit and wide linear range in the spiked detection of soy products, pork and milk samples for BAs. Thus, providing a reliable method for food safety and forestalling food freshness fraud.
研究领域:
食品科学
·
分析化学
·
传感器
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Wei-Xian Wang,Yuqing Wu,Hong-Wei Li
The aggregation-induced emission (AIE) phenomenon of the metal nanoclusters (NCs) has been discovered quite recently, which is considered to be creative to improve the optical properties of NCs upon ligand aggregation. In the present study, we report an AIE system for double-stranded DNA-templated silver nanoclusters (AgNCs-dsDNA) by using bovine serum albumin (BSA) in solution, which induce a moderate emission enhancement of AgNCs (5-fold) and a blue-shift through a loosen interaction. In addition, significant luminescence enhancement (30-fold) is further stimulated by the addition of digestive enzyme to the system by altering the surface structure of the aggregated particles. The processes are observed directly through transmission electron microscopy (TEM), where the dispersed AgNCs spheres are aggregated in a large incompact sheet-like film by BSA; while further trypsin addition lead them into larger particles (>50 nm) with higher density. And the intrinsic mechanism is explained well by UV–vis absorption and time-resolved luminescence spectra. The observed luminescence enhancement in step-II is attributed to the AIE through stronger interaction between the hydrolysates of BSA and the ligand dsDNA. Therefore, the optical properties of AgNCs-dsDNA are regulated well by the addition of BSA and trypsin in different amounts, which relates directly to the degree of aggregation and can be extended to other metal nanoclusters by employing the pairs of protein and related enzyme.
研究领域:
纳米技术
·
光学材料
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2025
·Vol. 39
·期 9
·e70368
·
IF 0
Kai Wang,Peiwen Lv,Mingyang Liu,Yunjun Mei,Yifan Zhang,Yuqiu Zheng,Jintao Guan
Traditional fluorescent probes have challenges, including aggregation-induced quenching, biological incompatibility, and suboptimal selectivity. In this study, we developed a novel probe derived from natural rutin featuring an aggregation-induced emission (AIE) effect. Through hydroxy engineering of rutin, the optimized probe enables precise detection of Fe 3+ via 2:1 stoichiometric coordination. The probe demonstrates remarkable analytical performance, with a detection limit as low as 0.22 μM. Concentration-dependent responses were observed within 0–20 μM, with significant linearity ( R 2 > 0.99) in the 0–10 μM range. Density functional theory calculations reveal that the binding of Fe 3+ effectively suppresses intramolecular charge transfer. The hydroxy-engineered modification plays a pivotal role in facilitating complexation for bond formation and providing appropriate steric hindrance. This research establishes a new benchmark for natural product-based AIE probes and deepens understanding of the structure–activity relationships governing flavonoid-metal recognition.
研究领域:
分析化学
·
生物无机化学
·
材料科学
·
荧光传感
·
配位化学
·
天然产物化学
✓ 已验证
产品关联
DOI
Polymer Chemistry
·
2021
·Vol. 12
·期 26
·3775-3783
·
IF 5.582
Bingfeng Shi,Jianhua Lü,Ying Liu,Yang Xiao,Changli Lü
Nano-light materials have attracted great interest in materials research due to their excellent fluorescent properties. The hybrid assembly of various nano-optical materials combines their advantages, extending the scope of potential applications. Herein, we report a fluorescence organic–inorganic hybrid nanostructure (T-PNI@QDs) based on binding red-emitting CdTe/ZnS quantum dots (QDs) to blue-emitting aggregation-induced emission (AIE)-active polymeric micelles in aqueous media with dual-channel emission. The AIE-active polymeric micelles were obtained by the self-assembly of thiol-terminated tetraphenylethylene (TPE) functionalized poly(N-isopropylmethacylamide) (T-PNI-SH) in water. An interesting assembly behaviour of transformation from a worm-like to a core–shell structure was observed by controlling the ratio of QDs/polymers due to the coordinated interaction between the QDs and the thiol groups. The dual-emission of T-PNI@QDs has obvious temperature-sensitive behaviour on account of PNIPAM. The novel fluorescent hybrid nanostructure was used as a probe to selectively detect picric acid (PA) in pure water. We expect this work will open up a new perspective for the construction of organic–inorganic hybrids based on different nano-light materials.
