REACTIVE & FUNCTIONAL POLYMERS
·
2021
·
IF 3.975
Qiang Li,Xiaotai Zhang,Lianwen Zhou,Chunhui Li,Na Zhang,Tingting Yan,Shicai Xu,Jihua Wang,Xinsheng Liu
The fabrication of a polyelectrolyte-based nanofiltration (NF) membrane with combined functions by a straightforward and scalable approach draws great attention. Herein, a polypeptide modified 1.5-bilayer polyelectrolyte NF membrane was fabricated by a novel brush assisted layer-by-layer (LBL) assembly technology using poly(allylamine hydrochloride) and poly(sodium-4-styrene sulfonate) as a polycation and a polyanion , and polylysine as a surface modifier. A denser separation layer can be formed by this approach compared to the classical static LBL assembly under the same assembled layer number. The membrane has an ultrathin separation layer (25 nm), and negatively charged surface in a neutral solution. It exhibits high rejections to potassium citrate (96.6%) and tetrasodium ethylenediamine tetraacetate (96.8%), and moderate rejection to sodium sulfate (85.3%). The molecular weight cut-off (MWCO) is 1360 Da. It also shows excellent antimicrobial property for the representative Gram-negative bacteria and fouling resistance to humic acid as foulant model. Moreover, chlorination treatment was firstly utilized to optimize the membrane structure and enhance the permeability from ca. 1.96 to 15.2 L/m 2 h bar, simultaneously keeping a high salt rejection. It was found that the chlorination process increases the negative charge density of the membrane surface and enlarges the free volumes between the polyelectrolyte chains.
研究领域:
材料科学
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化学工程
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环境科学
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生物技术
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Bailong Tao,Weikang Zhao,Chuanchuan Lin,Zhang Yuan,Ye He,Lu Lu,Maowen Chen,Yao Ding,Yulu Yang,Zengzilu Xia,Kaiyong Cai
Bone implant-associated infection is one of the major concerns in orthopedics, and may even result in implant failure. To this end, we developed a strategy for the fabrication of an antibacterial coating on titanium (Ti) implants with pH-response to combat bacteria-mediated acidification of the local microenvironment. It includes three steps: first, we synthesized levofloxacin (Levo)-loaded zeolitic imidazolate framework-8 ( [email protected] ) nanoparticles; second, the nanoparticles were loaded onto the collagen-modified Ti substrates by the cathode electrophoresis deposition (EPD) method; third, gelatin (Gel) and chitosan (Chi) multilayers were spin-coated on the modified Ti substrates, since the chelating effect of Gel and Chi would reduce the hydrolysis of [email protected] for a sustained release of Levo and Zn 2+ . The fabricated samples of [email protected] /LBL promoted in vitro adhesion, proliferation, and differentiation of osteoblasts. Moreover, the [email protected] /LBL samples exhibited strong antibacterial ability against Escherichia coli and Staphylococcus aureus through hydrolysis of ZIF-8 nanoparticles, thereby creating a marginally alkaline microenvironment. Furthermore, in vivo implantation in a femur-infected rat model revealed that [email protected] /LBL implants effectively inhibited bacterial adhesion, apart from significantly improving osseointegration of the Ti implants. The study provides a promising alternative for fabricating multifunctional Ti implants with strong antibacterial capacity and enhanced bone formation for potential orthopedic application.
