JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 22
·50515
·
IF 3.125
Xiaojing Zhang,Yuquan Cai,Xianwei Zhang,Tariq Aziz,Hong Fan,Carla Bittencourt
A eugenol-based silicone-containing monomer 4,4′-(1,1,3,3-tetramethyldisiloxane-1,3-dipropyl)bis-2-methoxyphenol(EUSi) was synthesized from eugenol and 1,1,3,3-tetramethyldisiloxane via the hydrosilylation reaction. And waterborne polyurethane (WPU) with excellent properties was obtained by using EUSi as a type of diol chain extender. The unique combination of rigidity and flexibility in the chemical structure of EUSi greatly facilitated the mechanical properties, thermal properties, and water resistance of WPU. With only a 3% dosage of EUSi, the maximum tensile strength was increased from 6.2 to 22.4 MPa, while the water absorption was decreased from 31.3% to a surprisingly 7.6%. Our work provides a new convenient strategy for the preparation of organosilicon-modified WPU with improved performance.
研究领域:
材料科学
·
高分子化学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Clinics
·
2025
·
IF 2.4
Jingwei Liu,Xujie Sun,Junfeng Liang,Shiqiang Song
Introduction Renal Ischemia-Reperfusion Injury (RIRI) often arises due to heightened oxidative stress, rendering it a central focus of research. Sestrin2 plays a pivotal role in regulating oxidative stress; nevertheless, its impact on the renoprotective properties of Eugenol (EU) during RIRI warrants further investigation. Methods Mice and TCMK-1 cells were categorically assigned into six groups: Sham/Control, Ischemia-Reperfusion (IR)/HR (Hypoxia-Reoxygenation), IR/HR+EU, Sham/Control+Sestrin2-KO, IR/HR+Sestrin2-KO, and IR/HR+EU+Sestrin2-KO. The effects of EU and the involvement of Sestrin2 in RIRI/HR were evaluated using Urea Nitrogen (BUN), Creatinine (Scr), Superoxide Dismutase (SOD), Glutathione (GSH), Catalase (CAT), and Malondialdehyde (MDA) assay kits; western blotting; cell viability assays; HE-staining; and Reactive Oxygen Species (ROS) detection. Results Following RIRI/HR, a marked deterioration in kidney function and a significant surge in oxidative stress levels were observed. However, EU treatment ameliorated renal injury and inhibited oxidative stress. Additionally, EU upregulated Sestrin2 expression, and the renoprotective effects of EU were reversed upon Sestrin2 knockdown. Conclusion The present study posits that EU effectively mitigates RIRI/HRI (Hypoxia-Reoxygenation Injury), and its mechanism of renal protection potentially involves the upregulation of Sestrin2, coupled with the inhibition of oxidative and Endoplasmic Reticulum Stress (ERS).
研究领域:
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2011
·Vol. 71
·期 1
·207-213
·
IF 1.22
Wang Ting,Li Bin,Si Hongyan,Lin Li,Chen Li
A solid state eugenol/β-cyclodextrin inclusion complex (EG/β-CD) was prepared by lyophilization method and characterized by Powder X-ray Diffraction (XRD) and Fourier Fransform Infrared Spectroscopy (FTIR). UV–Vis spectrometer was used to determine the EG content encapsulated in the complex. In order to estimate the release characteristics of the EG/β-CD powder, Avrami’s equation and Thermogravimetric (TG) analyzer were, respectively, used. The loss percentage of EG was no more than 10 wt% for 4 week exposing at 25 °C and 75% humidity, and the release of EG is controlled by a combination mechanism of diffusion and first-order mode. TG results not only proved the thermo stability of the EG in EG/β-CD complex, but also clarified the thermal decomposition behaviors of the EG/β-CD. The antibacterial activity of the EG/β-CD complex was investigated using agar cup-plate diffusion method and bacterial strains of Escherichia coli , Salmonella paratyphi B, and Staphyloccocus aureus were used. The results indicated that EG/β-CD had a selective antimicrobial active against Escherichia coli .
