Cell Communication and Signaling
·
2026
·Vol. 24
·期 1
·322
·
IF 11.6
Chen Jiancong,Hu Yanhong,Xie Jiaxin,Zhou Haiping,Yang Tingting,Yu Mingjia,Wu Jingwen,Pan Suyue,Huang Kaibin
Background Status epilepticus (SE) is a life-threatening neurological emergency with high mortality, often leading to acute cerebral edema and chronic cognitive impairment. Its pathology involves both immune and vascular dysfunction. The complement C3/C3a receptor (C3/C3aR) signaling pathway has recently emerged as a key regulator of immune activation and blood-brain barrier (BBB) permeability. This study investigates whether bindarit, a potent anti-inflammatory drug, mitigates SE-induced brain injury through modulation of the C3/C3aR pathway. Methods SE modeling mice were randomized to receive daily bindarit or vehicle. To explore underlying mechanisms, C3aR antagonist (C3aRA) and recombinant C3a were used in additional groups. Post-SE brain injuries were assessed, including survival, memory performance, histopathology, brain edema, BBB integrity, neurovascular inflammation, microglia-astrocyte interactions, and microglial synaptic engulfment. Results We found that bindarit treatment improved survival and memory, reduced histological damage, alleviated brain edema, preserved BBB integrity, and attenuated endothelial inflammation in SE mice. It promoted a shift in microglia from a pro-inflammatory to an anti-inflammatory-associated features, reversed pathological microglia-astrocyte crosstalk, limited synaptic elimination, and restored microglial morphology. Mechanistically, bindarit inhibited neurotoxic astrocyte-derived C3 production and reduced C3aR expression in both microglia and endothelial cells. C3aRA produced comparable protective effects, whereas co-administration of C3a partially negated bindarit’s benefits. Conclusions Bindarit confers robust neuroprotection in SE by preserving BBB integrity, attenuating neurovascular inflammation, reducing synaptic loss, and improving cognitive outcomes. These effects are mediated predominantly through inhibition of the C3/C3aR pathway, highlighting bindarit as a promising therapeutic candidate for SE.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Peng Hu,Jialang Hu,Long Li,Gui Shi,Mingyuan Jiang,Yuhan Chen,Lvming Jin,Chao Xiong,Hongbing Ji
Effective methane separation of gaseous C2-C3 alkanes from natural gas is crucial yet challenging industrial process. Herein, we report the impressive MOF ( 1a ) with rigid topology and ultramicroporous characters that can realize effective methane purification. Adsorption isotherms on 1a show the differential adsorption capacity, with values of 22.7 cm 3 g −1 for CH 4 , 69.1 cm 3 g −1 for C 2 H 6 and 83.6 cm 3 g −1 for C 3 H 8 at 298 K and 1 bar. IAST analysis reveals the calculated C 3 H 8 /CH 4 selectivity of 1a is 1228/1776 with the molar ratio of 50/50 and 10/90 at zero coverage, respectively. The higher selectivity is also demonstrated by C 2 H 6 /CH 4 mixtures. Breakthrough tests reveal the effective purification of CH 4 /C 2 H 6 /C 3 H 8 (85/10/5, v/v/v) mixtures, achieving >99.95 % CH 4 purity at a productivity of 88.7 L kg −1 . Further, scalable 1a with customized grain-size (3.4 g) also reveal the breakthrough performance under higher gas flux (30 sccm or 1.50 × 10 −3 kg h −1 ), indicative of great potential for industrial methane upgrading. Experimental and theoretical calculations show that the pore polarity of 1a can be effectively modulated upon the adsorption of C 3 H 8 molecules with abundant methyl groups without post-modification of MOF structure or introducing heterogeneous species (such as metals or ligands). This guests-induced self-regulatory strategy and decent adsorption orientation further enhances the gas diffusion and continuous adsorption of subsequent C 3 H 8 molecules. Such a strategy affords a novel perspective in adjusting pore polarity and enables methane upgrading from natural gas mixtures.
