JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
·
2022
·Vol. 149
·期 2
·683-699
·
IF 4.322
Shen Chongxing,Yue Xiaofeng,Dai Linyong,Wang Jianwu,Li Jinjin,Fang Qiang,Zhi Yi,Shi Chunmeng,Li Weibing
Background Bladder cancer has a high rate of recurrence and drug resistance due to the lack of effective therapies. IR-780 iodide, a near-infrared (NIR) mitochondria-targeting fluorescent agent, has been demonstrated to achieve higher selectivity than other drugs in different tumor types and exhibited tumor-killing effects in some cancers. However, this therapeutic strategy is rarely studied in bladder cancer. Material and methods The accumulation of IR-780 in bladder cancer was measured by NIR imaging. Human bladder cell lines (T24, 5637, and TCCSUP) were treated with IR-780 or combined IR-780 and hyperbaric oxygen (HBO). Cell viability, cell apoptosis, cellular ATP production, mitochondrial reactive oxygen species (ROS), and plasma membrane potential were detected. Mitochondrial complex I protein NDUFS1 was measured by western blot. To confirm the anti-tumor efficacy of IR-780 + HBO, mouse bladder cell line (MB49) tumor-bearing mice were established and tumor size and weight were recorded. Besides, cell apoptosis and tumor size were assessed in drug-resistant bladder cancer cells (T24/DDP) and xenografts to evaluate the effect of IR-780 + HBO on drug-resistant bladder cancer. Results IR-780 selectively accumulated in bladder cancer (bladder cancer cells, transplanted tumors, and bladder cancer tissue from patients) and could induce cancer cell apoptosis by targeting the mitochondrial complex I protein NDUFS1. The combination with HBO could significantly enhance the anti-tumor effect of IR-780 in vitro by promoting cancer cell uptake and inducing excessive mitochondrial ROS production, while suppressing tumor growth and recurrence in animal models without causing apparent toxicity. Moreover, this combination antitumor strategy was also demonstrated in drug-resistant bladder cancer cells (T24/DDP) and xenografts. Conclusion We identified for the first time a combination of IR-780 and HBO (IR-780 + HBO), which exhibits mitochondria-targeting and therapeutic capabilities, as a novel treatment paradigm for bladder cancer.
研究领域:
肿瘤学
·
药理学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Membranes
·
2020
·Vol. 10
·期 1
·12
·
IF 3.094
Xi Yang
The interfacial polymerization (IP) of piperazine (PIP) and trimesoyl chloride (TMC) has been extensively utilized to synthesize nanofiltration (NF) membranes. However, it is still a huge challenge to monitor the IP reaction, because of the fast reaction rate and the formed ultra-thin film. Herein, two effective strategies were applied to reduce the IP reaction rate: (1) the introduction of hydrophilic interlayers between the porous substrate and the formed polyamide layer, and (2) the addition of macromolecular additives in the aqueous solution of PIP. As a result, in situ Fourier transform infrared (FT-IR) spectroscopy was firstly used to monitor the IP reaction of PIP/TMC with hydrophilic interlayers or macromolecular additives in the aqueous solution of PIP. Moreover, the formed polyamide layer growth on the substrate was studied in a real-time manner. The in situ FT-IR experimental results confirmed that the IP reaction rates were effectively suppressed and that the formed polyamide thickness was reduced from 138 ± 24 nm to 46 ± 2 nm according to TEM observation. Furthermore, an optimized NF membrane with excellent performance was consequently obtained, which included boosted water permeation of about 141–238 (L/m2·h·MPa) and superior salt rejection of Na2SO4> 98.4%.Keywords:interfacial polymerization;in situ FT-IR spectroscopy;thin-film composite membrane;nanofiltration membrane
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 19
·9871-9881
·
IF 11.301
Ronglei Fan,Qiaoqiao Mu,Zhihe Wei,Yang Peng,Mingrong Shen
Developing cost-effective bifunctional electrocatalysts with low kinetic overpotential and superior stability for both the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is crucial to build a water splitting system for advancing the production of hydrogen fuel. Herein, we report a bifunctional catalyst by doping atomic Ir into a NiCo layered double hydroxide (LDH) using a facile atmospheric solvothermal method and subsequent spontaneous galvanic displacement. The as-synthesized atomic Ir-doped NiCo LDH exhibits much better durability for over 200 h than the NiCo LDH with the loading of Ir nanoparticles, due to the fine doping of atomic Ir into the crystal lattice of LDH. Benefiting from the synergistic effects in the HER/OER processes, as well as the large electrochemically active surface area and the improved electrical conductivity, the atomic Ir-doped NiCo LDH couple results in an unprecedented performance for overall water splitting with a low cell voltage of 1.45 V at 10 mA cm−2 in a 1.0 M KOH electrolyte. Finally, a practical solar-driven water splitting system with a solar-to-hydrogen efficiency of 14.8% is demonstrated, outperforming the state-of-the-art analogous systems based on ordinary Si solar cells.
