NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 25
·12069-12076
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IF 3.925
Hongji Li,Hongda Xu,Jinyue Zhang,Yi Li,Haochen Yu,Yibo Zhao,Dandan Wang,Yunhui Li,Jianwei Zhu
A novel surface enhanced Raman scattering (SERS) substrate was synthesized by wrapping Ag nanoparticles on the surface of the MIL-101 (Fe) shell under the assistance of IP6, and combining with molecular imprinted polymers (MIPs) for the selective detection of 2,6-DCP. In this study, as a stabilizer and linking agent, IP6 can form a chemical bond with MIL-101 (Fe) to decrease the distance between two Ag nanoparticles and generate more “hot spots”. On the other hand, the inositol hexaphosphate (IP6) and MIL-101 (Fe) shell acted as a protective shell layer, preventing Ag nanoparticles from being polluted by the external environment and reduced SERS activity. In addition, the SERS-MIPs can selectively detect the target molecule, avoiding the influence of other interfering substances on the detection effect. The prepared sensor (Ag/IP6@MIL-101 (Fe)@MIPs, AIM@MIPs) presented sensitive SERS properties, and the detection of limit can reach 10−9 M. The AIM@MIPs also presented strong selective detection to the target molecules, and can be applied for practical sample detection. This test provides a potential application in the detection of environmental pollutants.
研究领域:
分析化学
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环境科学
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材料科学
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纳米技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Yahan Cui,Jie Ding,Yu Su,Lan Ding
While a number of methods towards water-compatible molecularly imprinted polymers (MIPs) have been reported, new strategies affording simple preparation process and enhanced adsorption selectivity towards templates are needed to promote the further development of MIPs. Herein, we propose a novel method for preparing water-compatible MIPs (Cu-CMMIPs) with enhanced selectivity for tetracycline (TC) based on the dynamic physically cross-linking. The as-synthesized styrene-methacrylic acid copolymer was introduced as hydrophilic cross-linking functional monomers instead of conventional functional monomers and cross-linkers, thus eliminating the need of optimizing the cross-linkers/functional monomers ratio. The copper ions served as cross-linker, and in view of increased adsorption capacity and enhanced selectivity of the prepared MIPs, it was hypothesized that the introduction of copper ions would result in the strong interaction between the polymer network and TC. The imprinting process of TC is carried out by direct physical cross-linking of active groups of TC with functional groups of the polymeric network. The resultant Cu-CMMIPs exhibited excellent hydrophilicity, outstanding adsorption capacity and selectivity towards TC in water. Finally, the developed Cu-CMMIPs were applied as magnetic solid phase extraction adsorbents for the specific recognition of TC in environmental water combined with HPLC-DAD detection (LOD is 3.75 μg/L and the recoveries ranging from 91.2 % to 101.3 %). The proposed concept in this work for fabrication of MIPs with facile preparation process, enhanced selectivity and satisfactory hydrophilicity would inspire more ideas to implement in cost-effective adsorbents construction.
研究领域:
材料科学
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环境科学
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分析化学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yalin Niu,Peng Jiang,Tianying Guo
Organophosphate nerve agents (OPs) are widely used as pesticides and chemical agents and pose a threat to human health and life. At present, most personal protective equipment usually only serves as physical protection and does not have an effect of chemical detoxification. In this work, ultra lightweight graphene oxide aerogels (GAs) have been used as a multifunctional skeleton to integrate the metal–organic frameworks (MOFs) and molecularly imprinted polymers (MIPs) together for obtaining a high-performance hybrid material (MOFs/MIPs@GAs) on hydrolysis detoxification of OPs. As a porous three-dimensional material full of carboxyl groups, GAs can not only support excellent mass transfer performance but also provide a proper pH self-buffering catalytic reaction external environment for hydrolyzing OPs. The obtained MOFs/MIPs@GAs can catalyze dimethyl-4-nitrophenyl phosphate (DMNP) hydrolysis detoxification rapidly in pure water (kobs = 0.2227 min–1, t1/2 = 3.11 min). This ternary hybrid material with exceptional performance and practical applicability has vast application prospects for the development of protective equipment.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2013
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IF 2.487
Shian Zhong,Yanyue Kong,Ling Zhou,Chengyun Zhou,Xiaona Zhang,Yan Wang
In this study, we developed an efficient conversion process of dihydromyricetin to myricetin from Ampelopsis grossedentata extracts. The content of myricetin increased from 2.38% to 85.57%, demonstrating the successful dehydrogenation of dihydromyricetin. Molecularly imprinted polymers (MIPs) were prepared by surface imprinting method using silica microspheres as the support matrices and myricetin as template. The MIPs were applied for the selective adsorption of myricetin. The chemical structure of the MIPs was characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. Static, dynamic and selective adsorption experiments showed that the MIPs exhibited good adsorption ability, rather fast template rebinding kinetics, and appreciate selectivity over structurally related compounds. Accordingly, the MIPs were applied as the selective sorbent in SPE to purify myricetin obtained through dehydrogenation, followed by HPLC-UV analysis. The recoveries of myricetin and dihydromyricetin were 92.7% and 55.6%, respectively. This study demonstrates the feasibility of using the developed MIP-SPE method to purify and enrich myricetin in the natural products.
