International Journal of Polymeric Materials and Polymeric Biomaterials
·
2025
·
IF 2.6
Shengnan Zheng,Chuzhou Wen,Jiaxue Tang,Changkai Sun,Fengtao Wang,Shui Guan
Pyrroloquinoline quinone (PQQ) is a redox cofactor that has been shown to have strong antioxidant capacity and neuroprotective effects and has been extensively studied in recent years. However, PQQ small molecule compounds have poorly stability and low bioavailability in vivo, making it difficult to exert drug activity for long periods of time. In this study, we employed the EDC/NHS method to graft PQQ onto carboxymethyl chitosan (CMCS) to improve the utilization of PQQ. The obtained PQQ-g-CMCS product was a water-soluble copolymer, and the grafting rate could be controlled by adjusting the pH and the raw material feeding ratio. The PQQ-g-CMCS samples were characterized using FT-IR, UR-Vis, NMR, and XRD spectroscopy, suggesting a conjugation reaction between the amino groups of CMCS and the carboxyl groups of PQQ. Specifically, the in vitro antioxidant experiments showed that the Fe2+ chelating activity of the grafted copolymer was significantly enhanced. In addition, the PQQ-g-CMCS copolymer also exhibited good biocompatibility and significant protective effect against H2O2-induced oxidative damage in SH-SY5Y cells. These results preliminarily indicate that PQQ-g-CMCS may be a promising antioxidant material for applications such as drug release and tissue engineering.
研究领域:
高分子化学
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神经科学
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药学
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材料科学
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生物化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 46
·期 4
·1569-1576
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IF 3.591
Zhuoyao Ni,Jiajie Hu,Hui Zhu,Yazhuo Shang,Daijie Chen,Yinghong Chen,Honglai Liu
Antibiotic resistance caused by long-term abuse of antibiotics has inevitably become a very serious problem and developing novel strategies to enhance the efficacy of treatments is exigent. Herein, a dual-antibacterial platform using sodium alginate (SA) and carboxymethyl chitosan (CMCS) as the framework was designed for NIR controlled pharmacotherapy and photothermal therapy of drug-resistant bacteria. The SA/CMCS solution can quickly transform into a hydrogel in response to Ca2+ and Mg2+ in biological bodies. By mixing indocyanine green (ICG) and thermosensitive drug-loaded liposomes into the solution, this designed platform can not only achieve near-infrared (NIR) controlled drug release properties but also possess dual-antibacterial capacity by combining pharmacotherapy and photothermal therapy (PTT). Local temperature rise induced by ICG will break the stability of thermosensitive liposomes, causing the release of the encapsulated drug. The in vitro antibacterial test and in vitro cytotoxicity experiment demonstrate the excellent antibacterial capacity and satisfactory biocompatibility of the prepared platform. The proposed NIR controlled dual-antibacterial platform can not only avoid bacterial resistance but also kill drug-resistant bacteria efficiently, which will provide a novel concept for the development of an intelligent antibacterial platform.
研究领域:
药学
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生物医学工程
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材料科学
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DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2023
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IF 5.8
Puxin Lang,Tiantian Liu,Shiqi Huang,Zhaojie Zhou,Mengxing Zhang,Yunzhu Lin,Qin He,Yuqin Yao,Zhenmi Liu,Ling Zhang
Tissue adhesions could occur following surgeries, and severe tissue adhesions can lead to serious complications. Medical hydrogels could be applied at surgical sites as a physical barrier to prevent tissue adhesion. For practical reasons, spreadable, degradable, and self-healable gels are highly demanded. To meet these requirements, we applied carboxymethyl chitosan (CMCS) to poloxamer-based hydrogels to generate low Poloxamer338 (P338) content gels displaying low viscosity at refrigerator temperature and improved mechanical strength at body temperature. Heparin, an effective adhesion inhibitor, was also added to construct P338/CMCS-heparin composite hydrogel (PCHgel). PCHgel presents as a flowable liquid below 20 °C and could rapidly transform into gel when spread on the surface of damaged tissue due to temperature change. The introduction of CMCS enabled hydrogels to form a stable self-healable barrier at injured positions and slowly release heparin during the wound healing period before being degraded after ∼14 days. Ultimately, PCHgel significantly reduced tissue adhesion in model rats and displayed higher efficiency than P338/CMCS gel without heparin. Its adhesion suppression mechanism was verified, and it also displayed good biosafety. Therefore, PCHgel showed good clinical transformation potential with high efficacy, good safety, and ease of use.
