POLYMER TESTING
·
2021
·
IF 4.282
Yanping Huang,Ye Dan,Nianhua Dan,Yining Chen
An inflammatory-responsive intelligent controlled-release drug-loaded membrane (polycaprolactone/poly (hydroxyethyl methacrylate hydroxyethyl-methacrylate -2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol -3-yl) acetoxy) ethyl meth acylate) PCL/P(HEMA-HEIn) was prepared. Drug precursors HEIn was synthesized by the esterification reaction between indomethacin (Indo) and hydroxyethyl methacrylate (HEMA) and the structure of HEIn was confirmed by 13 C NMR and ESI-MS. Through in-situ crosslinking polymerization and solvent evaporation, the drug-loaded membranes were fabricated. Furthermore, the morphology, chemical and physical properties demonstrated that HEIn and HEMA were copolymerized and well dispersed in the film. The drug released from PCL/P(HEME-HEIn) could be triggered by inflammation environment and the release amount increased along with the degree of inflammation. Results of in vivo evaluation proved that the PCL/P(HEME-HEIn) film had the capacity of inhibiting inflammation, which was beneficial to wound healing. The proposed strategy towards PCL/P(HEME-HEIn) opened new window for drug controlled-releasing via inflammatory response.
研究领域:
药学
·
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2013
·
IF 2.206
Jinming Peng,Yanlei Su,Wenjuan Chen,Xueting Zhao,Zhongyi Jiang,Yanan Dong,Yan Zhang,Jiazhen Liu,Xiaochen Fan
In this study, a solvent-free approach to antifouling membranes is tentatively presented. The membrane bulk matrix is formed through bulk polymerization of liquid monomer 2-hydroxyethyl methacrylate (HEMA) in the absence of an organic solvent. The membrane pores are formed via removal of silica particles generated from the sol–gel process of tetraethyl orthosilicate. The membranes have a homogeneous structure and acquire water flux around 1020 L m–2 h–1 at 0.1 MPa. The rates of rejection of the yeast and oil droplet for all the polyHEMA membranes are above 97.0 and 99.0%, respectively. The polyHEMA membranes exhibit strong hydrophilic and excellent fouling resistance properties as a result of hydrophilic HEMA. The flux recovery ratio is as high as 91.0% using protein as a foulant. After the fluorine-containing additive dodecafluoroheptyl methacrylate (DFHM) had been blended in a casting solution, the poly(HEMA/DFHM) membranes possess an amphiphilic surface and exhibit excellent fouling resistance as well as fouling release properties. The flux recovery ratio is >90%, and the total flux decline ratio is as low as 11.7% using an oil/water emulsion as the foulant.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Ya-Lan Yu,Ming-Xin Zhao,Xue-Ru Cao,Tong-Xiao Zhou
Monodisperse macroporous poly(methyl methacrylate- hydroxyethyl methacrylate) (poly(MMA-HEMA)) microspheres have been successfully prepared by microfluidic methods. In our experiment, numerous fine water droplets were at first fabricated by homogeneous emulsification method and were then evenly dispersed inside monodisperse poly(MMA-HEMA) microspheres as porogens by using a combination of the microfluidic emulsification and the free-radical polymerization method. The embedded fine water droplets within the poly(MMA-HEMA) microspheres resulted in highly controllable uniform porous structures. Fourier transform infrared (FT-IR) spectrometer and scanning electron microscopy (SEM) were employed to examine the chemical compositions and microstructures of the microspheres. The effects of porogen quantity on the macroporous structures have been investigated systematically. The macroporous microspheres samples showed superior adsorption performance. With a water-in-oil type emulsion (water-to-oil volume ratio = 40%) used as the porogen, the microporous microspheres adsorbed 3.18 and 2.80 times their own weight of oil in diesel and in ethylene glycol dimethacrylate (EGDMA), respectively, and the adsorption capacity of microspheres remained unchanged by repeating the process five times. The large adsorption capacity for oil and good reusability of the macroporous microspheres make them attractive when applied in the separation of water and oil.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 45
·25313-25318
·
IF 2.936
Lei Peng,Manjun Zhang,Musong Lin,Qiang Fu
The insulating materials used in power cables are susceptible to damage and cracks during installation and operation. To solve this problem, we have prepared a self-healing material PVP/p(HEMA-co-BA), which is synthesized by radical polymerization using HEMA, BA, PVP and a host–guest assembly. The host–guest assembly is constructed through interactions between host and guest molecules (CD–Al2O3 NPs act as the host, and HEMA–Ad acts as the guest). The characterization results of the materials show that there are two kinds of supramolecular interactions, namely, the host–guest interaction and the hydrogen bonding. The material possesses good thermal stability (heat-resisting temperature can reach 200 °C) and good electrical performance. The storage modulus of the material can be increased up to 432 MPa using a cross-linking agent at 20 °C. Furthermore, the material exhibits self-healing property, and it can self-heal several times; its self-healing efficiency is relative to the dosage of the cross-linking agent.
