Frontiers in Chemistry
·
2020
·
IF 3.693
Mei Qixiang,Deng Guoying,Huang Zehua,Yin Yue,Li Chunlin,Hu Junhui,Fu Yang,Wang Xingpeng,Zeng Yue
Severe acute pancreatitis (SAP) is associated with high rates of mortality and morbidity. Chitosan oligosaccharides (COSs) are agents with antioxidant properties. We developed porous COS@SiO2 nanocomposites to study the protective effects and mechanisms of COS nanomedicine for the treatment of acute pancreatitis. Porous COS@SiO2 nanocomposites released COSs slowly under pH control, enabling sustained release and maintaining the drug at a higher concentration. This study aimed to determine whether porous COS@SiO2 nanocomposites ameliorate SAP and associated lung injury. The SAP model was established in male C57BL/6 mice by intraperitoneal injection of caerulein. The expression levels of myeloperoxidase, malondialdehyde, superoxide dismutase, nuclear factor-kappa B (NF-κB), the NOD-like receptor protein 3 (NLRP3) inflammasome, nuclear factor E2-related factor 2 (Nrf2), and inflammatory cytokines were detected, and a histological analysis of mouse pancreatic and lung tissues was performed. In the SAP groups, systemic inflammation and oxidative stress occurred, and pathological damage to the pancreas and lung was obvious. Combined with porous COS@SiO2 nanocomposites before treatment, the systemic inflammatory response was obviously reduced, as were oxidative stress indicators in targeted tissues. It was found that Nrf2 was significantly activated in the COS@SiO2 treatment group, and the expressions of NF-κB and the NLRP3 inflammasome were notably decreased. In addition, this protective effect was significantly weakened when Nrf2 signaling was inhibited by ML385. This demonstrated that porous COS@SiO2 nanocomposites activate the Nrf2 signaling pathway to inhibit oxidative stress and reduce the expression of NF-κB and the NLRP3 inflammasome and the release of inflammatory factors, thus blocking the systemic inflammatory response and ultimately ameliorating SAP and associated lung injury.
研究领域:
药理学
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纳米技术
·
病理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Yuan Guan,Xinyi Gu,Qiankun Deng,Shaomang Wang,Zhongyu Li,Shicheng Yan,Zhigang Zou
Bismuth vanadate is a promising material for photoelectrochemical water oxidation. However, it suffers from a low quantum efficiency, poor stability, and slow water oxidation kinetics. Here, we developed a novel photoanode of CoS/Mo-BiVO4 with excellent photoelectrochemical water oxidation performance. It achieved a photocurrent density of 4.5 mA cm–2 at 1.23 V versus the reversible hydrogen electrode, ∼4 times that of BiVO4. The CoS/Mo-BiVO4 photoanode also exhibited good stability, and the photocurrent density generated by the CoS/Mo-BiVO4 photoanode did not significantly decrease after light irradiation for 2 h. Upon replacement of part of the V with Mo doping in BiVO4, the local electric field around the Mo–O bond was enhanced, thus promoting carrier separation in BiVO4. The CoS was deposited on the surface of Mo-BiVO4, forming a built-in electric field at the interface. Under the action of the bias electric field and the built-in electric field, the carriers of CoS/Mo-BiVO4 were efficiently separated in the direction of the inverse type II heterojunction. In addition, CoS improved the light absorption and charge injection efficiency of the CoS/Mo-BiVO4 photoanode.
研究领域:
材料科学
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光电化学
·
能源材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2023
·Vol. 10
·期 19
·5700-5709
·
IF 7
Yixian Liu,Ruqiang Wu,Yunliang Liu,Peiji Deng,Yaxi Li,Yuanyuan Cheng,Yongchao Du,Zenan Li,Xiong Yan,Naiyun Liu,Zhenhui Kang,Haitao Li
As an environmentally friendly and sustainable method for ammonia synthesis, nitrogen reduction reaction (NRR) by electrocatalysis possesses several advantages, including viability under mild conditions, abundant reaction raw materials and low energy consumption, and thus it is supposed to be a promising alternative to the traditional Haber–Bosch process. However, the stable NN bonds in the nitrogen (N2) and the competing hydrogen evolution reaction (HER) put harsh requirements on catalysts. In this study, the CoS/MoS2 heterojunction catalyst where CoS nanoparticles are anchored on the MoS2 nanosheets is reported as a high-efficiency NRR catalyst. The catalysts have high NH3 yield (23.23 μg h−1 mgcat.−1), reasonable faradaic efficiency (FE, 12.63%) and long-term electrochemical stability under −0.45 V vs. RHE in 0.1 M Na2SO4 solution, whose performance is better than MoS2 and CoS. The TPV results show rapid interfacial electron transfer and good conductivity of the material, and the DFT calculation reveals that the CoS attached to the (100) plane effectively enhances N2 adsorption and catalysis performance.
