MOLECULES
·
2019
·Vol. 24
·期 20
·3806
·
IF 3.06
Qiao Zhang,Yi Zhang,Shi-Kang Zhou,Kan Wang,Min Zhang,Pei-Dong Chen,Wei-Feng Yao,Yu-Ping Tang,Jian-Hua Wu,Li Zhang
The dried roots ofEuphorbia kansuiS.L.Liou ex S.B.Ho have long been used to treat edema in China. However, the severe toxicity caused byEuphorbia kansui(EK) has seriously restricted its clinical application. Although EK was processed with vinegar to reduce its toxicity, the detailed mechanisms of attenuation in toxicity of EK stir-fried with vinegar (VEK) have not been well delineated. Diterpenoids are the main toxic ingredients of EK, and changes in these after processing may be the underlying mechanism of toxicity attenuation of VEK. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol (3-O-EZ) is one of the diterpenoids derived from EK, and the content of 3-O-EZ was significantly reduced after processing. This study aims to explore the underlying mechanisms of toxicity reduction of VEK based on the change of 3-O-EZ after processing with vinegar. Based on the chemical structure of 3-O-EZ and the method of processing with vinegar, simulation experiments were carried out to confirm the presence of the product both in EK and VEK and to enrich the product. Then, the difference of peak area of 3-O-EZ and its hydrolysate in EK and VEK were detected by ultra-high-performance liquid chromatography (UPLC). Furthermore, the toxicity effect of 3-O-EZ and its hydrolysate, as well as the underlying mechanism, on zebrafish embryos were investigated. The findings showed that the diterpenoids (3-O-EZ) in EK can convert into less toxic ingenol in VEK after processing with vinegar; meanwhile, the content of ingenol in VEK was higher than that of EK. More interestingly, the ingenol exhibited less toxicity (acute toxicity, developmental toxicity and organic toxicity) than that of 3-O-EZ, and 3-O-EZ could increase malondialdehyde (MDA) content and reduce glutathione (GSH) content; cause embryo oxidative damage by inhibition of the succinate dehydrogenase (SDH) and superoxide dismutase (SOD) activity; and induce inflammation and apoptosis by elevation of IL-2 and IL-8 contents and activation of the caspase-3 and caspase-9 activity. Thus, this study contributes to our understanding of the mechanism of attenuation in toxicity of VEK, and provides the possibility of safe and rational use of EK in clinics.Keywords:Euphorbia kansui;diterpenoids;vinegar processing;zebrafish toxicity
研究领域:
药理学
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毒理学
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中药学
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化学
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生物学
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DOI
PubMed
高影响因子
OPTICAL MATERIALS
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2024
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IF 3.8
Worku Lakew Kebede,Kuo Dong-Hau,Chen Xiaoyun
Metal oxide semiconductor photocatalysts have received remarkable consideration as a promising technology for environmental remediation and energy conversion. Oxysulfide semiconductors have narrow band gaps which are appropriate for photocatalytic removal of toxic organic pollutants under visible light illumination. For the elimination purpose of these pollutants, Mo(O,S) 2 , Mn(O,S) 2 , and Mn–Mo(O,S) 2 oxysulfide catalysts containing various Mn contents were synthesized at low temperatures via a simple method. The structural, morphological, electrochemical, compositional, and optical properties of the as-synthesized catalysts were exhaustively characterized. The photocatalytic degradation activity of the bares Mo(O,S) 2 , Mn(O,S) 2 , and other Mn–Mo(O,S) 2 compositions were evaluated over different types of organic pollutants under visible light illumination. The addition of Mn in Mo(O,S) 2 structure improved the photodegradation activity, and Mn–Mo(O,S) 2 -30 was found to be the best composition with superior photodegradation performance towards the four cationic, anionic, and neutral dyes. The degradation efficiency of 10 ppm of MB, and MO dyes reach 99.7 % and 98.6 %, within 30 and 120 min, respectively. Mn–Mo(O,S) 2 -30 catalyst also shows a good photodegradation performance on Rh B and NR organic pollutants. According to the recycling test, the catalyst exhibited excellent performance. The photodegradation follows pseudo-first order kinetics with a rate constant of 0.097 and 0.036 min −1 for MB and MO dyes, respectively. The trapping experiment showed that superoxide anion radicals (O 2 •- ) and holes (h + ) are the responsible active species for the degradation on MO and MB, respectively. The novelty of using Mn–Mo(O,S) 2 -30 for various dyes degradation lies in its remarkable catalytic properties.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
CHEMBIOCHEM
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2024
·
IF 2.6
Wen Fu,Zhongli Shao,Zhiping Xu,Zhong Li,Xusheng Shao
Graphical NP-TBZ is developed by covalently linking o -nitrobenzyl ( NP ) with thiabendazole ( TBZ ). Compound NP-TBZ can be controlled to release TBZ in dependent to light, which resulted in controllable in-vivo activity against wheat scab. It is promising for spatiotemporal controlled-release of TBZ in factual applications, posing a theoretical guidance in development of controlled-release pesticides. Pesticides are essential in agricultural development. Controlled-release pesticides have attracted great attentions. Base on a principle of spatiotemporal selectivity, we extended the photoremovable protective group (PRPG) into agrochemical agents to achieve controllable release of active ingredients. Herein, we obtained NP-TBZ by covalently linking o -nitrobenzyl ( NP ) with thiabendazole ( TBZ ). Compound NP-TBZ can be controlled to release TBZ in dependent to light. The irradiated and unirradiated NP-TBZ showed significant differences on fungicidal activities both in vitro and in vivo. In addition, the irradiated NP-TBZ displayed similar antifungal activities to the directly-used TBZ , indicating a factual applicability in controllable release of TBZ . Furthermore, we explored the action mode and microcosmic variations by SEM analysis, and demonstrated that the irradiated NP-TBZ retained a same action mode with TBZ against mycelia growth.
