JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Qi Chen,Xingxing Huang,Cheng Liu,Yueling Chen,Jionghua Wu,Jimmy C. Yu,Ling Wu
The attainment of rapid charge mobility and effective N 2 activation is of critical importance for photocatalytic nitrogen fixation but it has always been a challenge. Such challenge may be met by the construction of a Type II MoS 2 nanoparticles/ MIL-100(Fe) heterojunction photocatalyst. The new material possesses charge migration channels that facilitate the separation of photogenerated carriers. This charge redistribution during photocatalysis is confirmed by experimental results showing a decrease of charge density on the Fe species and an increase of that on Mo. Moreover, DFT calculations show that the adsorption of N 2 and H 2 O is more likely to occur on Fe sites and Mo sites, respectively. These findings clearly suggest a drastically improved spatial isolation of reduction and oxidation sites on the photocatalyst as compared to pristine MIL-100(Fe). The optimized MoS 2 /MIL-100(Fe) exhibits a NH 4 + yield rate of 1.29 μmol·h −1 as excellent utilization of photoinduced electron-hole pairs and effective adsorption and activation of N 2 become possible. This work offers an insight on the synergy of heterojunction engineering with coordinated activation for photocatalytic ammonia synthesis.
研究领域:
材料科学
·
催化
·
纳米技术
·
化学工程
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理论化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xingping Fu,Qianqian Chen,Ye Zhang,Feng Yu,Junjie Pan,Xiaobing Yang
The overuse of antibiotics, coupled with inadequate wastewater treatment, has led to widespread environmental contamination, posing significant risks to ecosystems and public health. In this study, a novel BiOCl/Bi 2 MoO 6 /MIL-125(Ti) heterojunction catalyst featuring a Z -scheme and II-type dual-functional junctions was prepared via a two-step solvothermal method and employed for the degradation of tetracycline (TC). The synthesized samples were thoroughly characterized by XRD, SEM, BET, TEM, and UV–vis spectroscopy. The results indicate that the incorporation of BiOCl and Bi 2 MoO 6 effectively tunes the band structure of MIL-125(Ti), enhancing its visible-light absorption. Moreover, the formation of the heterojunction interfaces significantly suppresses recombination of photogenerated charge carriers, thereby improving photocatalytic performance. Under visible-light irradiation, the BiOCl/Bi 2 MoO 6 /MIL-125(Ti) catalyst generates reactive radicals (·OH and ·O₂ − ), enabling efficient degradation of TC with a removal efficiency of 95.71 %. The synergistic effect of the Z -scheme and II-type heterojunctions plays a crucial role in the efficient photocatalytic degradation of TC. This study provides new insights into the degradation mechanisms of bifunctional heterojunctions and presents a promising strategy for designing high-performance photocatalysts for tetracycline degradation.
研究领域:
环境科学
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材料化学
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光催化
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环境污染治理
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纳米材料
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药物降解
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半导体异质结
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产品关联
DOI
高影响因子
COPD-Journal of Chronic Obstructive Pulmonary Disease
·
2023
·
IF 2.2
Chuanxin Yang,Libing Deng,Fang Bao,Hui Jiang,Long Zhang
Chronic obstructive pulmonary disease (COPD) is a difficult-to-cure disease that mainly affects the respiratory system. Inhaled anesthetic drug such as sevoflurane plays a controversial role in COPD by different concentration, but the underlying epigenetic mechanism remains unclear. Here, we prepared lipopolysaccharide (LPS)-induced COPD rat model, and isolated Alveolar type II (ATII) cells. We mainly focused DNA methylation on the promoter of COPD-related genes including Sftpa1, Napsa, Ca2, Sfta2, Lamp3, Wif1, Pgc, and Etv5. We observed COPD rat treated by sevoflurane with low (0.5%) and high (2%) concentrations displayed an opposite DNA methylation pattern. These six genes' promoter were all hypomethylated by 0.5% sevoflurane whereas hypermethylated by 2% sevoflurane, accompanied with the opposite transcriptional activity. We further verified that the DNMT1 binding ability contributed to DNA methylation these six genes' promoter. Moreover, we also captured DNMT1 and identified REC8 meiotic recombination protein (REC8) as the specific binding protein only existed in ATII cells treated with 0.5% sevoflurane rather than 2% and control. The binding ability of REC8 on these target genes' promoter showed highly positive correlation with DNMT1. In summary, we uncovered a potential epigenetic role of sevoflurane with low concentration in ATII cells of COPD that may help us deeply understand the pathogenesis and treatment mechanism of inhaled anesthesia drugs in COPD via a dose-dependent manner.