研究领域:
生物医学工程
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材料科学
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外科研究
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药剂学
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DOI
PubMed
高影响因子
POLYMER
·
2026
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IF 5.1
Junqi Zhao,Zicheng Chen,Jiahao Huang,Jingxian Zhang,Langhuan Huang,Shaozao Tan,Yongqiang Xiong
Bacterial infections and excessive oxidative stress severely impede the wound healing process, and the development of multifunctional wound dressings with antibacterial, antioxidant, and biosafety properties is of great clinical significance. In this study, DAHA/CMCS/Ag@PDA (DCA) injectable hydrogels were successfully prepared by dual-dynamic crosslinking of Schiff base and hydrogen bonds. Dopamine graft-modified oxidized hyaluronic acid (DAHA) and carboxymethyl chitosan (CMCS) constructed a dynamic and reversible cross-linking network of the hydrogel, which endowed the hydrogel with excellent injectable, self-healing, shape-adaptive, and high adhesion properties. Meanwhile, DAHA and Ag@PDA, which are rich in catechol groups, provided the hydrogels with highly efficient synergistic antioxidant properties, which could effectively scavenge various free radicals. In addition, the loading of Ag@PDA endowed the hydrogel with excellent Ag + release and NIR-II photothermal conversion properties, and DCA2 could realize efficient killing (99.6%) of S. aureus and E. coli through the synergistic action of Ag + slow release and NIR-II photothermal, which could effectively promote the healing of bacterial-infected wounds. In conclusion, this study provides a new design strategy for hydrogel dressings for the treatment of bacterial-infected wound healing through the multifunctional integration of NIR-II photothermal synergistic antibacterial and antioxidant properties.
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DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
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2023
·
IF 6.6
Mei Zhang,Yizhong Yuan,Jie Jin,Jinyu Sun,Xiaohui Tian
Using natural rubber (NR)/chitosan (CS)/polyvinyl alcohol (PVA) as raw materials, biodegradable semi-IPN (semi-interpenetrating polymer network) composites were prepared by thiol-epoxy click reaction under UV light, which was used as the shell of sustained release preparation. Using polyvinyl alcohol (PVA)/carboxymethyl chitosan (CMCS) as raw material and vanillin as the cross-linking agent, hydrogen-bonded hybrid network hydrogel loaded with urea was prepared by freeze-thaw cycle, which was used as the core of sustained-release preparation. Finally, a green-coated urea fertilizer with core-shell structure was prepared to ameliorate the environmental pollution of slow-release fertilizer (for example, synthetic polymer-coated fertilizers are difficult to biodegrade), as well as to achieve the water retention and the effective slow-release. The high CS/PVA contents and the combination of the hydrogel core and the rubber shell significantly improved the mechanical properties of the coating material (tensile strength above 5 MPa, elongation at break up to 1400 %), hydrophilicity (to promote the degradation rate of the rubber shell) and soil water retention of the coating material (close to pure hydrogel), showing enhanced reaction. In terms of slow-release effect, coated nitrogen fertilizer with 3 % CS content, 5 % PVA content and 10-min coating time (SRP3/10) achieved the best slow-release effect of nitrogen (N) in water (62.7 % at 10 days), which was related to the hydrophilicity, semi-IPN skeleton and the cross-linking structure of the network, and the release conformed to the Korsmeyer-Peppas model with a non-Fickian diffusion release mechanism, indicating that the behavior of N release was mediated by a combination of drug diffusion and skeleton dissolution.
