Defence Technology
·
2023
·
IF 5.1
Shuai Ma,Qinghai Shu,Mengyang Zhang,Hongyu Huang,Yansong Shi,Xijuan Lv,Shuai Zhao
Boron is an ambitious fuel in energetic materials since its high heat release values, but its application is prohibited by low combustion efficiency and oxidization during storage. The polydopamine (PDA) was introduced into boron particles, investigating the impact of PDA content on the energetic behavior of boron. The results indicated that the PDA coating formed a fishing net structure on the surface of boron particles. The heat release results showed that the combustion calorific value of B@PDA was higher than that of the raw boron. Specifically, the actual combustion heat of boron powder in B@10%PDA increased by 38.08%. Meanwhile, the DSC peak temperature decreased by 100.65 °C under similar oxidation rate compared to raw boron. Simultaneously, the B@PDA@AP and B@AP composites were prepared, and their combustion properties were evaluated. It was demonstrated that B@10%PDA@AP exhibited superior performance in terms of peak pressure and burning time, respectively. The peak pressure is 12.43 kPa more than B@AP and burning time is 2.22 times higher than B@AP. Therefore, the coating of PDA effectively inhibits the oxidization of boron during storage and enhances the energetic behavior of boron and corresponding composites.
研究领域:
材料科学
·
化学工程
·
能源
✓ 已验证
产品关联
DOI
高影响因子
Communications Biology
·
2024
·Vol. 7
·期 1
·1-15
·
IF 5.2
Gong Ting-Ting,Liu Fang-Hua,Xiao Qian,Li Yi-Zi,Wei Yi-Fan,Xu He-Li,Cao Fan,Sun Ming-Li,Jiang Feng-Li,Tao Tao,Ma Qi-Peng,Qin Xue,Song Yang,Gao Song,Wu Lang,Zhao Yu-Hong,Huang Dong-Hui,Wu Qi-Jun
Platinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing chemotherapy failure and poor prognosis. SH3 domain containing ring finger 2 (SH3RF2) has been linked to the development of cancer. Here we find higher levels of SH3RF2 in the tumor tissues from cisplatin-resistant OC patients when compared to those from cisplatin-sensitive patients. Similarly, cisplatin-resistant OC cells also express higher levels of SH3RF2 than normal OC cells. Through in vitro and in vivo loss-of-function experiments, SH3RF2 is identified as a driver of cisplatin resistance, as evidenced by increases in cisplatin-induced cell apoptosis and DNA damage and decreases in cell proliferation induced by SH3RF2 depletion. Mechanistically, SH3RF2 can directly bind to the RNA-binding protein mRNA processing factor (RBPMS). RBPMS has been reported as an inhibitor of cisplatin resistance in OC. As a E3 ligase, SH3RF2 promotes the K48-linked ubiquitination of RBPMS to increase its proteasomal degradation and activator protein 1 (AP-1) transactivation. Impairments in RBPMS function reverse the inhibitory effect of SH3RF2 depletion on cisplatin resistance. Collectively, the SH3RF2-RBPMS-AP-1 axis is an important regulator in cisplatin resistance and inhibition of SH3RF2 may be a potential target in preventing cisplatin resistance.
研究领域:
肿瘤学
·
分子生物学
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Shilong Li,Xiaodong Gou,Wei Liu,Zhongliang Ma,Xiaojun Wang,Xiaojuan Yang
Comprehensive improvement in the thermal properties, energy characteristics, and hygroscopicity of ammonium perchlorate (AP) carries substantial significance to its utilization in solid propellants. In the present study, a novel coating agent, CuDHT, was synthesized via the self-assembly of 3,6-dihydrazino-1,2,4,5-tetrazine (DHT) and transition metal ions (Cu2+), which can comprehensively enhance the performance of AP. The morphology, composition, and thermal properties of samples prepared in this work were examined via scanning electron microscopy, Fourier transform infrared spectroscopy, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis techniques. Meanwhile, the burning rate and combustion temperature of AP@CuDHT-based solid propellants were tested via infrared thermography. The findings show that AP particles have their surfaces coated with a homogeneous and compact CuDHT coating layer. Moreover, the CuDHT coating layer is capable of markedly catalyzing AP’s thermal decomposition and reducing its hygroscopicity. As the CuDHT coating content increases, the peak temperature of AP@CuDHT’s high-temperature decomposition and moisture absorption rate gradually decrease. When the CuDHT content reaches 10 wt %, the HTD peak temperature of AP@CuDHT moves forward by 69.5 °C relative to pure AP, and the moisture absorption rate is cut by 0.326 wt %. Compared with pure AP, AP@CuDHT (10%)’s impact and friction sensitivities are higher by 4% and 8%. Additionally, CuDHT can remarkably enhance the combustion performance of solid propellants. With an increase in CuDHT content, the burning rate of AP@CuDHT-based propellants and their combustion temperature gradually increase. At 10 wt % CuDHT, the burning rate and combustion temperature are enhanced by 6.1 mm·s–1 and 572.6 °C, respectively, compared to those of pure AP-based propellants. In summary, this study provides references for comprehensively improving the hygroscopicity, energy, and thermal properties of AP and, meanwhile, demonstrates a significant application outlook for promoting the combustion performance in solid propellants.
