ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2021
·Vol. 413
·期 16
·4227-4236
·
IF 4.157
Chen Li,Liu Donghao,Zheng Limin,Yi Simin,He Hua
In the present work, a structure-dependent ratiometric fluorescence (RF) sensor constructed with boric acid–modified carbon quantum dots (B-CQDs) and Tb-MOF(MOF-76) was developed for sensing 2,6-pyridinedicarboxylic acid (DPA). Based on the distinct fluorescent responses of B-CQDs and MOF-76 to DPA, MOF-76/B-CQDs can be developed as a RF sensor for DPA detection. In this RF sensor, the reticulated cross-linked structure of MOF-76/B-CQDs can be destroyed by DPA due to a strong coordination effect between DPA and the Tb of MOF-76, resulting in the quenching of the fluorescence of B-CQD and the restoration of the fluorescence of MOF-76 after the addition of DPA. Benefiting from the confinement effect of the special structure change, the presented sensor showed high sensitivity toward DPA with a detection limit of 3.05 μM and excellent selectivity over the monochromatic fluorescence sensor. Graphical abstract
研究领域:
分析化学
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材料科学
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传感器
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yafei Chen,Huiying Mi,Haiyan Li,Jie Wen,Shangqing Zhang,Ronghuan He,Mingli Chen
The smart design of luminescent hydrogen-bonded organic frameworks (HOFs) as multi-functional optical sensors is of great significance for the development of advanced materials. In this context, we designed and synthesized a fluorescence probe (Eu-HOF/DPA) with the characteristics of dual emissions at 452 nm and 616 nm. The histamine introduction increased the system pH, enhancing the energy transfer efficiency from pH-sensitive antenna ligand DPA to Eu 3+ . This resulted in an intensified emission of Eu 3+ at 616 nm while the emission from ligand at 452 nm remained constant, enabling ratiometric fluorescence sensing and visual detection for histamine. Furthermore, a composite membrane was fabricated by embedding the probe onto a flexible substrate, which can be integrated with a smartphone for real-time monitoring the freshness of shrimp and crabs.
研究领域:
材料科学
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分析化学
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发光传感器
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食品安全
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纳米技术
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xin Tong,Zicheng Wang,Lina Zhao,Kai Wang,Yuxin Li
Lanthanide coordination compounds (LnCC), as excellent luminophores, exhibit ultrasensitive responses to the structural details of coordination environments, providing an effective platform for chemical and biomedical detection. Due to the overtones of molecular vibrations in water that cause luminescence quenching, LnCC-based sensors are typically used in heterogeneous systems, where the compounds are dispersed as solid nanoparticles in aqueous solvents. However, this reduces sensor stability, affecting sensitivity and selectivity, and complicates mechanistic analysis. In this work, we developed homogeneous luminescence detection techniques using LnCC and investigated the underlying chemical mechanisms. The Eu-DPA coordination compound was synthesized as a homogeneous detector with good water solubility (140.3 mg/g) and excellent luminescence (92.49% quantum efficiency and >2 ms lifetime at 1 g/L concentration) via multifaceted sonication. Thanks to its homogeneous nature, the sensor achieved high sensitivity, selectivity, and stability for detecting the carcinoid marker 5-hydroxyindoleacetic acid (5-HIAA) in water, plasma, and urine. Eu-DPA exposes numerous pyridine carboxylate oxygen sites that form hydrogen bonds with the amino groups in 5-HIAA. Transient Absorption Spectroscopy (TAS) and Time-Resolved Luminescence Spectroscopy (TRES) further confirm that electrostatic interactions between the hydrogen-bonding sites significantly influence the energy transfer process, as evidenced by changes in luminescence behavior. This work not only addresses the challenge of balancing water solubility and efficient luminescence in lanthanide complexes but also offers new insights into the development of practical biomedical luminescence sensors.
研究领域:
无机化学
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分析化学
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生物无机化学
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传感器
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生物医学检测
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配位化学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2019
·Vol. 29
·期 36
·1904056
·
IF 15.621
Jing Zhu,Chengchao Chu,Dongsheng Li,Xin Pang,Huili Zheng,Junqing Wang,Yesi Shi,Yang Zhang,Yi Cheng,En Ren,Jingliang Cheng,Xiaoyuan Chen,Gang Liu
To address the urgent need for effective sonodynamic therapy (SDT), a facile and efficient strategy is developed for fabricating a new class of sonotheranostics. Herein, a Fe(III)-porphyrin nano-sonosensitizer is prepared by a one-step coordination synthesis, and then anchored with Bis(DPA-Zn)-RGD and manganese superoxide dismutase (SOD2) siRNA. Benefiting from the delicate interactions of the Fe(III)-coordinated nanoformulations, a highly potent sono/gene combinational therapy guided by fluorescence/magnetic resonance imaging is achieved. Importantly, this sonotheranostics significantly enhances the SDT effect of porphyrin through the cancer-targeted delivery capability and enhanced reactive oxygen species production via triple-regulated approaches, including down-regulation of SOD2, depletion of glutathione, and generation of Fenton reaction. This work opens up new perspectives for developing versatile sonotheranostics to overcome the clinical challenges of SDT.