研究领域:
材料科学
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环境科学
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农业科学
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DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
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IF 15
Li Tingting,Zhao Yueming,Lin Mian,Hu Jiajun,Duan Kairui,Zhu Hu,Zi Taotao,Lee Bae Hoon
Obesity and its metabolic complications urgently require safe, effective, and minimally invasive interventions. Here, we engineered an injectable, self-healing hydrogel system (OCMU hydrogel) based on oxidized hyaluronic acid (OHA) and carboxymethyl chitosan (CMCS) for the localized delivery of plant-based ursolic acid (UA) loaded in mesoporous polydopamine (MPDA) nanoparticles. This system synergistically induces white adipose browning through combined photothermal therapy (PTT) and pharmacological action, effectively counteracting obesity. The OCMU hydrogel exhibited excellent self-healing properties, high UA loading capacity (81.04%), efficient photothermal conversion, and favorable biocompatibility. Mechanistically, the system promotes lipolysis, mitochondrial biogenesis, and adipose browning via activation of the AMPK/SIRT1/PGC-1α pathway, with a 439% increase in UCP1 expression in vitro. In obese mice, OCMU combined with PTT reduced body weight by 10.94% and inguinal fat by 56.32%, while significantly improving metabolic profiles and alleviating inflammation. Notably, the combination of mild PTT and naturally derived UA achieved superior anti-obesity efficacy compared to monotherapies, highlighting a favorable safety and efficacy profile. This work establishes a promising platform in which UA and mild PTT act in concert to reprogram adipocyte metabolism, offering a safe and synergistic approach to combat obesity. Graphical
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高影响因子
Polymers
·
2023
·Vol. 15
·期 12
·2744
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IF 5
Yue Jiang,Shanzhu Guo,Jingjing Jiao,Long Li
The treatment of osteochondral defects remains challenging due to the limited healing capacity of cartilage and the poor results of traditional methods. Inspired by the structure of natural articular cartilage, we have fabricated a biphasic osteochondral hydrogel scaffold using a Schiff base reaction and a free radical polymerization reaction. Carboxymethyl chitosan (CMCS), oxidized sodium alginate (OSA), and polyacrylamide (PAM) formed a hydrogel (COP) as the cartilage layer, while hydroxyapatite (HAp) was incorporated into the COP hydrogel to obtain a hydrogel (COPH) as an subchondral bone layer. At the same time, hydroxyapatite (HAp) was incorporated into the COP hydrogel to obtain a hydrogel (COPH) as an osteochondral sublayer, combining the two to obtain an integrated scaffold for osteochondral tissue engineering. Interlayer interpenetration through the continuity of the hydrogel substrate and good self-healing properties due to the dynamic imine bonding of the hydrogel resulted in enhanced interlayer bond strength. In addition, in vitro experiments have shown that the hydrogel exhibits good biocompatibility. It shows great potential for osteochondral tissue engineering applications.Keywords:biphasic scaffolds;self-healing hydrogel;osteochondral repair
研究领域:
组织工程
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生物材料
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骨科
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产品关联
DOI
PubMed
高影响因子
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
·
2026
·
IF 4.8
Xiaojie Ding,Kexin Cao,Yan Li,Xinchun Li,Qiu Zhong,Yong Chen,Mengnan An,He Liu,Rujun Zhou,Yuanhua Wu