研究领域:
材料科学
·
电气工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 24
·6071-6078
·
IF 5.256
Jiaqi Liu,Yuqi Zhang,Ru Zhou,Loujun Gao
Functional molecule-infiltrated inverse opal photonic crystals can exhibit reversible photonic stopband shifts as a response to the external environment, which enables them to be promising chemical or biochemical sensors. The present study reports on a copolymer, poly(2-hydroxyethyl methacrylate-co-methyl acrylate), infiltrated SiO2 inverse opal as visual sensor for the detection of volatile alcohols vapors. The constructed sensor generates remarkable stopband red-shifts when exposed to an atmosphere of volatile alcohols. Particularly for isopropanol and butanol, a red-shift of more than 85 nm can be obtained and the color of the sensor changes from green to red, which can be observed by the naked eye. This can be attributed to the increased effective refractive index of the inverse opal caused by the diffusion and adsorption of alcohol molecules into the pores. This is based on a combination of a three-dimensional macroporous structure of the inverse opal and strong affinity of the copolymer to alcohols. The exposure to air can reactivate the sensor because of the volatilization and desorption of alcohols. The selectivity, sensitivity and the reusability of the sensor have been investigated by monitoring the reflectance spectra. The results demonstrate that the prepared sensor can be used as a promising candidate as visual sensors for detecting volatile alcohol vapors.
研究领域:
材料科学
·
化学传感
✓ 已验证
DOI
高影响因子
POLYMER INTERNATIONAL
·
2016
·Vol. 65
·期 10
·1150-1156
·
IF 2.414
Lu Shen,Ying Wang,Qiang Zhao,Fubin Luo,Junhua Chen,Mangeng Lu,Liyan Liang,Kun Wu,Jun Shi
The dimethacrylate reactive diluent (HEMA-DDSA), a long-side-chain-containing reactive diluent, was prepared by reacting 2-dodecen-1-ylsuccinic anhydride with two equivalents of hydroxyethyl methacrylate. Its structure was characterized by IR and 1 H NMR spectroscopy. This new diluent was added into the formulation of UV-curable epoxy acrylate networks. Results show that the formulation with the addition of HEMA-DDSA has massively reduced viscosity and shows several attractive properties of epoxy acrylate oligomers. The mechanical resistance of the films is dramatically enhanced with the incorporation of long alkyl groups derived from HEMA-DDSA, the plastic deformation zone expands, thus decreasing the inner stress of the polymer structure. Moreover, the cured coatings have a higher glass transition temperature as the percentage of HEMA-DDSA is increased up to 5 wt%. Due to the excellent integrated performance of the polymeric films, HEMA-DDSA proved to be an effective reactive diluent, which is of potential interest for applications in high performance materials. © 2016 Society of Chemical Industry
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2016
·
IF 0.62
Zheng-Bai Zhao,Hai-Jiao Xie,Yan-Li Li,Yong Jiang
In this article, the multicomponent hydrogel was prepared by the copolymerization of the hydrophobic silicon-containing monomer tris(trimethylsiloxy)-3-methacryloxypropyl-sliane (TRIS) with the hydrophilic monomers 2-hydroxyethyl methacrylate (HEMA) and N-vinyl pyrrolidone (NVP). The ethanol extraction experiments as well as the FTIR, DSC results showed that the copolymerization was effective. The silicone hydrogel that had hydrophilic and hydrophobic phases could be loaded with hydrophilic drug (FITC) and hydrophobic drug (Nile Red) simultaneously. The drug release properties of the hydrogel were studied by taking advantage of its innate stimuli-responsiveness to solvent and pH. The release behaviors of hydrophilic and hydrophobic drugs were found to be solvent dependent. And the release behavior of hydrophilic drug was also pH sensitive. With the characteristics above, the silicone hydrogels can be good candidates for specified materials and may have broad applications in responsiveness, drug release, contact lens, etc.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
npj Materials Degradation
·
2023
·Vol. 7
·期 1
·1-10
·
IF 5.1
Yang Jingzhi,Ran Yami,Huang Luyao,Ren Chenhao,Hao Xiangping,Ma Lingwei,Zhang Dawei
2-hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) (PEG), and zwitterionic polymers are currently considered the most extensively studied antifouling hydrogel coatings. However, systematic identification of these coatings to unleash their potential properties is tremendously under-represented. Here, we report a high-throughput optimizing strategy that combines highly miniaturized hydrogel synthesis and screening to fine design zwitterion-based hydrogel coatings. Compared with the traditional one-by-one synthesis and characterization methods, the proposed high-throughput strategy accelerated the discovery of candidate materials with a high-efficiency and cost-effective approach. To tailor multiple parameters of coatings, 1575 unique coating combinations with continuous gradients were prepared only required 600 μL reactant. The mechanical stability and drug-loading capacity of the coating spots were sequentially evaluated via immersion swelling, flow, tape-peeling, and dye-retaining tests. This strategy could efficiently reveal the composition/structure-function relationships of the hydrogel coatings and also other materials, which is promising for the rapid screening and design of desired implantable device surfaces.
