Science China-Chemistry
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2020
·Vol. 63
·期 9
·1295-1305
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IF 6.356
Wang Xianheng,Yang Lei,Yang Peng,Guo Wancai,Zhang Quan-Ping,Liu Xianhu,Li Yiwen
Melanin-inspired polymers are currently the focus of growing interest for a wide range of applications ranging from energy to biomedical area. Whilst researchers have made numerous attempts to prepare and utilize polydopamine nanoparticles (PDA NPs), they have made limited progress in developing and discovering another typical functional mimic of natural melanin, poly (levodopa) (P(L-DOPA)) NPs, probably due to the lack of facile synthetic strategies towards satisfactory structural and functional control of melanin-like NPs. Herein, we reported a one-pot preparation method towards P(L-DOPA) NPs with good yields and controllable size/property in an aqueous solution assisted by various metal ions ( i.e. , Ni(II), Mg(II), Ca(II), Fe(III), Mn(II), Co (II), Zn(II) and Cd(II)). Interestingly, the resulting P(L-DOPA) NPs exhibited enhanced light absorption and photothermal behaviors compared with well-established PDA NPs, which can be employed to further fabricate kinds of photothermal composite actuators with promising performances such as folding, switching, and forward-moving. This study offers a facile and robust way to synthesize new synthetic melanins beyond PDA, and facilitates further functional discovery and evolution of melanin-inspired polymers and composites.
研究领域:
材料科学
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生物医学工程
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高分子化学
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产品关联
DOI
高影响因子
Analytical Methods
·
2014
·Vol. 7
·期 4
·1387-1394
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IF 1.938
Lu Lin,Hui-Ting Lian,Xiang-Ying Sun,Ya-Ming Yu,Bin Liu
A molecularly imprinted polymer (MIP) based sensor for detecting L-dopa was fabricated based on the composite of graphene (GR) and chitosan (CS). The microstructure and composition of the imprinted films characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR), Raman spectroscopy and electrochemical impedance spectroscopy (EIS) indicated that the modified film of GR-MIPs had been formed successfully. Electrochemical evaluation results showed that the sensor exhibited a satisfactory selectivity for molecular binding with an imprinting factor (IF) of 6.2 and a wide linear range from 0.4 μM to 100 μM with a low detection limit of 0.012 μM. This electrochemical sensor exhibited great promise for accurate determination of L-dopa in pharmaceutical preparations and human blood serum for recoveries ranging from 95.0 to 108.0%. Furthermore, compared to imprinted films without graphene doping, GR-MIPs showed a superior chiral sensing for L-dopa in the presence of D-dopa. The results reveal that the insertion of graphene brought about an enhanced sensitivity for chiral sensing and has the potential for application in chiral recognition.
研究领域:
分析化学
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材料科学
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生物医学工程
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产品关联
DOI
高影响因子
RSC Advances
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2017
·Vol. 7
·期 21
·12977-12983
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IF 3.108
Weini Jia,Qiang Wang,Xuerong Fan,Aixue Dong,Yuanyuan Yu,Ping Wang
Bio-inspired or bionic coloration of fiber assemblies based on chemical oxidation of phenolics has gained more and more attention in recent years. To overcome the challenges of protecting the ecology and environment in textile processes, a novel approach for the coloration of silk fabrics via laccase-mediated in situ oxidation of dopa (dihydroxy phenylalanine) has been investigated in this work. In view of the fact that laccase is able to catalyze the oxidation of benzenediol followed by polymerization to produce strongly colored phenolic polymers, two biological coloration processes of silk fabrics based on in situ oxidation of dopa using laccase were investigated: (i) the adsorption of silk fabrics with dopa, followed by further catalysis of laccase and (ii) the simultaneous laccase-mediated polymerization and coloration of silk fabrics. Dosages of laccase and incubation time were evaluated in order to increase the color depth and fastness of the silk fabrics. The increase in laccase dosage and reaction time allowed improvement in the depth of the final color. The properties of colored silk fabrics were evaluated in terms of UV-protection and color fastness. Finally, the binding of the polymers of dopa with silk fibers was verified by Fourier transform infrared spectroscopy (FT-IR). The silk fabrics treated with laccase/dopa by a one-step process obtained K/S values of 16.935, light fastness of 4–5 level, and UPF of 100+. SEM and AFM observations showed that the surface of silk samples treated with laccase/dopa had numerous small flakes, which can be regarded as the melanin particles of dopa molecules, attached by the grafting reaction. The FT-IR analysis showed that the functional groups on the surfaces of laccase/dopa-treated silk fabrics were changed with the introduction of carbonyl groups. The results of XPS showed that the elemental composition of the surface of laccase/dopa-treated silk fabrics was similar to oral melanin. This dyeing technique could also be extended to the treatments of other types of fibers in textile dyeing and finishing processes.