研究领域:
农业科学
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植物保护
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2025
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IF 7.2
Xuyao Qiao,Shuguang Ning,Hongyao Zhao,Ruiting Ni,Wanyu Zhang,Yangping Zhang,Linzhi Zhai,Danhong Shang,Yanyun Wang,Tongyi Yang,Mengnan Wang,Fu Yang
Addressing the dual challenges of freshwater scarcity and pollution elimination requires innovative technologies that rationally integrate multiple functions. This study developed a representative dual-functional solar evaporator by coupling photothermal Fe₃O₄ nanospheres with oxygen-doped CdS (CdS-O) within a sponge-based hydrogel matrix, achieving concurrent high-efficiency solar-driven water regeneration and pollutant degradation. The design leverages the unique roles of two unique components, wherein, Fe₃O₄ endows the evaporator with broadband solar absorption (300–800 nm) and an superior photothermal conversion efficiency of 80 %, while oxygen doping CdS-O narrows its bandgap (from 2.31 eV to 2.29 eV), enhancing visible-light harvesting and charge separation. Crucially, the synergistic interplay between Fe₃O₄ and CdS-O establishes a self-sustained photo-Fenton-like mechanism. CdS-O generates H₂O₂ via photogenerated electron reduction of O₂, and Fe₃O₄ acts as an electron acceptor to accelerate Fe 3 + /Fe 2+ cycling, Fe²⁺ ions react with H₂O₂ via a Fenton-like process to produce ·OH radicals for pollutant mineralization. Simultaneously, the hydrogel-sponge architecture ensures rapid water transport and localized heat confinement, enabling an evaporation rate of 1.55 kg·m −2 ·h −1 under 1 sun irradiation. The system demonstrates remarkable dual-functionality: 86.9 % tetracycline degradation in lake water within 240 minutes and 89 % photocatalytic activity retention after six cycles. This work overcomes the limitations of conventional single-function systems by unifying photothermal evaporation and photocatalytic oxidation into a scalable platform, offering a sustainable solution for simultaneous water production and purification through material synergy and energy-efficient design.
研究领域:
环境科学
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材料科学
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能源技术
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2020
·Vol. 21
·期 6
·2211
·
IF 4.556
Wei Zhang,Danyang Li,Jianguang Zhang,Lingli Jiang,Zhaofa Li,Jun Sheng Lin
The compound 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethane (o,p’-DDT) has been identified as one of the endocrine-disrupting chemicals causing adverse effects on wildlife and even humans through bioaccumulation. Its detection has become increasingly important. We have obtained candidate aptamers binding too,p’-DDT by a systematic evolution of ligands by exponential enrichment (SELEX) protocol. Five out of seventeen candidate sequences were selected for preliminary characterization by SYBR Green I assay. One sequence with highest fluorescence response witho,p’-DDT, designated DDT_13, was chosen for further characterization. Its dissociation constant (Kd) was determined to be 412.3 ± 124.6 nM. DDT_13 exhibited low cross-binding activities on other tested small molecules. The good bioactivities of DDT_13 were demonstrated for the analysis of spiked lake water and tap water samples. This study provides a novelo,p’-DDT-specific probe for its future applications.Keywords:o,p’-DDT;aptamer;SELEX;AuNPs;biosensor;real water sample
研究领域:
环境科学
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分析化学
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生物化学
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产品关联
DOI
PubMed
高影响因子
Science China-Materials
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2022
·Vol. 66
·期 3
·1062-1070
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IF 8.64
Wang Yang,Chen Sai,Sun Jiachen,Xie Yufei,Zhao Zhi-Jian,Pei Chunlei,Gong Jinlong
Supported vanadium oxides (VO x ) are alternative candidates for non-oxidative propane dehydrogenation (PDH) owing to their competitive performance. This paper describes the roles of V−O sites on PDH over monomeric VO x species supported on ZrO 2 , Al 2 O 3 and SiO 2 . With the control of pre-reduction, stable structures of V−O sites are obtained for PDH, including V−O-support (V−O−S), V−OH and V=O sites. By tuning the V densities over individual support, the propylene formation rate shows a linear correlation with the number of the V−O−S site, which indicates the V−O−S site plays a decisive role in PDH rather than V−OH and V=O sites. Moreover, the specific activity per V−O−S site over ZrO 2 (8.2 × 10 −3 s −1 ) is higher than those over Al 2 O 3 (6.7 × 10 −3 s −1 ) and SiO 2 (2.8 × 10 −3 s −1 ), due to the discrepant Lewis acidity of various V−O−S sites. This research provides a fundamental insight into the intrinsic nature of V−O sites for non-oxidative propane dehydrogenation.
