Science China-Materials
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2022
·Vol. 66
·期 3
·1180-1188
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IF 8.64
Luo Weihua,Xu Xingtang,Tang Yiyuan,Wu Zhen,Wang Guojie
Stimuli-responsive aggregation-induced emission (AIE) materials with regulated color and fluorescence have shown promising applications in smart optical systems, while most of them are only regulated by a single stimulus. Herein, a cyanostilbene-based fluorophore ( Z -BDPA) with AIE enhancement properties is elaborately designed, which exhibits multiple regulable color and fluorescence owing to its various photochemical reactions and reversible pH response. After exposure to 420 nm light, the green emission of Z -BDPA in tetrahydrofuran (THF) becomes brighter owing to the Z→E isomerization, which can be recovered under 365 nm irradiation; the yellow fluorescence of Z -BDPA in THF/H 2 O mixtures with 90% water fraction ( f w ) becomes stronger yellow-green fluorescence due to the photodimerization. At acidic conditions, Z -BDPA powder with yellow fluorescence can become another AIEgen Z - p -BDPA with blue fluorescence via protonation, which would be recovered through deprotonation under basic conditions. Under ultraviolet light irradiation, the blue fluorescence of Z - p -BDPA is blue-shifted and increased due to the photo-isomerization and subsequent photocyclodehydrogenation reactions. Based on the regulable color and fluorescence upon the photochemical and pH responses, Z -BDPA has been successfully applied in photo-patterning and anti-counterfeiting.
研究领域:
材料科学
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光学
·
化学
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DOI
高影响因子
Polymers
·
2020
·Vol. 12
·期 3
·551
·
IF 3.426
Jie Zhao,Xiangqiang Pan,Jian Zhu,Xiulin Zhu
Stimuli-responsive functional gels have shown significant potential for application in biosensing and drug release systems. In this study, aggregation-induced emission luminogen (AIEgen)-functionalized, diselenide-crosslinked polymer gels were synthesized via free radical copolymerization. A series of polymer gels with different crosslink densities or tetraphenylethylene (TPE) contents were synthesized. The diselenide crosslinker in the gels could be fragmented in the presence of H2O2or dithiothreitol (DTT) due to its redox-responsive property. Thus, the TPE-containing polymer chains were released into the aqueous solution. As a result, the aqueous solution exhibited enhanced fluorescence emission due to the strong hydrophobicity of TPE. The degradation of polymer gels and fluorescence enhancement in an aqueous solution under different H2O2or DTT concentrations were studied. Furthermore, the polymer gels could be used as drug carriers, suggesting a visual drug release process under the action of external redox agents. The AIEgen-functionalized, diselenide-crosslinked polymer gels hold great potential in the biomedical area for biosensing and controlled drug delivery.Keywords:polymer gels;redox response;aggregation-induced emission (AIE);fluorescent probes;drug release carriers
研究领域:
生物医学
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材料科学
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PubMed
高影响因子
BIOMATERIALS
·
2022
·
IF 15.304
Xiaoxue Ge,Meng Gao,Bairong He,Nannan Cao,Kerun Li,Yong Liu,Sanmei Tang,Kai Liu,Jing Zhang,Fang Hu,Lei Zheng,Bo Situ
The increasing resistance among fungi to antimicrobials are posing global threats to health. Early treatment with appropriate antifungal drugs guided by the antifungal susceptibility testing (AFST) can dramatically reduce the mortality of severe fungal infections. However, the long test time (24–48 h) of the standard AFSTs cannot provide timely results due to the slow growth of the pathogen. Herein, we report a new AFST that is independent of growth rate analysis using a luminogen with aggregation-induced emission characteristics (AIEgen) named DMASP. DMASP is a water-soluble small-molecule probe that can readily penetrate the dense fungal cell wall . Based on its mitochondria-targeting ability and AIE characteristics, fungal activity can be dynamically indicated via real-time fluorescence monitoring. This allows fungal susceptibility to various antimicrobials to be assessed within 12 h in a wash-free, one-step manner. This method may serve as a promising tool to rapidly detect possible drug-resistant fungal strain and guide the precise use of antimicrobial against fungal diseases.
