JOURNAL OF BIOMATERIALS APPLICATIONS
·
2015
·
IF 2.197
Yan-Ling Luo,Yuan Wang,Xuan Wang,Feng Xu,Ya-Shao Chen
Tribrachia star-shaped random copolymers with tunable thermosensitive phase transition temperature were designed and synthesized via a simple one-pot ammonolysis reaction approach with trimesic acid as cores. The self-assembly micellization behavior of the copolymers in aqueous solution was examined by surface tension, UV–vis transmittance, transmission electron microscope, and dynamic light scattering measurements, etc. The results indicated that the resultant copolymers formed thermosensitive micelle aggregates through hydrophobic interactions among the isopropyl groups of poly(N-isopropylacrylamide) PNIPAM chains and inter-star association at a polymer concentration above critical aggregation concentrations from 4.06 to 6.55 mg L−1, with a cloud point range from 36.6℃ to 52.1℃, and homogeneously distributed micelle size below 200 nm. The arm length and the compositional ratios of the two comonomers had effect on physicochemical properties of the polymer micelle aggregates. Particularly, the cloud point values were enhanced as the (N,N-dimethylacrylamide) DMAM monomer was introduced and reached to 36.6℃ and 41.0℃–44.7℃ when the mass ratio of NIPAM to DMAM was 90:10 and 80:20, respectively. The thermo-triggered drug release and cytotoxicity were evaluated to confirm the applicability of the random copolymer micelle aggregates as novel drug targeted release carriers.
研究领域:
材料科学
·
药学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 34
·8788-8795
·
IF 5.256
Xiaofang Qi,Jing Peng,Dongyan Tang,Ning Wang,Hongyun Zou
Molybdenum oxide nanomaterials have received increasing attention in recent years for their strong localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region and pH-dependent degradability. However, the rapid degradation of MoOx at physiological pH values would decrease the NIR photothermal effect. Here, we designed and prepared PEGMa–MoOx/p(NIPAM-co-MAA) microgels (NCs) exhibiting adjustable degradation. For that purpose, PEGMa (Mn = 400) modified MoOx was synthesized through a simple hydrothermal process. Then, PEGMa–MoOx with existing CC groups was continually polymerized with NIPAM and MAA through emulsion polymerization. MAA was introduced to provide an acidic microenvironment (pH at 3–5) to control the degradation rate of PEGMa–MoOx. The photothermal efficiency of the NCs could be maintained at 54% even after 14 days. Meanwhile, the NCs also displayed a pH-dependent thermal response. Moreover, PEGMa was added again in the emulsion polymerization process to elevate the photothermal efficiency, and the irradiation result indicated that the NCs could increase the temperature by 27 °C. The complex microgel integrates pH/temperature/photothermal triple response characteristics and exhibits huge potential for chemo-photothermal combination cancer therapy.
研究领域:
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Fangbin Fan,Licheng Wang,Yijing Li,Xusheng Wang,Xiaofeng Lu,Yong Guo
l -Cysteine (L-Cys) and N-Isopropyl acrylamide (NIPAM)-modified silica spheres as a novel stationary phase for hydrophilic interaction liquid chromatography (HILIC) was produced firstly by cross-linking polymerization. Some characterizations in this article confirmed that the synthesis of Cys-Si-NIPAM is successful. Some polymer layers can be observed through transmission electron microscopy (TEM). In addition, through nitrogen adsorption porosity method, scanning electron microscopy (SEM), thermal gravimetric analysis (TGA) and other characterization methods, we can find the significant changes after modify. It has good hydrophilic property and higher column effect than bare silica column, Si-Cys column and Si-NIPAM column under the same conditions. It has good separation effect for some hydrophilic analytes such as 5 nucleosides and nucleoside bases, 5 amino acids , 4 sulfonamide drugs and 10 saccharides . The effects including column temperature, pH and organic solvent content on chromatographic performance were studied, which proved that hydrophilic interactions can be simultaneously existed between the stationary phase and the analytes. In addition, reproducibility and efficiency of the Cys-Si-NIPAM column was also investigated, the results illustrated that the stationary phase have passable stability (the intraday RSDs 0.08–0.44%, n = 3 and the interday RSD 0.46–3.50%, n = 3) and ideal efficiency (plates per meter, ~45700 plates/m). In conclusion, the preparation process of this hydrophilic liquid chromatography stationary phase is not only simple, but also can meet the basic requirements for the separation of hydrophilic analytes.