研究领域:
材料科学
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化学工程
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能源技术
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高影响因子
PLANT SCIENCE
·
2025
·
IF 4.1
Ruilan Ran,Xiaofeng Li,Jiwei Zhang,Jiecai Zhao,Xin Zhao,Xiaoyun Cui,Guoxiong Chen,Pengshan Zhao
Sand rice ( Agriophyllum squarrosum (L.) Moq.), a species of Amaranthaceae sensu lato , is an annual psammophyte found mainly on sand dunes in arid and semi-arid regions of Central Asia. Trichomes on the leaf surface are a key adaptive feature of sand rice, however, their ecophysiological functions remain to be elucidated. In this study, the anatomical analysis of a leaf reveals that the foliage is characterized by its isobilateral and amphistomatic nature. Together with an average δ 13 C value of −28.57 ‰, these findings indicate that sand rice is a C 3 plant. Utilizing a trichome-defective mutant ( Agriophyllum squarrosum trichomeless1 , astcl1 ) identified from an EMS mutagenesis library by our group, alongside the wild type Shapotou (SPT), we observed that both epidermal surfaces on SPT leaves exhibit dense and dendritic trichomes, forming rough leaf boundary layers. Chlorophyll leaching analysis revealed that SPT has a higher epidermal permeability, with 86.32 % of chlorophylls leaching out within 30 minutes, compared to only 24.18 % for astcl1 . The astcl1 leaf displayed a higher leaf wettability, lower water loss, and thicker cuticle compared to SPT leaves, which may be associated with trichomes serving as the primary pathway for nonstomatal water movement. This is supported by the observation that toluidine blue staining is more intense in trichomes than in pavement cells. Our findings reveal that the correlation between trichomes and the cuticle appears to be a critical factor in managing water loss and overall plant hydration, highlighting the significant role of trichomes in the adaptation of sand rice to desert environments.
研究领域:
植物学
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生态学
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiaotong Yang,Kaiyu Dong,Zhe Zheng,Yuehuan Zhang,Qiang Yuan
Efficient C C bond cleavage and the complete oxidation of alcohols are key to improving the efficiency of renewable energy utilization. Herein, we successfully prepare porous Fe-doped hexagonal close-packed ( hcp )-PtBi/face-centered cubic ( fcc )-Pt heterostructured nanoplates with abundant grain/phase interfaces ( h -PtBi/ f -Pt@Fe 1.7 PNPs) via a simple solvothermal method. The open porous structure, abundant grain/phase interface and stacking fault defects, and the synergistic effect between intermetallic hcp -PtBi and fcc -Pt make h -PtBi/ f -Pt@Fe 1.7 PNPs an effective electrocatalyst for the glycerol oxidation reaction (GOR) in direct glycerol fuel cells (DGFCs). Notably, the h -PtBi/ f -Pt@Fe 1.7 PNPs exhibit an excellent mass activity of 7.6 A mg Pt −1 for GOR, 4.75-fold higher than that of commercial Pt black in an alkaline medium. Moreover, the h -PtBi/ f -Pt@Fe 1.7 PNPs achieve higher power density (125.8 mW cm −2 ) than commercial Pt/C (81.8 mW cm −2 ) in a single DGFC. The h -PtBi/ f -Pt@Fe 1.7 PNPs can also effectively catalyze the electrochemical oxidation of 1-propanol (17.1 A mg Pt −1 ), 1,2-propanediol (7.2 A mg Pt −1 ), and 1,3-propanediol (5.2 A mg Pt −1 ). The in-situ Fourier-transform infrared spectra further reveal that the C C bond of glycerol, 1-propanol, 1,2-propanediol, and 1,3-propanediol was dissociated for the complete oxidation by the h -PtBi/ f -Pt@Fe 1.7 PNPs. This study provides a new class of porous Pt-based heterostructure nanoplates and insight into the intrinsic activity of different C3 alcohols.
