Nanoscale Research Letters
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2016
·Vol. 11
·期 1
·1-9
·
IF 2.584
Ge Yuru,Li Yushu,Zu Baiyi,Zhou Chaoyu,Dou Xincun
Complex multiphase waste system purification, as one of the major challenges in many industrial fields, urgently needs an efficient one-step purification method to remove several pollutants simultaneously and efficiently. Multi-functionalized magnetic nanoparticles, Fe 3 O 4 @SiO 2 -MPS-AM-DMC-AMPS, were facilely prepared via a one-pot in situ polymerization of three different functional monomers, AM, DMC, and AMPS, on a Fe 3 O 4 @SiO 2 -MPS core-shell structure. The multi-functionalized magnetic nanoparticles (MNPs) are proven to be a highly effective purification agent for oilfield wastewater, an ideal example of industrial complex multiphase waste system containing cations, anions, and organic pollutants. Excellent overall removal efficiencies for both cations, including K + , Ca 2+ , Na + , and Mg 2+ of 80.68 %, and anions, namely Cl − and SO 4
2− , of 85.18 % along with oil of 97.4 % were shown. The high removal efficiencies are attributed to the effective binding of the functional groups from the selected monomers with cations, anions, and oil emulsions.
研究领域:
环境科学
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材料科学
·
化学工程
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DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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2024
·
IF 6
Jun Du,Changyan Yang,Yabo Deng,Hai Guo,Mengyun Gu,Danna Chen,Xia Liu,Jinqi Huang,Wenjin Yan,Jian Liu
The ample peptide field is the best source for discovering clinically available novel antimicrobial peptides (AMPs) to address emerging drug resistance. However, discovering novel AMPs is complex and expensive, representing a major challenge. Recent advances in artificial intelligence (AI) have significantly improved the efficiency of identifying antimicrobial peptides from large libraries, whereas using random peptides as negative data increases the difficulty of discovering antimicrobial peptides from random peptides using discriminative models. In this study, we constructed three multi-discriminator models using deep learning and successfully screened twelve AMPs from a library of 30,000 random peptides. three candidate peptides (P2, P11, and P12) were screened by antimicrobial experiments, and further experiments showed that they not only possessed excellent antimicrobial activity but also had extremely low hemolytic activity. Mechanistic studies showed that these peptides exerted their bactericidal effects through membrane disruption, thus reducing the possibility of bacterial resistance. Notably, peptide 12 (P12) showed significant efficacy in a mouse model of Staphylococcus aureus wound infection with low toxicity to major organs at the highest tested dose (400 mg/kg). These results suggest deep learning-based multi-discriminator models can identify AMPs from random peptides with potential clinical applications.
研究领域:
生物信息学
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微生物学
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药物开发
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DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2015
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IF 2.358
Lu Shen,Yinwen Li,Jian Zheng,Mangeng Lu,Kun Wu
A series of UV-curable oligomers based on bisphenol-F epoxy resin were synthesized via end-capping of acrylic acid (AA) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) in different ratios. Along with the increase of AMPS content, viscosities of modified resins reduced obviously. Integrated performance of cured films was also evaluated. Water swelling and contact angle tests indicated that the hydrophilicity was enhanced by the incorporation of sulfonate and amide groups into the coatings. Thermal degradation behaviors showed that the char residue, as well the glass transition temperature of the cured films was increased with the rising AMPS proportion, though the initial decomposition temperature declined. Moreover, doping of plentiful AMPS caused a remarkable enhancement in elongation at break, which was ascribed to greater flexibility of polymer chains and reduced density of crosslinking structure. Cured films with AMPS modified showed strong adhesive strength resulted from strong hydrogen bonding formed between amide sulfonate groups from AMPS and polar surface of glass substrates. For pure AA modified film, it was unaffected in NaOH solution (2 wt%) for 24 h. While for AMPS modified film, the film could be completely removed in several minutes when exposed to alkali solution. The modified epoxy films with these attractive features had prospective applications in temporary protective coatings, which could resist acid and organic solvents while would be easily wiped off from the substrate by soaking in the alkali solution.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
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2026
·
IF 3.6
Hang Shu,Tao Li,Jiating Liu,Yi Chen
In the field of advancing flexible sensor technologies, achieving both high conductivity and mechanical flexibility in hydrogel materials remains a critical challenge. To address this issue, a flexible conductive gel based on a synergistic P(AM-AMPS)-PVP network (PAAP) was developed. Through the formation of a hydrogen-bonding network and continuous ion transport pathways, the gel achieves a balanced improvement in electrical conductivity and mechanical flexibility. The resulting PAAP gel exhibits an exceptional tensile strain capacity of up to 1811%, notable ionic conductivity (59.41 mS/cm), and a very low elastic modulus (< 10 kPa), indicating strong structural resilience and adaptability under strain. These characteristics make the gel particularly suitable for use in flexible strain sensing and Morse code signal recognition. When integrated with a support vector machine (SVM) classification model, the system enables precise identification of “dot-dash” signal patterns, achieving classification accuracy exceeding 95%. This work provides a promising approach and theoretical basis for the development of flexible hydrogels in intelligent sensing, information decoding, and wearable communication technologies. Highlights A stretchable, soft, and conductive P(AM-AMPS)-PVP hydrogel for sensing. Integration of SVM enables intelligent signal recognition and interfacing. The SVM achieves a high accuracy in recognizing dot-dash signal patterns.