研究领域:
材料科学
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电化学
·
催化
·
可持续化学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Yicheng Wei,Xiaojian Li,Xu Sun,Hongmin Ma,Yong Zhang,Qin Wei
Combining dual-signal channels of differential pulse voltammetry (DPV) and amperometric i–t curve, we developed an amplified sandwich-type electrochemical immunosensor for ultrasensitive detection of prostate specific antigen (PSA). Due to the large specific surface area and good adsorption property, 3-aminopropyltriethox functionalized CeO 2 mesoporous nanoparticles (NH 2 -M-CeO 2 ) was used for supporting toluidine blue (TB) as the electron transfer mediator and anti-PSA as the signal response. To prevent the leak of TB and facilitate the electron transfer property of NH 2 -M-CeO 2 , ionic liquids doped carboxymethyl chitosan (CMC/ILs) were incorporated and TB/M-CeO 2 /CMC/ILs complex was gotten to act as the label of anti-PSA (Ab 2 ). Meanwhile, Au-CoS/graphene was as the matrix materials modifying the electrode to immobilize anti-PSA (Ab 1 ). Specifically, Au-CoS/graphene cannot produce electrochemical signals through DPV method but can provide an obviously electrochemical signal towards catalysis hydrogen peroxide (H 2 O 2 ) through amperometric i–t curve method. At the time of detection, with the increase of concentrations of PSA, the DPV signals from TB/M-CeO 2 /CMC/ILs were increased and the amperometric i–t curve signals from the Au-CoS/graphene were decreased. Under the optimum conditions, the immunosensor demonstrated remarkable analytical performance of a linear range of 0.5 pg/mL to 50 ng/mL with a detection limit of 0.16 pg/mL for quantitative detection of PSA (S/N=3).
研究领域:
生物医学工程
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 78
·49490-49497
·
IF 3.108
Lan-Fang Hu,Yang Li,Bin Liu,Ying-Ying Zhang,Xing-Hong Zhang
This study describes the catalytic formation of alternating and regioregular copolymers from carbonyl sulfide (COS) and epoxides along with eugenol-based glycidyl ether (EGE) and guaiacol-based glycidyl ether (GGE), derived from eugenol and guaiacol, respectively. The (salen)CrCl [salen = N,N′-bis(salicylidene) cyclohexanediimine] complex, accompanied with various organic bases, was highly active towards the EGE/COS, GGE/COS copolymerization and EGE/GGE/COS terpolymerization. The turnover of frequency (TOF) of the (salen)CrCl complex for the EGE/COS copolymerization was up to 12 000 h−1. The number-average molecular weight (Mn) of the resultant EGE/COS copolymer was up to 62.2 kg mol−1. In the presence of 0.5–1.5 mol% chlorohydrin, which was a by-product of the synthetic process of EGE, α-Cl, ω-OH EGE/COS copolymers were obtained. This result suggests that chlorohydrin could act as a very efficient chain transfer agent for the copolymerization. The EGE/COS, GGE/COS, and EGE/GGE/COS copolymers were soluble in most of the common solvents and exhibited a high refractive index of more than 1.58 with high Abbe numbers of up to 40.4. This study provides an unprecedented and sustainable synthetic route for making soluble sulfur-rich polymers with high optical properties.
