BIOSENSORS & BIOELECTRONICS
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2025
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IF 10.5
Yue Wang,Siyu Qian,Duo Zhao,Shiyu Jiang,Xin Wang,Junao Zhang,Shudong Zhao,Yang Gao,Shengchun Liu
Lipopolysaccharide (LPS), a key component of the outer membrane of Gram-negative bacteria, is the primary trigger of septic shock. The rapid and selective detection of LPS is essential for effective disease prevention and treatment. The conventional prism-based electrochemical surface plasmon resonance (EC-SPR) system is limited by their bulky optical configurations, making it difficult to integrate into portable devices. In this study, we present a compact and implantable electrochemical fiber optic surface plasmon resonance (EC-FO-SPR) sensor to detect LPS. The gold-coated optical fiber serves a dual function as both SPR optical probe and working microelectrode, enabling simultaneous acquisition of optical and electrochemical signals. The sensor ensures high sensitivity by electrochemical detection mode and real-time monitoring molecular adsorption processes by optical SPR mode. The fiber sensing surface is modified with boric acid molecules for highly specific detection of saccharides with cis -diol structures such as glucose and the biomacromolecule LPS, which contains glucose units. The electrochemical signal is collected by detecting changes in the charge distribution of [Fe(CN) 6 ] 4- / 3- near the electrode surface caused by boronate ester formation, and the optical signal is obtained through refractive index changes near the electrode induced by target molecules. The sensor shows a clear linear relationship between LPS concentration and both SPR wavelength shift and electrochemical peak current. The fiber-based design of EC-FO-SPR is easily integrable into compact, flexible platforms, enabling real-time, in situ monitoring of molecular interactions. It provides a reliable and versatile support for clinical and biomedical applications.
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PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2015
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IF 2.495
Xiaoqin Wang,Yong Zhang,Qiangqiang Xu,Jinxin Xu,Bohua Wu,Min Gong,Jia Chu,Shanxin Xiong
A low-cost quasi-solid dye-sensitized solar cell (DSSC) with a photoelectric conversion efficiency of 1.79% was assembled using PVDF-based gel electrolyte plasticized by PC–EC and electrodeposited Pt counter electrodes. Its morphology, chemical structure, electrochemical and photoelectric properties were examined by SEM, FTIR, EIS and I – V tests, respectively. The results showed that PC–EC plasticized gel electrolyte can greatly prevent the α-phase formation of PVDF, and had the loose structure & many interpenetrating holes due to the effective intercalation of PC & EC into PVDF chains through their dipole interaction. It made the migration or diffusion of iodide ions to electrodes easier. Furthermore, its conductivity was increased to 2.34 mS/cm from 1.00 mS/cm of unplasticized gel electrolyte. V oc , J sc , FF & η values of DSSC plasticized by PC–EC were all enhanced. Compared with Pt electrode obtained by thermal decomposition, electrodeposited Pt electrode had the lower charge-transfer resistance and the better contact with gel electrolyte in quasi-solid DSSC due to its orderly grain arrangement, more even, denser and larger active surface. Meanwhile, its process also had little influence on ITO sheet resistance. Thus, its quasi-solid DSSC has the higher photoelectric conversion efficiency.
研究领域:
材料科学
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可再生能源
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电化学
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太阳能电池
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DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2022
·Vol. 40
·期 9
·1101-1109
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IF 3.815
Li Yu-Tong,Sheng Si-Ting,Yu Bo,Jia Fan,Wang Kai,Han Hai-Jie,Jin Qiao,Wang You-Xiang,Ji Jian
Uveitis is a sophisticated syndrome showing a high relevance with reactive oxygen species (ROS). Herein, an ROS-responsive PEGylated polypeptide based macromolecular prodrug of herbaceous antioxidant ethyl caffeate (EC) is designed via phenylboronic esters with improved solubility for the alleviation of uveitis. The antioxidative 4-hydroxybenzyl alcohol (HBA) and EC can be released from the macromolecular EC prodrug under the stimulation of ROS, which can effectively protect cells against oxidative stress-induced injury in an ROS-depletion way. The antioxidative and protective effects of the macromolecular EC prodrug in vivo are further verified in a uveitis mouse model. Overall, this work not only provides a handy method to synthesize a phenylboronic ester-bearing EC prodrug which is highly sensitive to pathological ROS, but also depicts a promising future to apply macromolecular antioxidative prodrugs in the treatment of uveitis as well as other ROS-related diseases.
