APPLIED SURFACE SCIENCE
·
2018
·
IF 4.439
Xinshan Rong,Lu Zhang,Xiaoying Zhang,Jian Rong,Xiangtong Zhou,Haifei Chen,Shuang Liu,Fengxian Qiu,Zhiren Wu
Cross-weaved basalt fiber fabric (CBFF) woven from basalt fiber (BF), as a natural inorganic product, which presented a highly research value and widely application field, due to its high chemical stability, non-toxic, non-combustible and sound mechanical property. (Super)hydrophobic surface has recently received extraordinary attention, focusing both on novel preparation-used materials and application. In this work, cross-weaved basalt fiber fabric was synergistically decorated by MnO 2 nanosheets/stearic acid (SA) and the superhydrophobic inorganic/organic composite (CBFF@MnO 2 /SA) was obtained by hydrothermal processes. MnO 2 nanosheets self-assembled on the surface of CBFF (CBFF@MnO 2 ) presented honeycomb roughness with the micro/nanometer-sized spaces among the MnO 2 nanosheets. The water contact angles of CBFF, CBFF@MnO 2 and CBFF@MnO 2 /SA samples were 21.6, 120.0 and 155.5°, respectively. The result indicated that cross-weaved basalt fiber fabric exhibited an obvious superhydrophobic property after the modification by MnO 2 nanosheets and stearic acid. The as-prepared materials were applied in the simulation of oil/water separation and anti-icing process. Oil/water separation results not only displayed the separation efficiency up 95.0% by selective absorption for light oil/water system, but also showed the separation efficiency above 97.2% by filtration of oil for heavy oil/water system. Furthermore, CBFF@MnO 2 /SA could be used as the filter membrane in dynamic suction filtration device for oil recovery in oil spill accidents. Anti-icing experiments demonstrated that prepared CBFF@MnO 2 /SA had an obviously ice-over delay with the value of 166.6%.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Ying Qin,Yu Wu,Guojuan Chen,Lei Jiao,Liuyong Hu,Wenling Gu,Chengzhou Zhu
Generally, the photoactive materials are always tightly fixed on the photoelectrode of photoelectrochemical (PEC) sensors to produce excellent photocurrent response, while obvious and constant background currents will appear as well and then hamper the ultrasensitive sensing of target molecules. In this work, ultrasensitive detection of organophosphorus pesticides (OPs) is successfully fulfilled by using dissociable photoelectrode based on CdS nanocrystal-functionalized MnO 2 nanosheets . With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO 2 nanosheets, resulting in the dissociation of MnO 2 –CdS from the photoelectrode. Benefiting from the dissociation of photoactive materials, the background photocurrent induced by semiconductor itself dramatically decreases. OPs, as a specific inhibitor for AChE activity, can prevent the generation of TCh and the dissociation of MnO 2 nanosheets, building a relationship between OPs concentration and photocurrent. Under the optimized test conditions, the PEC sensor for the detection of paraoxon displays a wide linear range from 0.05 to 10 ng/mL with a detection limit of 0.017 ng/mL. Furthermore, the PEC sensor shows good sensitivity, stability, and promising application in practical samples.
研究领域:
分析化学
·
环境科学
·
生物传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Xinfa Cai,Meijuan Liang,Fei Ma,Zhaowei Zhang,Xiaoqian Tang,Jun Jiang,Can Guo,Sherif Ramzy Mohamed,Amira Abdel Goda,Dawood H. Dawood,Li Yu,Peiwu Li
Lateral flow immunoassay (LFIA) is the most effective real-time detection method for aflatoxin B 1 (AFB 1 ). Here, we constructed a nanozyme-strip based on MnO 2 nanosheets (MnO 2 NSs) as a catalytic label for detection of AFB 1 . By taking advantage of the MnO 2 -TMB catalytic amplified system, the new test achieves rapid detection with high sensitivity and ultrawide range. The limit of detection of the assay was 15 pg mL −1 , which was over 100-fold lower than the maximum limit set by the European Union (EU) of AFB 1 in foods. In addition, the strip test could offer 7 dynamic detection ranges, spanning 4 orders of magnitude, which could cater to the varieties of limits on AFB 1 residues in foods and feeds set by different countries. The estimated recoveries were in the range of 85.67%-106.38% with coefficients of variations (CVs) less than 9.68%. Overall, the developed approach is a rapid, reliable, sensitive and widely available tool for on-site detection of AFB 1 .