研究领域:
微生物学
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分析化学
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医学诊断
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PubMed
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Shicheng Pei,Zhaohan Liu,Qishu Jiao,Qiling Jin,Xuan Luo,Yuanyuan Liu,Shuyao Zhou,Shuqin Pang,Xiaoxing Wu,Keming Xu,Wenying Zhong
Efficacious chemotherapy and real-time therapeutic monitoring remain major challenges in cancer treatment. Traditional systems often lack tumor specificity, limiting efficacy, and hindering therapy optimization. Moreover, the absence of real-time monitoring can lead to missed opportunities and increased risks of side effects. Herein, we designed a self-reporting ratiometric AIEgen-peptide nanoprobe (TPE-1(Hyd-DOX)-DEVD) for activatable chemotherapy and noninvasive imaging of therapeutic outcomes. When doxorubicin (DOX) in the nanoprobe is selectively activated in the acidic tumor microenvironment, the ensuing caspase-3 cascade triggers a morphological transformation of the nanoprobe that amplifies the TPE fluorescence. This enhancement allows the TPE/DOX fluorescence ratio to serve as an indicator for monitoring DOX activation and for providing therapeutic feedback. Both in vitro and in vivo studies demonstrated that TPE-1(Hyd-DOX)-DEVD exhibited an impressive tumor suppression efficacy and excellent biocompatibility. This study highlights the strong potential of this nanoprobe as a valuable tool for cancer theranostics, offering hope for more effective and personalized treatment strategies.
研究领域:
肿瘤学
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生物医学工程
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分子影像学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2022
·
IF 10.383
Yanhong Duo,Meng Suo,Daoming Zhu,Zihuang Li,Zheng Zheng,Ben Zhong Tang
Relative to traditional photosensitizer (PS) agents, those that exhibit aggregation-induced emission (AIE) properties offer key advantages in the context of photodynamic therapy (PDT). At present, PDT efficacy is markedly constrained by the hypoxic microenvironment within tumors and the limited depth to which lasers can penetrate in a therapeutic context. Herein, we developed platelet-mimicking MnO2 nanozyme/AIEgen composites (PMD) for use in the interventional PDT treatment of hypoxic tumors. The resultant biomimetic nanoparticles (NPs) exhibited excellent stability and were able to efficiently target tumors. Moreover, they were able to generate O2 within the tumor microenvironment owing to their catalase-like activity. Notably, through an interventional approach in which an optical fiber was introduced into the abdominal cavity of mice harboring orthotopic colon tumors, good PDT efficacy was achieved. We thus propose that a novel strategy consisting of a combination of an AIEgen-based bionic nanozyme and a biomimetic cell membrane coating represents an ideal therapeutic platform for targeted antitumor PDT. This study is the first to have combined interventional therapy and AIEgen-based PDT, thereby overcoming the limited light penetration that typically constrains the therapeutic efficacy of this technique, highlighting a promising new AIEgen-based PDT treatment strategy.
研究领域:
生物医学工程
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癌症研究
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纳米技术
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治疗学
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DOI
PubMed
高影响因子
Biosensors-Basel
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2022
·Vol. 12
·期 9
·745
·
IF 5.743
Li Gao,Yixi Deng,Haolu Liu,King Solomon,Bianjiang Zhang,Huimei Cai
Tea is an important economic crop and health beverage in China. The presence of heavy metal ions in tea poses a significant threat to public health. Here, we prepared an aptamer biosensor labelled with AIEgen nanospheres to detect Pb2+in tea. The dsDNA modified by amino and phosphoric acid was combined with the carboxylated AIEgen NPs to form AIEgen-DNA with a fluorescence group, which was then fixed to the surface of Zr-MOFs to quench the fluorescence of AIEgen NPs. At the same time, PEG was added to remove nonspecific adsorption. Then Pb2+was added to cut the DNA sequences containing the cutting sites, and AIEgen NPs and part of the DNA sequences were separated from the Zr-MOFs surface to recover the fluorescence. By comparing the fluorescence changes before and after adding Pb2+, the detection limit of Pb2+can reach 1.70 nM. The fluorescence sensor was applied to detect Pb2+in tea, and the detection results showed that the tea purchased on the market did not contain the concentration of Pb2+within the detection range. This study provides new insights into monitoring food and agriculture-related pollutants based on fluorescent biosensors.Keywords:lead ions;fluorescent biosensors;metal-organic frames;tea
研究领域:
分析化学
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食品科学
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环境科学
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DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
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2018
·Vol. 5
·期 9
·2183-2188
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IF 5.106
Chen Wang,Qinglan Li,Bolun Wang,Dongdong Li,Jihong Yu
Aggregation-induced emission luminogen (AIEgen)-functionalised mesoporous silica nanoparticles were synthesized by post-grafting two types of tetraphenylethene derivatives on mesoporous materials. The fluorescent chemical sensors, denoted as FMSN-1 and FMSN-2, emitted strong blue fluorescence under UV irradiation. Both of them exhibited quick and sensitive responses to 2,4,6-trinitrophenol (PA) and 2,4-dinitrophenol (2,4-DNP) via a fluorescence quenching process. In particular, the obtained materials also showed remarkable sensing ability for the antibiotics furazolidone (FZD) and nitrofurazone (NF) with low detection limits. The highly efficient sensing abilities of FMSNs for PA, 2,4-DNP, FZD, and NF can be attributed to fluorescence resonance energy transfer (FRET) from AIEgens to analytes. These results demonstrate the potential value of AIEgen-functionalised mesoporous materials in environmental protection.
