Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 24
·5565-5573
·
IF 7
Xuran Zhang,Jianfei Ding,Liang Zou,Huihui Tian,Ying Fang,Jinfen Wang
Near-infrared optogenetics based on up-conversion materials provides a promising tool for the dissection of neural circuit functions in deep brain regions. However, it remains a challenge to combine near-infrared up-conversion optogenetic stimulation with high-density electrophysiological recording in a minimally invasive manner. Here, we develop a flexible device for simultaneous electrophysiological recording and near-infrared optogenetics. The flexible device is constructed by integrating polymer-based flexible recording microelectrodes with electrodeposited NaYF4:Yb3+, Er3+ up-conversion films that can convert deep-tissue-penetrating near-infrared light into visible light for optogenetic activation of C1V1-expressing neurons. The emission properties of the up-conversion films are optimized for green light emission to stimulate C1V1 opsins. Owing to their minimized surgical footprint and high mechanical compliance, chronically implanted devices enable simultaneous electrophysiological recording and near-infrared optogenetic modulation of neuronal activities in the brain.
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MATERIALS & DESIGN
·
2023
·
IF 8.4
Shuai Zha,Siyu Pan,Yuehan Jian,Yunhui Peng,Lijun Jiang
Hydrogen sulfide (H 2 S), a third gas signaling molecule, is considered to play a vital role in the development and treatment of diseases. To elucidate the intricate role of H 2 S in the organism and its participation in disease processes, there is an urgent need to visualize the dynamics of H 2 S. However, most currently available molecular probes have limitations in terms of sensitivity, specificity, and precision. In this study, the safe and biocompatible upconversion nanosensor NaYF 4 :Yb 3+ , Tm 3+ @NaYF 4 anchored with Ag 2 O was successfully fabricated for H 2 S detection with an ultralow detection limit at 0.93 ng/mL. NaYF 4 :Yb 3+ , Tm 3+ @NaYF 4 @Ag 2 S is formed through in situ sulfuration reaction, and second near-infrared (NIR-II) fluorescence can be recorded upon the presence of H 2 S under 808 nm excitation. The results demonstrate the exceptional detection linearity and high specificity for H 2 S quantification. Additionally, NaYF 4 :Yb 3+ , Tm 3+ @NaYF 4 @Ag 2 O possesses a safe nature in normal and cancer cells. This nanosensor presents a NIR fluorescence imaging strategy for highly sensitive and specific detection of H 2 S, which has promises to be a practical tool for biomedical applications.
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Materials Research Express
·
2023
·Vol. 10
·期 8
·086201
·
IF 2.3
Bing Liu,Jingheng Liang,Lili Wang,Zian Cheak Tiu
β-NaYF4: Yb3+/Tm3+/Zr4+ microcrystals are synthesized by a facile hydrothermal route. The up-conversion (UC) luminescence and photoelectric effects are enhanced simultaneously with the introduction of Zr4+ ions under IR excitation. With the Tm3+ ions fluorescence spectra under 980 nm excitation, the blue and red emissions reached the highest intensity in the case of 4 mol% Zr4+ doping. Taking the advantage of Zr4+ stimulates the free electrons transfer from the valence band (VB) to the conduction band (CB) in β-NaYF4:Yb3+/Tm3+/Zr4+ microcrystals, the photocurrent reached the highest intensity in the case of 4 mol% Zr4+ doping at 780 nm excitation. The β-NaYF4: Yb3+/Tm3+/Zr4+ microcrystals with both enhanced UC luminescence and photoelectric properties are highly potential to contribute in photovoltaic and infrared sensors application.
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DALTON TRANSACTIONS
·
2021
·Vol. 50
·期 31
·10838-10844
·
IF 4.39
Xia Xu,Meirong Fu,Penghui Li,Min Yang
While photothermal therapy is widely applied in phototherapy, there are still challenges in developing new generation phototherapy materials with precise diagnostic functions. Here we report the construction of a pH responsive upconversion fluorescence imaging precisely guided photothermal therapy system, namely NaYF4:Yb3+/Er3+@NaYF4@MnO2@Au nanocomposites, which can effectively avoid light damage to non-target tissues. Owing to the fluorescence resonance energy transfer between the upconversion nanocrystal donor and MnO2 and Au acceptor, the upconversion fluorescence is completely quenched. However, in pH 5.3 PBS buffer, MnO2 is gradually broken down, and the upconversion fluorescence is partially recovered, which could be used for upconversion fluorescence imaging to precisely guide photothermal therapy under 980 nm excitation. Simultaneously, due to the absorption of 980 nm excitation light and the emission bands of Er3+ (2H11/2 → 4I15/2 and 4S3/2 → 4I15/2 transition), temperature increment of core@shell@MnO2@Au could reach 35.5 °C under 980 nm excitation at 0.8 W cm−2. The core@shell@MnO2@Au nanocomposites are supposed to contribute significantly in the biological applications of photoluminescence imaging and photothermal therapy.
