PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
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2026
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IF 2.5
Fuyou Wang,Qingmin Liu,Wenhui Wu,Yuxiao Su,Zhimei Song,Runliang Feng
Purpose In order to develop reduction-responsive nano-drug delivery system for encapsulating antifungal drugs.Methods Herein, with poly (isobutene-alt-maleic anhydride) as skeleton, we synthesized a polymer containing cross-linked disulfide bonds to prepare reduction-responsive ketoconazole-loaded nanoparticles (MPEG-P-KET). The in vitro reduction-responsive behavior and antifungal activity of MPEG-P-KET were investigated.Results The MPEG-P-KET improved the dispersion and solubility of lipophilic KET. KET’s imidazole group formed a salt with the free carboxyl groups in the polymer carrier, resulting in delayed drug release from MPEG-P-KET. However, MPEG-P-KET still exhibited reduction-sensitive drug release behavior, and showed comparable antifungal activity with KET in vitro. Interestingly, MPEG-P-KET demonstrated higher ability to inhibit biofilm formation and disrupt mature biofilms than KET.Conclusion The polymeric nanoparticles with disulfide bonds could be used for the encapsulation and controlled delivery of antifungal drugs in the field of fungal infection treatment.
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高影响因子
Journal of Advanced Research
·
2024
·
IF 11.4
Kai Lin,Lei Yue,Longyu Yuan,Kui Kang,Yibing Zhang,Rui Pang,Wenqing Zhang
Introduction During the adaptation to host plant resistance, herbivorous insects faced the challenge of overcoming plant defenses while ensuring their own development and reproductive success. To achieve this, a strategic allocation of energy resources for detoxification and ecological fitness maintenance became essential. Objective This study aimed to elucidate the intricate energy allocation mechanisms involved in herbivore adaptation that are currently poorly understood. Methods The rice Oryza sativa and its monophagous pest, the brown planthopper (BPH), Nilaparvata lugens were used as a model system. An integrated analysis of metabolomes and transcriptomes from different BPH populations were conducted to identify the biomarkers. RNA interference of key genes and exogenous injection of key metabolites were performed to validate the function of biomarkers. Results We found that alanine was one of the key biomarkers of BPH adaptation to resistant rice variety IR36. We also found that alanine flow determined the adaptation of BPH to IR36 rice. The alanine aminotransferase (ALT)-mediated alanine transfer to pyruvate was necessary and sufficient for the adaptation. This pathway may be conserved, at least to some extent, in BPH adaptation to multiple rice cultivars with different resistance genes. More importantly, ALT-mediated alanine metabolism is the foundation of downstream energy resource allocation for the adaptation. The adapted BPH population exhibited a significantly higher level of energy reserves in the fat body and ovary when fed with IR36 rice, compared to the unadapted population. This rendered the elevated detoxification in the adapted BPH and their ecological fitness recovery. Conclusion Overall, our findings demonstrated the crucial role of ALT-mediated alanine metabolism in energy allocation during the adaptation to resistant rice in BPH. This will provide novel knowledge regarding the co-evolutionary mechanisms between herbivores and their host plants.
研究领域:
昆虫学
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植物科学
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分子生物学
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生态学
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PubMed
高影响因子
POLYMER
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2020
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IF 4.231
Yufei Liu,Siyuan Jiang,Wei Yan,Jun Qin,Min He,Shuhao Qin,Jie Yu
Improving complexation at the interfaces and regulating the crystal transformation behaviors of polyamide 6 (PA6) composites with high mechanical and thermal properties are essential for the industrial applications of PA6. In this work, the effects of adding p (N-(4-F-phenylmaleimide)-alt-styrene) (PFS) on the crystal transformation, thermostability, thermal conductivity , and mechanical properties of PA6 were investigated and discussed systematically. The resu---lts from heat deflection temperature (HDT), dynamic mechanical analysis (DMA ) and thermal conductivity tests indicate that PFS greatly increases the HDT, glass-transition temperature ( T g ), and thermal conductivity of PA6. Simultaneously, when the content of PFS is 10%, the tensile strength and flexural moduli of PA6/PFS composites are increased by 10.5 and 17.8% compared with that of pure PA6, respectively. The results from differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) show that PFS induces the transformation of PA6 from γ to α crystals by interfacial complexation. This work offers a facile approach for producing materials with high thermal and mechanical performances that can be potentially used in automobiles, electronics, and related technologies.