研究领域:
药物化学
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Shuai Chen,Xin Wu,Shengguo Tang,Jie Yin,Zehe Song,Xi He,Yulong Yin
The present study investigated the effect of eugenol (EUG) on dextran sulfate sodium (DSS)-induced colitis and explored the underlying mechanisms. C57BL/6 mice were intragastrically administered normal saline or EUG (20 mg/kg body weight) for 17 days, and colitis was induced by using 3% DSS from day 7. The results showed that EUG increased the body weight and reduced the disease activity index score and colon pathological scores in DSS-treated mice (P < 0.05). Further, EUG preserved the proinflammatory cytokines (interleukin (IL)-6, -12, -21, and -23), lowered (P < 0.05) colonic malondialdehyde (MDA), uncoupling protein 2 (UCP2) expression and p65 phosphorylation, and activated (P < 0.05) colonic kelch-like ECH-associated protein 1 and nuclear factor (erythroid-derived 2)-like 2 expressions but did not affect the intestinal microbiota in DSS-treated mice. Furthermore, EUG ameliorated colitis in antibiotic-treated mice, while fecal microbiota transplantation from EUG preadministered mice failed to ameliorate colitis. In conclusion, EUG could alleviate colitis by attenuating colonic inflammation and oxidative stress independent of intestinal microbiota.
研究领域:
药理学
·
免疫学
·
胃肠病学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2023
·
IF 5.6
Xu Liu,Qi Tao,Youming Shen,Xiwang Liu,Yajun Yang,Ning Ma,Jianyong Li
Introduction: Inflammation is a defensive response of the body and the pathological basis of many diseases. However, excessive inflammation and chronic inflammation impair the homeostasis of the organism. Arachidonic acid (AA) has a close relationship with inflammation and is the main mediator of the pro-inflammatory response. Based on the prodrug principle, the new pharmaceutical compound aspirin eugenol ester (AEE) was designed and synthesized. However, the effects of AEE on key enzymes, metabolites and inflammatory signaling pathways in the AA metabolic network have not been reported. Methods: In this study, the anti-inflammation effects of AEE were first investigated in mice and RAW264.7 cells in LPS induced inflammation model. Then, the changes of the key enzymes and AA metabolites were explored by RT-PCR and targeted metabolomics. Moreover, the regulatory effects on NF–kB and MAPKS signaling pathways were explored by Western Blotting. Results: Results indicated that AEE significantly reduced the number of leukocyte and increased the lymphocyte percentage. AEE decreased the expression levels of IL-1β, IL-6, IL-8 and TNF-α both in vivo and in vitro . In the liver of mice, AEE downregulated the levels of AA, prostaglandin D 2 (PGD 2 ) and upregulated 12- hydroxyeicosatetraenoic acid (12-HETE). However, the changes of PGE 2 , PGF 2α , 6-keto-prostaglandin F 1α (6-KETO-PGF 1α ), 9-hydroxy-octadecenoic acid (9- HODE), 13-HODE, 15-HETE, docosahexaenoic acid (DHA) and thromboxane B 2 (TXB 2 ) were not significant. Additionally, it was found that AEE decreased the relative mRNA expression levels of p65 and p38 and the ratio of p-p65/p65. Discussion: It was concluded that AEE might inhibit the LPS-induced inflammatory response through the regulation of AA metabolism. This study provides the theoretical foundation for the development of AEE as a medicinal anti-inflammatory drug.
研究领域:
药理学
·
免疫学
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Ningning Lv,Ming Zhao,Li Hao,Xinhua Zhou,Huayao Chen,Hongjun Zhou
Eugenol (EUG) is a natural compound with antibacterial and insect repellent activity. Its processing, utilization, and storage are limited due to its strong volatility, instability, and low solubility in water. In this study, an amphiphilic polymer-based nano-green coating (CMC-CYST-EUG) based on carboxymethyl cellulose (CMC) has been prepared, EUG was grafted into CMC by thiol-ene click reaction of Cysteamine hydrochloride (CYST) to reduce the volatility of EUG. When exposed to the same environment, the antibacterial duration of CMC-CYST-EUG increased by 7.8 times compared with pure EUG. Liquid holding capacity of CMC-CYST-EUG on pakchoi leaf surface increased by 81% compared with EUG solution. It shows that CMC-CYST-EUG has good adhesion to fruits and vegetables and can prevent the loss of EUG. Strawberry treated with CMC-CYST-EUG can be stored for 7 days. Within the concentration range of 0.5–0.25 mg/mL, the antifeedant rate of CMC-CYST-EUG to pests was significantly higher than that of EUG. Importantly, cytotoxicity tests show that CMC-CYST-EUG is considered safe at low concentrations. This synthetic material provides a strategy for the development and utilization of volatile active substances.