研究领域:
纳米技术
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癌症研究
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诊疗学
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生物医学工程
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分子生物学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Huifang Wu,Yuwei Ling,Shiying Ju,Yubing Chen,Mengqi Xu,Yanfeng Tang
Phosphate (Pi) plays an essential role in aquatic ecosystems as well as in physiological processes. Here, a dual-emission probe for the sensitive, specific and visual analysis of Pi is fabricated by coordinating Eu 3+ with luminol and 2,6-pyridinedicarboxylic acid (DPA). Pi can significantly enhance the characteristic fluorescence of Eu 3+ at 615 nm by promoting energy transfer from DPA to Eu 3+ and reducing the quenching effect of water molecule, luminol with inherent emission at 423 nm further enhances the Eu 3+ fluorescence. Accordingly, ratiometric detection of Pi can be achieved with the fluorescence ratio F 615 /F 423 as a function of Pi concentration. Linearity between F 615 /F 423 and Pi concentration in the range of 0.1–25 μM is shown, and the limit of detection (LOD, 3σ/K) for Pi is 0.027 µM. In addition, a continuous change in the fluorescence color of the probe from blue to red is observed with increasing Pi concentration under a UV lamp, and a smartphone-based visual method is used for the convenient and effective semi-quantitative determination of Pi. The dual-emission probe has been successfully applied to ratiometric and visual analysis of Pi in human urine and environmental water samples, and adequate results are obtained.
研究领域:
分析化学
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环境科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2023
·
IF 6.1
Jiaqi Dang,Min Li,Wenhui Fang,Ying Wu,Shixian Xin,Yutao Cao,Hong Zhao
The abnormal concentration of anthrax spore biomarker 2,6-pyridinedicarboxylic acid (2,6-DPA) will seriously affect public health. Therefore, a sensitive and rapid assay for 2,6-DPA monitoring is of vital importance. In this work, novel nano-sized amorphous Eu-NH 2 BDC (amEu-NH 2 BDC) and amorphous Tb-NH 2 BDC (amTb-NH 2 BDC) metal organic frameworks are prepared by adjusting the ratio of metal and ligand, respectively. Both of them exhibit highly sensitive and selective ratiometric fluorescence detection for 2,6-DPA with wider linear range and lower detection limit in aqueous solutions and human serum. Attributed to the coordination effect of 2,6-DPA in triggering the characteristic fluorescence emissions of Eu 3+ or Tb 3+ by replacing coordinated solvent molecules, as evidenced by ultraviolet–visible spectroscopy, the fluorescence lifetimes analysis, thermal gravimetric analysis , Fourier-transform infrared spectroscopy, density functional theory (DFT) simulations and X-ray photoelectron spectroscopy. In addition, the amEu-NH 2 BDC or amTb-NH 2 BDC loaded paper-based microsensors are constructed for real-time and sensitive detection of 2,6-DPA and coupled with a smartphone-assisted visual portable device.
研究领域:
分析化学
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材料科学
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生物技术
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公共卫生
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Xiaoye Wen,Fang Li,Furong Liu,Zhefeng Fan
As one of the gaseous signaling molecules , aberrant levels of SO 2 are usually associated with many diseases. it is of great significance to develop sensitive methods for detection SO 2 on real. In this paper, a D-π-A near-infrared aggregation-induced fluorescent probe (DPA-CN) was built using diphenylamino-4-benzaldehyde and malononitrile for sensing SO 2 . The DPA-CN exhibit AIE characterization that can quickly recognize SO 2 via the Michael addition mechanism. The DPA-CN displayed emission blue drift from 650 nm to 560 nm after adding SO 2 , thereby realizing rapid and sensitive colorimetric detection of SO 2 . The mechanism for recognition of SO 2 was verified via magnetic resonance imaging (1 H NMR), electrospray ionization mass spectrometry (ESI-MS), scanning electron microscopy (SEM) and dynamic light scattering (DLS). The DPA-CN realized rapid and sensitive recognition of SO 2 with high specificity in 10 s within the concentration range of 0–100 μM. The limit of detection (LOD) is as low as 0.31 μM. Owing to its high sensitivity and low toxicity, the DPA-CN can be applied in monitoring of SO 2 in living cells and food analysis. Furthermore, the DPA-CN was used to prepare a visible and ultrafast semiquantitative paper-based SO 2 sensor with low cost and easy operation.
