JOURNAL OF CHEMICAL RESEARCH
·
2014
·
IF 0.697
Man Liu,Ji Zhang,Jian Yang,Bo Yang,Wei Cui
Two routes for the synthesis of the flavones chrysin are described. In the first 1,3,5-trimethoxybenzene was converted to 2-hydroxy-4,6-dimethoxyacetophenone and then by condensation with benzaldehyde to 2′-hydroxy-4′,6′-dimethoxychalcone. The latter was cyclised with iodine and demethylated with pyridine hydrochloride to form chrysin in 53% overall yield. In the second route, 1,3,5-trimethoxybenzene was acylated with cinnamic acid to form the chalcone which was then converted to chrysin in 30.7% overall yield.
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DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2015
·
IF 0.633
Qian Wang,Wei Cui,Man Liu,Ji Zhang,Rong-qiang Liao,Xia-li Liao,Jian Yang
Two routes for the synthesis of the flavone apigenin are described. In the first, taxicatigenin was converted to 2-hydroxy-4,6-dimethoxyacetophenone and then by condensation with anisaldehyde to 2′-hydroxy-4,4′,6′-trimethoxychalcone. The latter was cyclised with iodine and demethylated with pyridine hydrochloride to form apigenin in 53% overall yield. In the second route, a single step for the preparation of the chalcone was used in which 1,3,5-trimethoxybenzene was acylated with p-methoxycinnamic acid. Although the synthesis of apigenin was achieved in a lower overall yield of 34%, the process was simpler.
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高影响因子
Energy Storage Materials
·
2018
·
IF 0
Qian Liang,Fuming Chen,Shaofeng Wang,Qiang Ru,Qinyu He,Xianhua Hou,Ching-yuan Su,Yumeng Shi
Renewable energy-related technologies have become more important due to the increasing energy consumption. Herein, we put forward a novel organic flow desalination battery (ORFDB) using redox-active organic molecule electrolyte materials dissolved in the aqueous sodium chloride feed. Riboflavin-5’-phosphate sodium salt dihydrate (FMN-Na) is used as the anolyte, and the catholyte is 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO). Sodium and chloride ions in salt feed were moved respectively to anolyte and catholyte by electrochemical reaction of electrolytes during the charge process, and return to the feed during the discharge process. This ORFDB system possesses the stable stability up to fifty cycles and the excellent rate performance. This ORFDB exhibits the cost-effective renewable energy storage and the possibility of salt removal based on the electrochemistry of organic molecules.
研究领域:
能源科学
·
电化学
·
材料科学
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DOI
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Zhengge Chen,Yi Hong,Futao Lin,Xiongfei Zha,Fengcheng Lin,Yang Li,Bin Hu,Qi Huang,Lei Li,Zhengxu Huang,Li Ding,Zhen Zhou
The demand for high-resolution, high-throughput and spatially resolved mass analysis has been a key focus in developing mass spectrometers. We have developed a novel high-performance mass spectrometer by integrating matrix-assisted laser desorption/ionization (MALDI) source with a new planar electrostatic ion trap mass analyzer for ultrahigh-resolution MALDI source mass analysis. Performance characterization experiments show that with a transient time of 800 ms, the resolution for 392 Th can exceed 530 K by utilizing high-order harmonics, and the spectrometer can distinguish the isotopic peaks in the Met-Arg-Phe-Ala acetate salt (MRFA) M+2 peak family. Preliminary results also show an overall mass range from 133 to 9500 Th by stitching together multiple single scans with at least 6-fold mass range, and a low detection limit of 32 fg. Initial tests on analysis of edible oils demonstrate its capability to distinguish plant and animal oils based on triacylglycerols.
研究领域:
分析化学
·
质谱技术
·
生物医学工程
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DOI
PubMed
高影响因子
Electronics
·
2024
·Vol. 13
·期 8
·1485
·
IF 2.6
Dongyu Xie,Xiaoci Liang,Di Geng,Qian Wu,Chuan Liu
Oxide electrolyte-gated transistors have shown the ability to emulate various synaptic functions, but they still require a high gate voltage to form long-term plasticity. Here, we studied electrolyte-gated transistors based on InOxwith tungsten doping (W-InOx). When the tungsten-to-indium ratio increased from 0% to 7.6%, the memory window of the transfer curve increased from 0.2 V to 2 V over a small sweep range of −2 V to 2.5 V. Under 50 pulses with a duty cycle of 2%, the conductance of the transistor increased from 40-fold to 30,000-fold. Furthermore, the W-InOxtransistor exhibited improved paired pulse facilitation and successfully passed the Pavlovian test after training. The formation of WO3within InOxand its ion intercalation into the channel may account for the enhanced synaptic plasticity.