研究领域:
肺病学
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分子生物学
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表观遗传学
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药理学
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DOI
高影响因子
JOURNAL OF PHARMACOLOGICAL SCIENCES
·
2024
·
IF 3
Zhihang Zhang,Yalan Luo,Xijing Zhuang,Haifeng Gao,Qi Yang,Hailong Chen
Acute lung injury (ALI) is closely related to high mortality in severe acute pancreatitis (SAP). This study unveils the therapeutic effect and mechanism of miR-217-5p on SAP-associated ALI. The miR-217-5p RNA expression was significantly up-regulated in lipopolysaccharide (LPS)-stimulated primary rat alveolar epithelial type II cells (AEC II) and sodium taurocholate-treated pancreas and lung in SAP rats. miR-217 inhibition protected AEC II from LPS-induced damage by inhibiting apoptosis and reducing the TNF-α, IL-6, and ROS levels. miR-217 inhibition suppressed apoptosis and alleviated mitochondrial damage through mitochondria-mediated apoptotic pathway in vitro . Sirt1 is a direct target of miR-217-5p. Dual-luciferase reporter assay confirmed the binding of miR-217-5p to Sirt1 mRNA 3′-UTR. The rescue experiment identified that the anti-apoptotic, anti-inflammatory, and anti-oxidative effects of miR-217 inhibition were mediated by Sirt1 in vitro . Emodin (EMO) protected AEC II from LPS-induced damage and alleviated pancreatic and lung tissue injuries. EMO exerted similar effects as miR-217 inhibition in vitro and in vivo . The effects of EMO were abolished by miR-217 overexpression. In conclusion, miR-217-5p inhibition exerts protective effects on SAP-ALI in vitro and in vivo by repressing apoptosis, inflammation, and oxidative stress through Sirt1 activation. EMO protects against lung injuries in SAP-associated ALI rats through miR-217-5p/Sirt1 axis.
研究领域:
药理学
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分子生物学
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病理生理学
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内科学
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产品关联
DOI
PubMed
高影响因子
Advanced Energy Materials
·
2021
·Vol. 11
·期 18
·2100292
·
IF 29.368
Xiayan Chen,Yongkang Xia,Qingyi Huang,Zhe Li,Anyi Mei,Yue Hu,Ti Wang,Rongrong Cheacharoen,Yaoguang Rong,Hongwei Han
Printable hole-conductor-free perovskite solar cells (PSCs) have attracted intensive research attention due to their high stability and simple manufacturing process. However, the cells have suffered severe potential loss in the absence of the hole transporting layer. The dimensionality of the perovskite absorber in the mesoporous carbon electrodes by conducting post-treatments is reduced. The low-dimensional perovskites possess wide-bandgaps and form type-II band alignment, favoring directional charge transportation and thus enhancing the device performance. For the cells using MAPbI 3 (MA = methylammonium) as the light absorber, the open-circuit voltage ( V OC ) is significantly enhanced from 0.92 to 0.98 V after posttreatment, delivering an overall efficiency of 16.24%. For the cells based on FAPbI 3 (FA = formamadinium), a high efficiency of 17.47% is achieved with V OC of 1.02 V, which are both the highest reported values for printable hole-conductor-free PSCs. This strategy provides a facile method for tuning the energy level alignment for mesoscopic perovskite-based optoelectronics.
研究领域:
材料科学
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光伏技术
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纳米结构材料
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能源化学
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半导体物理
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表面与界面工程
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功能材料
✓ 已验证
DOI
高影响因子
Nature Physics
·
2016
·Vol. 12
·期 12
·1105-1110
·
IF 18.791
Deng Ke,Wan Guoliang,Deng Peng,Zhang Kenan,Ding Shijie,Wang Eryin,Yan Mingzhe,Huang Huaqing,Zhang Hongyun,Xu Zhilin,Denlinger Jonathan,Fedorov Alexei,Yang Haitao,Duan Wenhui,Yao Hong,Wu Yang,Fan Shoushan,Zhang Haijun,Chen Xi,Zhou Shuyun
Weyl semimetal is a new quantum state of matter1,2,3,4,5,6,7,8,9,10,11,12 hosting the condensed matter physics counterpart of the relativistic Weyl fermions13 originally introduced in high-energy physics. The Weyl semimetal phase realized in the TaAs class of materials features multiple Fermi arcs arising from topological surface states10,11,14,15,16 and exhibits novel quantum phenomena, such as a chiral anomaly-induced negative magnetoresistance17,18,19 and possibly emergent supersymmetry20. Recently it was proposed theoretically that a new type (type-II) of Weyl fermion21,22 that arises due to the breaking of Lorentz invariance, which does not have a counterpart in high-energy physics, can emerge as topologically protected touching between electron and hole pockets. Here, we report direct experimental evidence of topological Fermi arcs in the predicted type-II Weyl semimetal MoTe2 (refs 23,24,25). The topological surface states are confirmed by directly observing the surface states using bulk- and surface-sensitive angle-resolved photoemission spectroscopy, and the quasi-particle interference pattern between the putative topological Fermi arcs in scanning tunnelling microscopy. By establishing MoTe2 as an experimental realization of a type-II Weyl semimetal, our work opens up opportunities for probing the physical properties of this exciting new state.