研究领域:
材料科学
·
电催化
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2017
·Vol. 19
·期 7
·1766-1774
·
IF 9.125
Minghui Tang,Shanjun Mao,Xuefeng Li,Chunhong Chen,Mingming Li,Yong Wang
On the way to exploring superior hydrogenation catalysts, Ir-based catalysts with a record catalytic activity (up to 40 h−1) for the hydrogenation of benzoic acid to cyclohexanecarboxylic acid under mild reaction conditions (85 °C, 0.1 MPa H2, in water) have been successfully developed. By excluding various factors, the experimental results showed that the main factor governing the activity discrepancy between the Ir-based catalysts is actually the dispersion stability of the supports (such as N-doped carbon, active carbon, SBA-15 and various metal oxides) in the reaction solution, rather than the interaction between the Ir active component and the supports. Combined with theoretical investigation from first principles, an activity volcano curve considering the competing adsorption between the reactants (H2) and solvent (H2O) for aqueous aromatic ring hydrogenation was presented for the first time. The high activity of Ir can be deduced by the proper discrepancy of dissociation energies or adsorption energies between H2 and H2O on the catalysts. This activity volcano curve provides guidance for further rational design of promising catalysts for benzoic acid or even aromatic ring hydrogenation under true reaction conditions for practical applications.
研究领域:
催化化学
·
理论化学
✓ 已验证
DOI
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Xuyan Zong,Xianjiang Zhou,Xinyue Cao,Shun Gao,Dongyang Zhang,Haoran Zhang,Ran Qiu,Yi Wang,Jianhang Wu,Li Li
Craft beer brewers need to learn process control strategies from traditional industrial production to ensure the consistent quality of the finished product. In this study, FT-IR combined with deep learning was used for the first time to model and analyze the Plato degree and total flavonoid content of Qingke beer during the mashing and boiling stages and to compare the effectiveness with traditional chemometrics methods. Two deep learning neural networks were designed, the effect of variable input methods on the effectiveness of the models was discussed. The experimental results showed that the CARS-LSTM model had the best predictive performance, not only as the best quantitative model for Plato in the mashing (R 2 p = 0.9368) and boiling (R 2 p = 0.9398) phases but also as the best model for TFC in the boiling phase (R 2 p = 0.9154). This study demonstrates the great potential of deep learning and provides a new approach to quality control analysis in beer brewing.
研究领域:
食品科学
·
化学计量学
·
人工智能
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yuhua Xie,Yumei Feng,Chen Li,Fang Luo,Qing Li,Shiao Zhu,Mingxing Gong,Zehui Yang
The industrial development of acidic water splitting significantly counts on the activity associated with stability of oxygen evolution reaction (OER) electrocatalyst. In this work, we have constructed cubic Rh@Ir core–shell for acidic water splitting. The formed Rh@Ir electrocatalyst shows a high HER performance with only 29 mV overpotential for 10 mA cm −2 , stemming from the upshifted and downshifted d band center of Ir and Rh, leading to a moderate hydrogen binding strength. The Ir atom donates its electrons to nearby Rh atoms triggering a high susceptibility in nucleophilic attack by H 2 O to generate *OOH; thereby, the overpotential required to achieve 10 mA cm −2 is 216 mV for Rh@Ir core–shell, better than commercial IrO 2 . Moreover, the stability is superior to commercial IrO 2 and pure Ir electrocatalyst due to the strong electronic interplay in Rh@Ir contributing to a better resistance towards electrochemical dissolution proved by operando Raman and electrochemical impedance spectroscopies. Only 1.55 V is needed for Rh@Ir to drive overall water splitting at 10 mA cm −2 .