研究领域:
生物材料
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骨科
·
生物医学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
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2018
·
IF 3.468
Yun Liu,Quan-Quan Wang,Zhi-Ming Jiang,Chuan-Jie Zhang,Zhong-Fang Li,Hua-Qi Chen,Ping Zhu
Chitosan was added to cotton fabrics coated with sodium phytate and 3-Aminopropyl triethoxysilane (APTES) to further enhance the fire retardant property by the layer-by-layer (LBL) assembly. The surface morphologies before and after flaming and structure of coated cotton fabrics were evaluated by scanning electron microscopy and Fourier transform infrared analysis. The thermal degradation properties, fire retardancy, and combustion properties of this system were investigated by Fourier transform infrared analysis, thermogravimetric analysis coupled with Fourier transform infrared analysis (TG-FTIR) in the N 2 atmosphere, the thermogravimetric analysis in air atmosphere, limiting oxygen index test (LOI), vertical burning test and cone calorimeter test, respectively. Sodium phytate, chitosan and hydrolyzed APTES were successfully deposited and well distributed on the surface of cotton fibers. The LOI value of the coated cotton fabric with 15BL was 29.0%, and it extinguished at once in the vertical burning test, while the coated cotton fabrics with 5BL and 10BL were burned out. The deposition of sodium phytate, chitosan and hydrolyzed APTES led to the decrease of heat release rate, total heat release, total smoke release and smoke production rate. The promoted fire retardancy was assigned to thermally stable residuals formed on the surface of cotton fibers, which prohibited heat/mass transfer from combustion zone to polymer degradation zone. TG-FTIR results indicated that flame retardant cotton fabrics produced more nonflammable gases (CO 2 and H 2 O) and less combustible gases than them of the control sample did, increasing flame retardant properties of flame retardant cotton fabrics.
研究领域:
材料科学
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纺织工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yanrui Chen,Xingran Zhang,Fang Li,Jinxing Ma,Zhiwei Wang
Biofouling remains to be one of major obstacles for membrane-based technology in water and wastewater treatment, calling for the development of antibiofouling membranes. For the traditional release-killing strategy, uncontrollable release of biocides and thus a short lifetime as well as the potentially environmental risk are thorny issues for the modified membranes. Herein, hydrophilic hydrogel multilayers with controllable thickness at nanometer scale on a poly(vinylidene fluoride) (PVDF) microfiltration membrane were constructed via layer-by-layer (LbL) self-assembly of non-drug-resistant antimicrobial peptides (AMPs) and alginate . The AMPs/alginate multilayers modified membranes exhibited enhanced hydrophilicity, well-controlled pore size distribution and prominent antimicrobial ability against Escherichia coli and Staphylococcus aureus . As the number of multilayers of alginate increased, both initial and steady release rate of Ponericin G1 reduced; in particular, the AMPs/alginate modified membranes with fifteen multilayers (MSA 15 ) had the slowest release kinetics ( i.e., an initial release rate of 1.79 ± 0.07 μg/cm 2 d and a steady release rate of 0.55 ± 0.03 μg/cm 2 d), resulting in about 60% less release compared with the AMPs/alginate modified membranes with five multilayers (MSA 5 ). Long-term antibiofouling tests showed that the AMPs/alginate modified membranes with ten multilayers (MSA 10 ) exhibited a significantly reduced transmembrane pressure increase rate of 0.81 ± 0.01 kPa/d which was much lower than that of the control membranes (1.80 ± 0.20 kPa/d), mainly attributed to the antibacterial activity imparted by the lasting release of AMPs and competing membrane basic properties. Furthermore, the AMPs/alginate multilayers modified membranes revealed high stability suffering from long-term operation and chemical cleaning cycles. The novel AMP/alginate-incorporated modifying method provides a new dimension to enhance antibiofouling performance of membranes for water and wastewater treatment.
研究领域:
环境工程
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材料科学
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水处理
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膜技术
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2014
·Vol. 5
·期 11
·3563-3575
·
IF 5.368
Hongju Zhou,Chong Cheng,Hui Qin,Lang Ma,Chao He,Shengqiang Nie,Xiang Zhang,Qiang Fu,Changsheng Zhao
Research on the interface self-assembly of functional layers is fuelled by diverse biomedical needs, like drug encapsulation and release, stem cell proliferation and differentiation, cell and tissue cultures, as well as artificial organs. In this study, a novel and biocompatible 3D composite layer is fabricated on a membrane substrate by the layer-by-layer (LBL) self-assembly of graphene-based 2D supermolecules. The graphene-based 2D supermolecules are prepared by grafting poly(styrenesulfonate) (PSS, polyanion) and poly(acrylamide) (PAM, polycation) onto graphene oxide (GO) through free radical polymerization. Then, the prepared graphene-based supermolecules are taken to construct a 3D porous thin film layer through a LBL process. Polyethersulfone (PES) membrane is chosen as the model substrate. The chemical composition, surface morphology, water contact angle, surface zeta-potential, blood compatibility and the cell compatibility are systematically investigated. The results indicate that the 2D graphene-based supermolecules are successfully assembled into a 3D porous thin film layer structure on the membrane surface. The assembled layer shows increased hydrophilicity, suppressed platelet adhesion, and a limited hemolysis ratio and complement activation compared to the pristine substrate. The cell morphology observation and cytotoxicity assays demonstrate that the 3D graphene layer shows superior performance both in endothelial and hepatocyte cells proliferation and morphology differentiation. In addition, the excellent anticoagulant bioactivities indicate that the 2D graphene-based supermolecules have heparin-mimicking biological activity. In general, the protocol of interface thin film layer self-assembly confers the modified substrates with integrated blood compatibility, cell proliferation and biological activity; which may forward the fabrication of multi-functional biomedical devices by using the 2D graphene-based supermolecules.