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Nanoscale
·
2012
·Vol. 5
·期 3
·1047-1053
·
IF 5.914
Fuyao Liu,Qi Zhao,Hongpeng You,Zhenxin Wang
Here, a two-step method has been developed for synthesizing carboxy-terminated NaYF4: Yb3+, Er3+@SiO2 core@shell nanoparticles (UCNP@SiO2) with ultrathin shell (1.5 nm). First, the NaYF4: Yb3+, Er3+ upconverting nanoparticles (UCNPs) were prepared using solvothermal technology; then, silica shells (SiO2) were deposited on the nanocrystals to form core–shell structures by the hydrolysis of tetraethylorthosilicate (TEOS). The ultrathin SiO2 shell was obtained by increasing surfactant amount and decreasing TEOS amount in the reaction mixture. Carboxyethylsilanetriol (CTES) was used to generate the carboxy group on the particle surface. The carboxy-terminated UCNP@SiO2 are ideally suited for biolabeling and bioimaging applications because the as-prepared nanoparticles have extreme colloidal and optical stabilities, and the carboxy groups on the particle surface easily react with amino residues of biomolecules. As an example, we reported on the interactions of Ricinus Communis Agglutinin (RCA 120) conjugated UCNP@SiO2 with HeLa cells. The excellent performance of the RCA 120 conjugated UCNP@SiO2 in cellular fluorescence imaging was demonstrated.
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RSC Advances
·
2014
·Vol. 4
·期 107
·62802-62808
·
IF 3.708
Yan Song,Guixia Liu,Xiangting Dong,Jinxian Wang,Wensheng Yu,Jingmei Li
Bifunctional hybrid nanocomposites based on upconversion luminescence and photothermal properties have a wide range of application, especially biomedical diagnosis and therapy. Herein, the hybrid nanocomposites were prepared via combining NaYF4:Yb3+,Er3+/Ho3+ nanocrystals as shell layer materials and Au nanoparticles as the cores. The as-prepared nanocomposites can simultaneously take advantage of both the upconversion luminescence of NaYF4:Yb3+,Er3+/Ho3+ nanocrystals and the photothermal transduction property of Au nanoparticles. The structure, morphology and composition of the nanocomposites were confirmed by X-ray powder diffraction (XRD), transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS). In addition, the upconversion luminescence and photothermal transduction were evaluated. We observed an overlap between the absorption band of Au nanoparticles and the upconversion emission peaks of the Er3+/Ho3+ ions, and the luminescence resonance energy transfer (LRET) was studied and demonstrated. Under 980 nm laser irradiation, upconversion luminescence and efficient photothermal transduction of the hybrid nanocomposites were found. Moreover, the bifunctional nanocomposites also have shown excellent biocompatibility.
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Catalysis Science & Technology
·
2025
·
IF 4.2
Yuangong Ma,Youlin Huang,Wensheng Zhang,Zhishan Liang,Bo Ding,Dongfang Han,Dongxue Han,Li Niu
In the domain of photocatalysis, harnessing solar energy, particularly the near-infrared (NIR) spectrum, presents formidable challenges. To overcome these, a novel NIR-responsive photocatalyst, denoted as NYT@ZnO@RGO@Ag, was meticulously crafted. This photocatalyst comprises a NaYF4: Yb3+, Tm3+@ZnO structure supported on reduced graphene oxide (RGO) and further composited with silver nanoparticles. It was rigorously evaluated for its performance in photodegrading tetracycline (TC) antibiotics as a model compound. Leveraging the unique properties of upconversion materials, wide bandgap semiconductors, and localized surface plasmon resonance (LSPR), the NYT@ZnO@RGO@Ag catalyst exhibited an impressive photodegradation rate of 93.6% for TC under NIR light exposure. This efficiency surpassed that of NYT@ZnO (38.2%) and NYT@ZnO@RGO (72.3%). The remarkable enhancement in NIR-driven photocatalysis observed in NYT@ZnO@RGO@Ag is primarily attributed to the efficient process of fluorescence resonance energy transfer (FRET) from NYT to its each component. This process enhances photo-induced carrier generation and facilitates efficient transfer and energy utilization under NIR irradiation. The present study offers a promising approach for NIR-driven photocatalytic degradation of pollutants in environments with limited light exposure or even under dark conditions.
