JOURNAL OF DRUG TARGETING
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2025
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IF 3.9
Jinmei Ren,Shuxia Wang,Zhaoli Wu,Chenghao Zhang,Qing Zhang,Xinran Cui,Jiaxin Liu,Jingling Tang
Objective Sildenafil citrate (SC) could promote uterine lining development, leading to successful embryo implantation. Due to the low oral bioavailability of the first-pass elimination of SC, it is necessary to develop a gel for vaginal administration to improve the efficacy.Methods A vaginal gel was prepared using the cold method to increase the retention of SC in the uterus, which allows for prolonged contact between SC and the vaginal mucosa. A poloxamer-based thermosensitive in situ gel containing SC (SC-Tsgel) and an HPMC-based standard gel containing SC (SC-Cogel) were prepared. The rheological properties, in vitro drug release, and in vivo retention in the uterus of SC-Tsgel and SC-Cogel were compared.Results The gel formulations significantly prolonged the time it took for drugs to be released following a release study. SC-Tsgel and SC-Cogel administered vaginally increased the duration of drug administration compared to SC solutions injected through the tail vein. Nevertheless, compared with tail vein injection of SC solutions or vaginal administration of the SC-Cogel, the retention of SC in the uterus was increased significantly after vaginal administration of the SC-Tsgel.Conclusions Novel formulations of SC prepared with poloxamer 407 show promise as vaginal medication preparations for the management of a thin endometrium.
研究领域:
药剂学
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药物递送
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妇科学
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生物利用度
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2020
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IF 4.006
Feilong Wei,Jianyin Miao,Huiyou Tan,Runqing Feng,Qianwang Zheng,Yong Cao,Yaqi Lan
In this study, the influence of crystal morphology and cooling temperature on the oxidative stability of oleogel-structured perilla oil emulsion was explored. The formation and distribution of the internal crystals were confirmed by differential scanning calorimetry and polarized light microscopy. All beeswax (BW) crystals existed in the internal phase while stearic acid (SA) crystals appeared in the aqueous phase as well. As the crystal grew, the HPMC/SDS emulsified layers were pierced, leading to release of the SA crystals into the aqueous phase with partial droplet flocculation. As a result, the physical and oxidative stability of the BW-structured emulsion was significantly better than that of SA-structured emulsion. The crystallinity of the emulsion increased with higher gelator concentration. The denser crystal network were more effective preventing the penetration of pro-oxidants into the internal phase, resulting in the stronger the oxidation stability. Processing methods with different cooling temperature affected more of the properties of bulk oleogels rather than the oleogel-structured emulsion for long-term storage. Overall, choosing a gelling agent that forms relatively small crystals and preparing an oleogel-structured emulsion with appropriate crystallinity can effectively improve the oxidative stability of structured emulsion with longer shelf life.
研究领域:
食品科学
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化学工程
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材料科学
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产品关联
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 19
·6962
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IF 4.6
Yanxiong Gan,Yaxin Xu,Xue Zhang,Huiling Hu,Wenke Xiao,Zheng Yu,Tao Sun,Jinming Zhang,Chuanbiao Wen,Shichao Zheng
As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs (BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the gastrointestinal tract, leading to less qualified in vitro–in vivo correlation (IVIVC). This study aims to develop a physiologically based multi-cup dissolution approach to improve the evaluation of the supersaturation for a higher quality of IVIVC and preliminarily explores the molecular mechanism of supersaturation and precipitation of ketoconazole affected by Polyvinylpyrrolidone–vinyl acetate copolymer (PVPVA) and hydroxypropyl methyl-cellulose (HPMC). The concentration of ketoconazole in each cup of the dynamic gastrointestinal model (DGIM) was measured using fiber optical probes. Molecular interactions between ketoconazole and PVPVA or HPMC were simulated by Materials Studio. The results demonstrated that PVPVA and HPMC improved and maintained the supersaturation of ketoconazole. PVPVA exhibited superior precipitation inhibitory effect on ketoconazole molecule aggregation due to slightly stronger van der Waals forces as well as unique electrostatic forces, thereby further enhancing in vitro drug absorption, which correlated well with in vivo drug absorption. Compared with a conventional dissolution apparatus paddle method, the DGIM improved the mean prediction error through the IVIVC from 19.30% to 9.96%, reaching the qualification criteria. In conclusion, the physiologically based multi-cup dissolution approach enables improved evaluation of supersaturation in gastrointestinal transportation of BCS IIB drug ketoconazole, enabling screening screen precipitation inhibitors and achieving qualified IVIVC for drug formulation studies.Keywords:supersaturation;precipitation inhibitor;dissolution model;molecular dynamics;in vitro–in vivo correlation
研究领域:
药剂学
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药物递送系统
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分子模拟
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生物药剂学
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产品关联
DOI
PubMed
高影响因子
Antioxidants
·
2023
·Vol. 12
·期 3
·552
·
IF 7
Abid Naeem,Chengqun Yu,Zhenzhong Zang,Weifeng Zhu,Xuezhen Deng,Yongmei Guan