研究领域:
材料科学
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环境科学
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化学
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DOI
高影响因子
MICROCHIMICA ACTA
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2026
·Vol. 193
·期 9
·635
·
IF 5.4
Wang Yu,Zhang Shumin,Shi Jiale,Wang Yuetong,Mao Yexuan,Dang Meng,Huang Xianqing,Song Lianjun,Zhang Xiya,Bu Tong
A novel fluorescent lateral flow assay (FLFA) based on a zirconium-based metal aggregation-induced emission luminogen framework (Zr-MAF) is reported for the highly sensitive detection of zearalenone (ZEN) in cereals. A carambola-like Zr-MAF with a high fluorescence quantum yield of 36.9% was synthesized via a hydrothermal method using Zr 4+ and 1,1,2,2-tetra(4-carboxylphenyl) ethylene (TCPE). The prepared Zr-MAF-labeled monoclonal antibody probe exhibited intense luminescence, robust stability, and high affinity toward ZEN, collectively contributing to a significant enhancement in detection sensitivity. Under optimal conditions, the Zr-MAF-FLFA achieved an ultralow detection limit (IC 10 = 0.014 ng/mL) and a sensitivity (IC 50 ) of 0.046 ng/mL, representing a 2.6-fold improvement over traditional gold nanoparticles-based FLFA. Notably, the assay exhibited significant cross-reactivity only with the ZEN homologues α-ZAL, β-ZAL, and β-ZOL, which shared similar electrostatic potentials and substantial 2D molecular similarities with ZEN. Furthermore, the proposed method was successfully applied to real food matrices, including flour, glutinous rice, sweet corn, and glutinous corn, yielding satisfactory recoveries ranging from 85.37% to 106.42%. With detection limits in these food samples (0.68-0.78 µg/kg) falling well below national regulatory limits, this work provides a robust analytical platform for trace mycotoxin monitoring in food safety. Graphical abstract
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Lingchen Wang,Yue Huang,Linlin Sun,Xiaojuan Gong,Chuan Dong,Shaomin Shuang
Herein, a novel rapid, specific, and sensitive probe for adenosine triphosphate (ATP) detection is developed. We have pioneered the integration of split ATP aptamers with aggregation-induced emission (AIE) via chemical binding to obtain a novel ATP detection probe (TPE probe). Upon the binding of the ATP split aptamer to the target, the intermolecular distance of the AIE molecules decreases, restricting their spatial rotation, which leads to an enhancement of the fluorescence signal, thereby enabling the detection of ATP. This unique design provides the probe with both target-specific recognition capability of the aptamer and sensitive signal-reporting function. Under the optimized experimental conditions, the probe exhibits a linearity range from 1-1000 nM with limit of detection 0.14 nM, displaying a comparative advantage over previously reported methods in terms of sensitivity and selectivity. Additionally, this method demonstrated satisfactory performance for ATP detection in beer samples, with recoveries between 97.5 % to 104.6 %. More importantly, the current research is expected to provide an effective monitoring method for beer quality control.