研究领域:
纺织科学
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生物化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2023
·
IF 3.9
Nor Hafiza Ismail,Wan Norharyati Wan Salleh,Farhana Aziz,Norhaniza Yusof,Juhana Jaafar,Ahmad Fauzi Ismail,Ahmad Hafizal Mohd Yamin
Oily wastewater poses a significant environmental concern as it has adverse effects on both ecosystems and human health. The development of highly efficient and robust antifouling membranes for oily emulsion is in great demand to prevent these serious issues in oil/water emulsion filtration. Moreover, fouling was inevitable when dealing with membrane separation . In order to overcome the addressed matters, this paper reported sprayed hydrophilic surface coating using commercialized levodopa ( L -DOPA). The coated solution was mixed with 3-amino-propyltriethoxysilane in various ratios to obtain a smooth coated layer. Based on the results, the highest pure water flux and rejection efficiency of 586.51 ± 23.95 L/m 2 ‧h and 98.22% was achieved in this study, respectively. The abundant hydroxyl and carboxyl functional groups on the membrane surface from L -DOPA benefit the membrane in many ways, especially the membrane wetting properties. The water and oil contact angles of the coated membrane increased by approximately 75% and 85%, respectively. The fouling behaviors are influenced by the presence of the coated layer, resulting in the attainment of 90% fouling resistance ratio (FRR). This is mostly due to the reduction in adherence of oil droplets on the membrane surface, hence enhancing the effectiveness of the anti-oil fouling membrane . Additionally, this provides excellent properties of the membrane to be applied in oily wastewater treatment .
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
ANALYST
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2025
·
IF 3.3
Jiahui Lai,Danni Wang,Xiuqin Sheng,Chuan-Fan Ding,Yinghua Yan
In large-scale glycoproteomics studies, reducing the experimental duration and enhancing digestion efficiency are crucial. In this work, a magnetic nanomaterial featuring a surface rich in hydrophilic groups and uniformly distributed trypsin (Fe3O4@DOPA/PEI@Au@DNA TET-trypsin) was developed for efficient digestion of proteins and specific enrichment of glycopeptides. The material surface exhibits a regular distribution of trypsin coupled with abundant hydrophilic groups. Thus, the material can demonstrate excellent performance in experimental studies related to glycoproteomics. Fe3O4@DOPA/PEI@Au@DNA TET-trypsin showed an excellent limit of detection (0.001 amol·μL−1) and high selectivity for glycopeptides (BSA : HRP = 5000 : 1) in a short reaction time, and it showed good performance in the processing of practical samples. Gene Ontology (GO) analysis suggests that complement activation, extracellular space, antioxidant activity and complement binding may be associated with tuberculosis. These analytical results provide new insights for determining and clarifying the pathogenesis and pathology related to tuberculosis.
研究领域:
蛋白质组学
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生物化学
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医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2024
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IF 8.3
Xiaoyan He,Dan Su,Xiuqin Bai,Chengqing Yuan
Ceria (CeO2) nanoparticles with haloperoxidase (HPO)-like activity have gained attention as a biologically benign antifoulant. 3,4-Dihydroxy-l-phenylalanine (DOPA), a main composition in mussel foot proteins, plays a crucial role in the biofouling process. However, the impact on the HPO-like activity and antifouling performance of CeO2 nanoparticles when DOPA molecules adsorb on them remains unexplored. This interesting question warrants investigation, particularly considering that it may occur in an actual marine environment. Herein, the interaction between DOPA and CeO2 is explored. Despite the higher Ce3+ fractions and the lower band gap energies due to the electron transfer from DOPA to the CeO2 surface, DOPA still had a slightly negative effect on the HPO-like activity of CeO2 since they decreased the exposed Ce3+ sites. The DOPA-CeO2 nanocomposites with HPO-like activities could kill bacteria and trigger quorum-sensing signaling quenching, achieving a biofilm inhibition performance. Amazingly, 0.1% DOPA-CeO2 nanocomposite exhibited higher antibacterial activity and better biofilm suppression activities due to its HPO-like activity and positive zeta potential. The remarkable results demonstrated that DOPA, as a participant in the biofouling process, could enhance the antibacterial activity and antifouling performance of CeO2 nanoparticles at an appropriate concentration.