研究领域:
神经科学
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材料科学
·
电子工程
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DOI
高影响因子
npj Science of Food
·
2022
·Vol. 6
·期 1
·1-11
·
IF 7
Chen Xuan,Wu Xiaoping,Wang Shaoyun
The misuse of antibiotics in animal protein production has driven the emergence of a range of drug-resistant pathogens, which threaten existing public health security. Consequently, there is an urgent need to develop novel antimicrobials and new infection treatment options to address the challenges posed by the dramatic spread of antibiotic resistance. Piscidins, a class of fish-specific antimicrobial peptides (AMPs), are regarded as promising therapies for biomedical applications. Progress towards potential analogs from the piscidin family has been hampered by unenforceable structural optimization strategies. Here, we leverage a strategy of bioinformatics analysis combined with molecular dynamics (MD) simulation to identify specific functional hotspots in piscidins and rationally design related analogues. As expected, this approach yields a potent and non-toxic PIS-A-1 that can be used as an antibiotic adjuvant to reverse methicillin-resistant Staphylococcus aureus (MRSA) pathogens. Remarkably, the structural optimization scheme and application strategy proposed here will contribute richer therapeutic options for the safe production of animal protein.
研究领域:
微生物学
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药学
·
生物信息学
·
分子生物学
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DOI
PubMed
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Xiaomeng Ren,Ningning Wang,Yaxin Zhou,Aixin Song,Guoxia Jin,Zhonghao Li,Yuxia Luan
Arginase 1 (ARG1) inactivates T cells by degrading L-arginine, severely reducing the immunotherapeutic efficacy. Effectively blocking the ARG1 pathway remains a challenge. L-norvaline is a very cheap and negligible side effects inhibitor of ARG1. However, its blockage efficacy for ARG1 is impeded by its high half-maximal-inhibitory concentration (IC50) requiring high drug loading content of L-norvaline in carriers. Moreover its high water solubility results in bursting and uncontrolled release. Herein we reported an injectable hydrogel strategy via an L-norvaline-based immunomodulating gelator that could effectively block ARG1 pathway. The designed gelator was a diblock copolymer containing L-norvaline-based polypeptide block, which could construct a thermally responsive injectable hydrogel by its self-gelation in tumor microenvironments. The hydrogel not only ensures high drug loading of L-norvaline, but also ensures controlled release of L-norvaline through responsive peptide bond cleavage, thereby solving the problems encountered by L-norvaline. The injectable hydrogel in combination with doxorubicin hydrochloride demonstrated a potent immunotherapy for removal of primary tumors, suppression of abscopal tumors and inhibition of pulmonary metastasis by combining the blockage of ARG1 pathway and the immunogenic cell death. Our immunomodulating gelator strategy provides a robust injectable hydrogel platform to efficiently reverse ARG1 immunosuppressive environments for amplified immunotherapy. Statement of Significance We designed an injectable hydrogel via an L-norvaline-based immunomodulating gelator. The designed gelator, a diblock copolymer containing an L-norvaline-based polypeptide block, enabled a thermally responsive injectable hydrogel by its self-gelation in tumor microenvironments. The injectable hydrogel not only guarantees high drug loading of L-norvaline, but also ensures controlled release of L-norvaline through responsive peptide bonds cleavage, thereby solving the problems encountered by L-norvaline. By further introducing doxorubicin hydrochloride in the hydrogel for inducing immunogenic cell death, the hydrogel showed remarkable immunotherapeutic efficacy towards ablation of primary tumors, suppression of abscopal tumors and inhibition of pulmonary metastasis. Our immunomodulating gelator strategy provides a new concept to efficiently reverse Arginase 1 immunosuppressive environments for amplified immunotherapy.
研究领域:
生物医学工程
·
肿瘤学
·
免疫学
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DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
·
2019
·
IF 4.474
Xiaohui Niu,Xing Yang,Zunli Mo,Jia Wang,Zhao Pan,Zhenyu Liu,Chao Shuai,Guigui Liu,Nijuan Liu,Ruibin Guo
We report a novel chiral interface based on polysaccharides that was integrated via an amidation reaction between the COOH of sodium alginate and the NH 2 of chitosan to form a chiral selector (SA-CS) with three dimensional N-doped graphene-CNT (NGC) as the substrate material. This interface was used for chiral discrimination of tryptophan (Trp) enantiomers via electrochemical measurements. The FT-IR, SEM, TEM and XPS characterization showed that the chiral selector and substrate materials were prepared successfully. Compared with individual SA-CS and NGC, the integrated polysaccharides/3D NGC showed higher enantioselectivity for L-Trp than D-Trp due to the smaller steric hindrance for D-Trp during the formation of three-point interactions between the two diastereoisomeric enantiomer-selector complexes, which allowed L-Trp to more easily detach from the electrode modification layer and approach the electrode surface, facilitating its approach and confirming that SA-CS had a higher constant for L-Trp when applied to real samples.
