NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 6
·4653-4660
·
IF 3.201
Peipei Chen,Ting Wang,Xiangli Zheng,Dong Tian,Fangquan Xia,Changli Zhou
A convenient, highly efficient and ultrasensitive electrochemical immunosensor was developed using in situ deposited silver nanoparticles (Ag NPs) as tracing tags for fetoprotein (AFP) detection. The function of the immunosensor was achieved by a co-catalytic effect on the surface of nanocomposites containing polyamidoamine (PAMAM) dendrimers coated with C60 (PAMAM-C60 NPs) and gold nanoparticles (Au NPs). On the surface of Au@PAMAM-C60 NPs labeled with an antibody (Ab2), via a sandwich-type immunoreaction, silver ions in solution were reduced to metallic Ag NPs. The electrochemical signal of the in situ deposited Ag NPs could be utilized to monitor the immunoreaction. Under optimum conditions, the peak current of the Ag NPs increased with increasing AFP concentration in the range from 0.1 pg mL−1 to 10 ng mL−1, with a detection limit of 0.03 pg mL−1. Importantly, the designed electrochemical immunoassay strategy exhibited excellent sensitivity, stability, selectivity, and reproducibility.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yifan Liu,Yiyu Yang,Minjie Peng,Wen Zang,Chaozhen Wang,Yuenan Zhang,Changyong Gao,Aiguo Wu,Yujie Zhang
Heparin, as a glycosaminoglycan with multiple physiological functions, performs important roles in clinical practice. The core function of heparin is its anticoagulant effect, which is commonly used to prevent and treat thrombotic diseases. However, when the heparin content in human blood exceeds the standard, it can result in thrombocytopenia, thereby posing threat to human health. Therefore, rapid, sensitive and accurate detection of heparin is of great practical importance in assessing the anticoagulant effect, prevention of thrombophilia, guidance on personalized medication, and avoiding side effects caused by excessive use. A new colorimetric sensor for detecting the anticoagulant heparin is introduced in this work. The sensor is low cost, fast, and simple. In the absence of heparin, protamine protects copper‑gold nanoparticles from the etching of iodide ions through electrostatic interaction, and the solution's color and spectral properties remain essentially the same as those of pure copper‑gold nanoparticles. When heparin is present, due to the strong electrostatic adsorption between heparin and protamine, protamine preferentially binds heparin and forms a complex. Cu-Au NPs are not protected and are etched into spherical Au NPs by iodide ions. The solution's color shifted from dark gray and purple to pink, thus colorimetric detection of heparin is realized rapidly based on the etching mechanism. The detection time is 15 min, and the detection limit is as low as 1 ng/mL. Compared with HPLC detection method, the colorimetric detection of heparin in serum samples has the recovery rate of 98.8–108.8 %, which has good prospects for application.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Jing Wen,Jiayi Wang,Jiamin Sun,Baichao Zhang,Chao Suo,Jing Cui,Xuchuan Cao,Yaxin Yang,Yuexian Hao,Shaohui Guo,Xiaojian Bai,Xian-Ming Zhang
Non-extra-artificial destructive detection of trace residual detached wall painting pigments is an important prerequisite for wall paintings restoration work. As the amount available for detection of artifacts is relatively small, the relevant information must be derived through microanalysis. To this end, the trace molecules can be concentrated and enriched for surface-enhanced Raman scattering (SERS). In this work, the ZIF-67 was Ni 2 + -acid etched into Co–Ni layered double hydroxide (LDH) hollow nanocages. After introducing Au nanoparticles (NPs), Au NPs@Co–Ni LDH core–shell structured composites with a very low detection limit for RhB (10 –10 mol L −1 ) were formed. The composites were applied to non-extra-artificial destructive detection of green, red, and blue trace mural mineral pigments, in which the main components were identified as chlorocopperite, vermilion and ultramarine, respectively. This result proves the universality of the composites to mural pigments of different types in different regions. Experimental data and finite element simulation results show that the etching treatment endowed the SERS substrate materials with a concentration effect, which led to more molecules of the substances to be measured aggregating around the Au NPs, enhanced the detection signals of the molecules, and achieved the concentration in the plasmonic field, which in turn improved their adsorption capacity and enrichment function of the target molecules. This work realizes the innovative application of the concentration effect in the SERS detection of ancient mural pigments, which is important for the analysis, identification, and restoration of mural paintings and other cultural relics.