研究领域:
药学
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眼科学
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生物医学工程
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药物递送系统
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高影响因子
FOOD CONTROL
·
2025
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IF 6.3
Xishun Peng,Zhongchen Bai,Caizhen Zu,Yuxue He,Qi Zhao
The presence of thiram residues on fruit peels posed a significant risk to human health. Here, we prepared an electrochemical surface-enhanced Raman spectroscopy (EC-SERS) sensor of SPE/RGO/Au@Ag flexible film to detect thiram residues on fruit peel. The surface of this film was evenly covered with Au@Ag nanoparticles, which allowed it to specifically identify thiram residues through the formation of Ag-S bond. In addition, an electrochemical method was used to modulate the energy level matching between the SERS film and the thiram molecules to improve the chemical enhancement effect of the SERS. The results indicated that the charge transfer degree between the SERS film and the thiram molecules was up to 0.875. The SPE/RGO/Au@Ag film achieved a limit of detection (LOD) of 2.1 pM at -1.3 V. Owing to its excellent SERS performance, the SPE/RGO/Au@Ag film could successfully recognize the thiram residues on apple and orange peels, with recoveries of 91% to 107% and from 89% to 102%, respectively. The flexible EC-SERS sensor offers considerable promise for sensitively recognizing thiram residues on fruit peels.
研究领域:
分析化学
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食品安全
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传感器与生物传感器
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纳米材料
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环境监测
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DOI
高影响因子
International Journal of Nanomedicine
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2024
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IF 6.6
Kunzhao Huang,Xiaoyuan Yi,Huaying Xie,Jianzhang Luo,Qingyu Zeng,Feifei He,Liyan Wang
Purpose Ferroptosis is a regulated form of cell death characterized by iron-dependent accumulation of associated lipid peroxides (LPO), which can induce cell death when a certain level is reached. However, the extremely complex tumor microenvironment (TME) has the characteristics of antioxidant, even if it induces ferroptosis of tumor cells, its killing effect on tumor cells is still very limited. To solve this problem, we constructed a novel nanomaterials (GOx/EC@Fe3O4@CCM). We evaluated the anticancer effect of this nanomaterial in inhibiting tumor growth through comprehensive in vitro and in vivo experiments.Methods We successfully synthesized GOx/EC@Fe3O4 by one-pan synthesis method, then coated the Hepatocellular carcinoma cell membrane on its surface by co-extrusion technology, and finally synthesized the GOx/EC@Fe3O4@CCM nanoplatforms. We characterized the compounds in terms of morphology, particle size, and Zeta potential. In addition, we also studied the anti-tumor effect of GOx/EC@Fe3O4@CCM nanoplatforms from the following aspects, including the performance test of the nanoplatform, the intracellular effect of the nanoplatform, the anti-tumor effect in vitro, the intracellular ROS analysis, the intracellular effect of EC, and the anti-tumor effect in vivo.Results The iron-based carriers in GOx/EC@Fe3O4@CCM nanoplatforms are released and produce ferrous ions (Fe2+) in an acidic environment. Due to the limitation of the endogenous level of hydrogen peroxide (H2O2), we introduced GOx into the TME or tumor cells. Under the catalysis of GOx, glucose reacted rapidly to produce a large amount of H2O2, which then combined with Fe2+ to produce a large number of Hydroxyl radical (·OH). Its toxicity leads to dysfunction of cell membrane and organelles, and then causes cell damage. EC inhibits Nuclear factor erythroid 2-related factor 2 (Nrf2) in cancer cells, which effectively down-regulates downstream gene products, including NAD(P)H quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HMOX1). A series of chain reactions reduce the escape effect of oxidative stress (OS) and effectively maintain a high level of intracellular oxidation. Furthermore, it induces sustained and intense ferroptosis in tumor cells. Finally, the use of cancer cell membrane modified nanoplatforms due to the homology of membrane protein components improves the tumor cell targeting of the nanoplatforms, showing significant tumor cell inhibition and killing effect in vivo.Conclusion The results showed that the GOx/EC@Fe3O4@CCM nanoplatforms successfully induced significant ferroptosis of Hepatocellular carcinoma cells through a cascade effect, and finally effectively promoted cancer cell regression.