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Science of Advanced Materials
·
2017
·
IF 1.671
Li Zhaozhi,Li Yuebin,Zhang Xianghui,Wang Lin,Hu Bo,Zhang Yi,Gu Haoshuang,Chen Wei
Near infrared (NIR)-to-visible upconversion nanoparticles of pure hexagonal phase β-NaYF4: Yb3+, Er3+ nanocrystals were successfully synthesized by a high boiling temperature organic phase synthesis strategy in oleic acid (OA), which acted
as a ligand. The upconversion photoluminescence intensity of the nanocrystals was modulated by varying the reaction temperature and the concentration of sensitizer Yb3+ ions and activator Er3+ ions. The prepared nanocrystals were investigated by transmission electron
microscopy (TEM), X-ray powder diffraction (XRD), and photoluminescence spectroscopy. All the results show that the as-prepared monodispersed upconversion nanocrystals emit high photoluminescence when excited by a 980 nm laser. It was found that the up-conversion emission spectra of β-NaYF4:
Yb3+, Er3+ presented three peaks at about 655, 540, and 521 nm. The optimized concentrations of the sensitizer Yb3+ and the activator Er3+ are 20% and 2% mmol, respectively. These highly efficient nanocrystals have exhibited great potential in bioimaging
and photoelectronic devices.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2015
·
IF 2.999
Chuanying Wang,Xianhua Cheng
β-NaYF 4 :Yb 3+ /Er 3+ microcrystals codoped with Cr 3+ ions were prepared for the first time via a facile hydrothermal method . The influence of doping concentration of Cr 3+ ions on growth and upconversion (UC) luminescence properties of β-NaYF 4 :Yb 3+ /Er 3+ microcrystals were investigated in detail. Scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectra and photoluminescence (PL) spectra were used for characterization. The results demonstrated that the morphology and size of β-NaYF 4 :Yb 3+ /Er 3+ microcrystals were influenced by doping concentration of Cr 3+ ions, the possible mechanism was proposed. The UC intensity of β-NaYF 4 :Yb 3+ /Er 3+ microcrystals was significantly enhanced by doping of Cr 3+ ions. In contrast to β-NaYF 4 :Yb 3+ /Er 3+ microcrystals without doping of Cr 3+ ions, the green and red emission intensities of the microcrystals codoped with 15 mol% Cr 3+ ions were enhanced by 16 and 7 times, respectively. The enhancement of the UC intensities should be ascribed to the distortion of local symmetry around Er 3+ ions, the UC mechanism was discussed. This work will be helpful for improving the UC intensity of other lanthanide-doped UC nano- and micro-crystals.
研究领域:
材料科学
·
无机化学
·
光功能材料
·
纳米医学
·
生物成像
·
分子影像学
·
光学材料
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OPTICAL MATERIALS
·
2023
·
IF 3.9
Xiandi Yu,Qianshu Xia,Peng Liu,Yan Xu
Lanthanide-doped upconversion (UC) nanomaterials with zero background auto-fluorescence are of extensive interest in optical fields. Here, a NaYF 4 :Yb 3+ /Er 3+ @Zr-UiO-66 nanostructure was prepared by simultaneously encapsulating NaYF 4 :Yb 3+ /Er 3+ nanoparticles (NPs) and promoting the nucleation of UiO-66 under solvothermal condition. Traditional nanosize-surface induced defects and grain boundaries of NaYF 4 :Yb 3+ /Er 3+ upconversion nanoparticles (UCNPs) were greatly minimized; enabling a highly efficient energy transfer confirmed by the prolonged fluorescence lifetime and enhanced UC emission of NaYF 4 :Yb 3+ /Er 3+ @Zr-UiO-66 nanocomposite. The optical thermometry property of nanocomposite was investigated based on the fluorescence intensity ratio (FIR) technique in the temperature range of 303–393 K. The maximum relative temperature sensitivities (S r ) were calculated to be 1.02 and 0.73% K −1 based on a pair of thermally coupled energy levels (TCLs) of ( 2 H 11/2 → 4 I 15/2 , 4 S 3/2 → 4 I 15/2 ) and another pair of non-thermally coupled energy levels (NTCLs) of ( 2 H 11/2 → 4 I 15/2 , 4 F 9/2 → 4 I 15/2 ), respectively. Besides, it exhibited effective internal optical heating property due to the thermal excitation between the two adjacent TCLs of 2 H 11/2 and 4 S 3/2 in NaYF 4 :Yb 3+ /Er 3+ UCNPs as heated by increasing the laser power. This work demonstrates a feasible confined synthesis of NaYF 4 :Yb 3+ /Er 3+ @Zr-UiO-66 nanocomposite with extreme UC emitting performance, and it holds great potential acting as both ratiometric thermometer and optical heater for multifunctional applications.
