JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Keting Feng,Kangqi Wu,Kai Li,Weijun Wang,Shihui Gao,Jun Fan,Tao Sun,Enzhou Liu
Localized surface plasmon resonance (LSPR) effect plays a crucial role in the field of solar energy utilization. In this work, we successfully prepared a Cu 2-x Se/ZnSe S-scheme heterojunction with a broad-spectrum response using the hot-injection and low-temperature water bath method. Importantly, we demonstrated that the photothermal effect induced by the LSPR of nonstoichiometric Cu 2-x Se can significantly improve the slow kinetics of water splitting, resulting in an apparent activation energy reduction from 50.1 to 28.7 kJ·mol −1 . This improvement is responsible for achieving the highest photocatalytic H 2 evolution rate of 63.6 mmol·g −1 ·h −1 over 2.7 % Cu 2-x Se/ZnSe under the wavelength ranged from 200 to 2500 nm, which is 3.4 and 5.6 times higher than that of ZnSe and Cu 2-x Se, respectively. Furthermore, the composite exhibits a remarkable H 2 production rate of 0.108 mmol·g −1 ·h −1 under near-infrared spectroscopy (800<λ<2500 nm), while ZnSe shows limited capability in H 2 releasing. Additionally, Cu 2-x Se/ZnSe demonstrates distinct photocurrent response when λ > 800 nm. The enhanced performance in H 2 evolution can be attributed to the synergistic effect of LSPR-induced light absorption and S-scheme heterojunction, which not only expands the light absorption range to the near-infrared region but also facilitates hot electron injection, charge carrier separation and transfer, leading to a faster surface reaction kinetics. This study provides an effective approach for designing a broad-spectrum light responsive non-precious metal-based photothermal-assisted photocatalytic system.
研究领域:
材料科学
·
光催化
·
太阳能利用
·
纳米技术
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jiaying Chang,Man Wang,Junrong Wang,Guoqing Zhu,Yulin Xie,Yanrong Qian,Qianqian Sun,Chunxia Li
Autologous tumor cells demonstrate considerable promise as individualized therapeutic vaccines owing to their endogenous neoantigen repertoire. Nevertheless, their suboptimal immunogenicity substantially impedes clinical translation. Herein, we engineered an innovative whole tumor cell vaccine platform utilizing photothermal Cu 2- x Se nanoparticles, which encapsulate comprehensive tumor-associated antigens and intrinsic immunostimulatory molecules to elicit a polyvalent antitumor immune response. In this work, Cu 2-x Se was applied to prepare the whole tumor cell vaccine for the first time. As a pyroptosis inducer, Cu 2-x Se triggered the expression of damage-associated molecular patterns (DAMPs) as endogenous adjuvants in 4T1 cells (mouse breast cancer cells) under near-infrared (NIR) irradiation. Repeated freeze-thaw cycles inactivated and lysed Cu 2-x Se-loaded 4T1 cells, releasing DAMPs for laser-activated Cu 2-x Se-based whole tumor cell vaccine (LC-TCV) preparation. Mild photothermal therapy (PTT) at the vaccination site by NIR irradiation effectively suppressed tumor growth. This efficacy was primarily attributed to the synergistic effects of multiple natural antigens and adjuvants in LC-TCV, which promoted dendritic cells (DCs) maturation and subsequent immune activation. Consequently, it potentiates the recruitment of cytotoxic T lymphocytes, elicits immunogenic cell death (ICD), and consequently initiates a potent antigen-specific immune cascade. Collectively, this study presents an innovative approach to unleash the potential of personalized whole tumor cell vaccines in cancer therapy.