研究领域:
化学
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分析化学
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生物化学
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材料科学
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食品科学
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细胞生物学
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Huijun Li,Xin Xu,Yonghui Liu,Yanan Hao,Zhouqing Xu
Developing multifunctional luminescent switches for detecting various poisons are urgent given the continuous deterioration of the environment. Herein, a new porous fluorescent metal–organic framework [Tb 2 (TPTC)(DMA) 4 (NO 3 ) 2 ] n (HPU-25) was initially designed. Then, fluorophore molecule tris(2,2′-bipyridine) dichlororuthenium(II) hexahydrate (Ru(bpy) 3 2+ ) was loaded onto HPU-25 by a simple post-synthesis strategy to prepare a new ratio fluorescence sensor Ru(II)@HPU-25 . As a sensor, it can detect 2,6-pyridinedicarboxylic acid (DPA) content in real-time, with high sensitivity and selectivity, without being disturbed by probe concentration and environment. Evident changes in fluorescence color and intensity are observed in distinguishing DPA contents. In addition, after detecting DPA, it can be used for consecutive visual detection of dichromate anion (Cr 2 O 7 2− ) in water. This multifunctional fluorescence sensor could make up for the defects of single fluorescence and single function of the traditional fluorescence sensor by using the dual strategies of ratio sensing and cascade sensing. Interestingly, DPA and Cr 2 O 7 2− in samples can be visually detected rapidly in real-time through the chroma acquisition APP on smartphone. More importantly, we also designed the combination of two logic gate operations for sensing the two targets. In the poison detection in daily life, these intelligent applications of fluorescence sensors have a broad development space.
研究领域:
材料科学
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分析化学
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环境科学
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纳米技术
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传感器技术
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 27
·13078-13096
·
IF 4.682
Xie Ruihang,Yuan Yexin,Sun Pengbo,Liu Zhe,Ma Jinpeng,Yang Guorui,Wang Kui,Li Ming,Shang Lei,Ao Yuhui
The preparation of bio-based epoxy resin with excellent thermal properties and flame retardant properties from green renewable resources had attracted extensive attention in recent years. Starting from the driving structural properties, the purpose of this study is to prepare multifunctional triglycidylester- diphenolic acid- bio-based epoxy (TDBE) with diphenolic acid (DPA), triglycidyl isocyanurate (TGIC), and 9,10-dihydro-9-oxa-10-phosphophenanthrene 10 oxide (DOPO) as raw materials. TDBE/DDM and bisphenol A epoxy resin curing agent (DGEBA/DDM) was prepared with 4,4 '- diaminodiphenylmethane (DDM) as curing agent. TDBE/DDM has excellent fire safety. LOI value rose from 24.5 to 42.0%, and the UL-94 test level passes V-0 level. In the cone calorimeter test, the peak heat release rate (pHRR) is decreased by 69.3%. Besides, the lap shear TDBE adhesive strength was 42.9 MPa, which increased by 62.5%. This new multifunctional bio-based flame retardant epoxy resin provides a broader application prospect for high-performance materials. Graphical Abstract
研究领域:
材料科学
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化学工程
·
可持续化学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Di Huang,Jing Zhu,Meng-Fan Xu,Jie Chen,Xing Gao,Long Zhao,Feng Ding,Cheng-Zhu Wu
Nano-drug carriers responsive to external stimuli have attracted greater scientific attention for the treatment of cancer. In this study, biodegradable DPA-DSDMA-PEG microgels were prepared as a drug delivery system via emulsion polymerization while using Doxorubicin (DOX) as the model drug. In this system, Bis(2-methacryloyloxyethyl) Disulfide (DSDMA) served as redox responsive cross-linker, 2-(Diisopropylamino) ethyl methacrylate (DPA) acted as monomers , and Poly (ethylene glycol) methyl ether methacrylate (PEG) was used as hydrophilic shells. The inclusion of PEG imparts excellent stability and good anti-fouling properties to the prepared microgel. Moreover, the microgels displayed dual pH/redox responsiveness, attributed to the pH sensitivity of DPA and the presence of disulfide bonds of DSDMA. Similarly, MTT assays showed that the DPA-DSDMA-PEG microgels displayed low cytotoxicity, even at concentrations of up to 100 μg/mL. Further, DOX@DPA-DSDMA-PEG inhibited the proliferation of 4T1 cells. In vivo studies showed that DOX@DPA-DSDMA-PEG microgels significantly enhanced the suppression of tumor growth. This work offers a promising strategy to design and develop dual-responsive and biocompatible nanomaterials for the treatment of cancer.
研究领域:
癌症治疗
·
纳米技术
·
药物递送系统
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）