研究领域:
凝聚态物理学
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量子材料
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拓扑材料
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表面科学
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Jiali Wu,Yaokun Pang,Dan Liu,Jianxia Sun,Weibin Bai
Aloe-emodin (AE) is a natural compound with photodynamic properties. The aim of this study was to investigate the inhibitory effect of AE-mediated photodynamic inactivation (PDI) on Staphylococcus aureus ( S. aureus ). The bacteriostatic efficiency under different photodynamic conditions and photosensitizing mechanism was studied in detail. The results showed that AE-mediated PDI exhibited a typical concentration and time-dependent characteristics. In terms of bactericidal mechanism, disruption of membrane integrity and increase of cell membrane permeability was observed. Type II reaction was assumed as the main photochemical reaction involved in AE-mediated PDI as evidenced by the action of different ROS quenching agents. Furthermore, AE-mediated PDI decreased the bacterial survival in freshly squeezed apple juice and maintained its quality. The combination of blue light and AE enlarged the application of AE as an effective natural photosensitizer suitable for a food system.
研究领域:
微生物学
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食品科学
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药学
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Jiahao Ni,Lichao Yu,Yixuan Wang,Tong Yang,Yueqi Bai,Bowen Zheng,Manshan Liang,Xiaoxia Ye,Yun-Yun Quan,Feifei Lin,Zu-Sheng Huang
Background Photodynamic therapy (PDT) is a pioneering and effective anticancer modality with low adverse effects and high selectivity. Hypochlorous acid or hypochlorite (HClO/ClO − ) is a type of inflammatory cytokine. The abnormal increase of ClO − in tumor cells is related to tumor pathogenesis and may be a “friend” for the design and synthesis of responsive phototherapy agents. However, preparing responsive phototherapy agents for all-in-one noninvasive diagnosis and simultaneous in situ therapy in a complex tumor environment is highly desirable but still remains an enormously demanding task. Results An acceptor-π bridge-donor-π bridge-acceptor (A-π-D-π-A) type photosensitizer TPTPy was designed and synthesized based on the phenothiazine structure which was used as the donor moiety as well as a ClO − responsive group. TPTPy was a multifunctional mitochondria targeted aggregation-induced emission (AIE) photosensitizer which could quickly and sensitively respond to ClO − with fluorescence “turn on” performance (19-fold fluorescence enhancement) and enhanced type I reactive oxygen species (ROS) generation to effectively ablate hypoxic tumor cells. The detection limit of TPTPy to ClO − was calculated to be 185.38 nM. The well-tailored TPTPy anchoring to mitochondria and producing ROS in situ could disrupt mitochondria and promote cell apoptosis. TPTPy was able to image inflammatory cells and tumor cells through ClO − response. In vivo results revealed that TPTPy was successfully utilized for PDT in tumor bearing nude mice and exhibited excellent biological safety for major organs. Significance and novelty A win-win integration strategy was proposed to design a tumor intracellular ClO − responsive photosensitizer TPTPy capable of both type I and type II ROS production to achieve photodynamic therapy of tumor. This work sheds light on the win-win integration design by taking full advantage of the characteristics of tumor microenvironment to build up responsive photosensitizer for in situ PDT of tumor.
研究领域:
癌症研究
·
药学
·
生物医学工程
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化学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yubo Zhou,Xinbo Zhao,Zan Li,Junchao Yin,Liangmin Yu
To address ion interference in photocatalytic antibiotic degradation within high-salt seawater, this study innovatively designed and synthesized a titanium-based metal–organic framework (MOF) heterojunction composite. Specifically, a solvothermal technique was used to create MIL-125(HAC)/TiO 2 (TAC) photocatalysts using commercial TiO 2 (P25) and MIL-125(Ti) that had been treated with acetic acid. Remarkably, under 60 min of visible-light irradiation, the optimized TAC-2 sample achieved 95.7 % tetracycline (TC) degradation in seawater (compared to 98.1 % in deionized water) and retained >85 % efficiency after four cycles. Critically, its degradation rate constant (k=0.0355 min −1 ) in seawater was 44.4 times higher than that of P25, demonstrating exceptional resistance to salt-ion interference and photocatalytic activity. Mechanistic studies revealed that the performance enhancement arises from three synergistic mechanisms: (1) A mesoporous structure mitigating ion interference and strengthening TC-selective adsorption; (2) A Type-II heterojunction enabling efficient charge separation; (3) •O 2 − and h + identified as dominant active species (confirmed by EPR and quenching tests). Collectively, this work establishes an effective MOF heterojunction engineering strategy for efficient antibiotic removal in saline environments, ultimately contributing to marine pollution remediation.