研究领域:
材料科学
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生物医学工程
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微生物学
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产品关联
DOI
PubMed
高影响因子
Nano Research
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2021
·Vol. 15
·期 2
·1069-1078
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IF 8.897
Wang Bin,Ma Junjie,Li Zehua,Chen Gangshu,Gu Qiang,Chen Shuyao,Zhang Yiqiang,Song Yanlin,Chen Jingbo,Pi Xiaodong,Yu Xuegong,Yang Deren
Trap-mediated energy loss in the buried interface with non-exposed feature constitutes one of the serious challenges for achieving high-performance perovskite solar cells (PSCs). Inspired by the adhesion mechanism of mussels, herein, three catechol derivatives with functional Lewis base groups, namely 3,4-Dihydroxyphenylalanine (DOPA), 3,4-Dihydroxyphenethylamine (DA) and 3-(3,4-Dihydroxyphenyl) propionic acid (DPPA), were strategically designed. These molecules as interfacial linkers are incorporated into the buried interface between perovskite and SnO 2 surface, achieving bilateral synergetic passivation effect. The crosslinking can produce secondary bonding with the undercoordinated Pb 2+ and Sn 4+ exhibited the best performance and operational stability. Upon the DOPA passivation, a stabilized power conversion efficiency (PCE) of 21.5% was demonstrated for the planar PSCs. After 55 days of room-temperature storage, the unencapsulated devices with the DOPA crosslinker could still maintain 85% of their initial performance in air under relative humidity of ≈15%. This work opens up a new strategy for passivating the buried interfaces of perovskite photovoltaics and also provides important insights into designing defect passivation agents for other perovskite optoelectronic devices, such as light-emitting diodes, photodetectors, and lasers.
研究领域:
材料科学
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能源科学
·
化学
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
·
IF 8.6
Hongying Li,Fei Shi,Shuhui Chen,Yifan Li
Two Dimensional membranes, which are usually constructed by inorganic nanosheets, have shown great potentials in efficient separation of low-molecular-weight chemicals. In this study, a novel type of organic–inorganic hybrid two-dimensional membrane is designed and prepared by co-assembly of a two-dimensional organic building block, Dopa thin-walled microcapsule, and a typical inorganic nanosheet, MXene. The introduction of MXene not only increases the distance between adjacent Dopa microcapsules and improves the solvent flux of the membrane, but also improves the structural stability by modulating the chelation strength of MXene with the Dopa microcapsules. The optimal Dopa/MXene composite membrane shows good performance in the field of organic solvent nanofiltration (OSN), with a flux of 723 L m −2 h −1 bar −1 for methanol and reactive black rejection of more than 90%. All the Dopa/MXene hybrid membranes show better stability than MXene lamellar membranes and MXene/Dopa hybrid membranes (where Dopa microcapsule is inserted into MXene membrane), demonstrating the advantages of organic species in enhancing interfacial adhesion. More interestingly, since the chelation between Dopa and MXene mainly depends on the presence of TiO 2 in MXene, the oxidation of MXene, which often raises concerns of instability, herein is found to further increase the rejection and stability of Dopa/MXene hybrid membranes with only slight decrease of solvent flux.
研究领域:
材料科学
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分离技术
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纳米科技
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产品关联
DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Jin-ao Li,Nana Pan,Zichun Qi,Jiahua He,Yifan Wei,Weilong Chen,Jian-Bo Qu,Xiaojuan Wang,Fang Huang
Elevated hydrogen peroxide (H 2 O 2 ) levels not only inflict cellular damage but also serve as a harbinger for various diseases. Tumor cells, in particular, often exhibit an abundance of H 2 O 2 . Hence, the detection of this pivotal molecule assumes paramount importance in monitoring physiological states and expediting cancer diagnosis. To this end, we have ingeniously devised an enzyme-free and monomeric system for intracellular H 2 O 2 detection. Our astute selection of dopa-containing peptidomimetics, replete with ortho-bisphenol and amino acid moieties, has engendered the synthesis of distinctive fluorescent gold nanoclusters (AuNCs). These nanoclusters not only function as a peroxidase-like catalyst, catalyzing the decomposition of H 2 O 2 into hydroxyl radicals (·OH), but also serve as an indicator, with their fluorescence quenched in response to varying H 2 O 2 concentrations. Experimental results evince that our GDpE-AuNCs exhibit remarkable sensitivity, boasting a detection limit of 0.49 μM and a linear range of 5–1000 μM. Moreover, the amalgamation of catalyst and indicator within a single structure, facilitating efficient cellular uptake, engenders intracellular H 2 O 2 detection and discernment of tumor cells. This pioneering approach bequeaths a valuable assay probe for monitoring physiological states and ushering in early disease diagnosis.