研究领域:
食品科学
·
材料科学
·
生物学
✓ 已验证
DOI
高影响因子
CATALYSIS TODAY
·
2015
·
IF 3.893
Jing Xing,Liang Song,Cong Zhang,Mingdong Zhou,Li Yue,Xuebing Li
Upgrading of lignin derived bio-oil is a very promising way to relieve humankind's dependence on traditional fossil fuels. Eugenol, a model compound for lignin monomers with a methoxyl group and a hydroxyl group, was hydrodeoxygenated in aqueous phase with Pd/C as hydrogenation catalyst and ZSM-5 zeolite as hydrolysis and dehydration catalysts. The bulky lignin monomers had difficulty in accessing the acid sites of the micropores of ZSM-5 zeolite, thus we introduced mesopores via alkaline treatment under various conditions. Alkali-treated ZSM-5 zeolites showed higher conversion and hydrocarbon selectivity compared to the parent ZSM-5 zeolite. When ZSM-5 zeolite was treated at 338 K, the conversion and the hydrocarbon selectivity increased by 21% and 24%, respectively. In addition, much more weak acid sites of ZSM-5 zeolites after alkaline treatment also promoted the hydrolysis and dehydration process.
研究领域:
化学工程
·
能源科学
✓ 已验证
DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2026
·
IF 3.2
Jinhe Gao,Shuangle Xue,Caizhao Liu,Mehdi Derradji,Mianyuan Wu,Yize Wu,Zhigang Yuan,Mingming Sun,Xugang Zhang,Jianhui Li,Bin Zhang
This study reports the synthesis of a eugenol-derived benzoxazine resin (AEM) from 3-ethynylaniline and bio-based eugenol, and its structural characterization using Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance ( 1 HNMR). Subsequently, the AEM resin was copolymerized with bisphenol-type epoxy resin (E51) in varying proportions to form an EP-AEM modified resin system, whose processability, dynamic thermomechanical properties, thermal stability, dielectric properties, mechanical properties, and adhesion performance were investigated. The flexural strength, tensile strength, and elongation at break of EP-2AEM resins were 7.6%, 53.7%, and 41.2% higher than EP resins, respectively. In particular, AEM markedly increases the residual carbon yield ( Y c ) after high-temperature combustion in a nitrogen atmosphere, and this improvement becomes more pronounced as the AEM concentration increases. Compared with neat EP resin (14.92%), EP-4AEM resin exhibits a significantly higher value (21.59%). The high-temperature adhesion strength of EP-2AEM increases by 51.5%. Moreover, EP-4AEM shows the lowest dielectric constant (2.49) and dielectric loss tangent (0.022). Highlights AEM improves the comprehensive performance of epoxy resin.
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2022
·
IF 4.966
Yi Ning,Dian-sen Li,Lei Jiang
This work proposes a facile and solvent-free synthesis of a renewable toughening agent (EGFD) from eugenol , formaldehyde and polyetheramine through the Mannich reaction . EGFD was used to modify bismaleimide (BMI) monomer to synthesize toughened EGFD/BMI resin. Cured EGFD/BMI resin exhibited great toughness evidenced by its tensile elongation at break above 8%. Meanwhile, the cured EGFD/BMI resin showed unique deformation reversibility performance: the compressed resin samples could be quickly restored to its original state when heated at 100 °C for 10 min. In addition, cured EGFD/BMI resin displayed good thermostability with their highest 5% weight loss temperatures (T 5 ) and glass transition temperatures (T g ) of 333 and 122 °C. All the EGFD/BMI resin showed great film uniformity and good dielectric properties : their dielectric constants were from 3.20 to 3.78, and dielectric loss were from 0.0093 to 0.022.