研究领域:
材料科学
·
纳米技术
·
光学材料
·
化学传感
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2023
·
IF 5.5
Shunfeng Yu,Kang Liu,Yueyi Tian,Xiaoxiao Chen,Jie Zhang,Mei Gao,Jinhui Wang,Mingming Zhang,Chuanzhuang Zhao
The design of thermoresponsive luminescent polymers with both a tunable upper critical solution temperature (UCST) and a tunable color is of great challenge. Herein, a series of thermoresponsive copolymers with UCST and aggregation-induced emission (AIE) behaviors are prepared, and a color-shifting fluorescent system based on the energy conversion between the AIE polymers and fluorescent dyes is constructed. The copolymers are prepared from acrylamide and 6-(4-vinylphenyl)-2,4-diamino-1,3,5-triazine (VPhDT). Benefitting from VPhDT, an AIE-active monomer that can provide multiple hydrogen bonds and enhance association of the polymer chains, the obtained copolymers exhibit both UCST and AIE behaviors in aqueous solutions. Utilizing the AIE copolymers as the donor and fluorescent dyes as the acceptors, color-shifting fluorescent systems that can emit blue, green, and red lights are established. The color-shifting fluorescent systems also exhibit tunable luminescent intensities and colors with the stimuli of temperature and pH. Such a color-shifting fluorescent system may have promising applications in the fields of temperature sensors and information displays.
研究领域:
聚合物化学
·
材料科学
·
光学材料
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Yingao Yang,Zixuan Zhou,Tao Wang,Daoming Tian,Shuyue Ren,Zhixian Gao
We explored a novel preparation method for MOF-on-MOF heterostructured material (Zn-BTEC@ZIF-8). This prepared heterostructured material acts as a container, capable of adsorbing tetracycline hydrochloride molecules into its backbone through hydrogen bonding and π-π interactions. This phenomenon triggers an aggregation induced emission (AIE) effect, leading to the formation of luminescent bodies. The coordination between histamine and MOF was found to collapse the originally stabilized MOF-on-MOF structure. This collapse causes the splitting of the initially stabilized MOF-on-MOF structure from the aggregated state into fragments, resulting in the quenching of fluorescence in the fluorophore. Remarkably, the fluorescence quenching efficiency of this composite surpasses that of single-layer metal−organic framework (MOF) zeolitic imidazolate framework-8 (ZIF-8) or zinc-based MOF of pyromellitic acid (Zn-BTEC), enabling more sensitive detection of histamine. In this investigation, we constructed a label-free fluorescent sensor specifically designed for the detection of histamine, capitalizing on the AIE effect inherent in MOF-on-MOF architecture and the presence of tetracycline hydrochloride (Tet). The sensor demonstrates a rapid, straightforward, and stable response, allowing for histamine detection within 20 min. Notably, the sensor covers a detection range of 2–400 mg L −1 , achieving a low detection limit of 1.458 mg L −1 The practical application of this sensor for quantitative detection of histamine in river water and various fish species exhibited robust performance, ensuring reliability and accuracy in real samples. Its potential application in food safety and environmental monitoring is evident, making it a valuable tool for addressing histamine-related challenges in these domains.