研究领域:
药学
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分析化学
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天然产物化学
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产品关联
DOI
PubMed
高影响因子
TALANTA
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2023
·
IF 6.1
Yulin Lu,Qunshan Liu,Bangguo Fu,Pan Li,Weiping Xu
Early diagnosis of colorectal cancer can significantly improve the overall survival rate of patients, thus selective and sensitive detection of biomarkers in serum samples is vital for early detection and dynamic monitoring of cancer. Nucleoside diphosphate kinase NM23-H2 (NDKB) is an important biomarker and therapeutic target for the diagnosis of colorectal cancer (CRC). Here, a label-free and ultrasensitive biosensor for NDKB protein markers is presented for the first time, combining the characteristic capture selectivity of molecularly imprinted polymers (MIPs) and the ultrasensitivity of surface-enhanced Raman Spectroscopy (SERS) technique. The imprinted cavity serves as the only channel for Raman reporter to approach the SERS substrate, providing highly complementary non-covalent binding sites that selectively capture the target protein based on ionic, hydrogen bonding or hydrophobic interactions. Specific recognition of the NDKB protein will perfectly fill the imprinted cavity, which makes it difficult for the Raman reporter to get close to the SERS substrate, and the Raman signal decreases significantly, while the proteins of other structural sizes can not match the imprinted cavity. Through the change of the Raman signal, the proposed biosensor can realize the ultra-sensitive detection of NDKB, and the limit of detection (LOD) is 0.82 pg/mL. Compared with the traditional immunoassay technology, this combined approach with the advantages of low cost, fast response, high sensitivity and selectivity, provides clinical application potential for the early diagnosis of CRC.
研究领域:
癌症生物学
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分析化学
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生物医学工程
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医学诊断
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2023
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IF 3.8
Pan Wang,Mengdei Zhou,Zhuangxin Wei,Lu Liu,Tao Cheng,Xiaohua Tian,Jianming Pan
Molecularly imprinted polymers (MIPs) have great potential as adsorbents for selective adsorption and separation of nucleoside compounds, but effectively enhancing the affinity of recognition sites by adjusting the forces between template molecules and functional monomers remains an important challenge. In this work, a surface imprinting strategy was used to construct bowl-shaped molecularly imprinted composite sorbents (BHPN@MIPs) based on polydopamine (PDA) particles and have achieved selective separation and purification of 2′-deoxyadenosine (dA). Where by the base complementary pairing interaction of the combined template molecule dA and the pyrimidine functional monomer can enhance the pre-assembly force, and the hydrophilic bowl-shaped PDA can provide a larger storage space contact efficiency of dA in the test solution, causing the site utilization much higher and improving the kinetic adsorption performance. The equilibrium adsorption time and maximum adsorption capacity of 60 min and 328.45 μmol·g −1 were observed by static adsorption experiments, and the selectivity experimental results showed an imprinting factor IF of 1.30. After four adsorption–desorption cycles, the initial adsorption equilibrium adsorption capacity of BHPN@MIPs still retained 91.14%. By evaluating the selective adsorption of dA in spiked human serum solutions, BHPN@MIPs can be used to selectively enrich and analyze target dA in complex biological samples.