研究领域:
分析化学
·
色谱技术
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yuanpeng Cai,Danyang Li,Yufei Ling,Huihui Jiang,Hui Liu
A novel triple-responsive composite hydrogel, p(NIPAM-co-MAA-co-SPMA), was designed and synthesized via free radical polymerization, incorporating N-isopropylacrylamide (NIPAM) for temperature responsiveness, methacrylic acid (MAA) for pH sensitivity, and spiropyran methacrylate (SPMA) for light responsiveness. This study aimed to develop a novel stimuli-responsive sustained release drug delivery system. The composition and structure of the hydrogel were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Doxorubicin (DOX) was used as a model drug to evaluate loading and release behavior. The hydrogel achieved a drug loading content (DLC) of 25.7% and a drug loading efficiency (DLE) of 74.3% and enabled controlled release with approximately 89% cumulative DOX release within 6 h under combined thermal, acidic, and ultra-violet light stimuli. Cytotoxicity assays and cellular uptake studies confirmed the excellent biocompatibility of the hydrogel and its efficacy in suppressing cancer cell growth. These results highlight the potential of p(NIPAM-co-MAA-co-SPMA) as an intelligent platform for on-demand targeted anticancer therapy.
研究领域:
高分子材料科学
·
肿瘤学
·
药物递送系统
·
生物医学工程
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智能药物释放
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yanhua Liu,Yuanyue Li,Geoffrey I.N. Waterhouse,Chenchen Liu,Xiaohui Jiang,Zhiming Zhang,Liangmin Yu
A smart composite system based on thermosensitive polymers and photosensitive polyaniline (PANI) was constructed in this work, enabling efficient photo-driven adsorption and separation of anionic dyes within a short time. Thermosensitive copolymers (P(NIPAM-NVK)) of N -isopropylacrylamide (NIPAM) and N -vinylcarbazole (NVK) with adjustable low critical solution temperatures (LCST) were synthesized via a free radical copolymerization method. PANI was then composited with P(NIPAM-NVK) as a photothermal agent and dye adsorbent. The developed P(NIPAM-NVK)/PANI composite systems showed a rapid temperature increase under visible light irradiation, triggering the transition of P(NIPAM-NVK) from the sol state to a bulk gel state. Simultaneously, PANI and Congo Red (CR) anionic dye were efficiently encapsulated within the gel state of P(NIPAM-NVK) via intermolecular interactions, facilitating the rapid separation of aqueous CR through a direct solid–liquid process to yield clean water. The P(NIPAM-NVK 10 )/PANI 0.5 composite system afforded a removal efficiency > 98 % for CR (80 mg/L) within 5 min under visible light illumination. These findings hold great promise for the eco-friendly treatment of dye-containing wastewater.
研究领域:
材料科学
·
环境科学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 111
·91308-91314
·
IF 3.84
Chunning Heng,Meiying Liu,Ke Wang,Xiaoyan Zheng,Hongye Huang,Fengjie Deng,Junfeng Hui,Xiaoyong Zhang,Yen Wei
A highly benign, simple and effective strategy was successfully developed for the first time for the fabrication of hydrophilic thermo-responsive polymer modified silica nanoparticles (SiO2-PDA-poly(NIPAM)) at low temperature and under mild reaction conditions via a combination of mussel inspired chemistry and SET-LRP. The SiO2 NPs were first modified with polydopamine (PDA), which was formed by the self-polymerization of dopamine under rather mild conditions. 2-Bromo-2-methylpropionyl bromide was covalently attached on the surface of the PDA modified SiO2 NPs. Afterward, the poly(NIPAM) was grown in situ on the surface of the Br-containing SiO2 NPs by the SET-LRP method. Consequently, the surface of the SiO2-PDA nanoparticles is intrinsically covered by a layer of free poly(NIPAM) chains, which enables the poly(NIPAM) to be colloidally stable not only at room temperature, but also upon incubation in the presence of proteins under physiological conditions. After modifying with PNIPAM, the functional SiO2 NPs retain their pristine structure, however their dispersibility was significantly improved in polar and nonpolar solutions. As compared with previous methods, the strategy developed in this work is rather simple and effective. More importantly, due to the universality of mussel inspired chemistry, this novel strategy could also be used for the surface modification of many other materials.