研究领域:
材料科学
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能源化学
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电化学
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DOI
PubMed
高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2017
·Vol. 122
·期 2
·1031-1047
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IF 1.264
Meng Chen,Cao Gui-Ping,Yan Yi-Zhen,Zhao En-You,Hou Lin-Yi,Shi Hua-Yi
In this work, during the synthesis and hydrolysis of cellulose acetate propionate (CAP), the research not only focused on the contents, but also the distributions of acetyl and propionyl groups in the different positions of anhydroglucose unit, i.e. C2, C3 and C6. It was investigated that cellulose propionylation was more difficult than acetylation, which required larger amounts of reagents. At the same temperature, the reaction rate constant of cellulose acetylation was much higher than that of propionylation. Furthermore, the partial degrees of propionyl substitution in CAP were 0.54, 0.54, and 0.48 for C2, C3, and C6. The contents of propionyl distributed on C2 and C3 positions were higher than that on C6 indicating that acetyl took the position of C6 preferentially. During the hydrolysis of CAP, the degrees of hydrolysis were 0.1 for acetyl and 0.3 for propionyl. Acetyl groups in the C6 position and propionyls in the C2 position were hydrolyzed much easier with the degrees of hydrolysis of 0.16 and 0.32, respectively. In addition, it has been investigated that hydroxyl groups in the C3 position exhibited the lowest reactivity during the synthesis of CAP, while acyl groups on C3 was also the hardest to be hydrolyzed.
研究领域:
材料科学
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化学工程
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Hao Wang,Nianzu Zhang,Xiaopo Wang
The volumetric and viscometric properties of the liquid mixtures are of importance for industrial application and theoretical calculation. This work reports the density and viscosity of the binary mixtures of n -nonane with 1-propanol, 1-butanol, 1-pentanol, and 1-hexanol from 303.15 K to 333.15 K at atmospheric pressure in the whole composition ranges. Excess properties such as excess molar volumes and viscosity deviations were calculated and correlated as the type of Redlich-Kister equation. In addition, the densities and viscosities for the studied mixtures were correlated using PC-SAFT equation and McAllister four-body viscosity model. For n -nonane with 1-propanol, 1-butanol, 1-pentanol, and 1-hexanol mixtures, the average absolute relative deviations between the experimental density data and calculate values from PC-SAFT equation are 0.39%, 0.46%, 0.31%, and 0.38%, respectively. And the average absolute relative deviations of viscosity from McAllister four-body model are 0.82%, 0.86%, 1.32%, and 1.01%, respectively.
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高影响因子
Science Advances
·
2017
·Vol. 3
·期 6
·
IF 0
Pengwei Wang,Guofeng Zhao,Yu Wang,Yong Lu
Oxidative coupling of methane (OCM) is a promising method for the direct conversion of methane to ethene and ethane (C2 products). Among the catalysts reported previously, Mn2O3-Na2WO4/SiO2 showed the highest conversion and selectivity, but only at 800° to 900°C, which represents a substantial challenge for commercialization. We report a TiO2-doped Mn2O3-Na2WO4/SiO2 catalyst by using Ti-MWW zeolite as TiO2 dopant as well as SiO2 support, enabling OCM with 26% conversion and 76% C2-C3 selectivity at 720°C because of MnTiO3 formation. MnTiO3 triggers the low-temperature Mn2+↔Mn3+ cycle for O2 activation while working synergistically with Na2WO4 to selectively convert methane to C2-C3. We also prepared a practical Mn2O3-TiO2-Na2WO4/SiO2 catalyst in a ball mill. This catalyst can be transformed in situ into MnTiO3-Na2WO4/SiO2, yielding 22% conversion and 62% selectivity at 650°C. Our results will stimulate attempts to understand more fully the chemistry of MnTiO3-governed low-temperature activity, which might lead to commercial exploitation of a low-temperature OCM process.