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OPTICAL MATERIALS
·
2026
·
IF 4.3
Yunqing Lu,Yu Feng,Mengmeng Li,Ji Xu,Jin Wang
The photocatalytic conversion of CO 2 into solar fuels presents a sustainable approach to alleviate climate change and address energy crisis. To address the limitations of conventional photocatalysts, such as their restricted visible-light response and rapid charge recombination, we have developed a ternary nanocomposite consisting of zeolitic imidazolate framework-8 (ZIF-8), plasmonic gold nanoparticles (Au NPs), and titanium dioxide (TiO 2 ). In this system, ZIF-8 provides high-density CO 2 adsorption sites, enhancing the local concentration of CO 2 and facilitating its subsequent reduction. The incorporation of Au NPs induces a strong localized surface plasmon resonance (LSPR) effect, significantly broadening the visible-light harvesting capability of the composite and promoting efficient charge transfer between TiO 2 and ZIF-8. TiO 2 serves as a stable photocatalytic platform, enabling effective charge separation and transfer. Comprehensive characterization verifies the uniform integration of the three components and the formation of close interfacial contacts. The ternary nanocomposite demonstrates significantly improved visible-light absorption, reduced charge recombination, and enhanced photogenerated carrier separation and transfer, as supported by UV-vis diffuse reflectance spectroscopy (DRS), photoluminescence (PL), electrochemical impedance spectroscopy (EIS), and photocurrent measurements. Under simulated sunlight, the ZIF-8/Au/TiO 2 photocatalyst achieves CO 2 -to-fuel conversion rates of 1.56 μmol g −1 h −1 for methane (CH 4 ) and 4.65 μmol g −1 h −1 for carbon monoxide (CO). This enhancement is attributed to the synergistic effects of plasmonic sensitization by Au nanoparticles and CO 2 adsorption enrichment by ZIF-8, which collectively enhance photon utilization, reactant concentration, and interfacial charge transfer dynamics.
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TALANTA
·
2022
·
IF 6.556
Jin Wang,Lin Zhou,Jiali Bei,Qiyuan Zhao,Xue Li,Jiaqi He,Yan Cai,Tingting Chen,Yukou Du,Yong Yao
Pillar [5]arene, a new water-soluble carboxylatopillar [5]arene ammonium salts (WP5), has been employed as the host for complexation of guest molecules. Herein, a visible light driven WP5 functionalized gold nanoparticles (Au@WP5) was fabricated for ultrasensitive photelectrochemical (PEC) detection of caffeic acid (CA). The ultraviolet–visible spectrum characteristics, PEC response results of samples in caffeic acid solution confirm the localized surface plasmon resonance effect of Au NPs and the host-guest interaction between WP5 and CA are responsible for the enhanced PEC sensing performance. Under optimal conditions, the sensitive PEC sensor constructed with Au@WP5 exhibited the concentration linear range from 0.025 μM to 370 μM and a detection limit of 0.01 μM (S/N = 3). Importantly, the good anti-interference ability, stability and reproducibility of the proposed PEC sensor providing the promising detection application of pillar [5]arene functionalized photoactive materials in food and drinks.
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PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Ruyi Tang,Xuemin Xia,Xia Zhang,Huan Jiang,Baihui Wang,Peilei Zhang,Yujin Zhang,Yanxue Tang,Yi Zhou
A novel Au NPs/GeO 2 nanozymes are developed as Surface-Enhanced Raman Scattering (SERS) substrates with the promising prospect for detection ChI. Herein, it is discovered that both Au NPs and GeO 2 nanozymes have peroxidase-like activity, catalyzing colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to produce blue TMB ox . Interestingly, compared with single Au NPs or GeO 2 nanozymes, the Au NPs/GeO 2 nanozymes show stronger peroxidase-like activity, and significantly ameliorated SERS signal of TMB ox . The mentioned two enhancements are ascribed to a positive synergistic function of Au NPs/GeO 2 nanozymes. Surprisingly, choline iodide (ChI) can inhibit the positive synergy in Au NPs/GeO 2 nanozymes, and slow down the reaction of TMB-H 2 O 2 -Au NPs/GeO 2 system. On this foundation, a new Au NPs/GeO 2 SERS technique with high sensitivity, label-free detection method of choline iodide (ChI) is established, suggesting that Au NPs/GeO 2 nanozymes have the potential application of water environment.