研究领域:
生物医学工程
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材料科学
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生物材料
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组织工程
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
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2021
·
IF 5.89
Guofeng Wang,Yaxin Zhu,Xingjie Zan,Meng Li
There is a substantial global market for orthopedic implants, but these implants still face the problem of a high failure rate in the short and long term after implantation due to the complex physiological conditions in the body. The use of multifunctional coatings on orthopedic implants has been proposed as an effective way to overcome a range of difficulties. Here, a multifunctional (TA@HA/Lys) n coating composed of tannic acid (TA), hydroxyapatite (HA), and lysozyme (Lys) was fabricated in a layer-by-layer (LBL) manner, where TA deposited onto HA firmly stuck Lys and HA together. The deposition of TA onto HA, the growth of (TA@HA/Lys) n , and multiple related biofunctionalities were thoroughly investigated. Our data demonstrated that such a hybrid coating displayed antibacterial and antioxidant effects, and also facilitated the rapid attachment of cells [both mouse embryo osteoblast precursor cells (MC3T3-E1) and dental pulp stem cells (DPSCs)] in the early stage and their proliferation over a long period. This accelerated osteogenesis in vitro and promoted bone formation in vivo . We believe that our findings and the developed strategy here could pave the way for multifunctional coatings not only on orthopedic implants, but also for additional applications in catalysts, sensors, tissue engineering, etc.
研究领域:
生物材料
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骨科
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组织工程
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生物医学工程
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纳米技术
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2019
·Vol. 40
·期 22
·1900441
·
IF 4.078
Hanzhi Zhang,Tongtong Zhou,Jiwei Shen,Ping Zhang,Xin Chen,Yongming Chen,You Yu
Finely tuning the photodegradation behavior of the layer-by-layer (LbL) film from the view of controlling the chemical structure of the film-building polymer is still a challenge in related fields. To meet this requirement, a photodegradable polymer (P1) is rationally designed for assembling a visible-light-degradable multilayer film with polystyrene sulfonate (PSS). Compared with similar photopolymers (P2 and P3), this asymmetric picolinium-containing polymer can significantly enhance the degradation rate of as-prepared LbL films; under the same degradation condition, the degradation rate of (P1/PSS)10 is 3 and 6.6 times that of (P2/PSS)10 and (P3/PSS)10, respectively. Moreover, near-infrared light (NIR) is available for triggering the degradation of this film with the assistance of upconversion nanoparticles of YbTm@Lu. The cell cytotoxicity and cell proliferation experiments reveal that P1 is nontoxic and favorable for cell proliferation at concentrations of up to 500 μg mL −1 . As for (PSS/P1)10 films, the ratio of cell number of these two samples ((PSS/P1)10 modified: photodegraded) increases dramatically and reaches about 1.67:1 after 72 h incubation. On the basis of these results, it is anticipated that P1 and this LbL film is an exceptional candidate for visible-light/NIR degradable materials in materials and biological science, medicine, and optics.
