POLYHEDRON
·
2024
·
IF 2.4
Gao-Sheng Zhu,Yu-Meng Wei,Dan Wang,Xuan-Zu Guo,Long Li,Yan-Ying Zheng,Yi Jia,Bao-Yi Yu,Qiao-Xia Shang
Four new Zn(II)-, Cd(II)-, Mn(II)-, and Co(II) - based 1D to 2D coordination polymers (CPs) were synthesized from metal salts and 1,4-di(1-imidazol-1-yl)naphthalene (DIN) ligand via the coordination reaction under hydrothermal conditions with quantitative yields , namely, [Zn(SO 4 )(DIN)(H 2 O)] ( CP-1 ), [Cd(NO 3 ) 2 (DIN)] ( CP-2 ), [Mn(SO 4 )(DIN)(H 2 O) 3 ] ( CP-3 ), and [Co(NO 3 ) 2 (DIN) 2 (H 2 O) 4 ] ( CP-4 ). The CPs were analyzed and characterized using FT-IR, Elemental Analysis , TGA , SC-XRD, and PXRD . CP-1 was selected as a model sensor for fluorescence detection , and the sensor exhibited high quenching rates at two excitation wavelengths of λ ex = 230 and 290 nm, and at a single emission wavelength of λ em = 350 nm. At these two different excitation wavelengths, CP-1 behaved differently during the sensing of pesticides, and the highest quenching rate was achieved by the sensor for nitenpyram ( λ ex = 230 nm) and imidacloprid ( λ ex = 290 nm). Furthermore, during the sensing of vitamins, CP-1 encountered a strong quenching effect toward vitamin B2 . During the sensing processes, the inner filter effect (for nitenpyram , imidacloprid , and vitamin B2), fluorescence resonance energy transfer (for nitenpyram, imidacloprid, and vitamin B2), and photo-induced electron transfer (for vitamin B2) were the mechanisms responsible for fluorescence quenching .
研究领域:
化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2024
·
IF 4
Xiaofang Li,Jinyan Li,Yongwei Feng,Liqiang Liu,Hua Kuang,Chuanlai Xu,Lingling Guo
Fumonisin Bs (FBs) are the most common toxic and carcinogenic substances found among naturally occurring contaminants of cereals. A group-specific monoclonal antibody (mAb) 2H7 was prepared that equably recognized fumonisins B 1 (FB 1 ), B 2 (FB 2 ), and B 3 (FB 3 ) with a half-maximal inhibitory concentration (IC 50 ) value for the three forms of 1.52, 2.93, and 3.85 ng/ml, respectively. On this basis, a fluorescent microsphere-based immunochromatographic strip (FM-ICS) was established for the rapid qualitative and quantitative detection of total FBs (FB 1 , FB 2 , and FB 3 ) in corn , wheat, and rice. A recovery test showed that the recovery of FM-ICS was 92.8–108.3% with coefficients of variation of 1.2–7.9%. This method has the same reliability as seen with liquid chromatography-tandem mass spectrometry. And the accuracy was further confirmed by certified reference materials. Therefore, it can be used for the detection of FBs in cereal samples.
研究领域:
食品科学
·
分析化学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2023
·
IF 6.8
Binhong Hu,Songqing Liu,Yuanyue Luo,Jingyu Pu,Xin Deng,Wenjing Zhou,Yuqing Dong,Yichuan Ma,Gang Wang,Fan Yang,Tianhui Zhu,Jiasui Zhan
Environmental exposure to hazardous materials causes enormous socioeconomic problems due to its deleterious impacts on human beings, agriculture and animal husbandry. As an important hazardous material, cadmium can promote uterine oxidative stress and inflammation, leading to reproductive toxicity. Antioxidants have been reported to attenuate the reproductive toxicity associated with cadmium exposure. In this study, we investigated the potential protective effect of procyanidin oligosaccharide B2 (PC-B2) and gut microbiota on uterine toxicity induced by cadmium exposure in rats. The results showed that the expression levels of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were reduced in utero. Proinflammatory cytokines (including tumor necrosis factor-α, interleukin-1β and interleukin-6), the NLRP3 inflammasome, Caspase-1 and pro-IL-1β were all involved in inflammatory-mediated uterine injury. PC-B2 prevented CdCl 2 -induced oxidative stress and inflammation in uterine tissue by increasing antioxidant enzymes and reducing proinflammatory cytokines. Additionally, PC-B2 significantly reduced cadmium deposition in the uterus, possibly through its significant increase in MT1, MT2, and MT3 mRNA expression. Interestingly, PC-B2 protected the uterus from CdCl 2 damage by increasing the abundance of intestinal microbiota, promoting beneficial microbiota, and inhibiting harmful microbiota. This study provides novel mechanistic insights into the toxicity of environmental cadmium exposure and indicates that PC-B2 could be used in the prevention of cadmium exposure-induced uterine toxicity.