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PubMed
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Analytical Methods
·
2025
·
IF 2.6
Xinxing Jiang,Jihong Fu,Shuxian Ren,WenXia Xue
Substrate materials with high sensitivity and good reproducibility are highly desirable for the practical applications of surface-enhanced Raman scattering (SERS) techniques. In this study, a novel Ni-based metal-organic frameworks loaded gold nanoparticles (Ni-BDC-NH2/Au NPs) SERS substrate was successfully synthesized via electrostatic self-assembly method. The enhancement of the SERS signal is achieved owing to the synergy between chemical enhancement (CM) effect of Ni-BDC-NH2 and the electromagnetic enhancement (EM) of Au NPs, and the enriching of the analyte near the SERS “hot spots” through the strong adsorption capacity of the Ni-BDC-NH2. The Ni-BDC-NH2/Au NPs exhibited a high enhancement factor (EF) of 1.10×107 and a low detection limit of 5×10-9 mol/L. Besides, the substrate material showed exceptional stability up to 45 days at room temperature. The Ni-BDC-NH2/Au NPs was used to detect methylene blue (MB) that displayed a wide linearity (5×10-7-5×10-5 mol/L) and high recoveries (86.82-104.46%). These indicate that the Ni-BDC-NH2/Au NPs hybrid substrate has great potential for the detection of environmental pollution in practical applications.
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PubMed
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Mengtian Cui,He Wang,Xia Fan,Jianhao Zhang,Changrui Xing,Wenjing Yan
The widespread use of organophosphorus pesticides (OPPs) in foods, poses a serious threat to human and environmental health, it is crucial to develop methods that can efficiently degrade residual OPPs . Herein, a chiral TiO 2 photocatalyst was developed by modification TiO 2 with D-cys/Au NPs (DAT) for the simultaneous degradation of four OPPs (chlorpyrifos, chlorpyrifos-methyl, malathion, and parathion) by natural light. The influence of D-Au NPs concentration on the degradation process was optimized, along with the initial pesticide concentration. Under optimal conditions, the photocatalytic degradation efficiencies of DAT for four OPPs were 96.7 %, 56.9 %, 42.6 %, and 49.2 %, respectively, after 12 h of natural light exposure. 12 degradation products of OPPs were identified, among which three products were identified for the first time. The degradation pathway revealed that the degradation of OPPs by DAT involves the oxidation of the P═S bond and the cleavage of the P-O bond and C-O bond. This study establishes a theoretical foundation for applying chiral TiO 2 nanomaterials for the photocatalytic degradation of OPPs in foods.
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JOURNAL OF RAMAN SPECTROSCOPY
·
2017
·Vol. 49
·期 2
·245-255
·
IF 2.969
Xiu Liang,Xiao-Juan Zhang,Ting-Ting You,Nan Yang,Guang-Sheng Wang,Peng-Gang Yin
MoS 2 , a novel inorganic graphene analogues with typical two-dimensional structure, has attracted increasing interest in various fields. MoS 2 -based hybrid plasmonic structures have been extensively investigated as higher quality surface enhanced Raman scattering (SERS) substrates. Herein, we have designed a three-dimensional (3D) MoS 2 nanospheres (NSs) based hybrid nanostructure as SERS sensor by decorating Au nanoparticles (NPs) on the surface of 3D MoS 2 -NSs (3D MoS 2 -NS@Au-NPs). 3D MoS 2 -NSs acts as (a) a stable scaffold for Au NPs decoration via microwave-irradiation hydrothermal process, (b) a chemical mechanism source for Raman enhancement, and (c) a 3D spatial structure for generation of more effective hot spots due to Au coupling effect and supply larger surface area for adsorbing probe molecules. The 3D MoS 2 -NS@Au-NPs hybrid structure exhibits 56-fold improvement on enhancement factor compared to two-dimensional MoS 2 -NST@Au-NPs hybrid structures. SERS performance was easily and effectively optimized with the tuning of the density and sizes of Au NPs. The optimized 3D MoS 2 -NS@Au-NPs was applied as SERS sensor for melamine detection in milk. Quantitative detection was realized in the range of 1 ppb–10 ppm with a linear coefficient of .997. Excellent sensitivity of 1 ppb and uniformity of 10.12% relative standard deviation was achieved, which could meet the demand for melamine detection as prescribed by the U.S. Food and Drug Administration.