研究领域:
生物化学
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医学诊断
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纳米生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2020
·
IF 4.152
Yufeng Shou,Jiahui Zhang,Shifeng Yan,Pengfei Xia,Pengliang Xu,Guifei Li,Kunxi Zhang,Jingbo Yin
Chitosan (CS) hydrogels are widely used in wound hemostatic agents due to their superior biocompatibility, biodegradability, and hemostatic effect. However, most of them fail to achieve great hemostatic effect because of poor adhesion to bleeding tissues. Also, the conventional implantation surgery of hemostatic hydrogels to internal bleeding wounds may cause secondary trauma to the human body. In this work, catechol-hydroxybutyl chitosan (HBCS-C) has been designed and prepared by grafting hydroxybutyl groups and catechol groups to the CS backbones. The multifunctional HBCS-C hydrogels are fabricated with the properties of thermosensitivity, injectability, tissue-adhesion, biodegradation, biocompatibility, and wound hemostasis. They exhibit excellent liquid-gel transition at different temperatures, through the changes of hydrophilic–hydrophobic interaction and hydrogen bonds generating from hydroxybutyl groups. By the multiple interactions between catechol groups/amino groups and tissues, the biocompatible hydrogels can strongly adhere on the surface of tissue. To further study, the bleeding rat-liver models are made to evaluate the hemostatic effects. After injecting the hydrogel precursor solution into the rat body, the hydrogels are not only formed in situ within 30 s but are also firmly adhered to the bleeding tissues which shows effective hemostasis. The injectability and tissue-adhesion improvement in this study gives a new insight into hemostatic agents, and the multifunctional hydrogels have a great potential in the biomedical application.
研究领域:
生物材料学
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医学工程
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创伤修复
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2018
·Vol. 36
·期 11
·1251-1261
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IF 2.016
Zhang Pei-Bin,Tang An-Qi,Wang Zhang-Hui,Lu Jing-Yu,Zhu Bao-Ku,Zhu Li-Ping
Developing a low-cost and well-recyclable adsorbent with high adsorption capacity is greatly desirable in dye wastewater treatment. Here, we demonstrate a kind of novel tough and reusable hydrogel beads with quite high capacity of dye adsorption via incorporating mussel-bioinspired poly(L-DOPA) (PDOPA) into alginate/poly(acrylamide) double network (DN) hydrogels. The synthesized PDOPA nanoaggregates were introduced into the DN hydrogels by simple one-pot mixing with the monomers prior to polymerization. The fabricated hydrogel beads exhibited high mechanical strength and good elastic recovery due to the interpenetrating Ca 2+ -alginate and poly(acrylamide) networks. It was shown that the beads exhibited relatively high dye adsorption capacity compared to other adsorbents reported in literature, and the introduction of PDOPA with an appropriate amount raised the adsorption capacity. It is believed that the addition of PDOPA and the matrix of double network architecture contributed synergistically to the high adsorption capacity of hydrogel beads. Moreover, the desorption of dyes could be easily realized via rinsing in acidic water and ethanol solution. The hydrogel beads remained the high adsorption capacity even after 5 times of adsorption and desorption cycles. This tough and stable hydrogel with high adsorption capacity may have potential in treatment of dye wastewater released by textile dyeing industry.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qing Li,Congnan Wu,Jiaxing Zhang,Rongxin Su,Yuefei Wang,Wei Qi
The development of enantioselective nanozymes holds profound significance in synthesizing chiral compounds and elevating analytical precision. Herein, we have synthesized chiral gold/iron hierarchically organized particles (Cys@Au/Fe Hops) possessing peroxidase-like catalytic activity, through a one-pot method using cysteine as a chiral inducer. The nanozymes exhibited remarkable enantioselective catalytic activity to 3,4-dihydroxy-phenylalanine (DOPA) enantiomer. Notably, L -Cys@Au/Fe Hops, comprising right-handed helical nanopetals, exhibited elevated catalytic efficiency for L -DOPA over D -DOPA, whereas the reverse held for D -Cys@Au/Fe Hops. The molecular dynamics simulations demonstrated hydrogen bonding interactions between the active site and substrate, thereby revealing how steric effects affected the enantioselective catalysis of chiral DOPA by L/D -Cys@Au/Fe Hops. Moreover, the chiral nanozymes were developed into a test paper sensor due to their exceptional stability, which can achieve the visual detection of DOPA enantiomer combined with a smartphone platform. This work is significant in advancing the design and practical utility of highly selective enzyme mimics.
研究领域:
生物化学
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纳米技术
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）