研究领域:
癌症免疫治疗
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纳米医学
·
光热治疗
·
疫苗研发
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肿瘤免疫学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Xu Chen,Mengjun Qiu,LiPing Liu,Qin Ji,Zushun Xu,Zhifan Xiong,Shengli Yang
A novel nanoplatform that supports multimodal imaging has been designed for deep tumor therapy. In this study, Bi 2 Se 3 @Cu 2−x Se heterojunction nanocomposites with tunable spectral absorption, effective electron–hole separation and high photothermal conversion efficiency were prepared for the combination therapy of phototherapy (PT), chemodynamic therapy (CDT) and radiotherapy (RT). By adjusting the doping ratio, the heterojunction nanoparticles show obvious tunable ability of local surface plasmon resonance and the ability to promote electron-hole separation with significantly enhanced reactive oxygen species production capacity. The band structure and charge density difference calculated by density functional theory further reveal that the change of band gap and the decrease of free carriers can regulate the spectral absorption of nanomaterials and promote electron-hole separation. In addition, the photothermal conversion properties of low carrier density semiconductors are related to their inherent deep level defects. The formation of heterojunctions making the Se atoms deviate from the Bi 2 Se 3 lattice, resulting in more deep level defects and stronger photothermal conversion properties. Meanwhile, this nanoplatform presented features similar to catalase activities and glutathione (GSH) consumption characteristics, which was capable of effectively alleviate the tumor-specific hypoxia environment to enhance the efficacy of O 2 -dependent photodynamic therapy (PDT) and radiotherapy (RT) and depletion GSH to prevent the reduction of therapeutic efficacy due to the clearance of reactive oxygen species. In addition to therapeutic enhancement, heterojunction nanomaterials have excellent nuclear magnetic resonance imaging (MRI), infrared thermal imaging (IR) and computed tomography (CT) properties due to their significant paramagnetism and excellent photothermal conversion and X-ray attenuation capacities. In conclusion, our findings provide a new strategy for designing multi-function and efficient nanoplatform to treat tumor.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
医学影像
✓ 已验证
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Xiaodong Lin,Bergoi Ibarlucea,Tao Peng,Ren Shen,Peiyue Li,Pan Zhang
Susceptibility point-of-care testing (POCT) and bacterial inactivation are crucial for food safety and clinical diagnosis since bacteria pose a severe hazard to public health and healthcare. To enable photothermal determination and hyperthermal inactivation of bacteria, vancomycin-modified near-infrared (NIR)-responsive copper selenide nanoparticles (Cu 2−X [email protected] NPs) with excellent photothermal conversion are synthesized here. Cu 2−X [email protected] NPs can be trapped on the surface of Gram-positive bacteria such as Staphylococcus aureus ( S. aureus ), forming a Cu 2−X [email protected] NPs/ S. aureus complex. Suspension (Cu 2−X [email protected] NPs) and sediment (Cu 2−X [email protected] NPs/ S. aureus ) can convert the NIR laser energy into a thermal signal that can be detected by the thermal camera at concentrations as low as 6.0 CUF mL −1 . Meanwhile, S. aureus can be effectively inactivated by localized temperature rises during temperature-based signal detection. The antibacterial efficiency can reach as high as 99.53%. The proposed strategy not only provides a sensitive POCT strategy for bacterial determination but also implements efficient inactivation of bacteria simultaneously.
研究领域:
细菌学
·
纳米技术
·
生物医学工程
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食品安全
·
临床诊断
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materiomics
·
2019
·Vol. 5
·期 4
·626-633
·
IF 0
Zhiming Geng,Dongliang Shi,Lu Shi,Ying Li,G. Jeffrey Snyder,Kwok-ho Lam
As the featured material of the superionic thermoelectric (TE) material family, copper-chalcogenide Cu 2- x Se is attracting growing research interest for its excellent TE performance derived from the satisfactory power factor and the ultra-low thermal conductivity induced by the superionic effect. Various efforts have been made and proved to be effective to further enhance the TE performance for Cu 2- x Se. However, this material is still far from the application stage, which is mainly due to concerns regarding control of the properties and the costly complex fabrication technology. Here we report a scalable pathway to achieve high-performance and tunable Cu 2- x Se, utilizing conventional sintering technology and copper (Cu)-vacancy engineering with an effective mass model. The figure of merit zT is a competitive value of 1.0 at 800 K for the optimized binary Cu 2- x Se, based on the precise modeling prediction and Cu-vacancy engineering. The changes in TE properties of Cu 2- x Se under heating-cooling cycle tests are also revealed. Our work offers the referable method along with the decent parent material for further enhancement of TE performance, paving a possible route for the application and industrialization of Cu 2- x Se TE materials.