研究领域:
材料科学
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高分子化学
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高影响因子
EXPERIMENTAL PARASITOLOGY
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2016
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IF 1.623
Xiaochuan Zhang,Lili Jin,Zhe Cui,Changhao Zhang,Xue Wu,Hyun Park,Hongmei Quan,Chunmei Jin
Toxoplasma gondii ( T . gondii ) is an important pathogen which can causes serious public health problems. Since the current therapeutic drugs for toxoplasmosis present serious host toxicity, research on effective and new substances of relatively low toxicity is urgently needed. This study was carried out to evaluate the anti-parasitic effect of oxymatrine (OM) and matrine (ME) against T . gondii in vitro and in vivo . In our study, the anti- T . gondii activities of ME and OM were evaluated in vitro using cell counting kit-8 assay, morphological observation and trypan blue exclusion assay. In vivo , mice were sacrificed four days post-infection and ascites were drawn out to determine the extent of tachyzoite proliferation. Viscera indexes and liver biochemical parameters, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutathione (GSH) and malondialdehyde (MDA), were examined to evaluate the toxicity of compounds to mice. As a result, OM and ME showed anti- T . gondii activity but low selectivity toxicity to HeLa cells. Both compounds also significantly decreased the number of tachyzoites in peritoneal cavity and recovered the levels of ALT, AST, GSH and MDA in liver. Moreover, the mice treated with OM or ME achieved better results in viscera index and survival rate than that of spiramycin. These results suggest that OM and ME are likely the sources of new drugs for toxoplasmosis, and further studies will be necessary to compare the efficacy of drug combination, as well as identify its action of mechanism.
研究领域:
寄生虫学
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药理学
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传染病学
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PubMed
高影响因子
BIOMACROMOLECULES
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2026
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IF 5.9
Dongfang Zhao,Tianqi Li,Lihang Jiang,Zheng Li,Zhibo Li
The global accumulation of plastic waste underscores the urgent need for sustainable polymers that combine commodity feedstocks, controlled synthesis, and closed-loop recyclability. Substituted six-membered lactones represent promising poly(ether-alt-ester) precursors owing to their tunable properties and inherent degradability, yet their structural diversity and recycling pathways remain limited. Here, we report a catalyst-modulated route to regioselectively synthesize methyl-substituted six-membered lactones from commodity methyl glycolate (MG) and propylene oxide (PO), which are subsequently polymerized into poly(ether-alt-ester)s capable of efficient chemical depolymerization. The choice of catalyst dictates both monomer structures and polymer microstructure, while thermal and stereochemical analyses reveal how subtle substitution patterns govern amorphous or semicrystalline behavior of the resulting polymers. Chemical depolymerization regenerates either mixed or pure lactones, demonstrating true closed-loop recycling. By integrating catalyst design, control over monomer regioisomer distribution, polymer microstructure and reversible polymerization, this work establishes a versatile platform for constructing recyclable poly(ether-alt-ester) systems, advancing circularity within polymer materials.
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高影响因子
Journal of Materials Research and Technology-JMR&T
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2020
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IF 5.289
Yufei Liu,Siyuan Jiang,Wei Yan,Jun Qin,Min He,Shuhao Qin,Jie Yu
In order to expand its application range in electronics and membrane industries, this paper aimed to develop polyamide 6 (PA6)/P ( N -(4-carboxyphenyl) maleimide-alt-triallyl isocyanurate) (PCT) composites with heat-resisting, thermally conductive and anti-moisture, by employing PCT as a reactive reinforcement material and applying irradiation for solid-state interfacial reaction (SSIR) between PCT and PA6. According to the results, the SSIR occurred between PA6 and PCT. Compared with non-SSIR PA6, the PA6/PCT composite with SSIR showed the highest heat resistance, thermal conductivity and anti-moisture absorption and its relative crystallinity ( X c ), glass transition temperature ( T g ), and heat deflection temperature ( HDT ), thermal conductivity and anti-moisture absorption were improved by 61.4, 24.0, 83.9, 18.5 and 40.2%, respectively. This is because that the chemical bond between the PCT surface and the PA6 matrix is formed by SSIR, which provides a theoretical basis either for the development of PA6 or other semi-crystalline polymers.
研究领域:
高分子材料科学
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材料工程
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JOURNAL OF APPLIED MICROBIOLOGY
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2019
·Vol. 127
·期 6
·1716-1726
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IF 2.683
Cheng R.,Wang L.,Li J.,Fu R.,Wang S.,Zhang J.