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高影响因子
APPLIED SURFACE SCIENCE
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2026
·
IF 6.6
Hepeng Zhou,Wenhao Jia,Wenfeng Pan,Yongbing Zhang,Chang Liu,Handan Wu,Xuekun Tang,Meifen Lei
The flotation separation of calcium-bearing minerals remains challenging due to their similar crystal structures and calcium active sites. Conventional depressants like sodium silicate are required in large dosages, leading to significant issues with wastewater treatment and economic viability. Herein, a novel depressant scheme combining poly(acrylic acid-2-acrylamido-2-methylpropane sulfonic acid) (AA/AMPS) and sodium oleate (NaOl) was employed for flotation separation of calcite from scheelite. The underlying mechanism was elucidated through surface analysis and density functional theory (DFT) calculations. The results demonstrate that at a pulp pH of 8.0 and with a low AA/AMPS dosage of merely 4 × 10 −6 mg/L, a scheelite concentrate with a WO 3 grade of 69.8% was obtained from the artificial mixed ore. This concentrate exhibited superior grade and recovery compared to those achieved using traditional sodium silicate and other reported novel depressants, while requiring a significantly lower reagent dosage. The study confirms that the –SO 3 − groups in AA/AMPS engage in strong, specific chemisorption with the active sites on the calcite surface via an electronic effect. The pronounced differences in adsorption thermodynamics and electrostatic repulsion enable AA/AMPS to achieve highly selective masking of the active sites on calcite. Consequently, this research presents an efficient depressant for the scheelite separation. These findings indicate that AA/AMPS is an efficient and environmentally benign depressant, demonstrating promising potential for industrial scheelite flotation.
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高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Dongdong Zhang,Huanhuan Li,Jingjing Li,Ziang Xu,Haozhe Liu,Yiping Zhao,Xia Feng,Li Chen
Heavy metal are harmful to the mankind and difficult to observe in water, so it is necessary for the detection and removal of metal ions. Carbon dots (CDs) are novel fluorescent materials for detecting metal ions and their modified nanocomposites have great potential for water treatment applications. Our research is developing a dual material of detecting and adsorbing metal ions based on poly acrylamide-co-CD-co-2-acrylamido-2-methylpropanesulfonic acid (poly (Am-CD-AMPS)) by inverse miniemulsion polymerization. Firstly, CDs were functionalized with glycidyl methacrylate (GMA) to obtain double bond which can be stably immobilized into the microgels network during the polymerization. The prepared poly (Am-CD-AMPS) microgels demonstrated the blue fluorescent property and excitation-dependent behavior under UV light and Fluorescence spectrophotometer. The microgels had sensitivity toward Hg 2+ , Fe 3+ and Cu 2+ and detection limit as low as 2.3 nM, 3.2 μM and 1.3 μM. Meanwhile, poly (Am-CD-AMPS) microgels had adsorption capacity of 102.13 mg·g −1 and 85.00 mg·g −1 toward to Fe 3+ and Cu 2+ , and detailing of the possible mechanistic insight into the ion adsorption was also discussed. Reusability measurements showed that the synthesized microgels had the better stability in application of detecting and adsorbing metal ions.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
·
IF 3.131
Jingqi Ji,Jianqing Zhao,Yangchuan Ke
In order to overcome the inherent defects of traditional polymer microspheres as plugging agent used in oilfields, including weak mechanical properties , low dispersity in water and poor adaptability to harsh conditions, an organo-modified montmorillonite (O-MMT) was incorporated to form an exfoliated structure in acrylamide/sodium 4-styrenesulfonate/2-acrylamido-2-methyl propane sulfonic acid (AM-SSS-AMPS) terpolymer matrix via in-situ polymerization. Such exfoliated structure not only exhibited a considerable enhancement in the comprehensive properties of nanocomposites , such as viscoelasticity , heat and shear-resistance, but also improved nanomechanical properties of microspheres. The results of nanomechanical