研究领域:
毒理学
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生殖健康
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环境科学
·
微生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2021
·
IF 6.475
Jing-Yu Feng,Kiran Thakur,Zhi-Jing Ni,Yun-Yang Zhu,Fei Hu,Jian-Guo Zhang,Zhao-Jun Wei
Due to highly nutritious and well-known prebiotic nature, okara (soy by-product) can improve the physiological benefits of probiotic consumption by enhancing the physicochemical stability and bioavailability of bacteria and metabolites, partially in food matrices and then in gastrointestinal tract. Initially, vitamin B 2 producing probiotic Lactobacillus plantarum UFG10 was immobilized with 4% okara for soy milk fermentation. SEM micrographs showed firm adherence of UFG10 to okara surface depicting efficient immobilization. Soy milk fermented with okara immobilized UFG10 showed enhanced β -glucosidase activity, stimulating the biotransformation of isoflavones from glucosides (daidzin, from 27.78 to 9.84 μg/mL; genistin, from 32.58 to 8.33 μg/mL) to aglycones (daidzein, from 0.19 to 30.84 μg/mL; genistein, from 1.42 to 33.10 μg/mL) and higher B 2 production (1.53 μg/mL, 12 h) confirmed by HPLC. Okara addition and B 2 enrichment could yield relatively higher antioxidant strength than control soy milk. PLSR correlation revealed the effects of okara and B 2 on the functional properties of soy milk. After okara immobilization, soy milk showed higher soy protein digestibility after in vitro digestion for 225 min, higher aggregation, and lower protein molecular chains, qualitatively confirmed with Atomic force microscope. Okara immobilized bacterial cells exhibited relatively greater resistance up to 55.1% (p < 0.05) in simulated GIT, indicating okara as an ideal substrate for an efficient immobilization which ultimately improved the fate of soy B 2 and protein bioaccessibility and functional products such as isoflavones for micro structural design of soy milk with improved nutrition and digestibility.
研究领域:
食品科学
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营养学
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微生物学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHIC SCIENCE
·
2020
·Vol. 58
·期 7
·678-685
·
IF 1.28
Zhang Hui-Xian,Zhang Ping,Fu Xiao-Fang,Zhou You-Xiang,Peng Xi-Tian
This paper reports a simple, sensitive and reliable method for the simultaneous detection of aflatoxin B1, B2, G1 and G2 in vegetable oils. Aflatoxins were extracted by magnetic solid phase extraction followed by high-performance liquid chromatography, then postcolumn photochemical derivatization and finally detected by fluorescence detector. Vegetable oil samples were first diluted with hexane and then commercial bare Fe3O4 nanoparticles were directly employed as sorbents to extract aflatoxins from complex vegetable oil samples, which significantly simplified the procedure of sample preparation and largely improved the sample analysis throughput. The effects of various parameters such as the amount of sorbent, loading, washing and eluting conditions were carefully optimized to improve the extraction efficiencies of aflatoxins. Under the optimal conditions, the limits of detection of four aflatoxins ranged from 0.01 μg/kg to 0.16 μg/kg, and squared regression coefficients (R2) >0.9990 were obtained within the linear range of 0.1–20 μg/kg (except for aflatoxin G2 with 0.5–20 μg/kg). Furthermore, the recoveries spiked at four concentration levels in a blank vegetable oil sample were from 82.6 to 106.2%, with inter- and intraday relative standard deviations <9.8%, indicating good accuracy and precision of the proposed method.