研究领域:
化学工程
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催化
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能源化学
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DOI
PubMed
FOOD CHEMISTRY
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2023
·
IF 8.8
Xuejing Liu,Yaoyao Zhang,Shangde Sun
Caffeic acid (CA), as a potential green antioxidant, plays an important role in food processing. However, the low liposolubility of CA limits its applications. To overcome this issue, CA is normally modified by introducing a lipophilic group, such as alkyl alcohols, resulting in the formation of alkyl caffeate, which can significantly enhance the liposolubility of CA. In this study, a binuclear ionic liquid , 1,1-bis(2-pyrrolidinone) sulfate ([C 3 (Hnhp) 2 ][HSO 4 ] 2 ), is successfully synthesized and characterized by FT-IR and 1 H NMR. The physico-chemical properties of [C 3 (Hnhp) 2 ][HSO 4 ] 2 , including the density, viscosity, thermal stability and Brønsted acidity, were analyzed. As a novel catalyst for the esterification of CA with model dodecanol , its catalytic performance was investigated and optimized by response surface methodology. Under the optimal conditions, a 95.42 ± 1.01% yield of dodecanol caffeate was achieved. Moreover, the [C 3 (Hnhp) 2 ][HSO 4 ] 2 exhibits excellent stability and reusability, making it a highly promising catalyst for the synthesis of various lipophilic alkyl caffeates.
研究领域:
食品科学
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有机化学
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绿色化学
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PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
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2021
·
IF 3.498
Lingyao Wang,Wanqi Sun,Simon Duttwyler,Yuanbin Zhang
A closo -dodecaborate [B 12 H 12 ] 2- functionalized metal organic framework (MOF), BSF-3, constructed by the self-assembly of the Cu(II) cation, 1,4-di(pyridin-4-yl)benzene linker and cluster [B 12 H 12 ] 2- pillar was investigated for the adsorption separation of light hydrocarbons. The activated MOF exhibited efficient uptake of CO 2 and C2–C3 hydrocarbons with high separation selectivity of C 3 H 8 (138), C 2 H 2 (205), C 2 H 4 (23), C 2 H 6 (13) and CO 2 (9) over CH 4 , outperforming many popular MOFs. The practical gas separation ability for C 2 H 2 /CH 4 , CO 2 /CH 4 and C 3 H 8 /C 2 H 6 /CH 4 was confirmed by mixed gas breakthrough experiments with no capacity loss after 7 cycles, indicating its potential for purification of methane from natural gas and pyrolysis gas. The gas bonding sites within the framework were further studied by modelling studies, which indicated that the anionic [B 12 H 12 ] 2- pillar contributed the most to capturing hydrocarbon molecules by multiple B-H δ- ···H δ+ -C interactions.
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高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Yufang Wu,Zewei Liu,Junjie Peng,Xun Wang,Xin Zhou,Zhong Li
Here, we reported a strategy for channel methylation to construct a robust ultramicroporous metal–organic framework (MOF) Ni(TMBDC)(DABCO)0.5 through hydrothermal synthesis method and investigated its adsorption performance for recovering ethane (C2) and propane (C3) from natural gas. The as-synthesized Ni(TMBDC)(DABCO)0.5 featured ultramicroporosity with a uniform pore size of 0.5 nm. The resulting sample showed a strong adsorption interaction with C3H8 and C2H6, and its C3H8 adsorption capacity at a low pressure of 1 kPa was up to 2.80 mmol/g and its C2H6 adsorption capacity at a low pressure of 10 kPa reached as high as 2.93 mmol/g, exhibiting strong binding affinity for ethane and propane. The enhanced adsorption can be attributed to the presence of the dense and accessible methyl and methylene groups in the channels of the sample. Grand Canonical Monte Carlo (GCMC) simulations also confirmed that the methylene groups from the DABCO pillar and the methyl groups from the TMBDC ligand play an important role in enhancing the adsorption of ethane and propane. Its ideal adsorbed solution theory (IAST)-predicted selectivity of C2H6/CH4 reached unprecedentedly 29, much higher than most of the reported data for MOFs. The stability test confirmed that the crystal structure of Ni(TMBDC)(DABCO)0.5 still remained intact after it was exposed to moist air with a relative humidity of 100% for days. The breakthrough experiment demonstrated that the CH4/C2H6/C3H8 ternary mixture was completely separated using a fixed bed of Ni(TMBDC)(DABCO)0.5 at ambient temperature, showing a great potential for recovering the low content of ethane and propane from natural gas.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