Nanocarrier-mediated delivery of double-stranded RNA (dsRNA) is a promising strategy for plant disease control. Our previous study has shown that the self-assembled ε-poly- l -lysine/carboxymethyl chitosan (ε-PL@CMCS) nanocarrier significantly improves the efficiency of RNA interference (RNAi) against Rhizoctonia solani AG3 TB. However, the molecular mechanisms underlying this enhancement and the potential ecological impacts on phyllosphere microbial communities remain unclear. In this study, we confirmed that ds RsGH1 @ε-PL@CMCS had no adverse effects on the growth and development of plants. Transcriptome analysis revealed that DEGs were significantly enriched in ‘SNARE interactions in vesicular transport’ pathway. Among them, ds RsGH1 @ε-PL@CMCS specifically upregulate the vesicle transport protein SEC22 in Nicotiana tabacum. Surface plasmon resonance (SPR) assay demonstrated that the ds RsGH1 @ε-PL@CMCS binds to SEC22 protein with 7.6-fold higher affinity than that of the naked ds RsGH1 . Silencing SEC22 in the ds RsGH1 @ε-PL@CMCS treatment reduced the silencing efficiency of RsGH1 from 53.3% to 39%, confirming its essential role. Concurrently, high-throughput sequencing revealed that SIGS treatments did not disrupt bacterial community structure but increased fungal diversity and suppressed the pathogen, while enriching beneficial fungi such as Tulasnella . Our findings elucidate a molecular link between nano-bioprotectant ds RsGH1 @ε-PL@CMCS-enhanced RNAi and host vesicle transport, while confirming the biocompatible and microbiome-modulating potential. This provides a dual perspective for developing efficient and sustainable RNAi-based strategies for protecting plants.
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Na Wen,Shuangshuang Li,Hongzhi Jiang,Jiachao Yang,Weibo Yang,Yunhao Song,Jinlin Long,Jiwu Zhao,Zhihui Lin,Xunbin Yu,Yen Wei,Shiyun Lu,Xueping Huang,Tianhua Zhou
Gastric ulcers accompanied by acute or chronic bleeding represent a significant risk of fatality. However, the development of effective strategies for achieving rapid hemostasis and wound healing in gastric ulcer bleeding represents a formidable challenge. To address this challenge, thrombin-derived C-terminal peptide (TCP-25) is employed as a targeted agent, and it is incorporated into two novel injectable and biocompatible carboxymethyl chitosan (CMCs) hydrogels via Schiff's base reaction. The TCP-25 peptide hydrogels display optimal adaptability within the distinctive gastrointestinal microenvironment, demonstrating a balance of acid resistance and degradation, along with controlled release and bioactivity, and good bio-adhesive properties. Both in vitro and in vivo reveal that the hydrogel achieves rapid hemostasis. In an ethanol-induced gastric ulcer model in rats, it demonstrates that the hydrogel effectively inhibits gastric ulcer bleeding by 92% within 24-h, exhibiting efficacy that surpasses that of omeprazole medicine, a commonly used clinical treatment. This enhanced performance is attributed to the synergistic effects of the CMCs hydrogel and TCP-25 peptide in effectively achieving hemostasis, inhibiting bacterial growth, and promoting gastric wound healing in acute or chronic bleeding gastric ulcers. Consequently, the present work offers promising clinical applications for rapid hemostasis and wound healing in gastric ulcers.
研究领域:
生物医学工程
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材料科学
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药学
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胃肠病学
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产品关联
DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2019
·
IF 1.479
Yong Zhang,Zhishan Bai,Wenqiang Luo,Linlin Zhai,Bingjie Wang,Xiaohu Kang,Jieqiong Zong
In this paper, a selective nickel ions chelating adsorbents (Ni-CMCS) were prepared based on carboxymethyl chitosan by ion imprinting technique. Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) were used to investigate their physicochemical properties. Brunauer-Emmett-Teller (BET) analysis showed that the BET surface area of Ni-CMCS had a significant increase after ion imprinting process. The effects of pH value, contact time and initial concentration of Ni(II) were studied. The adsorption kinetics were investigated, which indicated that Ni-CMCS was better fitted with pseudo-second-order kinetic model (R2 = 0.9991) with film diffusion process as rate controlling step. The adsorption isotherms study indicated that Langmuir model matched better with the experimental data for Ni-CMCS (R2 = 0.9617). Besides, the maximum adsorption capacity calculated from the Langmuir equation was 82.78 mg g−1. Moreover, the selectivity experiment suggested that Ni-CMCS had good selectivity in the presence of Co(II), Mn(II), or Cd(II). After used four cycles, Ni-CMCS kept great adsorption capacity.