研究领域:
电化学
·
材料科学
·
催化
·
能源材料
✓ 已验证
产品关联
DOI
高影响因子
ChemCatChem
·
2021
·Vol. 13
·期 7
·1834-1846
·
IF 5.686
Ruihuan Jiang,Shaomian Liu,Liang Li,Yongjun Ji,Huifang Li,Xiangfeng Guo,Lihua Jia,Ziyi Zhong,Fabing Su
Graphical Single Ir atoms : In the CO+NO reaction, the catalyst with single-sited Ir atoms (0.28 wt %) anchored on a mesoporous WO 3 (Ir 1 /mesoporous-WO 3 ) showed much higher NO conversion and N 2 selectivity under oxygen-rich conditions than the catalysts supported with Ir nanoparticles on the same catalyst support (Ir NPs/mesoporous-WO 3 ) and on a non-mesoporous WO 3 (Ir/non-mesoporous-WO 3 ). Under oxygen-rich conditions, achieving a selective and efficient reduction of NO by CO is always challenging. Here, we report the synthesis of the catalyst consisting of single Ir atoms anchored on mesoporous WO 3 (denoted as Ir 1 /m-WO 3 ) using a facile template method followed by wet impregnation. X-ray diffraction and transmission electron microscope studies indicated that the Ir atoms were distributed uniformly on the internal surface of m-WO 3 . When tested for the reduction of NO by CO, the Ir 1 /m-WO 3 catalyst with a low Ir loading of 0.28 wt % exhibited excellent catalytic performance in the presence of 2 vol % O 2 (volume ratio of CO to O 2 being 1 : 10), achieving a NO conversion of 73 % and N 2 selectivity of 100 % at 350 °C. In particular, its turnover frequency (TOF) value reached 0.30 s −1 at 200 °C, which is six times higher than that of the catalyst with Ir nanoparticles supported on mesoporous WO 3 (0.05 s −1 ). The superior catalytic performance of Ir 1 /m-WO 3 is attributed to the formation of the isolated Ir atoms and the more newly generated Ir-WO 3 interfaces that can promote the adsorption and activation of NO, and the presence of accessible mesopores in m-WO 3 that facilitates the mass transfer of NO and CO. This study brings a new fundamental understanding of active sites in Ir-based catalysts for the CO+NO reaction and provides a new way to the design and synthesis of single-atom catalysts, especially precious metal catalysts for emissions control.
研究领域:
催化化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Yixi Wang,Wenqing Xu,Zhi Liu,Yulong Shan,Wanrong Chen,Xinyu Zhang,Tingyu Zhu
Controlling both CO and NOx pollutants without additional cost is necessary but challenging, especially in industrial flue gas with complex components. Previous studies mainly focused on the effect of O 2 and SO 2 on the CO oxidation side reaction and valence state of Ir species on various catalysts, while neglecting the impact on NO conversion pathway. Herein, we propose an "ineffective reaction pathway" in the presence of O 2 with nitrate as an intermediate according to the results of in situ DRIFTS and DFT. And we also reveal the contribution of SO 2 in inhibiting the adsorption of O 2 and promoting the selective adsorption of NO and CO even at lower injection concentrations, based on the oxidation of SO 2 on Ir(111). This is quite a favorable characteristic for the treatment of industrial flue gas, resolving the long–standing dispute on the involvement of these components in the CO–SCR reaction. Under specific conditions (CO/NO=20, O 2 =5%, SO 2 =200 ppm) at 250 °C, the NOx conversion is as high as 78%. These results will contribute to the development of more efficient catalysts in the future for simultaneously controlling two pollutants (CO and NOx).