Molecular Medicine Reports
·
2015
·Vol. 11
·期 6
·4321-4326
·
IF 1.554
Lei Lan,Yongsheng Han,Wei Ren,Jielong Jiang,Peng Wang,Zhao Hu
The present study aimed to determine the molecular mechanisms leading to the production of advanced glycation end‑products (AGEs) and their effect on the morphology and function of rat glomerular capillary endothelial cells (GECs). Primary rat GECs were treated with AGE‑modified human serum albumin (AGE‑HSA) and divided into groups according to AGE concentration and treatment time. The structure and distribution of cytoskeletal protein F‑actin and the cortical actin binding protein, cortactin, were analyzed using immunofluorescence and confocal microscopy. As the Ras‑related C3 botulinum toxin substrate 1 (Rac1) signaling pathway was previously identified to be involved in mediating the contraction of endothelial actin‑myosin activity, Rac1 was examined subsequent to treatment of the cells with the Rac1 agonist 2'‑O‑methyladenosine‑3',5'‑cyclic monophosphate (O‑Me‑cAMP) for 1 h using a pull‑down assay. Cell permeability was determined by the leakage rate of a fluorescein isothiocyanate fluorescent marker protein. AGE‑HSA treatment resulted in alterations in the structure and distribution of F‑actin and cortactin in a dose‑ and time‑dependent manner, while no effect was observed with HSA alone. The effect of AGE on the cytoskeleton was inhibited by the addition of O‑Me‑cAMP. AGE‑HSA significantly reduced the level of Rac1 activity (P<0.05); however, no effect was observed on total protein levels. Furthermore, AGE‑HSA treatment led to a significant increase in the permeability of endothelial cells (P<0.01), which was inhibited by O‑Me‑cAMP (P<0.01). The Rac1 signaling pathway is thus suggested to serve an important function in mediating AGE‑induced alterations in GEC morphology and function.
研究领域:
分子生物学
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医学
·
细胞生物学
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DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2011
·
IF 4.749
Quan Gu,Xianliang Fu,Xuxu Wang,Shifu Chen,Dennis Y.C. Leung,Xiuqiang Xie
The adsorption behavior and the photocatalytic reforming (PR) process of 2-propanol over Pt (1 wt.%)/TiO 2 (PT) photocatalyst have been investigated by Fourier transform infrared (FTIR) spectroscopy. Both the adsorption complexes and the reforming intermediates formed on the PT and the gas-phase were determined and identified by FTIR spectra. The results indicated that the first layer surface of the PT mainly consisted of chemisorbed 2-propanol (Ti–OCH(CH 3 ) 2 ) through the condensation of 2-propanol with surface Ti–OH or dissociative adsorption with undercoordinated Ti atoms, while the second layer consisted of physisorbed 2-propanol by interaction with the chemisorbed one or the formed H 2 O via hydrogen-bond. Under UV irradiation, a rapidly deprotonation of 2-propoxide occurred by the attack of holes (h + ) and resulted in the formation of acetone, which was then slowly oxidized to acetate and formate species by the hydroxyl radicals ( OH). The carboxylates finally decarboxylate over the PT to evolve CO 2 and CH 4 via the photo-Kolbe reaction. According to the results, a reforming mechanism was proposed. The role of the OH groups contained in 2-propanol and its intermediates were found to serve as anchors for their adsorption and to involve the formation of h + transport ways.
研究领域:
光催化
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氢能
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表面科学
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红外光谱学
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环境催化
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DOI
高影响因子
危险品化学品经营许可证（带存储）