研究领域:
材料科学
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聚合物化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2013
·
IF 5.008
Yi Gong,Ai Mei Zhu,Qiu Gen Zhang,Mei Ling Ye,Hai Tao Wang,Qing Lin Liu
Cell encapsulation by locking the interfacial microgels in a water-in-oil Pickering emulsion has currently been attracting intensive attention because of the biofriendly reaction condition. Various kinds of functional microgels can only stabilize an oil-in-water Pickering emulsion, and it is thus difficult to encapsulate cells in the emulsion where the cells are usually dispersed in the continuous phase. Herein, we introduce a facile method for preparing cell-embedded colloidosomes in an oil-in-water emulsion via polyelectrolyte complexation. Escherichia coli (E. coli) was chosen as a model cell and embedded in the thin shell of chitosan/poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AAc)) microcapsules. This is beneficial for expressing cell function because of the little resistance of mass exchange between the embedded cells and the external environment. Cells can be used in biocatalysis or biomedicine and our product will hold great promises to improve the performance in those fields. The synthesis route presents a platform to prepare cell-embedded microcapsules in an oil-in-water Pickering emulsion in a facile and biocompatible way. First, an emulsion stabilized by P(NIPAM-co-AAc) microgels was prepared. Then, the interfacial microgels in the emulsion were locked by chitosan to form colloidosomes. The mechanism of cell encapsulation in this system was studied via fluorescent labeling. The viability of E. coli after encapsulation is ca. 90%. Encapsulated E. coli is able to metabolize glucose from solution, and exhibits a slower rate than free E. coli. This demonstrates a diffusion constraint through the colloidosome shell.
研究领域:
生物技术
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Xiaobing Tang,Aihua Sun,Chengyi Chu,Chongyang Wang,Zhenzhong Liu,Jianjun Guo,Gaojie Xu
Multiresponsive photonic hydrogels (MRPHs) were prepared by magnetically controlled self-assembly of Fe 3 O 4 @C nanoparticles and these are sensitive to temperature, humidity, compression, tension and ethanol. This exhibits brilliant structural color thanks to the combination of AM and NIPAM monomers. Along with the increase of compression and tension on the MRPHs, the reflection peak of the samples blue shifts. When exposed MRPHs in environments with different humidity, its structure color red shifts as the humidity increases from 33% RH to 95% RH. Besides, the reflection peak redshift was observed when the MRPHs was immersed in absolute ethyl alcohol. This work may provide a new way to prepare smart photonic hydrogel with integrated functions of mechano-, humidity-, temperature- and solvent- responses.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2013
·Vol. 21
·期 12
·1338-1348
·
IF 1.639
Xu Yiting,Xie Jianjie,Chen Lingnan,Yuan Conghui,Pan Yinyin,Cheng Ling,Luo Weiang,Zeng Birong,Dai Lizong
A novel organic/inorganic hybrid amphiphilic random copolymer poly(methacrylate isobutyl POSS- co -N-isopropylacrylamide- co -oligo(ethylene glycol) methyl ether methacrylate- co -2-vinylpyridine), poly(MAPOSS- co -NIPAM- co -OEGMA- co -2VP), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The self-assembly behavior of random copolymers in aqueous solution was investigated by dynamic light scattering (DLS) as well as transmission electron microscopy (TEM). The results indicate the novel random copolymer in water could self-assemble into spherical aggregates and the self-aggregate size displays a remarkable dependence on pH. The stimuli-responsive characteristics of these assembles were tested by means of UV-vis spectra, DLS and TEM. There is a critic Zn 2+ concentration over which the aggregates can be coordinated into well-define spherical aggregate clusters. The critic Zn 2+ concentration can be tuned finely through adjusting solution concentration or 2VP amount. Results from UV-vis and DLS reveal that the copolymer solutions exhibit a sharp and intensive lower critical solution temperature (LCST). Some factors such as the solution concentration, molecular weight, pH and copolymer generation, which could affect the cloud point, were studied systematically. The essentially predetermined LCST can be achieved by altering the content of 2VP or pH. In addition, these novel hybrid aggregates can undergo an association/disassociation cycle with the heating and cooling of solution and the degree of reversibility shows a strong concentration dependence. As a novel organic-inorganic hybrid material which can respond to multiple external stimuli including temperature, pH, metal ions with sharp stimuli-responsive behaviors, it is potentially used for biomedicine, catalysis, diagnostics, bioseparations, biosensors and for fundamental investigation.