研究领域:
环境科学
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材料科学
·
化学工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Shanshan Jin,Rajib Mia,Md All Amin Newton,Hongju Cheng,Weihong Gao,Yuansheng Zheng,Zijian Dai,Jie Zhu
The escalating global health concern arises from chronic wounds induced by bacterial infections, posing a significant threat to individuals. Consequently, an imperative exist for the development of hydrogel dressings to facilitate prompt wound monitoring and efficacious wound management. To this end, pH-sensitive bromothymol blue (BTB) and pH-responsive drug tetracycline hydrochloride (TH) were introduced into the polysaccharide-based hydrogel to realize the integration of wound monitoring and controlled treatment. Polysaccharide-based hydrogels were formed via a Schiff base reaction by cross-linking carboxymethyl chitosan (CMCS) on an oxidized sodium alginate (OSA) skeleton. BTB was used as a pH indicator to monitor wound infection through visual color changes visually. TH could be dynamically released through the pH response of the Schiff base bond to provide effective treatment and long-term antibacterial activity for chronically infected wounds. In addition, introducing polylactic acid nanofibers (PLA) enhanced the mechanical properties of hydrogels. The multifunctional hydrogel has excellent mechanical, self-healing, injectable, antibacterial properties and biocompatibility. Furthermore, the multifaceted hydrogel dressing under consideration exhibits noteworthy capabilities in fostering the healing process of chronically infected wounds. Consequently, the research contributes novel perspectives towards the advancement of intelligent and expeditious bacterial infection monitoring and dynamic treatment platforms.
研究领域:
生物医学工程
·
材料科学
·
伤口护理
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药学
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组织工程
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产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2020
·
IF 4.152
Wanjun Hu,Zhigang Zhang,Long Zhu,Yazhou Wen,Tianzhu Zhang,Pengfei Ren,Faming Wang,Zhenling Ji
Polypropylene (PP) mesh has been used successfully for a long time in clinical practice as an impressive prosthesis for ventral hernia repair. To utilize a physical barrier for separating mesh from viscera is a general approach for preventing adhesions in clinical practice. However, a serious abdominal adhesion between the mesh and viscera can possibly occur post-hernia, especially with the small intestine; this can lead to a series of complications, such as chronic pain, intestinal obstruction, and fistula. Thus, determining how to prevent abdominal adhesions between the mesh and viscera is still an urgent clinical problem. In this study, a dopamine-functionalized polysaccharide derivative (oxidized-carboxymethylcellulose-g-dopamine, OCMC-DA) was synthesized; this was blended with carboxymethylchitosan (CMCS) to form a hydrogel (OCMC-DA/CMCS) in situ at the appropriate time. The physical and chemical properties of the hydrogel were characterized successfully, and its excellent biocompatibility was presented by the in vitro cell test. The combination of this hydrogel and PP mesh was used in laparoscopic surgery for repairing the abdominal wall defect, where the hydrogel could become fixed in situ on the PP mesh to form an anti-adhesion gel-mesh. The results showed that the gel-mesh could prevent abdominal adhesions effectively in the piglet model. Moreover, the histology and immunohistochemical staining proved that the gel-mesh could effectively alleviate the inflammation reaction and deposition of collagen around the mesh, and it did not disturb the integration between mesh and abdominal wall. Thus, the gel-mesh has superior tissue compatibility.
研究领域:
手术材料
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生物材料
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组织工程
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医疗器械
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外科技术
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动物模型
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）