AimsTo purify and characterize an exopolysaccharide (EPS) from an Agrobacterium strain ZCC3656 with high EPS‐secreting performance and investigate its anti‐inflammatory activity using lipopolysaccharide (LPS)‐induced macrophage cells in an acute liver injury mouse model.Methods and ResultsTwelve rhizobial strains were compared for EPS fermentation production in modified M9 salts supplemented with mannitol or sucrose as the sole carbon source. Agrobacterium sp. ZCC3656 exhibited the highest EPS yield (21·1 g l−1) and was characterized for EPS production by carbon source utilization, time course fermentation and serial subcultivation assays. The EPS, designated Riclin, was purified by deproteinization using the Sevag method. The combined results of gel permeation chromatography, monosaccharide composition, methylation analysis and nuclear magnetic resonance analyses indicated that Riclin is a succinoglycan‐like polysaccharide comprised of glucose, galactose, succinate and pyruvate at a ratio of 7·8. : 1·0 : 0·9 : 1·1 and has an molecular weight of approximately 2·5 × 106 Da. Riclin inhibited TNF‐α, IL‐1β and IL‐6 expression in LPS‐stimulated RAW 264.7 macrophage cells in a dose‐dependent manner. In addition, Riclin pretreatment increased the survival rate of D‐Gal/LPS treated mice, inhibited serum ALT and AST activities and reduced the production of the inflammatory mediators TNF‐α, IL‐1β and IL‐6.ConclusionsAgrobacterium sp. ZCC3656 is a highly stable EPS‐producing strain. The EPS Riclin from ZCC3656 is a succinoglycan‐type polysaccharide that is noncytotoxic and exhibits remarkable anti‐inflammatory effects in vivo and in vitro.Significance and Impact of the StudySuccinoglycans are well known for good rheological properties and their physiological interactions with plants. However, their potential activity towards mammals has received little attention. Our study revealed that the succinoglycan Riclin exhibited excellent anti‐inflammatory activities and could be considered as a promising reagent in anti‐inflammatory treatment.
研究领域:
微生物学
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免疫学
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药理学
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PubMed
高影响因子
SOLID STATE IONICS
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2018
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IF 2.751
Minsui Li,Youhao Liao,Qiuyu Liu,Jiaxin Xu,Fangbin Chen,Jinhong Huang,Weishan Li
To compensate the disadvantage of traditional poly(vinylidene fluoride- co -hexafluoropropylene) (P(VdF-HFP)) based gel polymer electrolyte (GPE) with poor rate performance, new GPE system consisted of P(VdF-HFP) and poly(methyl vinyl ether- alt -maleic anhydride) (P(MVE-MA)) with different ratios were prepared by electrospinning technology using polyethylene (PE) as support. After introducing P(MVE-MA) into P(VdF-HFP) system, the performance of the blended membrane and the GPE was significantly improved. Especially M4 based GPE blended with the mass ratios of P(MVE-MA): P(VdF-HFP) = 75: 25 exhibited the best physical and electrochemical characterizations. The developed membranes with interconnected fibrous structure showed the average diameter of 0.1–2.0 μm, which were facilitated for uptaking the liquid electrolyte and improving the ionic conductivity for corresponding GPEs. The introduced P(MVE-MA) copolymer presented higher decomposition voltage than P(VdF-HFP) copolymer from the calculation result of oxidation potential, leading to higher oxidative stability for blended GPE than pure P(VdF-HFP) based GPE. Furthermore, M4 based GPE presented remarkable interfacial compatibility with electrode and the lower polarization resistance , resulting in better cycling stability and rate performance, which had 96.5% capacity retention after 100 cycles and the discharge capacity at 5 C kept 91.6% of 1 C capacity in Li/GPE/LiNi 0.5 Mn 1.5 O 4 coin cell, compared with P(VdF-HFP) based GPE that had 87.8% retained capacity after 100 cycles and 48.7% retention capacity at 5 C .
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高影响因子
Polymer Chemistry
·
2023
·Vol. 14
·期 11
·1275-1281
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IF 4.6
Yuanzuo Zou,Jingzhou Guo,Yinglu Liu,Yudi Du,Yuan Pu,Dan Wang
Process intensification technologies based on novel reactors have been considered to be the most promising progress paths for developing more efficient chemical processes. In this work, the synthesis of poly(9,9-dioctylfluorene-alt-benzothiadiazole), abbreviated as F8BT, was achieved via Suzuki cross-coupling polymerization in a rotating packed bed (RPB) reactor maintained in an oxygen-free environment. The synthesized F8BT has a number average molecular weight of 35.2 kDa, a polymer dispersity index of 2.47 and double band absorption and yellow-green photoluminescence properties. An aqueous dispersion of F8BT nanoparticles was then prepared by solvent–antisolvent recrystallization in an external circulation RPB reactor, and spherical nanoparticles with an average particle size of 175.6 nm and a particle dispersion index within 0.2 were obtained. The nanoparticles, which appear yellowish green in color under 365 nm excitation, were uniformly incorporated into polyvinyl alcohol by virtue of the compatibility brought about by hydrogen bonding to obtain PVA composite films containing F8BT nanoparticles. The composite film has a shape memory function, and the irreversible shape change process from the initial “closure” to the final “blooming” is completed in about 15 min at an ambient temperature of 20 °C and 60% relative humidity. It is expected to be used as an optical functional device to monitor the cold chain.