研究领域:
食品安全检测
·
生物化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2025
·Vol. 15
·期 1
·49
·
IF 5.6
Yijiong Xue,Chengqi Bao,Hui Liu,Fanghui Ma,Minghui Yang,Xiaoqing Li
A fluorescence probe for “switch-on” detection of alkaline phosphatase (ALP) was developed based on Au nanoclusters anchored MnO2nanosheets (Au NCs-MnO2NSs), which were synthesized using bovine serum albumin (BSA) as template through a simple one-pot approach. In the sensing system, MnO2NSs function as both energy acceptors and target identifiers, effectively quenches the fluorescence of Au NCs via fluorescence resonance energy transfer (FRET). The presence of ALP catalyzes the hydrolysis of L-ascorbic acid-2-phosphate (AAP) to ascorbic acid (AA), reducing MnO2NSs to Mn2+and facilitate the fluorescence recovery of Au NCs. The fluorescence assay offers the advantages of facile preparation, cost-effectiveness, good specificity, and high sensitivity. Moreover, the assay exhibits a broad linear range (0.005 U/mL to 8 U/mL) for ALP detection with a remarkable limit of detection of 0.0015 U/mL. Notably, this assay demonstrates promising applicability for detection ALP in human serum samples, thereby providing valuable potential for clinical applications.
研究领域:
生物化学
·
分析化学
·
医学检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Lei Han,Shi Gang Liu,Jia Yu Liang,Nian Bing Li,Hong Qun Luo
Glutathione (GSH) plays a critical role in the living system and its abnormalities are closely associated with numerous clinical diseases. Thus, monitoring and detecting the content of GSH in the living system is still of great importance. Herein, a novel dual-signal responsive optical sensor is developed by using resonance Rayleigh scattering (RRS) and colorimetry for sensitive detection of GSH. In this sensor, MnO 2 nanoflakes are used as both GSH recognizer and signal transducer of RRS and colorimetry. The solution of MnO 2 nanoflakes shows strong RRS and absorption signals because MnO 2 nanoflakes possess a large surface area and high molar extinction coefficient. However, MnO 2 can be reduced to Mn 2+ and MnO 2 nanoflakes can be etched to small nanoparticles by GSH, causing both the RRS and absorption signals to decrease. Based on the change of RRS signal and absorbance of MnO 2 nanoflakes, a novel dual-signal responsive optical sensor is successfully constructed to detect the content of GSH. The as-developed optical sensor toward GSH presents a favorable sensitivity with a detection limit of 0.033 and 0.67 μM for RRS and colorimetry, respectively. Furthermore, the as-developed approach is straightforward, quickly responsive, free-label, and cost-effective. More significantly, this method combines the advantages of RRS and colorimetry for the detection of GSH. Beyond this, the proposed RRS method has also been successfully utilized to detect the content of GSH in glutathione injection samples.
研究领域:
分析化学
·
生物传感器
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2017
·
IF 5.099
Jingjing Deng,Dingkun Lu,Xiaolei Zhang,Guoyue Shi,Tianshu Zhou
In this study, we demonstrated an assay with turn-on fluorescence for monitoring cerebrospinal acetylcholinesterase (AChE) fluctuation as a biomarker for organophosphorus pesticides (OPs) poisoning and management based on single layer MnO 2 nanosheets with graphene quantum dots (GQDs) as signal readout. Initially, the fluorescence of GQDs was quenched by MnO 2 nanosheets mainly due to the inner filter effect (IFE). However, with the presence of reductive thiocholine (TCh), the enzymatic product, hydrolyzed from acetylthiocholine (ATCh) by AChE, the redox reaction between MnO 2 and TCh occurred, leading to the destruction of the MnO 2 nanosheets, and thereby IFE was diminished gradually. As a consequence, the turn-on fluorescence of GQDs with the changes in the spectrum of the dispersion constituted a new mechanism for sensing of cerebrospinal AChE. With the method developed here, we could monitor cerebrospinal AChE fluctuation of rats exposed to OPs before and after therapy, and could thereby open up the pathway to a new sensing platform for better understanding the mechanism of brain dysfunctions associate with OPs poisoning.