研究领域:
材料科学
·
热电学
·
固体物理
·
能源材料
✓ 已验证
DOI
CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Fangfang Kong,Jiang Bai,Peng Bi,Xiaowei Liu,Ziyu Wang,Rui Xiong
As a promising thermoelectric material, copper selenides have attracted the interest of researchers owing to their low cost, abundance in earth, environmental friendliness, and low thermal conductivity . In this study, copper selenide (Cu 2-x Se) powders with controllable sizes from nanoscale to mesoscale were obtained by a facile one-pot solvothermal method. After treatment with spark plasma sintering , the nanoscale Cu 2-x Se pellets exhibited excellent thermoelectric properties such as sharply reduced thermal conductivity and enhanced Seebeck coefficient as well as a suppressed electrical conductivity . The figure of merit ( ZT ) of the nanoscale Cu 2-x Se reached up to ∼1.51 at 873 K, which is about 2.67 times higher than that of the meso-Cu 2-x Se. This study confirms that thermoelectric properties can be enhanced by the size effect.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Biao Zhang,Danfeng Cai,Yihan Lang,Xiaodong Lin,Ke Yang,Xuping Shentu,Xiaoping Yu
A smartphone-integrated multi-model thermal immunochromatographic assay has been constructed for the detection of histamine by using anti-histamine antibody coupled Cu 2−x Se nanoparticles (Cu 2−x Se@antibody) as photothermal nanoprobes. Base on a competitive format, the coated histamine antigen on T-line and histamine simultaneously competed for binding the lateral flow photothermal signal probes . With the increase of histamine concentration, the temperature of Cu 2−x Se@antibody on T-line was decreased under the 808 nm laser irradiation , which can be monitored via the smartphone-thermal imager combination device. In addition, the color on T-line from nanoprobes gradually disappeared, and the inhibition rate calculated from the obtained temperature on T-line was increased. The smartphone-integrated multi-model thermal immunochromatographic assay enables detection of histamine in the range of 0.1–10.0 μg/L with limit of detection as low as 0.09 μg/L. The histamine concentrations in crab, tuna, saury, mackerel, shrimp were 5.67 mg/kg, 83.73 mg/kg, 14.03 mg/kg, 21.30 mg/kg, 3.22 mg/kg detected by the developed thermal immunochromatographic assay, respectively. The developed multi-model strategy provided good sensitivity, simple operation, effectiveness and practicability for histamine in real samples compared to ultra-performance liquid chromatography-tandem mass spectrometry UPLC-MS/MS and ELISA .
研究领域:
食品安全检测
·
生物传感
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2016
·Vol. 408
·期 30
·8771-8778
·
IF 3.125
Zhang Fang Fang,Zou Hong Yan,Lan Jing,Wang Hong,Huang Cheng Zhi
It is very important to be able to accurately and rapidly measure the cholesterol level in the human body, as cholesterol is associated with various diseases, such as Alzheimer’s disease. In this work, a novel method of detecting cholesterol using chemiluminescence (CL) based on a newly prepared semiconductor catalyst, Cu 2− x
Se nanoparticles (Cu 2− x
Se NPs), was developed. It was found that the Cu 2− x
Se NPs strongly enhanced the CL signal by producing a large number of reactive oxygen species (ROS) in the luminol–Cu 2− x
Se NPs system. Based on the UV-vis-NIR absorption spectra, zeta potential, CL spectrum, and an investigation of the ROS, a possible mechanism for the CL was proposed. This CL-based method was successfully applied to determine cholesterol. It was found that the enhanced CL was proportional to the concentration of cholesterol over the range of 82 nM to 1.96 μM with a detection limit of 0.062 nM, and that added cholesterol was successfully detected in human serum with a mean recovery of 97 %.
研究领域:
医学诊断
·
生物化学
·
纳米材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2026
·Vol. 19
·期 16
·3496
·
IF 3.7
Yunfei Cai,Caiyan Gao,Cun-Yue Guo
Copper selenide compounds, owing to their excellent electrical transport properties and low thermal conductivity, are promising thermoelectric materials, but their poor mechanical flexibility limits practical applications in flexible devices. Herein, a simple all-electrochemical strategy was developed to fabricate polypyrrole (PPy)/Cu2−xSe composite thermoelectric films through sequential electropolymerization of pyrrole and electrodeposition of Cu2−xSe. By optimizing the deposition potential of Cu2−xSe and pyrrole polymerization time, the thermoelectric performance of the composite films was significantly enhanced. The optimized PPy/Cu2−xSe composite film achieved a maximum power factor of 174.05 ± 9.87 μW m−1K−2, nearly 300 times higher than that of pristine PPy, while maintaining a low thermal conductivity of 0.30 W m−1K−1. The composite film also exhibited excellent flexibility, retaining 94.77% of its initial power factor after 1000 bending cycles. A flexible thermoelectric device assembled from the composite films delivered a maximum output power of 240.5 nW at ΔT= 50 K. This work provides an effective strategy for developing Cu2−xSe-based flexible thermoelectric composites.