研究领域:
生物化学
·
分析化学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2024
·Vol. 48
·期 11
·5025-5031
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IF 2.7
Shang Zhang,Qiuhong Li,Hao Liu,Xueshu Li,Xuemei Wang,Xueqin Du,Cuiling Lv,Zhaodong Wang,Aixiang Li,Lin Niu
Redox stimulation at the molecular level has been the focus of many fields, especially in electrofluorochromic (EFC) devices with individually addressable pixels and switching function. In this study, the fluorescent molecule ((1E)-1-((4-(1,2,2-triphenylvinyl)benzylidene)-hydrazineylidene)ethyl)ferrocene (FcMe-TPE) with aggregation-induced emission (AIE) properties was synthesized and mixed with PVA to prepare an EFC hydrogel material (PVA/FcMe-TPE) with high conductivity. The obtained hydrogel exhibited reversible fluorescent switching behavior, which could be achieved by adding a redox agent alternately based on the redox properties of the FcMe-TPE molecule. The fluorescence intensity of the hydrogel increased by 700 times after adding oxidant and could almost return to the initial value by adding reductant. Interestingly, the effect of the oxidant could be replaced by applying a voltage and the hydrogel exhibited good EFC behaviors. When the voltage increased from 0 V to 1 V, the fluorescence intensity of the hydrogel gradually increased and reached the maximum value at 1 V. The obtained fluorescent hydrogels could be customized to different appearance according to needs, and the EFC devices with individually addressable pixels and switching function were fabricated successfully. Finally, by introducing phytic acid (PA), the mechanical strength of the PVA/FcMe-TPE hydrogel was greatly improved without affecting its EFC performance. This study provides a new idea and solution for the intelligent display field, such as advanced anti-counterfeiting and information encryption.
研究领域:
材料科学
·
化学
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DOI
高影响因子
DYES AND PIGMENTS
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2026
·
IF 3.9
Wenlong Xing,Yin Zhu,Jiahao Wu,Shijia Li,Zhenyu Zhao,Jinsong Zhang,Shaowei Bo,Ji Zeng,Jiangling Peng
The rapid and accurate detection of adenosine 5′-triphosphate (ATP) is crucial for clinical diagnostics, bioanalysis, and food safety. This study presents two novel aggregation-induced emission (AIE)-active probes, BIP-PP-1 and BIP-PP-2 , derived from a new N-heterocyclic AIEgen core, benzo[4,5]imidazo[1,2- c ]pyrimidine (BIP). The optimized probe, BIP-PP-2 , functions as a high-performance ATP sensor with a large Stokes shift, high sensitivity (LOD = 0.85 μM, linear range 0 – 90 μM), and excellent selectivity over structurally similar anions such as ADP, AMP, CTP, TTP, and UTP, a feature seldom achieved in small-molecule ATP probes. This unique selectivity is attributed to the novel BIP core, where specific π-π stacking and hydrogen-bonding interactions with the adenine moiety of ATP provide a superior stereoelectronic match, driving precise recognition and AIE-based fluorescence enhancement via a synergistic combination of electrostatic and non-covalent forces. BIP-PP-2 was successfully applied in real-time ATP imaging within live bacterial cells and, notably, in the rapid visual detection of bacterial contamination in beverages using a portable 365 nm UV lamp, achieving a visual detection limit of 3.9 × 10 5 CFU mL −1 under ambient light. This work introduces the BIP scaffold as a promising platform for functional dye design and establishes BIP-PP-2 as a robust analytical tool for on-site bioanalysis and food safety monitoring. © 2001 Elsevier Science. All rights reserved.
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高影响因子
Materials Chemistry Frontiers
·
2019
·Vol. 3
·期 6
·1151-1158
·
IF 0
Yan Jie Li,Hao Tian Zhang,Xiao Ying Chen,Peng Fei Gao,Chang-Hua Hu
Aggregation-induced emission luminogens (AIEgens) with a definite structure–activity relationship play important roles in site-specific bio-imaging and applications. However, the lack of a clear structure–activity relationship for the excited-state intramolecular proton transfer (ESIPT) molecules, which are a series of powerful AIEgens, restricts their biological applications. Herein, the cell-penetrating capability of 4-N,N-dimethylaminoaniline salicylaldehyde Schiff-bases (DSS) with different substituents was investigated. The diethylamino functionalized ESIPT Schiff base (DSS-4-DEA) displayed high cell-penetrating capacity, making this simple AIEgen turn into a more powerful fluorescent functional material in biosystems. The DSS-4-DEA was successfully used for a fluorescence assay of the intracellular Cu2+. Besides, the DSS-4-DEA could also be used as an efficient transmembrane carrier to drastically enhance the internalization of DSS-5-Cl to achieve two-color imaging. In addition, the DSS-4-DEA could be used to improve the transportation of anticancer drug curcumin (Cur) into HeLa cells, leading to increased apoptosis. The complete exploration of the structure–activity relationship of ESIPT molecules might supply lots of new applications of AIE materials in biological systems.
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危险品化学品经营许可证（带存储）