研究领域:
生物化学
·
毒理学
·
医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Interfaces
·
2022
·Vol. 9
·期 17
·2200271
·
IF 6.389
Ke Wang,Enhui Ma,Hong Wang
Self-propelled magnetic MnO 2 @pollen micromotors have been developed as active heterogeneous catalysts of peroxymonosulfate (PMS) activation for efficient degradation of antibiotics. The MnO 2 nanosheets (NSs) and Fe 3 O 4 nanoparticles (NPs) are constructed on hollow pollens with small openings, endowing the natural materials with multifunctional properties. MnO 2 NSs can decompose H 2 O 2 to provide propulsion for micromotor movement, and also cooperate with Fe 3 O 4 NPs to activate PMS to produce active free radicals SO 4 ·− . Together with the OH· generated by Fe 3 O 4 NPs and H 2 O 2 , the prepared micromotor catalyst can realize the degradation of tetracycline (TC) within several minutes. The self-propulsion and abundant bubble formation cause effective fluid mixing and intensification of mass transfer, making up the low diffusivity defect of traditional heterogeneous catalysts. Moreover, the magnetic properties lay a foundation for the long-range magnetic control and reutilization of heterogeneous catalysts, avoiding wastage and secondary contamination. The proposed self-propelled pollen micromotors provide a highly efficient, economic, and environmentally friendly platform for the degradation of antibiotics.
研究领域:
环境科学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Meilin Shi,Shan Wang,Shaohui Zheng,Pingfu Hou,Lina Dong,Meijuan He,Chen Wu,Xiuli Zhang,Fengmei Zuo,Kai Xu,Jingjing Li
Multifunctional nanocarriers, which can be used for molecular imaging and drug delivery simultaneously, favor the fabrication of theranostic platforms in a less cost- and time-consuming way. Polyethylene glycol (PEG)-modified manganese dioxide (MnO 2 ) nanosheets (PEG-MnO 2 ), used as two-dimensional nanomaterials, not only possess the high surface-to-volume ratio necessary for drug delivery but also display a redoxable property in the tumor microenvironment, producing Mn 2+ ions for magnetic resonance imaging (MRI). In this study, we constructed a PEG-MnO 2 -OPN siRNA nanocomplex via a modular streptavidin bridge for the theranostic treatment of renal carcinoma in vitro and in vivo . This strategy of utilizing PEG-MnO 2 nanosheets for OPN siRNA delivery showed effective tumor growth inhibition of 786-O tumor-bearing mice, and such a process could be monitored by the activated T 1 -weight MRI, illustrating the promising potential of PEG-MnO 2 nanosheets for the fabrication of an MRI-based theranostic system.
研究领域:
生物医学工程
·
药学
·
癌症研究
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-9
·
IF 5.3
Yan Qinghua,Wu Ruixue,Wang Jiaxin,Mao Jian,Nan Wenbin
Abstract To accurately detect tumor marker carbohydrate antigen 72-4 (CA72-4) of serum samples is of great significance for the early diagnosis of malignant tumors. In the present study, MnO 2 /hollow nanobox metal-organic framework (HNM)-AuPtPd nanocomposites were prepared via multi-step synthesis and superposition method and a series of characterizations were carried out. A highly sensitive immunosensor Ab/MnO 2 /HNM-AuPtPd/GCE based on the composite nanomaterial was further prepared and used to detect the tumor marker CA72-4. The constructed immunosensor achieved signal amplification by increasing the electrocatalytic activity to H 2 O 2 by means of the synergistic effect of MnO 2 ultra-thin nanosheets (MnO 2 UNs) and HNM-AuPtPd. At the same time, the electrochemical properties of the immunosensor were analyzed using cyclic voltammetry, electrochemical impedance, amperometry (with the test voltage of −0.4 V), and differential pulse voltammetry. The experimental results showed that the MnO 2 /HNM-AuPtPd nanocomposites were successfully prepared, and the immunosensor Ab/MnO 2 /HNM-AuPtPd/GCE demonstrated an excellent electrochemical performance. The electrochemical immunosensor had the highest detection sensitivity under the optimal experimental conditions, such as incubation pH of 7.0, incubation time of 60 min, with the addition of 15 μL of H 2 O 2 , and in the concentration range 0.001–500 U/mL. It had a low detection limit of 1.78×10 −5 U/mL (S/N = 3). Moreover, the serum sample recovery were in the range from 99.38 to 100.52%. This study provides a new method and experimental basis for the detection of tumor markers in clinical practice. Graphical Abstract
研究领域:
生物医学工程
·
分析化学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 37
·16475-16480
·
IF 2.7
Xiaoxu Zhang,Xiangyu Cai,Yanqun Fei,Yuying Jia,Hongyan Shan,Yanfu Huan
In this article, a CRET-based chemiluminescent sensor was developed for ascorbic acid detection. Au/Pt@Cu2O/CuO NPs with peroxidase activity were prepared to catalyse the decomposition of H2O2 to produce free radicals, which led to the enhancement of the chemiluminescence (CL) signal, and the CRET between luminol and MnO2 NSs was able to take place and the CL signal was reduced; the presence of ascorbic acid would reduce MnO2 NSs, which was able to weaken the energy transfer between luminol and MnO2 NSs and restored the CL signal. Under the optimal experimental conditions, the detection range of ascorbic acid was 1–1000 μM, and the LOD was 0.35 μM. The method is sensitive and has a wide linear range, and is expected to be applied to the detection of ascorbic acid in more complex environments.