Oxidants play a significant role in causing oxidative stress in the body, which contributes to the development of diseases. Rutin—a powerful antioxidant—may be useful in the prevention and treatment of various diseases by scavenging oxidants and reducing oxidative stress. However, low solubility and oral bioavailability have restricted its use. Due to the hydrophobic nature of rutin, it cannot be easily loaded inside hydrogels. Therefore, first rutin inclusion complexes (RIC) with hydroxypropyl-β-cyclodextrin (HP-βCD) were prepared to improve its solubility, followed by incorporation into xanthan gum-based (hydroxypropyl methylcellulose-grafted-2-acrylamido -2-methyl-1-propane sulfonic acid) hydrogels for controlled drug release in order to improve the bioavailability. Rutin inclusion complexes and hydrogels were validated by FTIR, XRD, SEM, TGA, and DSC. The highest swelling ratio and drug release occurred at pH 1.2 (28% swelling ratio and 70% drug release) versus pH 7.4 (22% swelling ratio, 65% drug release) after 48 h. Hydrogels showed high porosity (94%) and biodegradation (9% in 1 week in phosphate buffer saline). Moreover, in vitro antioxidative and antibacterial studies (Staphylococcus aureus,Pseudomonas aeruginosa, andEscherichia coli) confirmed the antioxidative and antibacterial potential of the developed hydrogels.Keywords:hydrogels;flavonoids;anti-oxidants;inclusion complexes;oral formulations
研究领域:
药剂学
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生物材料
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药物化学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Yunjie Ju,Wu Wei,Ying Wang,Zefang Xiao,Yonggui Wang,Kai Zhang,Yanjun Xie
The growing demand for green, low-carbon, and sustainable development has driven the advancement of window materials that integrate adaptive light modulation with energy conservation for residential and industrial buildings. This paper presented a systematic strategy using a phase change emulsion gel to construct smart windows capable of thermal energy storage and release. Based on the thermoresponsive behavior of hydroxypropyl methylcellulose (HPMC) as the matrix, combined with the solid–liquid phase change of the oil phase and a refractive index matching mechanism between the water and oil phase, the smart glass achieved bidirectional coordinated tunability in transmittance, haze, and thermal management with a high enthalpy of 96.56 J g −1 . Within the operating temperature range from 24°C to 40°C, the total transmittance remained consistently above 85 %, while the haze can be continuously adjusted from 3.98 % to 78.98 % in response to ambient temperature. Prototype validation in residential/office buildings and agricultural facilities demonstrated broad adaptability and scalability, indicating strong potential to support the green and sustainable transformation of the construction sector.
研究领域:
材料科学
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智能建筑技术
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节能材料
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可持续建筑
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热管理
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产品关联
DOI
高影响因子
FLUID PHASE EQUILIBRIA
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2023
·
IF 2.6
Long Cheng,Weikang Fan,Yuanhui Ji
In this work, the density and viscosity of five commonly used polymer aqueous solutions with a concentration range of 1–35 wt%, including polyvinylpyrrolidone (PVP) K25, PVP K30, PVP K90, polyethylene glycol (PEG) 6000 and hydroxypropyl methyl cellulose (HPMC), were determined at 293.15–313.15 K. The viscosity data were modeled by Simplified-Eyring-NRTL, Eyring-PC-SAFT and Simplified-Eyring-PC-SAFT models. Based on the correlation between the viscosity and the surface area fraction of solute and solvent, the Theta-Eyring-PC-SAFT model was proposed. The model had the best fitting effect on the viscosity data of PEG, PVP K25, PVP K30, PVP K90 and HPMC, and the correlation coefficients R 2 were 0.9998, 0.9988, 0.9995, 0.9999 and 0.9999, respectively. In addition, the viscosity data of other systems in the literatures were also fitted, and the R 2 values were all greater than 0.9900, which proved that the Theta-Eyring-PC-SAFT model was universal.
研究领域:
化学工程
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高分子科学
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热力学
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产品关联
DOI
高影响因子
Food and Bioprocess Technology
·
2025
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IF 5.8
Liu Chang,Luo Linjie,Lu Xueying,Li Xu,Liu Zhiming
This study presents the development of a novel multifunctional smart packaging film designed to enhance food freshness and possess ammonia-sensing capabilities. The film was fabricated using hydroxypropyl methylcellulose (HPMC) and zinc alginate (ZA), incorporating dragon fruit peel anthocyanins (DE) as pH-sensitive dyes. A hydrophobic layer composed of stearic acid and nano-silica (0.2 g SiO 2 in 1.5 mL solution) was uniformly spin-coated onto the HPMC/ZA/DE film surface and further modified via chemical vapor treatment to improve water resistance. The resulting HPMC/ZA/DE/SiO 2 film demonstrated excellent physical properties, including a high-water contact angle of 116.9°, indicating strong hydrophobicity and effective UV shielding. The film exhibited significant antibacterial activity, achieving 99.99% inhibition rates against Escherichia coli and Staphylococcus aureus . Mechanical tests showed better tensile strength (33.3 MPa) and reduced water vapor permeability (0.33 × 10⁻ 11 g/m·s·Pa) compared to the unmodified control film. In practical application, pork samples wrapped with the smart film were stored at 4 °C for 6 days. A distinct color change from purple to green was observed by day 6, corresponding to elevated pH and TVB-N levels, indicating spoilage. Specifically, on day 9, the packaged pork exhibited a TVB-N value of 49.57 mg/100 g, while the control group reached 51.4 mg/100 g, confirming the film’s spoilage-inhibiting effect. This work offers a promising strategy for developing intelligent active packaging and demonstrates potential for preserving a wide range of perishable foods beyond pork.
研究领域:
食品科学与技术
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智能包装
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纳米材料
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活性包装
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食品保鲜
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传感器与生物传感器
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）