研究领域:
高分子化学
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材料科学
·
可持续化学
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2024
·
IF 10.5
Yao Yao,Cheng Zhou,Ze-Lin Zhao,Gang-Gang Chang,Jian-Kun Wei,Ke-Xin Huang,Jing-Jing Xie,Jun-Sheng Li,Xiao-Yu Yang
Owing to high theoretical energy density and potentially low cost, lithium sulfur (Li–S) batteries have become a viable alternative for use in future energy storage devices. However, practical applications of this battery type are limited by the significant volume change of S and the undesired shuttle effect of polysulfides during cycling, ultimately causing rapid capacity decay. Herein, we developed a novel method to fabricate a N-doped hollow carbon composite (CoS/HNC) embedded with well-dispersed CoS nanoparticles (NPs) through inheritable carbonization of functionalized hollow metal-organic frameworks (MOFs). Specifically, the hollow UiO-66-NH 2 is created by a sequence involving (1) use of non-uniform nucleation-growth approach to generate inhomogeneous UiO-66-NH 2 that has more defects in the core, and (2) selective etching of the less stable core to obtain hollow structure. The CoS/HNC composite has advantages associated with not only hollow nanostructure that buffers the volume expansion of S species during cycling, but also CoS that prevents the shuttle effect. More importantly, both experimental and calculated results reveal that CoS/HNC could catalyze the reduction of LiPSs more effectively and CoS/HNC heterostructure enables the short-chain polysulfide that obtained from the catalytic conversion of soluble long-chain polysulfide by CoS NPs to be deposited on HNC. This process avoids passivation of the catalytic site and ensures continuity of the catalytic conversion. Benefiting from integration of its intriguing composition and morphology advantages, an as-prepared CoS/HNC–S cathode exhibits significantly improved electrochemical performance and cycling stability associated with a low capacity decay of 0.05% per cycle over 800 cycles at 1 C.
研究领域:
材料科学
·
能源存储
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Qingqing Chen,Jinlong Hu,Qi Xia,Lingzhi Zhang
The silicon oxycarbonitride with ultrafine CoS (CoS@SiOCN) spherical composite as anode material for lithium-ion batteries is synthesized through the pyrolysis of the polymerized product of Co(II) with Schiff-base ligand of aminoethyl-aminopropyl-trimethoxy silane and salicylaldehyde and the simultaneous in-situ formation of CoS. Owing to the molecular level complexation of Co(II) and the subsequent in-situ sulfidation, the generated ultrafine CoS is well-dispersed in SiOCN sphere. Compared with the Co@SiOCN and SiOCN anodes, the CoS@SiOCN anode displays the highest initial reversible capacity of 834 mAh g −1 with an initial Coulombic efficiency of 68.5% at 200 mA g −1 . At 1000 mA g −1 , the CoS@SiOCN anode still exhibits outstanding cycling performance, delivering a reversible capacity of 536 mAh g −1 after 800 cycles with a retention of 80.4%. The full cell with pre-lithiated CoS@SiOCN anode and LiFePO 4 cathode delivers an initial discharge capacity of 146 mAh g −1 at 0.2 C and maintains 115 mAh g −1 at 0.5 C after 50 cycles. The outstanding electrochemical performances can be attributed to the structure of SiOCN with the active SiO x C 4- x (0 ≤ x ≤ 4) nanodomain and free carbon conductive network, and well-dispersed CoS. The electrochemical analysis indicates both CoS and in-situ formed Co nanoparticles at the high redox voltage can contribute to the electrochemical properties .
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Kai Na,Jiani Wei,Li Zhang,Ying Fang,Xiangyu Li,Shuang Lu,Xiaohua Guo
Chitosan oligosaccharides (COS) show the potential to support the intestinal health, but the mechanism and role of COS-derived intestinal microbiota are unknown. We explored the protective effect of direct administration of COS on intestinal barrier function using an in vivo colitis mouse model and an in vitro enterotoxigenic Escherichia coli (ETEC)-challenged IPEC-J2 cell model. COS directly enhanced the intestinal barrier function. COS intervention also promoted the abundance and diversity of intestinal flora. Importantly, FMT intervention with a COS-derived microbiome decreased the disease index level and alleviated histopathological changes, and improved gut barrier function in the colitis model. Both COS and COS-derived microbiota suppressed ETEC-induced cellular apoptosis in IPEC-J2 cells. This study firstly confirms transplantation of COS-modified fecal microbiota can enhance the intestinal barrier function. The mechanism underlying COS benefits is due to a direct intervention by COS supplementation and an indirect improvement of the gut microbiota induced by COS exposure.