研究领域:
材料科学
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化学工程
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光学器件
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物流技术
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高影响因子
BIOMEDICINE & PHARMACOTHERAPY
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2018
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IF 3.457
Li Zhang,Hui-Xia Li,Wu-Si Pan,Farhan Ullah Khan,Cheng Qian,Feng-Rong Qi-Li,Xiaojun Xu
Background and aims Non-alcoholic steatohepatitis (NASH) is the hepatic manifestation of metabolic syndrome and is characterized by steatosis, inflammation, and fibrosis. We aim to characterize the hepatoprotective effects of Leonurine hydrochloride (LH) and the possible pathway in a cell and rodent model of diet-induced steatohepatitis (NASH). Methods For in vitro studies, Palmitic acid (PA) and free fatty acid (FFA) induced HepG2 and HL7702 steatosis cell models were used. For in vivo studies, NASH was induced by feeding mice MCD diet. These mice received either placebo or LH at three different doses (50、100、200 mg/kg/day) for 6 weeks. Histological staining’s, and commercially available kits for ALT and AST and hepatic contents of TG, TC, MDA, SOD, and GSH were used to assess NASH. Furthermore, relative liver protein and gene expression levels were determined by Western Blot and qPCR, respectively. Results After establishing NASH models, LH treatment improved lipid accumulation, hepatic contents of TG, TC, and expression levels of ALT and AST in dose-dependent manner. Also, LH improved MDA, SOD, and GSH expression levels. The results of RT-PCR and Western blotting showed that LH upregulated the expression of AMPK phosphorylation and downregulated SREBP-1c and its target genes expression level. Conclusions Our data reveal the promising role of Leonurine hydrochloride in the prevention and treatment of NASH, in vitro and in vivo . This effect may be partially mediated by the AMPK/SREBP1 pathway. These findings provide a novel therapeutic target for the clinical treatment of NASH.
研究领域:
药理学
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肝病学
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代谢性疾病
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PubMed
高影响因子
Frontiers in Nutrition
·
2022
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IF 6.59
Han Mengyao,Zhang Zhongshan,Li Xinyue,Tong Haibin,Xu Zhiguo,Ding Zikang,Yang Anquan,Xie Min,Wang Xiaomei
To investigate the protective effect of collagen peptide from Micropterus salmoides skin (CPMs) on oxidative damage induced by cyclophosphamide in mice. Balb/c female mice were divided into blank, model (cyclophosphamide, CTX), positive control (levamisole hydrochloride), and collagen peptide low-, medium-, and high-dose groups. The results showed that CPMs increase the body mass and immune-related organ indexes, such as liver and kidneys of immunosuppressed mice. The activities of ALT, AST, UA, BUN, and MDA in the liver and kidney tissues decreased significantly, while those of SOD and GSH-Px increased significantly. CPMs can relieve the pathological damage to immune organs. CPMs significantly increase the activities of IL-2, IgG, and TNF-α in serum and SOD activity, while the MDA content was decreased compared to the model group. CPMs can exert a protective effect on cyclophosphamide-induced oxidative damage and have application prospects in the field of health food.
研究领域:
药理学
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免疫学
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毒理学
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营养学
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高影响因子
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
·
2021
·Vol. 99
·期 12
·
IF 2.273
Weimin Xu,Peng Wang,Dalong Wang,Ke Liu,Shuaishuai Zhang,Wei Zhao,Guoqing Liu
The aim of the present study was to investigate the protective effect of S-ketamine (S-KET) against carbon tetrachloride (CCl4) – induced liver damage and oxidative stress, as well as to elucidate the related underlying mechanisms. Blood was collected to measure biochemical parameters (alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TB) and γ-glutamyltransferase (γ-GT)) and the liver was harvested for histopathological analysis of enzymes related to the antioxidant response (malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-PX)). Liver cell apoptosis was evaluated using the TUNEL assay. In addition, the expression levels of apoptosis-related proteins and the nuclear factor erythroid 2–related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway were detected by Western blot analysis to explore potential mechanisms. S-KET protected the liver from CCl4-induced damage. The changes to the liver biochemical parameters (increased ALT, AST, ALP, TB, and γ-GT) and oxidative stress-related indicators (increased MDA; depleted SOD, GSH, and GSH-PX) induced by CCl4 were inhibited by S-KET. S-Ket also inhibited CCl4-induced cell apoptosis, the changes in expression of related proteins, and blocked CCl4-induced liver injury and oxidative stress via activation of the Nrf2/HO-1 signaling pathway. S-KET effectively protected the liver by inhibition of CCl4-induced damage via upregulation the Nrf2/HO-1 signaling pathway.
研究领域:
药理学
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肝病学
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分子生物学
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毒理学
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PubMed
高影响因子
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