研究领域:
癌症研究
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纳米技术
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生物化学
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药理学
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DOI
PubMed
高影响因子
IONICS
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2025
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IF 2.6
Gu Bonwun,Kang Chankyu
In this study, the flash points and ionic conductivity of three ternary electrolyte solvents (ethylene carbonate (EC); diethyl carbonate (DEC); and dimethyl carbonate (DMC)) were investigated in lithium-ion batteries. The flash points of the solvent mixtures were experimentally measured and compared with predictions using Raoult’s law and multiple regression analysis. These results indicate that EC increases flash point temperature and ionic conductivity owing to its high dielectric constant and boiling point. In contrast, DMC has a lower flash point because of its low boiling point and high reactivity. The coefficient of determination ( R 2 ) and mean absolute error (MAE) suggest that Raoult’s law better predicts overall trends in flash points. Simultaneously, multiple regression analysis provided higher accuracy for specific mixture compositions. Additionally, the ionic conductivities of the ternary electrolyte mixtures were analyzed, demonstrating that DMC maintained high conductivity through polar conformers despite its low dielectric constant. The optimal mixture ratio of EC: DEC: DMC at 7:2:1 achieved a balance with a high flash point (55.5 °C) and high ionic conductivity (9.0 mS cm⁻ 1 ), enhancing battery safety and ionic conductivity. This study highlights the critical role of solvent composition in optimizing lithium-ion battery electrolytes for improved safety and ionic conductivity. Graphical
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Kun Zhao,Zhenhua Song,Zongqiang Gao,Wei Gao,Ming-Jin Liu,Bingni Gu,Junhong Guo,Yu-Lun Chueh
Triboelectric-electromagnetic hybrid nanogenerator (HNG) with high output performance provides a very promising solution for realizing self-powered microelectronic devices. However, the complex structures and large mass of traditional HNGs make them difficult to prepare and carry. In this study, a rotating HNG based on flexible neodymium iron boron/ethyl cellulose (NdFeB/EC) composite films was designed for wind energy scavenging. A lightweight composite film with triboelectric and ferromagnetic properties, which can significantly reduce the weight of the rotor, was prepared to replace the magnet. Operated at a wind speed of 15.5 m/s, the triboelectric nanogenerator (TENG) unit of the optimized HNG with an interdigitated electrode gap of 2 mm can generate an open-circuit voltage (V oc ) and a short-circuit current (I sc ) of 55 V and 5.4 μA, respectively. The maximum power of TENG is 99.2 μW under the condition of an external load resistance of 10 MΩ. The corresponding electromagnetic generator (EMG) unit can produce V oc and I sc of approximately 0.16 V and 59.3 μA, delivering an output power of 2.5 μW at a matched loading resistance of 2.3 kΩ. Compared to the individual TENG or EMG units, the HNG exhibited better charging performance. A 470 μF capacitor can charge to 3.4 V within 600 s, and the stored energy can successfully power a commercial soil temperature–humidity meter to work continuously for 75 s and light 30 blue LEDs in parallel. This research is of great scientific significance for developing triboelectric–ferromagnetic dual-functional materials and designing highly integrated and lightweight HNGs.