研究领域:
材料科学
·
分析化学
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2019
·Vol. 26
·期 16
·8829-8841
·
IF 3.917
Huang Hongye,Liu Meiying,Chen Junyu,Mao Liucheng,Wan Qing,Wen Yuanqing,Deng Fengjie,Zhou Naigen,Zhang Xiaoyong,Wei Yen
Abstract Since the first discovery by Tang in 2001, aggregation-induced emission (AIE) phenomenon has attracted considerable research interest in various fields. In this contribution, AIE-active composites (named as An-HPG-β-CD) have been fabricated via conjugation of AIE-active compound An-B(OH) 2 and hyperbranched polyglycerol functionalized β cyclodextrin (HPG-β-CD) based on dynamic phenyl borate for the first time. The potential biomedical applications of these AIE-active composites for biological imaging and drug delivery applications were further explored. The successful preparation of An-HPG-β-CD composites was confirmed through a series of characterization techniques. The An-HPG-β-CD composites possess great water dispersibility, low cytotoxicity, excellent fluorescence properties and uniform size and morphology, which make them promising for cell imaging. Furthermore, the cavities of An-HPG-β-CD composites could be utilized for loading with doxorubicin for drug delivery applications. In conclusion, we have developed a novel method for fabrication of AIE-active An-HPG-β-CD composites through formation of dynamic phenylboronic borate between β cyclodextrin containing hyperbranched polyglycerol and phenylboronic containing AIE dye. These AIE-active composites are of great potential in biological imaging and drug delivery applications. Graphic abstract
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 48
·30229-30241
·
IF 3.108
Kai Li,Yang Zhang,Bing Qiao,Furong Tao,Tianduo Li,Yunqiao Ding,Françisco M. Raymo,Yuezhi Cui
Four barbituric derivatives (1–4), were synthesized with obvious aggregation induced emission (AIE) or aggregation induced emission enhancement (AIEE) behaviors. The optical properties in different states and the mechanisms of the enhanced emission of 1–4 were investigated. We found that there were a large number of globular or blocky nanoparticles with average diameters from 229 to 394 nm in tetrahydrofuran (THF)/water solutions when the water fraction (fw) was 90%. The single crystal data of 2 and 4 reveal that multiple intermolecular interactions restrict the intramolecular motions, and promote the formation of a herringbone arrangement (4), thus permitting intense emission in the aggregate state. In addition, the frontier molecular orbital energy and band gap calculated by density functional theory (DFT) are consistent with the experimental results. Compound 4 is cell-permeable: upon entering the live cells, the dye molecules can accumulate in the lysosomes and turn on the fluorescence.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2019
·Vol. 15
·期 41
·8329-8337
·
IF 3.399
Hongyu Guo,Sining Zheng,Shibin Chen,Chenyang Han,Fafu Yang
Porphyrins are good near-infrared fluorescent materials, but the strong self-assembly stacking resulted in the aggregation-caused quenching (ACQ) effect, limiting their emissive performance in aggregated states. In this work, a novel diphenylacrylonitrile–porphyrin derivative with multiple polyglycol chains on the periphery was designed and synthesized as an excellent near-infrared-emissive liquid crystalline material in both solution and aggregated states, which was first observed for porphyrin liquid crystals. It exhibited a high self-assembly ability with the ordered hexagonal columnar mesophase between 70 and 120 °C approximately. The strong AIE-FRET effect was produced based on the overlap of the emission wavelength of diphenylacrylonitrile and the absorption wavelength of the porphyrin, resulting in the excellent near-infrared emission in both solution and aggregated states. The pseudo Stokes shift was as large as 210 nm and the fluorescence quantum yield reached 0.12 in the solid state. Moreover, this porphyrin liquid crystal displayed low biotoxicity and excellent fluorescence bio-imaging ability in living cells, opening a new application prospect for porphyrin liquid crystalline materials.
研究领域:
材料科学
·
生物学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Yuandong Lin,Nian Lu,Ji Ma,Jun-Hu Cheng,Da-Wen Sun
An emerging fluorescent ratiometric aptasensor based on gold nanoclusters (AuNCs) with aggregation-induced emission (AIE) properties was prepared and studied for deoxynivalenol (DON) detection. The ratiometric aptasensor used red fluorescent AuNCs 620 labelled with DON aptamer (Apt-AuNCs 620 ) as an indicator and green fluorescent AuNCs 519 modified by complementary DNA (cDNA) and magnetic beads (MBs) as internal reference, namely MBs-cDNA-AuNCs 519 . Under the optimal conditions, the aptasensor exhibited two good linear ranges of 0.1–50 and 50–5000 pg/mL for DON detection with coefficient of determination (R 2 ) of 0.9937 and 0.9928, respectively, and the low detection limit (LOD) of 4.09 pg/mL was achieved. Furthermore, this aptasensor was feasible to detect DON in positive wheat samples, and the results were in line with those from HPLC and ELISA, thus providing a promising route to detect DON with high sensitivity in cereals, even for other mycotoxins by replacing the suitable aptamer and cDNA.
研究领域:
分析化学
·
纳米技术
·
食品安全
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）