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Nanomaterials
·
2022
·Vol. 12
·期 5
·728
·
IF 5.719
Wei Zhang,Yang Zang,Yanli Lu,Jinghui Han,Qingyun Xiong,Jinping Xiong
In this study. a novel near-infrared fluorescent-driven contrast agent (Ag-doped NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4) was synthesized using a coprecipitation-hydrothermal-solvothermal-solvothermal (CHSS) method. The results shows that hexagonal NaYF4:Yb3+/Er3+with a diameter of 300 nm was successfully synthesized by the CHSS method. The new contrast agent was characterized using scanning electron microscopy, fluorescence spectrometry, transmission electron microscopy, energy-dispersive spectrometry and ultraviolet-visible light diffuse reflectance absorption spectroscopy. Even at low concentrations (0.2 M), this proposed contrast agent can be excited by near-infrared light with a wavelength of 980 nm and emits a dazzling green light with a wavelength of 540 nm, and the comparison of the luminescence intensity proves that doping with silver increases the luminescence intensity of the upconverted nanomaterial by nearly 13 times based on the calculated quantum yield. TEM images show the successful preparation of silver nanoparticles with a diameter of 30 nm, and the energy spectrum shows the successful doping of silver nanoparticles and the successful preparation of the core-shell structure of NaYF4:Yb3+/Er3+@NaYF4:Nd3+@NaGdF4. Furthermore, the mechanism of the increased luminous intensity has been studied using simulation calculations. Finally, cytotoxicity tests were used to test material which was modified by 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2K), and the biocompatibility was significantly improved, meeting the standard for biological applications.Keywords:upconversion;near-infrared;intensity;in vivo imaging
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TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
·
2020
·
IF 2.615
Yin CHEN,Shao-wen XIE,Chao TONG,Hai-hu TAN,Li-jian XU,Na LI,Jian-xiong XU
Novel hydrophilic NaYF 4 :Yb 3+ ,Tm 3+ @NaGdF 4 :Ce 3+ ,Eu 3+ double-jacket microtubes (DJMTs) with upconversion/ downconversion dual-mode luminescence were designed and prepared through epitaxial growth of NaGdF 4 :Ce 3+ , Eu 3+ shell onto the NaYF 4 :Yb 3+ ,Tm 3+ microtube via poly(acrylic acid) (PAA) mediated hydrothermal method. It is demonstrated that PAA ligand played an important role in guiding the direct growth of NaGdF 4 :Ce 3+ ,Eu 3+ shell onto the surface of NaYF 4 :Yb 3+ ,Tm 3+ parent microtubes. The growth of NaGdF 4 :Ce 3+ ,Eu 3+ shell experienced a crystal phase transition from β -NaGdF 4 and β -NaYF 4 mixture to β -NaYF 4 @NaGdF 4 composite crystal, and morphology evolution from mixture of β -NaGdF 4 :Ce 3+ ,Eu 3+ nanorods and β -NaYF 4 :Yb 3+ ,Tm 3+ microtubes to NaYF 4 :Yb 3+ ,Tm 3+ @NaGdF 4 : Ce 3+ ,Eu 3+ DJMTs. The formation mechanism of DJMTs was the dissolution−renucleation of β -NaGdF 4 :Ce 3+ ,Eu 3+ nanorods and the growth of β -NaGdF 4 :Ce 3+ ,Eu 3+ shell via the classical Ostwald ripening mechanism. The as-prepared DJMTs could exhibit blue upconversion and red downconversion luminescence, which was further made into environmentally benign luminescent inks for creating highly secured and fluorescent-based anti-counterfeiting patterns via inkjet printing.
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危险品化学品经营许可证（带存储）