研究领域:
材料科学
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能源技术
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纳米技术
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
·
IF 6.2
Bowen Xu,Yuhan Wen,Jia Zheng,Ying Lei,Haixiong Qin,Xinyi Huang,Zhengmin Xie,Dong Zhao,Jiayuan Zhao
Ethyl carbamate (EC) poses a potential public health risk; the reduction efficiency is limited by high ethanol and acidic conditions during fermentation. This study identified fungi as key EC-degrading microbes from Baijiu fermented grains. Aspergillus recifensis. EC-1 isolated from Baijiu fermented grains degraded 50.7% EC (5 g·L–1) in 7 days. Transcriptomics and metabolomics revealed EC hydrolysis via amidase into ammonia and ethanol: ammonia entered arginine biosynthesis, while ethanol fueled central carbon metabolism. TR3859 was identified as degrading enzyme. It remained highly active under 20% ethanol and 15% NaCl conditions (9.1 U·mg–1 and 38.8 U·mg–1), and the enzyme’s affinity for EC was Km = 6.0 mM. When coculture with strain EC-1 and Daqu, EC degradation reached 81.5% within 3 days, and the relative abundance of the genera Thermoascus and Thermomyces exceeds 65%. The objective of this study was to provide an efficient method for EC elimination in fermented foods by microbes and enzymes.
研究领域:
食品微生物学
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应用微生物学
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酶学
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发酵技术
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代谢组学
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转录组学
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食品安全
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 12
·5540-5550
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IF 3.591
Qiang Wei,Gang Zhang,Jie Yao,Xuejun Chen,Gongying Wang,Xiangui Yang
Dimethyl carbonate (DMC) is well known as an extremely industrially valuable substance. The demand for high-efficiency synthesis of DMC has greatly driven the exploration of novel catalysts and their low-cost preparation methods. Herein, a novel method for the rapid batch preparation of CaO/carbon catalysts using calcium citrate (CaCi) was provided, and these catalysts were used to catalyze the transesterification reaction of methanol and ethylene carbonate (EC) to synthesize DMC and ethylene glycol (EG). Accordingly, the structure and properties of the catalysts were characterized using XRD, FTIR, N2 adsorption–desorption, TG, TG-IR, CO2-TPD, XPS, SEM, TEM and ICP-OES techniques. Meanwhile, the effect of various process conditions such as carbonization temperature, reaction temperature, reaction time and catalyst amount has been extensively evaluated. Under the optimal process parameters, the conversion of EC and the selectivity of DMC and EG were 81.2, 99.3 and 99.5%, while the turnover number (TON) and turnover frequency (TOF) were 54.1 and 162 h−1, respectively. Furthermore, kinetic analysis was carried out, and the value of k (reaction rate constant) was ≈0.159 mol L−1 min−1. The reusability was also investigated.
研究领域:
化学工程
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催化材料科学
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DOI
高影响因子
JOURNAL OF POWER SOURCES
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2019
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IF 7.467
Yanbiao Zhao,Yang Bai,Anmin Liu,Weidong Li,Maozhong An,Yongping Bai,Guorong Chen
Solid polymer electrolytes (SPEs) have great potential to solve the safety issue of lithium batteries , nevertheless, the design of SPE with well comprehensive performance has always been a formidable challenge. As we know, in the polymer different groups have different functions, and there are complex interactions between them. Hence, the roles of various functional groups in electrolytes is too complex to be clearly understood, which restricts the structural design of SPE by experience. Herein, theoretical calculations are conducted in designing polymer electrolyte with dual functional groups of ethylene carbonate (EC) and ethyoxyl (EO) group, revealing the interaction between lithium ions and different groups as well as the lithium ions migration mechanism. Designed SPE demonstrates high conductivity of 1.84 × 10 −4 S cm −1 (30 °C), and wide electrochemical window of 4.75 V. Combining with in-situ interface modification technology, the SPE not only prolongs solid-state LiFePO 4 (LFP)/Li battery cycle life to 600 cycles (110 mA h g −1 retained), but also shows potential application in high energy density LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM523) cathode and Si anode batteries. In this work, theoretical calculation is demonstrated to be a high effective method for constructing the functional groups of polymer electrolyte matrix.