properties showed that the energy dissipation and adhesion of nanocomposite with 3.0 wt% O-MMT were decreased to only 1.9% and 4.7% of those of the original terpolymer, respectively, implying the reduction in the agglomeration and energy consumption of microspheres in aqueous suspension. Rheology test demonstrated that the suspension (5.0 wt%) of nanocomposite microsphere with 2.0–3.0 wt% O-MMT behaved as pseudoplastic fluid, Newtonian fluid and dilatant fluid in turn at the shear rate from 10 s −1 to 1000 s −1 , which indicated a better arrangement of microspheres in suspension under shear stress. G′ and G′′ of the suspension of nanocomposite microspheres with 3.0 wt% O-MMT were 696.6 times and 84.4 times higher than those of the terpolymer suspension, respectively, and the corresponding viscosity was 10.4 times higher at 90 ℃. These superior properties of nanocomposite microspheres will meet the tough requirements of oilfield development.
研究领域:
材料科学
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石油工程
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DOI
高影响因子
JOURNAL OF APPLIED PHYCOLOGY
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2024
·Vol. 36
·期 4
·1781-1792
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IF 2.8
Zhu Bingkui,Sun Fengjie,Gao Zhengquan,Yao Ting,Han Subing,Zhang Hao,Ma Yuyang,Wu Yuyong,Du Ran,Meng Chunxiao,Cui Yulin
As harmless alternative of antibiotics, two antimicrobial peptides (AMPs), including anti-lipopolysaccharide factor isoform 3 (ALFPm3) and cathelicidin (CATHPb1), were co-expressed in the common fish food Tetraselmis subcordiformis. Lysates from T. subcordiformis transformant were able to inhibit the bacterial growth of Staphylococcus aureus, Vibrio parahaemolyticus, and Vibrio splendidus. To test the effects of AMPs in vivo, turbot ( Scophthalmus maximus ) underwent three dietary treatments, including commercial feeds (CON group), commercial feeds mixed with wild-type T. subcordiformis (WT group), and commercial feeds mixed with a mutant strain of T. subcordiformis (CSD group). Compared to CON group , both CSD and WT groups showed an increase in both the relative abundance and diversity of beneficial bacteria. The content of malondialdehyde was reduced and the enzymatic activities of lysozyme were increased in plasma. Comparisons of the biochemical factors in CSD group with those in CON group revealed that the relative abundance of Vibrio was decreased from 92.7% to 75.1%, and the number of bacteria containing the potentially pathogenic phenotypes was reduced. In the CSD group, the enzymatic activities of catalase and the expression levels of IgM, NKEF, IFNγ, MHC I, and IL-8R were higher compared to the WT group, whereas the levels of both TNFα and IL-1β were reduced. These results indicated that as an oral delivery vehicle for the AMPs, T. subcordiformis transformant improved the immunity, inflammatory response, and gut microbiome community of turbot.
研究领域:
海洋生物学
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免疫学
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微生物学
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水产养殖
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2013
·Vol. 292
·期 3
·653-660
·
IF 2.161
Luo Jing,Zhou Qun,Sun Jun,Liu Ren,Liu Xiaoya
Well-defined water-dispersible polyaniline (PANI) nanoparticles were synthesized by in situ chemical oxidative polymerization of aniline in the presence of an amphiphilic P(AMPS- co -VM) copolymer micelle. P(AMPS- co -VM) copolymer was prepared by the free radical polymerization of 7-(4-vinylbenzyloxyl)-4-methyl-coumarin (VM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) which can self-assemble into micelles in aqueous solution. Here, P(AMPS- co -VM) copolymer micelle is used not only as soft template but also as acid dopant in our reaction system. The structure, size, and morphology of PANI nanoparticles were characterized by various experimental techniques. It is found that the morphology and the size of the PANI nanoparticles strongly depend on the molecular characteristics of the P(AMPS- co -VM) copolymer. The synthesized PANI nanoparticles behaved as particulate emulsifier for the stabilization of oil-in-water emulsions.