研究领域:
材料科学
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高分子化学
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生物医学工程
·
光学
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纳米技术
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光化学
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生物材料
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生命科学
✓ 已验证
DOI
高影响因子
Small
·
2023
·
IF 13.3
Taisong Fang,Songbai Liu
Probiotics-based oral therapy has become a promising way to prevent and treat various diseases, while the application of probiotics is primarily restricted by loss of viability due to adverse conditions in the gastrointestinal (GI) tract during oral delivery. Layer-by-layer (LbL) single-cell encapsulation approaches are widely employed to improve the bioavailability of probiotics. However, they are generally time- and labor-intensive owing to multistep operation. Herein, a simple yet efficient LbL technique is developed to coat a model probiotic named Escherichia coli Nissle 1917 (EcN) through polyphenol-Ca 2+ network directed allyl-modified gelatin (GelAGE) adsorption followed by cross-linking of GelAGE via photoinitiated thiol-ene click reaction to protect EcN from harsh microenvironments of GI tract. LbL single-cell encapsulation can be performed within 1 h through simple operation. It is revealed that coated EcN exhibits significantly improved viability against acidic gastric fluid and bile salts, and enhanced colonization in the intestinal tract without loss of proliferation capabilities. Furthermore, oral therapy of coated EcN remarkably relieves the pathological symptoms associated with colitis in mice including down-regulating inflammation, repairing epithelial barriers, scavenging reactive oxygen species (ROS), and restoring the homeostasis of gut microbiota. This simplified LbL coating strategy has great potential for various probiotics-mediated biomedical and nutraceutical applications.
研究领域:
生物医学工程
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药学
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微生物学
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营养保健品
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Shanshan Zhao,Xingyu Zhou,Junbo Dang,Yilong Wang,Junhui Jiang,Tianhao Zhao,Dahui Sun,Chen Chen,Xin Dai,Yan Liu,Mei Zhang
Carbon fiber-reinforced polyether ether ketone (CFRPEEK) implants have attracted widespread attention in the field of clinical bone defect repair. However, the surface bioinertness confines the application of CFRPEEK implants. Inspired by the study of rosmarinic acid (RA)-promoted osteogenic differentiation, a self-assembly surface modification method based on electrostatic interactions, involving deposition of sodium carboxymethyl cellulose/chitosan and rosmarinic acid layer by layer on the surface of poly-L-lysine modified hydroxy CFRPEEK (SCPP/CC5@RA), is proposed to introduce RA on the surface of CFRPEEK for bioactivation. After layer-by-layer self-assembly (LBL), the surface of SCPP/CC5@RA exhibits weak electrophoresis (11.43 eV), suitable hydrophilicity, and bioactivity. The results of in vitro studies indicate that the RA release behavior of SCPP/CC5@RA effectively regulates the immune-inflammatory response and promotes the differentiation of osteoblasts. The rapid release of RA (0.17 μg mL−1) in the initial stage can downregulate the secretion of inflammation-related cytokines and significantly reduce oxidative stress levels; the sustained release of RA (0.06 μg mL−1) in the late stage can upregulate the expression of osteogenesis-related genes and induce mineralization of osteoblasts. Moreover, the rabbit tibia defect model demonstrates that the LBL technique can enhance the osseointegration of CFRPEEK implants. Compared with the control group, the bone trabecular thickness of the SCPP/CC5@RA group increases by 1.36 times, and the maximum pushing force increases by 2.67 times. In summary, this study provides a promising LBL based RA delivery system for the development of a dual-functional CFRPEEK implant in the field of bone implant biomaterials.
研究领域:
生物材料
·
骨科
·
组织工程
·
药物递送系统
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Caiyun Zheng,Jinxi Liu,Que Bai,Yanxiao Quan,Zihao Li,Wenting Chen,Qian Gao,Yanni Zhang,Tingli Lu
Powder hemostatic particles have no limitation on wound type and a wide application prospect in the treatment of wound hemostasis. In this study, bioactive glass-based membrane-like structure camouflage composite particles ( [email protected] /CS) were prepared by Layer-by-layer (LBL) method to coat bovine serum albumin (BSA) and chitosan (CS) on the surface of the synthesized macroporous and mesoporous bioactive glass (MBG). The results showed that [email protected] /CS particles significantly improved the coagulation effect of MBG and could activated both endogenous and exogenous physiological coagulation pathways. [email protected] /CS had the excellent water absorption quality and could immediately release Ca 2+ to participate in the coagulation pathway. The main hemostatic mechanism of [email protected] /CS was that the membrane-like of BSA/CS could form a fibrin network by aggregating erythrocytes and activating platelets, thus rapidly aggregating coagulation factors. In addition, [email protected] /CS particles had a significant hemostatic effect on surface bleeding (tail-amputation model) and internal bleeding (liver injury model) in SD rats, which could shorten the bleeding time and reduce the amount of blood loss effectively. This research work stated that the MBG-based membrane-like structure camouflage composite particles might be with the potential applications as a hemostasis biomaterial for the emergency bleeding.