研究领域:
材料科学
·
化学工程
·
高分子科学
✓ 已验证
DOI
高影响因子
Food Chemistry-X
·
2026
·
IF 9.2
Kangqing Yuan,Fangxuan Yi,Jiawei Wang,Xiangyou Wang
The postharvest quality of Agaricus bisporus declines rapidly during refrigerated storage. A controlled-release system (Eugenol@MCM-41) was prepared by loading eugenol into MCM-41, with a loading capacity of 51%. Physicochemical characterization and all-atom molecular dynamics (MD) simulations were combined to clarify the sustained-release mechanism. MD simulations provided supportive evidence for favorable eugenol–silica interfacial interactions and restricted surface-associated mobility in the mesoporous model. In vitro release exhibited clear medium dependence and followed the Weibull model, consistent with diffusion-dominated release under confinement. In storage trials at 4 ± 1 °C, Eugenol@MCM-41 extended acceptable mushroom quality to 15 days. The treatment reduced weight loss, maintained firmness, delayed browning, and lowered malondialdehyde accumulation versus the control and pristine MCM-41. These results connect nanoscale confinement with preservation performance and support Eugenol@MCM-41 as an effective eugenol delivery system for preserving highly perishable foods.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Jidi Liu,Huicong Feng,Yingqi Liu,Tong Zhu,Han Wang,Jing Wang,Fu Zhu,Shuang Gao,Xinru Wang,Rusi Zhang,Xifan Mei,Chao Wu,He Tian
Spinal cord injury (SCI) is a highly disabling trauma, and the inflammatory response plays a critical role in disease progression. The detrimental inflammatory microenvironment exacerbates neuronal apoptosis and suppresses axonal regeneration. Methyl eugenol (ME), the primary active ingredient in the traditional Chinese medicine Asarum, possesses multiple pharmacological activities, including anti-inflammatory and antioxidant. In this study, we developed glutathione-chitosan modified ME liposomes (GCME-LIPO) for the intranasal delivery in SCI treatment. The GCME-LIPO was achieved by encapsulating ME in liposomes, chitosan was electrostatically adsorbed on the surface to enhance mucosal adhesion, and Glutathione was covalently bonded to the amino groups of chitosan. The nanoparticles were well-dispersed, approximately 200 nm in size, and biocompatible. Following intranasal administration, GCME-LIPO showed enhanced accumulation in the injured spinal cord and increased localization around microglia. Both in vitro and in vivo experiments confirmed that GCME-LIPO significantly downregulated the expressions of TNF-α, iNOS and IL-1β and upregulated the levels of IL-4 and Arg-1. In addition, motor function in SCI mice was significantly improved after GCME-LIPO treatment. The underlying mechanism of GCME-LIPO was associated with the inhibition of the JAK2/STAT3 signaling pathway activation. This study provides a strategy for applying ME in SCI treatment, demonstrating considerable application potential.
✓ 已验证
DOI
PubMed
高影响因子
BMC Veterinary Research
·
2015
·Vol. 11
·期 1
·1-7
·
IF 1.777
Karam Isam,Ma Ning,Liu Xi-Wang,Li Shi-Hong,Kong Xiao-Jun,Li Jian-Yong,Yang Ya-Jun
Background Aspirin eugenol ester (AEE) is a promising drug candidate for treatment of inflammation, pain and fever and prevention of cardiovascular diseases with less side effects. The experiment will be conducted to investigate the efficacy of AEE on curing hyperlipidemia in Wistar rats. The rats were fed with high fat diet (HFD) for 8 weeks to induce hyperlipidemia. Results Compared with the model group, the results showed that AEE at 54 mg/kg dosage could significantly decrease the hyperlipidemia indexes including triglyceride (TG), low density lipoprotein (LDL) and total cholesterol (TCH) ( p < 0.01), increase high density lipoprotein (HDL) ( p < 0.05) for five weeks drug administration. Meanwhile, simvastatin had same effect on hyperlipidemia indexes such as TG, LDL, TC, but no significant increase in HDL. Conclusion AEE was effective against hyperlipidemia and had better anti-hyperlipidemic effect than its component, acetylsalicylic acid (Aspirin, ASA), eugenol and integration of ASA and eugenol. Under the experimental circumstance, the optimal dose of AEE to cure hyperlipidemia is 54 mg/kg for five weeks in Wistar rats.
研究领域:
药理学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）