✓ 已验证
产品关联
DOI
高影响因子
2D Materials
·
2022
·Vol. 9
·期 2
·025028
·
IF 6.861
Meng Yuan,Haodong Shi,Cong Dong,Shuanghao Zheng,Kai Wang,Shaoxu Wang,Zhong-Shuai Wu
Some vital challenges are main obstacles for further development of lithium–sulfur (Li–S) batteries such as low capacity and poor cycle stability resulted from polysulfide shuttling behavior, the physical/chemical entrapment is regarded as an effective method to inhibit and catalyze polysulfides. Herein we design a cross-linked framework of reduced graphene oxide anchored with Cu2−xSe nanoparticles (Cu2−xSe@rGO) by building an electrolyte/Cu2−xSe/graphene triple-phase interface to be a high-efficiency electrocatalyst for Li–S batteries. Importantly, this three-dimensional conductive network possesses a large specific surface area with high ion transport capability, meanwhile providing strong physical constraint for efficient adsorption of soluble polysulfides. Further, this triple-phase catalytic interface provides strong chemical adsorption and abundant Cu2−xSe nanoparticle sulfiphilic active sites, effectively inhibiting the dissolution of polysulfides and guaranteeing the efficient polysulfide adsorption catalysis as well as rapidly uniform Li2S nucleation. Consequently, with the Cu2−xSe@rGO separator, a lower capacity decay rate about 0.059% per cycle after 500 cycles at 2 C is obtained. What's more, with a higher areal sulfur loading of 3.0 mg cm−2, the capacity is still maintained at 805 mAh g−1 over 100 cycles. Therefore, this work will open new avenue to construct 2D transition metal selenide for superior performance Li–S batteries.
研究领域:
材料科学
·
能源存储与转换
✓ 已验证
DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
·
2018
·
IF 3.165
Shu Jun Zhen,Ting Ting Wang,Yu Xin Liu,Zhu Lian Wu,Hong Yan Zou,Cheng Zhi Huang
Recently, copper chalcogenide semiconductors have been reported as new near-infrared (NIR) photothermal agents. However, it is difficult to modify them with recognition molecules, and their photothermal conversion efficiencies are relatively low, making it difficult to achieve the targeted photothermal ablation of cancer cells with a high efficiency. In this study, reduced graphene oxide (rGO) was first coated on the surface of Cu 2-x Se nanoparticles (NPs) to provide abundant functional groups for the next modification and to increase the photothermal conversion efficiency. Then, doxorubicin (DOX) was loaded and folic acid (FA) molecules were covalently linked onto the surface of Cu 2 − x Se/rGO nanocomposites . The formed DOX@Cu 2 − x Se@rGO-FA nanocomposites were successfully used as chemo-photothermal agents for the targeted killing of cancer cells by utilizing the recognition ability of FA, chemotherapy effect of DOX and photothermal effects of rGO and Cu 2 − x Se NPs. Under the 980-nm NIR laser irradiation, the nanocomposites showed significantly enhanced chemo-photothermal therapy effect, which can be potentially applied in the nanomedicine field.
研究领域:
纳米医学
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanomedicine
·
2019
·
IF 4.717
Yali Liu,Wuyi Liu,Jingbin Huang,Wenjing Lai,Faning Leng,Changpeng Hu,Qian Zhang,Min Zhou,Qin Tang,Fangfang Sheng,Guobing Li,Rong Zhang
Aim: To confirm Cu2-xSe nanoparticles (NPs) could inhibit autophagic degradation and based on this property to develop a novel therapeutic strategy for cancer treatment. Materials & methods: Transmission electronic microscopy and confocal laser-scanning microscope were used to observe the accumulation of autophagosome. Western blot was used to investigate the expression of autophagy-associated proteins. Chemotherapeutic drug oxaliplatin was cotreatment with Cu2-xSe in vivo and in vitro to study therapeutic efficacy of autophagy caused by Cu2-xSe NPs. Results & conclusion: Cu2-xSe NPs significantly induce autophagosome accumulation in hepatocellular carcinoma cells, and they mainly inhibit the late-stage autophagy degradation through reducing lysosomal cathepsin activity. Moreover, Cu2-xSe NPs enhance the anticancer activity of oxaliplatin in vivo and in vitro through blocking autophagosome degradation.
研究领域:
肿瘤学
·
药理学
·
纳米技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）