研究领域:
分析化学
·
食品安全
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL UROLOGY AND NEPHROLOGY
·
2023
·
IF 2
Wang Zhi-shun,Shu Bo,Han Qi,Li Guo-hao,Guo Yong-lian
Purpose To investigate the effect of grape seed-derived proanthocyanidin B2 (GSPB2) pretreatment on acute renal ischemia–reperfusion injury model of mice. Methods 50 mice were divided into 5 groups: Sham group: mice were treated with right nephrectomy. GSPB2 group: GSPB2 was injected intraperitoneally 45 min before right nephrectomy. IRI group: right kidney was resected and the left renal arteriovenous vessel was blocked for 45 min. GSPB2 + IRI group: GSPB2 was intraperitoneally injected 45 min before IRI established. GSPB2 + BRU + IRI group: GSPB2 and brusatol (BRU) were injected intraperitoneally 45 min before IRI established. Creatinine and urea nitrogen of mice were detected, and the kidney morphology and pathological changes of each group were detected by HE staining, PAS staining and transmission electron microscopy. Expressions of Nrf2, HO-1, GRP78, CHOP, and cleaved-caspase3 were detected by immunofluorescence staining and western blotting. Results Morphology and mitochondrial damages of kidney in GSPB2 + IRI group were significantly alleviated than those in IRI group. Expression levels of Nrf2 and HO-1 were significantly higher in GSPB2 + IRI group than those in IRI group. Expression levels of GRP78, CHOP and cleaved-caspase3 were significantly lower in GSPB2 + IRI group than those in IRI group. However, compared to GSPB2 + IRI group, protective effects of GSPB2 pretreatment were weakened in GSPB2 + BRU + IRI group. Conclusions GSPB2 pretreatment could alleviate oxidative stress damage and reduce apoptosis of renal tubular epithelial cells, which might be related to activating the antioxidant system, up-regulating the expression of Nrf2 and HO-1, inhibiting the expressions of GRP78, CHOP and cleaved-caspase3. However, the protective effect could be reversed by brusatol.
研究领域:
药理学
·
肾脏生理学
·
分子生物学
·
病理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Yunzheng Wang,Lanling Chu,Jiansong Qu,Bo Ding,Xuejun Kang
A novel analytical method based on nanofiber-packed solid-phase extraction (PFSPE) combined with HPLC-FLD has been successfully developed and applied to determine aflatoxin B1, B2, G1, G2 in foods. In order to effectively adsorb analytes from complex food matrices, four types of nanofibers based on skeleton of polystyrene–polyvinyl pyrrolidone were prepared by electrospinning and applied as adsorbent to home-made solid-phase extraction device. The effects of type of nanofibers, pH of sample, type and concentration of salt ion, type of activation solvent, type and volume of eluent, amount of nanofibers, and extraction time on the adsorption/desorption were investigated and optimized. Under optimal conditions, the method showed satisfactory linear relationship, with limits of detection (LODs) of 0.07–0.17 ng g −1 , intra-day and inter-day RSDs for spiked samples of 1.3–8.0 % and 1.9–5.8 %, and absolute recoveries in the range of 60.1–98.4 %. The results presented the great potential to be utilized to determine AFs in foodstuffs.
研究领域:
分析化学
·
食品科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Yanxia Yu,Chunying Zuo,Mingrui Li,Yuanyuan Tang,Lingxi Li,Fang Wang,Shuting Zhang,Baoshan Sun
In this study, an effective method for preparation of bioactive galloylated procyanidin B2-3′-O-gallate (B2-3′-G) was first developed by incomplete depolymerization of grape seed polymeric procyanidins (PPCs) using l-cysteine (Cys) in the presence of citric acid. The structure–activity relationship of B2-3′-G was further evaluated in vitro through establishing lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. The results suggested that the better protective effects of B2-3′-G against inflammation were attributed to its polymerization degree and the introduction of the galloyl group, compared to its four corresponding structural units. In vivo experiments demonstrated that the B2-3′-G prototype was distributed in plasma, small intestine, liver, lung, and brain. Remarkably, B2-3′-G was able to penetrate the blood–brain barrier and appeared to play an important role in improving brain health. Furthermore, a total of 18 metabolites were identified in tissues. Potential metabolic pathways, including reduction, methylation, hydration, desaturation, glucuronide conjugation, and sulfation, were suggested.
研究领域:
药理学
·
生物化学
·
分子生物学
·
药学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOORGANIC & MEDICINAL CHEMISTRY
·
2025
·
IF 3
Jiangye Zhang,Rui Cai,Changxu Ning,Zhongxiang Zhou,Yibo Zhang,Shisheng Wang,Yueqing Li,Xiuhan Guo
Ferroptosis is a newly discovered form of cell death that is closely related to the occurrence of various diseases, such as neurodegenerative diseases, cardiovascular and cerebrovascular ischemic damage, and organ fibrosis. Therefore, the discovery of new active compounds with ferroptosis inhibitory activity is regarded as a new strategy for the clinical treatment of these diseases. In this study, a multifunctional prodrug molecule PNX-B2 with a phenoxazine structure was designed based on the oxidative microenvironment characteristic of ferroptosis. PNX-B2 can recognize the ferroptosis-associated oxidative conditions and simultaneously release compounds with ferroptosis-inhibitory activity. Moreover, it integrates diagnostic and therapeutic functions and offers a fluorescent indication of the ferroptosis microenvironment. PNX-B2 has demonstrated excellent ferroptosis-inhibitory activity with an EC 50 value of 1.7 nM. This intelligent multifunctional compound shows great potential as a novel clinical agent for ferroptosis inhibition and presents broad prospects for future development.