研究领域:
材料科学
·
推进剂化学
·
热力学
·
应用化学
·
能源材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2026
·
IF 4.6
Yunshu Zhao,Yibo Zhou,Xiaoyan Zhang,Guiying Li,Tiying Jiang,Li Su,Shanhu Sun,Jinjiang Xu,Zhirong Suo,Jie Sun
Ammonium dinitramide (ADN) and ammonium perchlorate (AP) are two representative mainstream oxidizers. However, their practical applications in advanced energetic formulations are severely limited by multiple factors, such as high hygroscopicity and insufficient thermal stability for ADN, relatively low energy density for AP, and unfavorable enthalpy of formation for both. To address these drawbacks, this work introduces 4-amino-1,2,4-triazole (4-ATA), a coformer with a high enthalpy of formation, to prepare two ionic energetic cocrystals with excellent comprehensive properties: ADN/4-ATA (cocrystal 1) and AP/4-ATA (cocrystal 2). Compared with their respective raw oxidizers, cocrystal 1 exhibits higher thermal stability (Td > 200 °C) and lower impact sensitivity (2-kg drop hammer, H50 = 51.5 cm), whereas cocrystal 2 shows significantly improved detonation performance, with its detonation velocity (VD) and detonation pressure (P) increased by 12.6 and 23.7%, respectively. Therefore, the preparation of ionic cocrystals offers an effective approach to enhancing the overall performance of ionic oxidizers.
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Zhenzhen Luo,Dunhuang Wang,Lie Lin,Rui Zhou,Yuanyuan Su,Zongkai Zhang,Jing Hu,Yaqing Dai,Jingjing Wu,Xiaoyan Huang,Yufei Zhou,Liuyun Gong
Introduction Intensive cancer treatment with nanoplatform is widely exploited in the clinic, the emerging nanomedicine offers an unparalleled opportunity for encapsulating potential antitumor drugs in a nano-carrier. Apoptin (AP), a coding protein of VP3 gene, stem from the chicken anemia virus (CAV), can be activated in malignant cells selectively and prevents the dividing cancer cells from repairing their DNA lesions, thereby forcing them to undergo apoptosis. Herein, a three-step intelligent biodegradable drug delivery nanoplatform was designed.Methods First, a hollow ZIF-8 was synthesized, embedded with platinum nanoparticle to form ZIF-8Pt, and then loaded with AP, and lastly formed AP@ZIF-8Pt, which possess pH-responsive drug release and cancer-targeted ability.Results As expected, both in vitro and in vivo experiment demonstrated that AP@ZIF-8Pt performed treatment effects in hepatocarcinoma through relieving tumor-hypoxic microenvironment, inhibiting cell proliferation and promoting cell apoptosis. Further transcriptomic analysis showed that the specific mechanism of the AP@ZIF-8Pt was thermogenesis, signaling pathways regulating pluripotency of stem cells, ribosome, prion disease and PI3K-Akt signaling pathway.Discussion This work highlights a new strategy for liver cancer treatment and provides a reference for treating malignant tumors.