研究领域:
材料科学
·
生物医学工程
·
止血
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Jian Feng,Jinghong Wang,Huanhuan Wang,Xinyin Cao,Xiaoliang Ma,Yu Rao,Huimin Pang,Sulei Zhang,Yuheng Zhang,Lei Wang,Xiaoli Liu,Hong Chen
Anticoagulant surface modification of blood-contacting materials has been shown to be effective in preventing thrombosis and reducing the dose of anticoagulant drugs that patients take. However, commercially available anticoagulant coatings, that is, both bioinert and bioactive coatings, are typically based on a single anticoagulation strategy. This puts the anticoagulation function of the coating at risk of failure during long-term use. Considering the several pathways of the human coagulation system, the synergy of multiple anticoagulation theories may provide separate, targeted effects at different stages of thrombosis. Based on this presumption, in this work, negatively charged poly(sodium p-styrenesulfonate-co-oligo(ethylene glycol) methyl ether methacrylate) and positively charged poly(lysine-co-1-adamantan-1-ylmethyl methacrylate) were synthesized to construct matrix layers on the substrate by electrostatic layer-by-layer self-assembly (LBL). Amino-functionalized β-cyclodextrin (β-CD-PEI) was subsequently immobilized on the surface by host–guest interactions, and heparin was grafted. By adjusting the content of poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA), the interactions between modified surfaces and plasma proteins/cells were regulated. This multistage anticoagulant surface exhibits inertness at the initial stage of implantation, resisting nonspecific protein adsorption (POEGMA). When coagulation reactions occur, heparin exerts its active anticoagulant function in a timely manner, blocking the pathway of thrombosis. If thrombus formation is inevitable, lysine can play a fibrinolytic role in dissolving fibrin clots. Finally, during implantation, endothelial cells continue to adhere and proliferate on the surface, forming an endothelial layer, which meets the blood compatibility requirements. This method provides a new approach to construct a multistage anticoagulant surface for blood-contacting materials.
研究领域:
材料科学
·
生物材料
·
生物医学工程
·
表面化学
·
止血
·
血栓
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DESALINATION
·
2022
·
IF 11.211
Shao-Lu Li,Juntao Wang,Yaxu Guan,Junping Miao,Runsha Zhai,Jindi Wu,Yunxia Hu
Membrane fouling is the major obstacle to hinder the extensive application of polyamide thin-film composite reverse osmosis (PA TFC RO) membranes in the water purification and reclamation fields. In this study, a series of hydrophilic and charge-tuned antifouling RO membranes were fabricated by grafting three kinds of small molecules of multi-grade amines N , N -dimethylethylenediamine (DMEDA), (2-aminoethyl) guanidine (AEGu) and (2-aminoethyl)triethylenediamine (AEDABCO) via layer-by-layer interfacial polymerization (LbL-IP). Detailed characterizations revealed that the three tailored membranes presented obviously diminished surface negative charge and reduced PA layer thickness, the water permeability increased by 67.4 %, 34.7 % and 75.6 % compared to the pristine membrane , reached 4.05 L m −2 h −1 bar −1 , 3.26 L m −2 h −1 bar −1 , and 4.28 L m −2 h −1 bar −1 , respectively, meanwhile kept high NaCl rejection > 98.5 %. The dynamic fouling tests indicated that the tailored membranes exhibited much improved antifouling performance towards most of the model organic foulants. Meanwhile the membranes assembled with cationic groups exhibited an enhanced antibacterial property against E. coli . These functional small charged molecules and the convenient modification method provide a valuable pattern for designing antifouling PA TFC RO membranes, which is important for sustainable water purification.
研究领域:
材料科学
·
环境工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）