研究领域:
材料科学
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化学工程
·
纳米技术
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2019
·
IF 7.65
Yanyan An,Huaili Zheng,Xinyu Zheng,Qiang Sun,Yuhao Zhou
In this study, our group grafted 2-acrylamido-2-methylpropane sulfonic acid (AMPS) onto the surface of hollow glass microspheres (HGM) and successfully prepared AMPS grafted floating adsorbent (AFA). The prepared AFA carries a large amount of negative charges, and the adsorptions of cationic dyes are achieved under the action of strong electrostatic interaction. Furthermore, due to the unique shell structure of AFA, it has a stable self-floating ability, which may change the traditional separation method to make the adsorbent easier to enrich and separate from water surface. Characterizations of AFA by scanning electron microscope , energy dispersive spectrometry , X-ray photoelectron spectroscopy. Fourier transform infrared spectra , Brunauer-Emmett-Teller surface areas, thermogravimetric analysis , and X-ray diffractometer shows the successful grafting of AMPS. Adsorption experiments confirmed that the adsorption capacities of AFA for methylene blue , malachite green, basic fuchsin and crystal violet under optimum conditions were 436.8 mg g −1 , 637.6 mg g −1 , 457.8 mg g −1 , and 399.4 mg g −1 , respectively. At the same time, AFA has excellent recyclability , and its adsorption capacity can be maintained after 6 cycles of reuse.
研究领域:
环境科学
·
材料科学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Xiaomin Tang,Ting Huang,Shixin Zhang,Wei Wang,Huaili Zheng
Hematite wastewater containing dissolved heavy metals is a potential threat to eco-environment and human health. Flocculation as an efficient and cost effective water treatment technology should be applied in its treatment. A sulfonated chitosan-based flocculant (CS-g-P(AM-AMPS)) was prepared via graft copolymerization. Two synthesis pathways and reaction products with different molecular structure were discovered in processes. CS-g-P(AM-AMPS) possessed the multifarious functional groups that contributed to its excellent performance in hematite wastewater treatment. Bridging, adsorption and entrapment in coagulation-flocculation were enhanced due to CS-g-P(AM-AMPS), and the impressive floc size and high removal efficiency were represented in the treatment as well. Dissolved heavy metals in the wastewater were removed by the chelation of sulfonate group in CS-g-P(AM-AMPS), the adsorption of other functional groups and the co-settlement with flocs. CS-g-P(AM-AMPS) will have the potential application in industrial wastewater treatment for its high flocculation performance, thermal stability and solubility.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 137
·期 11
·48460
·
IF 2.188
Kaixiang Cui,Chuanxian Li,Bo Yao,Fei Yang,Guangyu Sun
The CaCO 3 deposits exist widely in the petroleum industry, causing severe damage to the equipment and production. In this article, a novel environment-friendly terpolymer scale inhibitor Poly (maleic anhydride - acrylic acid -2- acrylamide -2- methyl propanesulfonic acid) (P(MA-AA-AMPS))-containing carboxylic acid group, sulfonic acid group, and amide group was synthesized. The structure and molecular weight were characterized by FTIR, 1 H-NMR, and GPC. The static scale inhibition experiment was conducted to study the influence of factors such as the dosage, monomer ratio, temperature, pH, Ca 2+ concentration, and concentration on the scale inhibition performance of CaCO 3 . The results show that when the monomer ratio is 2.0:1.0:0.5 and the dosage is 20 mg L −1 , the maximum scale inhibition efficiency is 95.52%. Even when Ca 2+ concentration exceeds 1200 mg L −1 and temperature reaches 90 °C, the scale inhibition efficiency is still larger than 80%. The results of SEM and XRD show that P(MA-AA-AMPS) interferes with the growth of CaCO 3 crystal by adsorption, dispersion, and chelation. The effect leads to changes in the morphology of CaCO 3 crystals, the size of which drops from 20–30 μm to 2–5 μm. The P(MA-AA-AMPS) can transform CaCO 3 from stable calcite crystals to unstable aragonite and vaterite. Finally, the formation of CaCO 3 scale is well inhibited. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48460.
研究领域:
材料科学
·
石油工程
·
环境科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）