研究领域:
医学
·
生物学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF NON-CRYSTALLINE SOLIDS
·
2023
·
IF 3.5
Mingjun Zhao,Yiting Tao,Panting Wang,Ting Wu,Danping Chen,Wei Chen
This study discovered that a transparent BaF 2 -B 2 O 3 glass system without rare-earth ions prepared under CO-reducing atmosphere exhibited orange-red self-luminescence under near-UV light, generating broadband luminescence from 550∼850 nm centered at 650 nm under broadband light excitation at about 397 nm. Based on the results of spectra, electron spin resonance, Raman, and X-ray photoelectron spectroscopy, it is proposed that the luminescence phenomenon is due to the s→p transition of B 2+ generated inside the glass under the reducing atmosphere. This new luminescent glass has the potential to be an orange-red luminescent material excited by a light-emitting diode.
研究领域:
材料科学
·
光学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Zi-Ping Wang,Yu Wang,Xin-Yu Li,Lin-Fang Jia,Ai-Zhen Yang,Wen-Ting Zhao,Yi Jia,Bao-Yi Yu,Han-Qing Zhao
The synthesis and characterization of three 2D to 3D metal-organic frameworks (MOFs) with mixed ligands, namely {[Cd(DINT)(TPA)(H 2 O)]ACN} n (BAO24) (H 2 TPA = tere phthalic acid, DINT = 1,4-di(imidazol-1-yl)naphthalene, and ACN = acetonitrile), {[Cd(DINT)(IPA)]DMF} n (BAO25) (H 2 IPA = iso phthalic acid and DMF = N,N -dimethylformamide), and [Cd(DINT)(PA)] n (BAO26) (H 2 PA = phthalic acid), were reported herein. The structures and purities of the MOFs were revealed and confirmed by single-crystal X-Ray diffraction, Fourier transform infrared spectroscopy, powder X-Ray diffraction, thermogravimetric analysis, and elemental analysis. The MOFs exhibited a fluorescence emission peak around λ em = 340 nm with relative excitation wavelengths at both 230 and 290 nm. Since the MOFs showed similar fluorescence properties, BAO24 was selected as a representative MOF in the fluorescent sensing processes. The result showed that BAO24 exhibited a high sensitivity for vitamin B2. However, when sensing pesticides, the sensor performed differently at each excitation wavelength. At λ ex = 230 nm, the sensor was quenched the most significantly with the nitenpyram analyte, while at λ ex = 290 nm, the highest fluorescence quenching was achieved by the imidacloprid analyte.
研究领域:
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2022
·
IF 6.057
Chengliang Wang,Xu Zhang,Wei Zhao,Xin Liu,Qingfu Wang,Jingjiang Sun
Hyperbranched aliphatic polycarbonates (HBPCs) have attracted significant attention in the field of biomedical application owing to their abundant end groups, biocompatibility, and nontoxic degradation products. However, their practical application is hampered by tedious synthesis procedures. The present work described a novel organo-catalyzed “A1+B2”-ring-opening polymerization (ROP) using a monofunctional primary alcohol (A1) as an initiator and a bicyclic carbonate monomer (B2) for the straightforward synthesis of HBPCs under mild conditions. No gelation was observed up to 90% conversion of the cyclic carbonate ring. HBPCs with molar masses in the range from 7 to 20 kg/mol were obtained. Based on the “A1+B2”-ROP, HBPCs bearing a variety of functionalities including alkene, alkyne, aldehyde, furan, azide, and mPEG groups, which are of great significance in the field of click chemistry, have been successfully prepared by using functional alcoholic initiators. This polymerization strategy allowed for precise control over the HBPC structure: (1) the hyperbranched polymer (HBP) backbone can be adjusted by design of a bicyclic carbonate monomer with various linkages; (2) the use of an appropriate initiator leads to the introduction of functional end groups. Overall, the “A1+B2”-ROP provides an efficient method for preparing a variety of HBPs like hyperbranched polyester, polyether, polyphosphate, and poly(amino acid) with complex architectures in a single step.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）