研究领域:
胃肠病学
·
微生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.3
Zhe Bai,Ruichen Liu,Zehao Dong,Tianren Zhang,Xiangwen Zhang,Guozhu Li
Selective hydrodeoxygenation (HDO) is one of the most effective ways to convert renewable biomass to high-value chemicals and fuels. Co-doped MoS2 exhibited high selectivity of C–O bond cleavage, but its activity should be simultaneously improved for efficient aromatics production. In this work, CoS-MoS2 nanoflowers with in-plane heterostructures are synthesized by a one-pot solvothermal method using lactic acid as an organic regulator for efficient and selective hydrodeoxygenation. A series of characterization methods illustrate that the introduction of lactic acid promotes the dispersion of CoS phase on MoS2 and formation of active CoS-MoS2 heterostructures. The results of H2-TPD and H2-TPR show that the as-prepared catalyst exhibits enhanced hydrogen adsorption and dissociation capabilities. Density functional theory (DFT) calculations demonstrate that the heterointerface between CoS and MoS2 effectively facilitates hydrogen activation, thereby improving the catalytic performance of hydrogenation. In the hydrodeoxygenation of diphenyl ether (DPE) at 300 °C and 4 MPa, CoS-MoS2-LA-1.0 exhibited a DPE conversion of 99.5% and a benzene selectivity of 97.2% in 4 h. Moreover, the catalyst exhibited excellent durability under harsh reaction conditions.
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Fei Lu,Bin Zhang,Lifeng Shen,Anjie Chen,Yuhe Chen,Yuxue Zhou,Xiuyun Zhang,Bitao Liu,Min Zhou
Replacing the sluggish anodic water oxidation reaction with the glucose oxidation reaction (GOR) offers an energy-saving strategy to obtain value-added products during the hydrogen production process. However, rational design of the GOR electrocatalyst with an explicit structure–property relationship remains a challenge. In this study, by using cobalt chalcogenides as model catalysts, we performed an in-depth study of the GOR catalytic mechanism of CoS and CoSe nanosheets. Experimental and theoretical results revealed that the reaction pathway on cobalt chalcogenides strongly depends on their binding energy to hydroxyl (OHBE). For CoS with a weak OHBE, the reaction proceeds through an “electrophilic oxygen” route. While for CoSe, due to the strong OHBE, a surface reconstruction occurs before the GOR and therefore follows the “electrochemical-chemical” route. Inspired by these findings, a customized strategy was proposed to regulate the OHBE of the catalysts, which involved introducing F atoms into CoS to enhance its OHBE, and weakening the OHBE of CoSe by doping with Zn atoms. The optimized F-doped CoS and Zn-doped CoSe catalysts both exhibited significantly improved performance for GOR. This study thus provides a verifiable paradigm for improving the GOR performance via a customized strategy and sheds light on the design of novel catalysts in the future.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Microbiology
·
2021
·
IF 5.64
Zheng Qiuling,Meng Xiangjun,Cheng Mingyang,Li Yanfeng,Liu Yuanpeng,Chen Xuehong
Chitosanase is a significant chitosan-degrading enzyme involved in industrial applications, which forms chitooligosaccharides (COS) as reaction products that are known to have various biological activities. In this study, the gene csnS was cloned from a deep-sea bacterium Serratia sp. QD07, as well as over-expressed in Escherichia coli, which is a new chitosanase encoding gene. The recombinant strain was cultured in a 5 L fermenter, which yielded 324 U/mL chitosanases. After purification, CsnS is a cold-adapted enzyme with the highest activity at 60°C, showing 37.5% of the maximal activity at 0°C and 42.6% of the maximal activity at 10°C. It exhibited optimum activity at pH 5.8 and was stable at a pH range of 3.4–8.8. Additionally, CsnS exhibited an endo-type cleavage pattern and hydrolyzed chitosan polymers to yield disaccharides and trisaccharides as the primary reaction products. These results make CsnS a potential candidate for the industrial manufacture of COS.
研究领域:
海洋生物技术
·
酶学
·
生物催化
·
工业微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Yujie Wang,Jiaying Liu,Yongbo Cui,Meng Liu,Wenxia Chen,Wei Wei,Haifeng Lu,Dongyun Han
The semi-hydrogenation of alkynes with high chemo and regioselectivity represents a significant yet challenging aspect in the synthesis of functionalized alkenes. A straightforward hydrothermal technique was utilized to synthesize amorphous cobalt sulfide polyhedra (CoS x ). This material facilitates the electrocatalytic semi-hydrogenation of terminal alkynes in water, particularly those possessing reducible groups such as C-I, C-Br, C-Cl, and C-O. The process yields impressive results, with a conversion rate of up to 99 % and a selectivity of as high as 95 %. Moreover, it demonstrates a wide substrate scope and excellent compatibility with a variety of functional groups. The high conversion rate of alkynes, coupled with the high selectivity for alkenes, and the catalyst's excellent versatility, collectively underscore the potential of our method.
研究领域:
化学
·
材料科学
·
催化反应
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）