研究领域:
生物材料
·
医学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2014
·
IF 2.613
Runnan Zhang,Jinming Peng,Yanlei Su,Xiaochen Fan,Zhongyi Jiang,Xueting Zhao,Jiazhen Liu,Yafei Li,Jiaojiao Zhao
In this study, a green approach to prepare both porous and dense antifouling membranes was developed through solvent-free bulk polymerization of the casting solution containing 2-hydroxyethyl methacrylate (HEMA) and pre-dispersed silica nanoparticles in two glass sheets under pressure. Porous polyHEMA membranes were prepared via removing the silica nanoparticles embedded in the polymer matrix . Dense poly(HEMA/MAA)/SiO 2 membranes were fabricated by adding methacrylic acid (MAA) as co-monomer without removing the silica nanoparticles . Membrane thickness could be conveniently controlled by varying the distance between the two slide glasses. Field emission scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS) and water contact angle measurement were employed to characterize the morphology and surface chemical composition of the resultant membranes. The porous polyHEMA membranes exhibited high efficiency in purification of bovine serum albumin (BSA) from BSA/yeast solution while the dense poly(HEMA/MAA)/SiO 2 membranes exhibited high rejection of orange GII. Both porous membranes and dense membranes exhibited strong hydrophilicity as a result of hydrophilic monomer HEMA, leading to good antifouling properties.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Fang Wang,Jiajun Wang,Wen Li,Yimao Wu,Jiaqi Liu
Smart hydrogel materials demonstrated promising application prospects in flexible electronic devices, human-machine interaction systems, and soft robotics owing to their exceptional electrical conductivity. However, significant technical challenges remained to be addressed for developing multifunctional hydrogel systems integrating both sensing and actuation capabilities. In this study, polydopamine (PDA) was employed to conduct in-situ reduction of graphene oxide (GO) under alkaline conditions, yielding reduced graphene oxide (rGO) with superior electrical conductivity and high photothermal conversion efficiency. The resulting nanomaterial was subsequently combined with natural polysaccharide starch to fabricate a poly (acrylic acid-2-hydroxyethyl methacrylate)/starch/reduced graphene oxide (P(AA-HEMA)/St/rGO) hydrogel composite. This hydrogel system exhibited not only exceptional mechanical properties (176 kPa tensile stress and 1258 % strain) and durability, but also demonstrated high conductivity (3.64 S/m) and sensitive sensing characteristics (achieving a gauge factor of 5.15 at 1300 % strain). The developed hydrogel sensor accurately detected various physiological signals including fist clenching, pulse vibration, and vocalization. Furthermore, by leveraging its excellent photothermal response properties, a three-dimensional array sensor configuration was established, enabling real-time monitoring of ambient temperature variations. Through ingenious material design and structural optimization, this research successfully developed a multifunctional smart hydrogel, providing a novel material solution for biomedical applications and flexible electronic devices.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Wei Dong,Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N - bis (acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content. It was demonstrated that DOX was efficiently loaded into the hydrogels and released in a controlled fashion via pH-control and swelling-shrinking mechanism. More importantly, DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell, and efficient cell killing was observed. Furthermore, a key point of this study was that the presence of disulfide linkage in system favored the degradation of hydrogels in the reductive environment. These results highlight the potential of Salecan- g -SS-poly(IA- co -HEMA) hydrogel as a novel system for the controlled release of anti-cancer drugs.
研究领域:
药学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2016
·Vol. 8
·期 5
·865-878
·
IF 5.687
Gehong Su,Tao Zhou,Xifei Liu,Yanan Ma
In this study, the micro-dynamics mechanism of the volume phase transition behavior of the poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate) (PNIPAM-co-HEMA) hydrogel was investigated by temperature-dependent FTIR spectroscopy in combination with the perturbation correlation moving window (PCMW2D) technique and generalized two-dimensional correlation analysis. In conventional 1D FTIR spectra analysis, Boltzmann fitting curves showed that the volume phase transition temperature and the phase transition degree of the PNIPAM-co-HEMA hydrogel were lower than those of the pure PNIPAM hydrogel. They also showed that the PHEMA segments exhibit a similar “phase transition” behavior to the PNIPAM segments, which can be ascribed to the driving effect of the phase transition of PNIPAM segments. Furthermore, we found that the rate at which water molecules were expelled out of the gel structure during phase transition changed in an anti-S shape. PCMW2D spectra revealed that the phase transition can be divided into two processes (named I and II) upon heating, and further determined the temperature regions of processes I and II to be 21.8–31.4 °C and 31.4–36.5 °C, respectively. Finally, generalized 2D correlation analysis found that both processes I and II can be further divided into nine steps. From the deduced nine steps of process I, the significant role of PHEMA in the phase transition of PNIPAM segments was revealed. As for the deduced nine steps of process II, the driving effect of the phase transition of PNIPAM segments for PHEMA segments was confirmed.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）