研究领域:
生物化学
·
材料科学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2017
·Vol. 5
·期 48
·25660-25671
·
IF 8.867
Jie Liu,Jun Liu,Sheng Wang,Jing Huang,Siwu Wu,Zhenghai Tang,Baochun Guo,Liqun Zhang
Rubbers are widely applied in tires, seals, biomedical materials and aerospace applications because of their unique high elasticity. However, combining high self-healing capability and excellent mechanical performance in a rubber remains a formidable challenge. In this work, inspired by the energy dissipation mechanism and the recoverability of sacrificial bonds, the authors describe a dual-dynamic network design of a high-performance elastomer in which weaker multiple hydrogen bonds and stronger Zn–triazole coordination have been engineered into an unvulcanized cis-1,4-polyisoprene (IR) matrix. Accordingly, the elastomer obtains high tensile strength (21 MPa) and toughness (60 MJ m−3). The facilitated chain orientation in such a dual-dynamic network is finely substantiated by the molecular dynamics simulation results. Significantly, this dual-dynamic network design enables a fully cut elastomer to be healed at mild temperature. Under healing at 80 °C for 24 h, the healed elastomer regains excellent mechanical properties (tensile strength of 15.5 MPa and fracture energy of 42.8 MJ m−3). We envision that this design concept can not only develop a new network construction method in rubbers instead of vulcanization, but also provide inspiration for preparing advanced elastomers with the combination of excellent mechanical performance and high self-healing capability.
研究领域:
材料科学
·
高分子化学
·
自修复材料
·
机械工程
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DOI
高影响因子
FOOD AND AGRICULTURAL IMMUNOLOGY
·
2018
·
IF 2.568
Jiajia Sun,Liqiang Liu,Shanshan Song,Gang Cui,Hua Kuang
The problem of waste oil is a food safety issue that requires urgent resolution. In this study, a novel hapten was designed for the rapid detection of capsaicinoids, a marker of waste oil, and a monoclonal antibody (MAb) 5D7 was generated that is specific for three major capsaicinoids: capsaicin (CPC), dihydrocapsaicin (DCPC), and N-vanillylnonanamide (N-V). The half maximal inhibitory concentrations of MAb 5D7 for CPC, DCPC, and N-V were 1.12, 0.8, and 0.87 ng/mL, respectively. An immunochromatographic strip test based on MAb 5D7 was established for these three capsaicinoids, with visual inspection limits of <1.0 ng/mL, which satisfies the requirement for the rapid on-site inspection of waste oil.
研究领域:
食品安全
·
免疫学
·
分析化学
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DOI
高影响因子
JOURNAL OF MEMBRANE BIOLOGY
·
2017
·Vol. 250
·期 5
·483-492
·
IF 1.696
Chai Ran,Chen Yafei,Yuan Hongbo,Wang Xuzhao,Guo Shuai,Qi Jinlong,Zhang Hailin,Zhan Yong,An Hailong
Calcium-activated chloride channels (CaCCs) play vital roles in a variety of physiological processes. Dysfunction of the CaCCs is implicated in many diseases. Drug discovery targeting at CaCCs has recently become possible with the determination that TMEM16A is the molecular identity of CaCCs. In this study, we demonstrated that resveratrol (RES), a Chinese traditional medicine compound, is a novel activator of TMEM16A. The yellow fluorescence protein quenching assay and measurement of intracellular calcium fluorescence intensity show that RES activates TMEM16A channels in an intracellular Ca 2+ -independent way. The data of inside-out patch clamp revealed that RES dose-dependently activates TMEM16A (EC 50 = 47.92 ± 9.35 μM). Furthermore, RES enhanced the contractions of the ileum of guinea pigs by activating the TMEM16A channel, which indicated that RES might be a promising drug for the treatment of gastrointestinal hypomotility. As RES was able to induce TMEM16A channel activation, TMEM16A can be added to the list of RES drug targets.
研究领域:
药理学
·
生理学
·
药物发现
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产品关联
DOI
PubMed
高影响因子
Electrocatalysis
·
2014
·Vol. 6
·期 2
·211-219
·
IF 2.089
Ouyang Lei,Miao Yuqing,Xu Lina,Xiao Mingshu,Liang Xiaocai,Li Weiwei,Yang Yang
Molecular self-assembly is an important aspect of bottom-up approaches for the nanofabrication of functional materials. The self-assembly of smaller-size units like ions has yet to be studied further. The self-adsorption of Bi III without applied potential and electrochemical deposition of Bi/Bi III were studied and compared through cyclic voltammetry. Both of them exhibit two pairs of redox peaks assigned to the (2 × 2)-Bi adlayer and incommensurate ( p × √3)-2 Bi adlayer. The adsorption of two Bi surface phases is related with the Bi salt concentration and adsorption time. Within a certain concentration or time range, the adsorption approaches to be saturated due to the surface limitation of self-adsorbed surface layers. The (2 × 2)-Bi adlayer firstly adsorbs to the active sites of Au where there is strong interaction between Bi and Au. With the increase of time, more Bi adsorbs onto the unoccupied sites of Au with a relatively weak interaction force to form a denser ( p × √3)-2 Bi layer. A new pair of redox peaks appears for the electrodeposition of the Bi/Bi III bulky layer which is easily stripped from the Au surface through a consecutive potential scan. Comparatively speaking, the adsorbed (2 × 2) and ( p × √3)-2 Bi adlayers are stable in the same potential scanning condition due to the strong interaction between the two surface Bi layers and the below Au atoms. Such a controllable self-adsorption of the Bi III ultrathin layer on foreign substrates exhibits a potential for the modification of materials in the size of ions.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
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