研究领域:
材料科学
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电化学
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储能
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理论与计算化学
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高分子科学
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DOI
高影响因子
JOURNAL OF RAMAN SPECTROSCOPY
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2024
·
IF 2.4
Xiujuan Zhang,Yaxin Wang,Yongjun Zhang,Kun Zhang,Ruoning Chu,Fengyi Zhang,Xiaoyu Zhao
Understanding the variation of proton concentration near the surface of the electrochemical interface is of great significance for understanding the mechanism of electrochemical reactions. In this work, 4-Mpy molecules that are protonated and deprotonated depending on the surrounding pH value adsorb on the Au nanoparticle film electrode with high SERS activity, and by virtue of the highly interfacial-sensitive EC-SERS technique, we systematically studied the effects of electrolyte pH value and external voltage on the protonation and deprotonation of 4-Mpy at the interface between Au-NP film electrode and phosphate buffer, to analyze the changes of near-surface proton concentration at the electrochemical interface. It is found that the pH value of the electrolyte plays a decisive role in the protonation process of 4-Mpy at the electrode interface at low reduction voltage (< −0.1 V). In acidic and neutral solution, 4-Mpy exists mainly in protonated form on the electrode surface. However, in alkaline solutions, 4-Mpy exists mainly on the electrode surface in the form of deprotonation. At high reduction voltage (≥ −0.1 V), the protonation and deprotonation of 4-Mpy on the electrode surface are mainly determined by the adsorption structure of 4-Mpy on the electrode surface. At the same time, we conducted a comparative study of 2-Mpy and 4-Mpy molecules and found that the adsorption modes were different depending on the position of the N atom. 2-Mpy is inclined adsorbed on the surface of the Au-NP film electrode, and 4-Mpy is vertically adsorbed on the surface of the Au-NP film electrode.
研究领域:
电化学
·
分析化学
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高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Rauf Muhammad,Wang Jingwen,Iqbal Waheed,Abbas Mazhar,Khan Sayed Ali,Khan Qudrat Ullah,Ren Xiangzhong,Zhang Peixin,Li Yongliang
The exploration of noble metal-free catalysts with efficient electrochemical performance toward oxygen reduction reaction in the acid electrolyte is very important for the development of fuel cells technology. Novel pyrolyzed heteroatom-doped Fe/N/C catalysts have been regarded as the most efficient electrocatalytic materials for ORR due to their tunable electronic structure, and distinctive chemical and physical properties. Herein, nitrogen- and sulfur-doped (Fe/N/C and Fe/N/C-S) electrocatalysts were synthesized using ferric chloride hexahydrate as the Fe precursor, N-rich polymer as N precursor, and Ketjen Black EC-600 (KJ600) as the carbon supports. Among these electrocatalysts, the as prepared S and N-doped Fe/N/C-S reveals the paramount ORR activity with a positive half-wave potential value (E1/2) 0.82 at 0.80 V vs. RHE in 0.1 mol/L H2SO4 solution, which is comparable to the commercial Pt/C (Pt 20 wt%) electrocatalyst. The mass activity of the Fe/N/C-S catalyst can reach 45% (12.7 A g−1 at 0.8 V) and 70% (5.3 A g−1 at 0.95 V) of the Pt/C electrocatalyst in acidic and alkaline solutions. As result, ORR activity of PGM-free electrocatalysts measured by the rotating-ring disk electrode method increases in the following order: Fe/N/C
研究领域:
材料科学
·
电化学
·
能源技术
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）