研究领域:
分析化学
·
生物传感
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 20
·4119-4126
·
IF 1.915
Lin Lin,Dongmin Shi,Quanfa Li,Guangfeng Wang,Xiaojun Zhang
Determination of nucleotide kinase activity is valuable due to its importance in regulating nucleic acid metabolism. In this work, a novel and simple colorimetric method for discriminative detection of T4 polynucleotide kinase (PNK) through a MnO2 nanosheet-3,3′,5,5′-tetramethylbenzidine (TMB) colorimetric system is developed. In aqueous solution at pH 7.4, the MnO2 nanosheet, a mimic enzyme, rapidly converts colourless TMB to a blue oxidized form. In the presence of T4PNK, a hairpin DNA could be phosphorylated and further cleaved by λ exonuclease (λ exo) and the ssDNA fragments would adsorb on the surface of the MnO2 nanosheet, resulting in the inhibition of the catalytic effect of the MnO2 nanosheet to the oxidation of TMB and weakening of the blue color of oxidized TMB with the absorption peak centred at 652 nm. The presence of T4PNK can in this way easily be detected with the naked eye, based on the obvious colour change. The experimental results revealed that the advanced strategy was sensitive for detecting T4PNK in the concentration range from 0.005 to 10 U mL−1 with a detection limit of 0.005 U mL−1. In addition, the relative standard deviation was 3.92% in 3 repetitive assays of 10 U mL−1 T4PNK, indicating that the reproducibility of this strategy was acceptable. By comparison with other relevant fluorogenic assays, the sensitivity of the developed chromogenic assays was satisfactory. The present approach opens the possibility for the design of simple and sensitive colorimetric assays for polynucleotide kinase using inexpensive and available TMB as a universal chromogenic compound. Therefore, besides desirable sensitivity and selectivity, due to the colorimetric system, the developed method for T4PNK detection also showed cost-effective, reliable and simplified operations and strategy, which has considerable potential for biological process research.
研究领域:
生物化学
·
分子生物学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Hongzhi Lu,Shoufang Xu
Nanoparticles are effective tools for signal amplification in chemical sensor construction. Herein, we present molecularly imprinted polymer (MIP)-based sandwich-structured fluorescence sensors for ultrasensitive detection of trace carcinoembryonic antigen (CEA) based on MnO2 nanosheet and MoS2 nanoflower dual signal amplification. MIPs were used as synthetic antibodies and prepared by a surface imprinting method using MnO2 nanosheet-loaded magnetic carbon fibers (CF/Fe3O4/MnO2) as solid supports by the self-polymerization of dopamine. The obtained CF/Fe3O4/MnO2/MIPs can specifically absorb the target CEA from complex samples, which can then be specifically labeled with boronic acid-modified MoS2-curcumin nanotags (BA-MoS2-CUR). Under alkaline conditions, CUR was detached from MoS2 and used as a fluorescence reporter molecule. Due to the high binding capacity of the MnO2 nanosheets and the high loading capacity of the MoS2 nanoflowers, the detection sensitivity of the molecularly imprinted fluorescence sensors was remarkably improved. Specific detection of CEA in the linear range of 0.01 ng/mL–10 μg/mL with a low LOD of 3.5 pg/mL (S/N = 3) was achieved. In addition, based on the MIPs and boronic affinity dual specific recognition ability, the detection selectivity was also improved. Finally, the concentration of CEA in human serum was determined by this approach.
研究领域:
生物化学
·
医学诊断
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）