研究领域:
材料科学
·
高分子化学
·
生物医药
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Huali Li,Liuqin Zhang,Xiaohu Zhang,Shuwen Luo,Baoshan Yang,Min Wu,Wei-Hua Li,Fa-Qian Liu
The antifouling of marine facilities placed below the waterline is a key constraint to the development of the marine economy. Currently, commercial Cu 2 O-based antifouling coatings still have defects such as agglomeration, oxidation, short duration and high dosage. For this reason, we developed for the first time a triple antifouling system consisting of Cu 2 O@poly(NIPAM-co-DAm) (Cu 2 O@PND) dynamic redox microgels triggered by copper ions and polydimethylsiloxane (PDMS). The catechol groups of PND nanogels can chelate Cu 2+ and reduce it in situ to obtain Cu 2 O@PND microgels, which guarantees the stable release of Cu + . Furthermore, Cu 2 O remains stable and free from oxidation because of the electron transfer between PND and Cu 2+ . Finally, superior antifouling performance was achieved by combining the stable Cu + released from Cu 2 O, in situ conversion of PND to hydrogel, and its oxidation to produce active substances and H 2 O 2 , and PDMS coating with low surface energy.
研究领域:
材料科学
·
化学
·
海洋工程
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2022
·Vol. 14
·期 3
·284-294
·
IF 5.364
Xu Yang,Maosheng Lin,Jirui Wei,Jing Sun
We report the preparation of a series of polypeptoid derivatives with different side-chain functionalities by sequential photocleavage and thiol–ene reactions with high efficiency. In particular, thermo-responsive N-isopropylacrylamide (NIPAM) motifs were grafted onto polypeptoids to achieve the lower critical solution temperature (LCST) property. The incorporation of allyl groups to a block copolymer poly(ethylene glycol)-b-poly(N-(S-(o-nitrobenzyl)-thioethyl)glycine)-co-poly(N-allyl glycine) (PEG-b-PNSN-co-PNAG) enables the preparation of UV-initiated self-crosslinking nanogels for further immobilization of lipase and gold nanoparticles in aqueous solution. The obtained hybrid nanogels exhibit significantly enhanced catalytic efficiency and adjustable bioactivity as compared to the free lipase and gold nanoparticles. The hybrid nanogel showed a significantly higher conversion value of >200% compared to native lipase. By incorporating the NIPAM motifs, thermoresponsive hybrid nanogels have been fabricated and 89.8% of the residual enzymatic activities are retained at 50 °C. This work provides a facile and efficient approach to prepare multifunctional bioinspired platforms under mild conditions that offer increased catalytic efficiency and stability.
研究领域:
材料科学
·
化学工程
·
生物催化
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2021
·Vol. 5
·期 3
·2223-2234
·
IF 5.693
Chen Ruixia,Shi Jun,Liu Chongchong,Li Jingguo,Cao Shaokui
Multi-responsive hybrid microgels have attracted lots of attention in biomedical filed owing to the tunable degree of flexibility, high particle stability, and remarkable sensitivity to external stimuli. In this paper, a novel remote drug delivery platform based on gold nanorods (AuNRs)-P(NIPAM-co-AAc) (PNA) hybrid microgel was prepared by electrostatic self-assembly approach. The electrostatic self-assembly of mercapto-modified polyethylene glycol (mPEG) and polyallylamine hydrochloride (PAH) was utilized to safeguard AuNRs, which could greatly enhance the stability of AuNRs and endow AuNRs-PNA hybrid microgels with excellent physiological dispersibility and stability. More importantly, due to the change of electrostatic force between microgels and DOX at different pH values, as well as the thermal sensitivity of PNA and NIR response of AuNRs, AuNR-PNA hybrid microgels displayed prominently pH/temperature/NIR synergistic responsive drug release performance. This paper furnishes a green and feasible method to prepare intelligently remotely controllable hybrid microgels with great physiological stability, which has great perspectives in photothermal therapy and remotely controllable drug delivery area. Graphical abstract pH/temperature/NIR synergistic responsive AuNRs-P(NIPAM-co-AAc) hybrid microgel for smart drug delivery was prepared by in situ self-assembly.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）