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2018
·
IF 9.89
Yecan Pi,Jun Guo,Qi Shao,Xiaoqing Huang
The design of efficient Ir-based catalyst for oxygen evolution reaction (OER) in acidic conditions is the key for realizing the commercialization of polymer electrolyte membrane technology. This study reports a class of highly porous Ir–Cu nanocrystals (P-IrCux NCs) through a facile chemical dealloying strategy. Featuring the increased active surface area and plenty of defects, the newly generated P-IrCux NCs are highly active and stable toward OER in acidic conditions. The optimized P-IrCu1.4 NCs exhibit the current density of 12.8 mA cm–2 at the potential of 1.55 V (vs RHE), presenting 3.5-fold improvement in mass activity and 1.8-fold improvement in specific activity over the pristine solid IrCu1.4 NCs (S-IrCu1.4 NCs). Moreover, the obtained P-IrCu1.4 NCs also show excellent OER stability with negligible potential shift after continuous electrolysis in 0.05 M H2SO4 for 10 h. Further analysis reveals that the coordinatively unsaturated atoms at defects result in the higher oxidation state of iridium, which promotes the optimized intrinsic activity of P-IrCux NCs. This work highlights a promising strategy to create three-dimensional porous Ir-based catalysts for enhancing OER electrocatalysis.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2021
·
IF 5.097
Hongbo Yu,Chunzheng Wu,Shiwei Wang,Tong Li,Hongfeng Yin
Modification of active metals with metal oxide modifiers has attracted considerable attention in heterogeneous catalysis due to their synergistic effect. However, a controllable synthesis of highly reactive and stable metal–metal oxide hybrid nanocatalysts is difficult. To solve this problem, presynthesized IrM (M = Fe, Co, and Ni) bimetallic nanoparticles were initially confined in the mesopores of SBA-15 and were then in situ transformed to Ir-MOx hybrids. The obtained Ir-MOx/SBA-15 nanocatalysts show superior activity and selectivity in the hydrogenation of substituted nitroaromatics to corresponding aromatic amines compared to Ir/SBA-15. Among these Ir-based catalysts, Ir-FeOx/SBA-15 exhibits the highest activity and selectivity and has a wider substrate scope due to the interaction between Ir and FeOx. Therefore, our research provides a way to design reactive and stable hydrogenation catalysts.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2019
·
IF 6.669
Lele Jin,Wenzhi Li,Qiying Liu,Longlong Ma,Chao Hu,Ajibola T. Ogunbiyi,Mingwei Wu,Qi Zhang
In this study, the Mo-promoted Ir/SiO 2 (Ir-MoO x /SiO 2 ) catalysts combined with the zeolite HZSM-5 were used for the direct conversion of microcrystalline cellulose (MCC) to liquid fuel (C 5 /C 6 alkanes) in n-dodecane/H 2 O system. A synergistic effect was formed between the partially reduced MoO x species and the Ir particles, which effectively promoted the catalytic activity of Ir/SiO 2 catalyst. When the Mo/Ir molar ratio was 0.5, a high yield of C 5 /C 6 alkanes (91.7%) was achieved at 210 ℃ for 12 h. In addition, the main component of C 5 /C 6 alkanes was n-hexane, which was proven to be obtained by the hydrogenolysis of the key intermediate, sorbitol, formed from the hydrolysis and hydrogenation of MCC.
研究领域:
催化化学
·
能源化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
·
2019
·Vol. 56
·期 5
·2355-2364
·
IF 1.85
Manzoor Muhammad Faisal,Zeng Xin-An,Rahaman Abdul,Siddeeg Azhari,Aadil Rana Muhammad,Ahmed Zahoor,Li Jian,Niu Debao
The aim of this paper is to investigate the combined impact of pulsed electric field (PEF) and ultrasound (US) to evaluate the physicochemical, bioactive compounds and chemical structure of almond extract. Almond extract was first treated with PEF and then with US. Combined treatment (PEF–US) has attained the highest value of total phenolics, total flavonoids, condense tannins, anthocyanin contents and antioxidant activity in DPPH, reducing power and metal chelating activity than all other treatments. Among all those treatments, there was slightly visible difference in the color. Moreover, FT-IR spectra indicate that the effect of PEF-US on almond extract did not produce new carbonyl compounds, but led to the higher concentration of these compounds. This study demonstrated that the PEF-US could be useful for the extraction of bioactive compounds as well as improving the stability of volatile compounds.
研究领域:
食品科学
·
植物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）