研究领域:
肿瘤学
·
纳米医学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Desheng Yang,Chaofei Bai,Jiaran Liu,Shengnan Li,Chengzhao Tu,Fengdan Zhu,Guoping Li,Yunjun Luo,Tianfu Zhang
The construction of ordered pore structure and heterostructure interface is considered as an effective strategy to optimize the activity and stability of nano catalysts. Herein, we have elaborately fabricated the p-n heterostructure nanocatalysts of three-dimensionally ordered macroporous (3DOM) Fe 2 O 3 -supported 2D copper oxide nanofilm using a simple impregnation method, abbreviated as 3DOM-Fe 2 O 3 /CuO. The prepared 3DOM Fe 2 O 3 /CuO shows interconnected and ordered macroporous channels, which provide considerable catalytic active sites and enrich the reactive oxygen concentration at the Fe 2 O 3 -CuO heterostructure interface. By adjusting the copper source concentration, 2D copper oxide nanofilm with varied thicknesses was introduced to readily regulate the morphology of the catalyst and the atom composition or electronic structure of the interface. When evaluated as a catalyst for ammonium perchlorate (AP) decomposition reaction, 3DOM-Fe 2 O 3 /CuO-3 testified the most satisfactory catalytic activity, reducing the high temperature decomposition peak of AP decreased by 105.27 °C and the decomposition activation energy (Ea) by 50 %. Based on the experimental results of this study and related theoretical researches, the following mechanisms are proposed: in the thermal decomposition process of AP, the generation of active oxygen is not only related to the active oxygen mechanism, but also may be related to the NO 2 -assisted mechanism.
研究领域:
材料科学
·
催化
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Molecular Catalysis
·
2019
·
IF 2.938
Qiaoyun Liu,Fei Liu,Yaru Zhang,Yang Su,Aiqin Wang,Tao Zhang
A highly active and robust catalyst composed of Ru nanoparticles highly dispersed on zeolite H-beta was developed for transforming furfural into 3-acetyl-1-propanol (3-AP) in good yield (81%)under mild conditions (80 °C, 1 MPa H 2 ). Both the support nature and the preparation methods had significant impacts on the dispersion of Ru, eventually on the yield of 3-AP. Ion-exchange method proved best for obtaining the highly active and selective catalyst for this reaction. Moreover, the catalyst can be regenerated easily by calcination and reduction. This catalyst was further explored for the one-pot conversion of xylose and xylan to 3-AP with a yield of 46% and 31%, respectively, thus opening a new feasible pathway from biomass to valuable fine chemicals.
研究领域:
催化化学
·
生物质转化
·
绿色化学
✓ 已验证
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2018
·
IF 4.514
Wenbing Li,Yanju Liu,Jinsong Leng
In the current study, a novel polymer composite with excellent light-actuated two-way shape memory effect (2W-SME) was fabricated using poly (ethylene-co-vinyl acetate) (EVA) as matrix and p -aminodiphenylimide ( p -AP) as both light-absorber and heat source (EVA/ p -AP). Unlike traditional thermally-driven two-way reversible shape memory polymers, in our concept, the EVA/ p -AP featured remotely controlled and light-manipulatable reversible two-way shape memory behaviors. Utilizing the distinct light-responsive behavior of p -AP in the irradiation of 365 nm ultraviolet (UV) light, the EVA/ p -AP composite exhibited excellent light-actuated reversible 2W-SME by a light-manipulated procedure. The results from this study indicated that the composite material could have greatly potential applications in soft reversible drivers.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
INORGANICA CHIMICA ACTA
·
2021
·
IF 2.545
Ming Zhang,Fengqi Zhao,Hui Li,Yifan Jiang,Yanjing Yang,Xiaoting Hou,Jiankan Zhang,Na Li
Graphene-based ferrocene nanocomposites play a positive role in improving the comprehensive properties of solid propellants containing ammonium perchlorate (AP). Novel graphene-based ferrocene nanocomposites with different molecular structures were successfully fabricated and characterized systemically using SEM, EDS, FTIR, RAMAN and XPS instruments. Additionally, the catalytic performance of the as-synthesized graphene-based ferrocene nanocomposites on the thermal decomposition and kinetics behavior of AP were studied using DSC and kinetic methods. The result showed the excellent catalytic performance of graphene-based ferrocene nanocomposites, and the molecular structure plays a significant influence on thermal decomposition of AP. Among the nanocomposites considered, the as-synthesized graphene-based ferrocene nanocomposite NG-550-Fe (γ-aminopropyl triethoxy silane as modifier) owns best catalytic activity, and the decomposition peak temperature and activation energy of AP + NG-550-Fe was reduced by 137.7 °C and 151.6 kJ·mol −1 respectively, compared with pristine AP. Combined with the reported studies, the relatively stronger combination of KH-550 and the better dispersion of Fe may be the reason why NG-550-Fe is more effective than other graphene-based ferrocene nanocomposites and traditional supported graphene nanocomposites studied. Results of this study have implications concerning the rational design of graphene-based catalyst, and help to better understand their catalytic performance and mechanism on AP decomposition.