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Nanoscale
·
2014
·Vol. 6
·期 14
·7954-7958
·
IF 6.739
Wenya Cai,Xianghu Tang,Bai Sun,Liangbao Yang
In this study, multifunctional Fe3O4/C/Au nanoparticles (NPs), which catalytically integrated active small Au NPs with surface-enhanced Raman scattering (SERS) active large Au NPs, were fabricated via a facile method and employed for the in situ SERS monitoring of a catalytic reaction of p-nitrothiophenol (p-NTP) to p-aminothiophenol (p-ATP). In addition, the effect of magnet power was tested and it was demonstrated that the SERS intensity of the reaction system was stronger, and the reaction proceeded more smoothly because more hot spots existed and remained the same in the magnetic field; hence, the catalytic rate could be determined.
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TALANTA
·
2015
·
IF 3.545
Yange Sun,Xingxing He,Jian Ji,Min Jia,Zhouping Wang,Xiulan Sun
This paper presents a new electrochemical DNA biosensor constructed using a substrate electrode composed of a novel nanocomposite material prepared using gold nanoparticles (Au-NPs) and multiwalled carbon nanotubes (MWCNTs) and further modified with an Au electrode (AuE), which was used as the substrate electrode. A single-stranded DNA (ssDNA) probe was immobilized on the Au-NPs/CS–MWCNTs/AuE electrode by means of facile gold–thiol affinity, which resulted in hybridization with the target ssDNA sequence. Hybridization reactions were assessed by using the reduction peak current of methylene blue (MB) as an electrochemical indicator. The advantages of the nanomaterials were found to include high surface area, favorable electronic properties, and strong electrocatalytic activity . The amount of ssDNA adsorbed on the electrode surface was increased and the electrochemical response of MB accelerated. The differential pulse voltammetric responses of MB were in line with the specific target ssDNA sequence within the concentration range 1.0×10 −15 –1.0×10 −8 M with the detection limit 3.3×10 −16 M (3 σ ). In the colony forming unit (CFU) we were able to detect 10 CFU mL −1 of Staphylococcus aureus in the tap water, achieving good discrimination ability between one- and three-base mismatched ssDNA sequences. The polymerase chain reaction (PCR) amplification products of S. aureus nuc gene sequence were also detected with satisfactory results.
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PubMed
高影响因子
Foods
·
2026
·Vol. 15
·期 4
·733
·
IF 6
Yiming Ou,Yuxin Zhang,Youzhi Wu,Yishan Song,Keqiang Lai
A simple and highly sensitive surface-enhanced Raman spectroscopy (SERS) method has been developed for the detection of thiram residues in fruit juices. Carboxymethyl cellulose (CMC) @ gold nanoparticles (Au NPs) hydrogel beads as SERS substrates were prepared through ionic crosslinking. The obtained porous CMC @ Au NPs hydrogel bead substrates showed excellent sensitivity for the detection of thiram in apple, grape, and orange juices, with detection limits of 0.001, 0.002, and 0.002 mg/L, respectively. The impact of primary non-target components in juices on SERS detection of thiram was investigated, revealing that the presence of sugars and acids caused varying degrees of interference in SERS measurements. This innovative, practical, and affordable CMC @ Au NPs porous hydrogel bead for thiram detection might be readily expanded to analyze a broad spectrum of other compounds found in food goods at trace amounts.
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