研究领域:
材料科学
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分析化学
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生物技术
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药学
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产品关联
DOI
高影响因子
Food Chemistry-X
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2023
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IF 6.1
Yiwei Tang,He Meng,Wenxiu Wang,Yang Song,Shuo Wang,Zhuanying Li,Xianghong Wang,Xuelian Hu
An innovative core–shell magnetic molecularly imprinted polymers, Fe 3 O 4 @SiO 2 @MIPs, was elaborately tailored for specific separation and enrichment of olaquindox (OLA) and its metabolic marker methyl-3-quinoxaline-2carboxylic acid (MQCA). Herein, benefiting from the combination of functionalized magnetic nanoparticles (Fe 3 O 4 @SiO 2 ) and MIPs, Fe 3 O 4 @SiO 2 @MIPs not only possessed favorable magnetic properties and stability, avoiding tedious sample pretreatment process, but also demonstrated exceptional selective recognition ability and adsorption capacity, suppressing influence of coexisting interfering substances. Encouraged by prominent merits, Fe 3 O 4 @SiO 2 @MIPs-based magnetic solid phase extraction with HPLC method was developed, realizing simultaneous measurement of OLA and MQCA. Under optimal conditions, excellent linear ranges of 0–100 μg/L with detection limit of 0.175–0.271 μg/L were obtained. The proposed method was finally utilized for determination of OLA and MQCA in fish muscle and milk samples with satisfactory recoveries (80.56–95.26%) and relative standard deviation below 8.1%, furnishing a reliable and sensitive strategy for enrichment and detection residual veterinary drugs in food samples.
研究领域:
分析化学
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食品安全
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兽药残留检测
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2016
·Vol. 39
·期 18
·3578-3585
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IF 2.741
Haibo Liu,Ning Gan,Yinji Chen,Qingqing Ding,Jie Huang,Saichai Lin,Yuting Cao,Tianhua Li
A quick and specific pretreatment method based on a series of extraction clean-up disks, consisting of molecularly imprinted polymer monoliths and C 18 adsorbent, was developed for the specific enrichment of salbutamol and clenbuterol residues in food. The molecularly imprinted monolithic polymer disk was synthesized using salbutamol as a template through a one-step synthesis process. It can simultaneously and specifically recognize salbutamol and clenbuterol. The monolithic polymer disk and series of C 18 disks were assembled with a syringe to form a set of tailor-made devices for the extraction of target molecules. In a single run, salbutamol and clenbuterol can be specifically extracted, cleaned, and eluted by methanol/acetic acid/H 2 O. The target molecules, after a silylation derivatization reaction were detected by gas chromatography-mass spectrometry. The parameters including solvent desorption, sample pH, and the cycles of reloading were investigated and discussed. Under the optimized extraction and clean-up conditions, the limits of detection and quantitation were determined as 0.018–0.022 and 0.042–0.049 ng/g for salbutamol and clenbuterol, respectively. The assay described was convenient, rapid, and specific; thereby potentially efficient in the high-throughput analysis of β 2 -agonists residues in real food samples.
研究领域:
分析化学
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食品安全
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生物技术
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DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 187
·期 1
·1-8
·
IF 5.479
Liang Yutao,He Juan,Huang Zhipeng,Li Huayu,Zhang Yunxia,Wang Huige,Rui Chaofan,Li Yuanyuan,You Liqin,Li Kai,Zhang Shusheng
A surface imprinted polymer of type UiO-66-NH2@MIP was prepared by combining molecular imprinted polymers (MIPs) and an amino-functionalized zirconium-based metal-organic framework. Quercetin is used as the virtual template, UiO-66-NH 2 acts as the carrier to which the monomer acrylamide can be copolymerized. The material was characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. It was used as a sorbent in a solid-phase extraction column. The extraction conditions were optimized. The adsorption capacities for aflatoxins AFB1, AFB2, AFG1 and AFG2 by this SPE and by the commercial SPE were compared. The method was successfully applied to quantify the aflatoxins in grain. Figures of merit include (a) good linearity (range from 0.20–45 μg·kg −1 ) with R 2 (range from 0.9986–0.9994), (b) low detection limits (90–130 ng·kg −1 ), (c) acceptable reproducibility (1.0–5.9%; for n = 6), and (d) relatively satisfactory recovery rates (74.3–98.6%). The new sorbent has good selectivity and reusability.