研究领域:
材料科学
·
化学动力学
·
固体推进剂研究
✓ 已验证
DOI
高影响因子
MATERIALS TECHNOLOGY
·
2021
·
IF 3.846
Ling Chen,Yang Qin,Xinfu Cao,Jianbing Gao,Shishuo Liu,Yang Zhang,Jing Tu,Yingbo Wang,Jie Liu,Weidong He
In this study, a novel nitrated bacterial cellulose/2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane/ammonium perchlorate nanoenergetic composite was successfully prepared by the sol–gel method and the freeze-drying technology. The structure and composition were characterised by means of scanning electron microscope, X-ray diffractometer and Fourier-transform infrared. The results demonstrated that the structure of the gel nanoparticles was granted with unique network cross-linked porous, wherein the hexaazaisowurtzitane and ammonium perchlorate nanoparticles were embedded and dispersed uniformly in the gel matrix. The thermal decomposition properties of composites were analysed by differential scanning calorimeter-thermogravimetric analysis, and the results revealed that the composites exhibited only two exothermal peaks which correspond to the nitrated bacterial cellulose/hexaazaisowurtzitane and ammonium perchlorate. In addition, the impact and friction sensitivities of composites were also performed and showed outstanding safety performance. Hence, this preparation strategy of nitrated bacterial cellulose-based nanocomposite energetic materials may provide promising application in high-performance and low-sensitivity propellants.
研究领域:
材料科学
·
能源与推进剂
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Wen-Long Ren,Yi-kai Wang,Mingxing Zhang,Chengchen Zhang,Qian Huang,Yuyang Zeng,Zhi-Wen Lin,Kaige Guo,Dehao Xiong,Chen-Guang Zhu
The development of efficient catalysts to regulate the thermal decomposition and combustion behavior of ammonium perchlorate (AP) is essential for improving the energy output of solid propellants. In this study, a LaFe0.5Co0.5O3/Ni–Fe Prussian Blue Analogue (PBA) composite was designed to synergistically enhance the decomposition kinetics and combustion performance of AP. The composite integrates perovskite-type oxides with a conductive PBA framework, forming a bifunctional electronic–geometric catalytic interface. Systematic characterization revealed that the optimized Ni–Fe PBA effectively balanced oxygen vacancy generation, Fe2+/Fe3+ redox cycling, and a multistage pore structure. This led to a 106.9 °C reduction in AP’s thermal decomposition temperature and a 56.2% decrease in activation energy. Combustion tests demonstrated a 48.1% increase in burning rate, a 35.0% increase in flame area, and a 45.8% increase in luminescence intensity, which may be attributed to improved charge transfer and gas diffusion facilitated by interfacial synergy between the two components. This work offers a strategy for designing high-performance catalysts via interfacial engineering, with promising potential for broad applications in fuel energy modulation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Hui Li,Jiankan Zhang,Fengqi Zhao,Xuefeng Huang
Optimizing the ignition and combustion characteristics of Al by fluorine-containing oxidizers have attracted significant interest. However, few of them dedicated to alleviate the incomplete combustion of Al in propellant. Herein, we demonstrated that the combustion of micron-Al in AP free nitramine-based propellants can be greatly enhanced by thin coating layer of PVDF, resulting decreased volume fraction of agglomerates exceeding the initial particle size and active Al content in condensed combustion products (CCPs). After extensive analysis from thermal reactivity, single particle ignition and observation of particles evolution from burning surface to flame zone, we propose that the combustion efficiency is promoted by the fragmentation of chain structured aluminum skeleton by gas recoil near burning surface, oxidation acceleration by diffusion of Al and oxidative gas through the cracks among the particle shell in the dark zone and the subsequent ejection of molten Al triggered by gasification of low boiling point AlF 3 in the flame zone. The findings in this work suggest that core–shell Al@PVDF has a great potential to be further used in the development of future highly energetic solid propellants.
研究领域:
材料科学
·
燃烧学
·
推进剂技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）