研究领域:
环境科学
·
材料科学
·
化学工程
·
光催化
·
海洋污染
✓ 已验证
产品关联
DOI
高影响因子
FlatChem
·
2024
·
IF 5.9
Dan Li,Mengyao Zhang,Yudai Huang,Xin Hu,Junqing Hu
This research explores the efficacy of photodynamic therapy (PDT) and photothermal therapy (PTT) in combating chemotherapy-resistant diseases. This study focuses on enhancing tumor treatment effectiveness by leveraging the synergetic effects of combining PDT and PTT through the development of Fe-nitrogen-carbon (FeNC) nanoparticles with superior photostability. These nanoparticles, functioning as photosensitizers for the combined PDT/PTT treatment, can generate both type I and type II ROS and heat upon 808 nm irradiation. Notably, the FeNC nanoparticles demonstrate an exceptional photothermal conversion efficiency (34 %), surpassing commonly used PTT photosensitizers. In vitro and in vivo experiments corroborate the efficiency of FeNC as a photosensitizer in achieving significant tumor inhibition. In conclusion, the FeNC nanoparticles present promising applicability in the synergistic PTT/PDT treatment of tumors.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Yaoli Guo,Qi Ye,Shuling Yang,Jinzhong Wu,Bingzhu Ye,Yanbin Wu,Zehao Huang,Chengjian Zheng
Anoectochilus roxburghii , a famous Chinese herbal medicine, has been commonly used for the treatment of liver disease, diabetes, and rheumatoid arthritis. Our study aimed to investigate the anti-rheumatoid arthritis effects of A . roxburghii polysaccharides (ARP), using the rat's model of type II collagen-induced arthritis (CIA). ARP was prepared by alcohol sedimentation and structurally characterized based on combined chemical, chromatographic and spectroscopic methods. High Performance Size Exclusion Chromatography-Multiangle Laser Light Scattering-Refrative Index (HPSEC–MALLS–RI) analysis revealed that ARP includes two peaks, and the weight-average molecular weight ( Mw ) of the principal one was estimated as 5.90 kDa with a relative content of 98.2%. Pharmacological results exhibited that ARP significantly decreased the arthritis index and ameliorated the inflammatory cell infiltration and the synovial tissue destruction in CIA rats. Additionally, ARP possessed significant NO production inhibitory effects and antioxidant activity. Further anti-inflammatory mechanism investigations indicated that ARP significantly inhibited the activation of nuclear factor κB (NF-κB) pathway by suppressing the phosphorylation of IκB and p65, which subsequently down-regulated the mRNA expressions of IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. These findings suggested that ARP has great potential in the development of functional foods and dietary supplements for the treatment of rheumatoid arthritis.
研究领域:
药理学
·
免疫学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2025
·
IF 5.7
Juan Liu,Yingnan Qin,Meiqi Wang,Hengjun Liu,Tao Zheng,Jing Tian,Jing Wang
BiVO 4 -based materials have attracted extensive research as advanced photoanode for photogenerated cathodic protection. However, the performance of BiVO 4 -based photoanodes is greatly hindered by its weak charge migration and positive conduction band potential. Herein, poly-2,6-diaminoanthraquinone (PDAAQ)/Bi was grafted on BiVO 4 to improve the separation efficiency of photogenerated carriers and enhance the reducing ability of photogenerated electrons. Studies show that a type II heterojunction can be formed between PDAAQ and BiVO 4 , which accelerates the separation of photogenerated carriers at the interface. In addition, the Bi monomers anchored on BiVO 4 /PDAAQ then expand the light absorption range through the surface plasmon resonance effect. Consequently, the obtained BiVO 4 /PDAAQ/Bi photoanode exhibits a promising photocurrent density of 40 μA·cm -2 , while the photoinduced potential drop is 540 mV, which is approximately 1.4 times of BiVO 4 materials. These outcomes provide general ideas for the design of organic-inorganic heterozygous systems for achieving eco-friendly corrosion protection.
研究领域:
材料科学
·
光电化学
·
腐蚀防护
·
半导体异质结
·
纳米复合材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）