UiO-66-NH 2 @MIPs were synthesized with modified UIO-66-NH 2 as core and quercetin as pseudo template. A cartridge was prepared with the polymers as the sorbent, and its performance was compared with different commercial SPE cartridges.
研究领域:
分析化学
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食品科学
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材料科学
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DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-10
·
IF 5.3
Liu Hao,Sun Xuyuan,Dai Zhengyuan,Wang Ying,Li Li,Fan Jie,Ding Yaping
Nifedipine (NIF), as one of the dihydropyridine calcium channel blockers, is widely used in the treatment of hypertension. However, misuse or ingestion of NIF can result in serious health issues such as myocardial infarction, arrhythmia, stroke, and even death. It is essential to design a reliable and sensitive detection method to monitor NIF. In this work, an innovative molecularly imprinted polymer dual-emission fluorescent sensor (CDs@PDA-MIPs) strategy was successfully designed for sensitive detection of NIF. The fluorescent intensity of the probe decreased with increasing NIF concentration, showing a satisfactory linear relationship within the range 1.0 × 10 −6 M ~ 5.0 × 10 −3 M. The LOD of NIF was 9.38 × 10 −7 M (S/N = 3) in fluorescence detection. The application of the CDs@PDA-MIPs in actual samples such as urine and Qiangli Dingxuan tablets has been verified, with recovery ranging from 97.8 to 102.8% for NIF. Therefore, the fluorescent probe demonstrates great potential as a sensing system for detecting NIF. Graphical abstract
研究领域:
分析化学
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材料科学
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药学
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产品关联
DOI
PubMed
高影响因子
ADSORPTION SCIENCE & TECHNOLOGY
·
2015
·
IF 0.669
Wenming Yang,Yang Cao,Xiaoni Ni,Weihong Hunag,Wanzhen Xu
We herein report the successful synthesis of molecularly imprinted polymers (MIPs) by surface imprinting methods. The synthesized MIPs were subsequently used to selectively adsorb indole from fuel oil. A new polymerization method (SR&NI ATRP), which combines the atom transfer radical polymerization (ATRP) and reverse atom transfer radical polymerization methods, is applied for the preparation of indole–MIPs. The indole–MIPs prepared have large specific surface area and porosity, as revealed by a series of morphology characterization studies. Static adsorption data indicate that the adsorption capacity of indole–MIPs was 55.8 mg g−1, and the adsorption equilibrium is achieved in 120 minutes. According to the results of thermodynamic analysis, the adsorption process is spontaneous. In addition, results of kinetics analysis indicated that the adsorption performances of indole–MIPs obey pseudo-second-order model. The Sips and Langmuir equations better fitted with the experimental isothermal data than the Freundlich equation. The selectivity of indole–MIPs was significant and the adsorbent could be reused even after five regeneration cycles.
研究领域:
化学工程
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环境科学
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材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Xiaoyu Xie,Qi Hu,Ruifang Ke,Xueyan Zhen,Yusi Bu,Sicen Wang
Stimulated response molecularly imprinted polymers (MIPs) have attracted wide attention not only because of their intriguing response to external stimuli, but also due to the desired molecular recognition ability. Herein, a novel dual responsive proteins MIPs with both photonic and magnetic stimuli has been developed by surface imprinting polymerization, where double bonds modified Fe 3 O 4 nanoparticles, a water-soluble azobenzene containing 4-[(4-methacryloyloxy)phenylazo]benzenesulfonic acid and bovine hemoglobin (BHb) were used as magnetic core, photoswitchable functional monomer and template protein, respectively. The resultant MIPs possessed a typical spherical structure with a relative rough imprinted layer of 15 nm thickness. Moreover, the MIPs had good binding behavior toward BHb with fast binding kinetics, high adsorption capacity and satisfactory selectivity. The MIPs were proved to be well photo-controlled toward the template protein BHb under the alternating irradiation of 365 and 440 nm: 31.4% BHb was released from the MIPs at 365 nm and 67.2% BHb was bound into the MIPs at 440 nm. As a result, the MIPs were successfully applied to specifically extract template protein from actual biological sample. As a consequence, combining photocontrolled release and uptake, rapidly magnetic separation and specific recognition, the resultant MIPs with photonic and magnetic dual responsive abilities show significant advantages in the enrichment of trace protein in biological samples.
研究领域:
纳米技术
·
生物材料
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分析化学
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生物技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）