研究领域:
催化化学
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材料科学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 15
·2769
·
IF 3.06
Xican Li,Xiaojian Ouyang,Minshi Liang,Dongfeng Chen
The biological process, 3-O-galactosylation, is important in plant cells. To understand the mechanism of the reduction of flavonol antioxidative activity by 3-O-galactosylation, myricetin-3-O-galactoside (M3OGa) and myricetin aglycone were each incubated with 2 mol α,α-diphenyl-β-picrylhydrazyl radical (DPPH•) and subsequently comparatively analyzed for radical adduct formation (RAF) products using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS) technology. The analyses revealed that M3OGa afforded an M3OGa–DPPH adduct (m/z873.1573) and an M3OGa–M3OGa dimer (m/z958.1620). Similarly, myricetin yielded a myricetin–DPPH adduct (m/z711.1039) and a myricetin–myricetin dimer (m/z634.0544). Subsequently, M3OGa and myricetin were compared using three redox-dependent antioxidant analyses, including DPPH•-trapping analysis, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•)-trapping analysis, and•O2inhibition analysis. In the three analyses, M3OGa always possessed higher IC50values than those of myricetin. Conclusively, M3OGa and its myricetin aglycone could trap the free radical via a chain reaction comprising of a propagation step and a termination step. At the propagation step, both M3OGa and myricetin could trap radicals through redox-dependent antioxidant pathways. The 3-O-galactosylation process, however, could limit these pathways; thus, M3OGa is an inferior antioxidant compared to its myricetin aglycone. Nevertheless, 3-O-galactosylation has a negligible effect on the termination step. This 3-O-galactosylation effect has provided novel evidence that the difference in the antioxidative activities of phytophenols exists at the propagation step rather than the termination step.
研究领域:
植物化学
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生物化学
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分析化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Wei Li,Chong Qiao,Jing Pang,Guolin Zhang,Yinggang Luo
Amaryllidaceae alkaloids are unique benzylphenethylamine derivatives that comprise of more than 600 members with a huge chemical diversity. Most of them showed interesting bioactivities, for instance, galanthamine (GAL) is clinically used for Alzheimer's disease treatment. All Amaryllidaceae alkaloids had been thought to be derived from 4′- O -methylnorbelladine originated from norbelladine catalyzed by norbelladine 4′- O -methyltransferase (N4OMT). Herein we mined the transcriptome datasets of Lycoris radiata , a GAL-producing plant. LrOMT was cloned, overexpressed in Escherichia coli , and purified to homogeneity. Bioinformatics analysis and enzymatic activity assays revealed that LrOMT is an S-adenosylmethionine-dependent Class I OMT. LrOMT exhibited both para - and meta - O -methylation activities toward norbelladine to give 4′- and 3′- O -methylnorbelladine. Twenty-four analogues, including the proposed biosynthetic intermediates, were introduced to investigate the substrate scope of LrOMT and it showed that the aromatic substrates should have two vicinal hydroxyl groups. The LrOMT-catalyzed O -methylation preference is dependent on the properties of the binding group of the substrates. The transcription levels of LrOMT were positively associated with the accumulation of the Amaryllidaceae alkaloids and the biosynthetic intermediates in L. radiata . The present work revealed that LrOMT catalyzes multiple O -methylation reactions and its characterization will be helpful to uncover novel biosynthetic genes for Amaryllidaceae alkaloids biosynthesis.
研究领域:
植物生物化学
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酶学
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分子生物学
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生药学
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产品关联
DOI
PubMed
高影响因子
Small
·
2021
·Vol. 17
·期 47
·2104083
·
IF 13.281
Lu Cheng,Fengxia Wu,Haibo Bao,Fenghua Li,Guobao Xu,Yongjun Zhang,Wenxin Niu
Nanozymes have offered remarkable advantages over natural enzymes and found widespread applications including biosensors, immunoassays, nanomedicines, and environmental remediation. Oxidation of o -phenylenediamine (OPD) by nanozymes has been listed as a standard protocol for determining nanozyme activities. Given the complexity of OPD oxidation processes, however, the mechanism of nanozyme-catalyzed oxidation of OPD remains elusive. In this report, mechanistic studies of nanozyme-catalyzed oxidation of OPD are performed and a distinguishably different mechanism from that of natural enzymes is found. A combination of Fourier transform infrared spectroscopy, nuclear magnetic resonance, electrospray ionization mass spectrometry, and electron microscopic studies provides compelling evidence that polymerization of OPD occurs on the surface of several different nanozymes. The unexpected polymerization causes a dense coating layer of poly( o -phenylenediamine) (POPD) on nanozymes renders the intrinsic properties of nanozymes. Therefore, this fundamental discovery raise serious concerns using OPD-based colorimetric method for determining nanozyme activities. Without examining the surface change of nanozymes after catalytic reactions, the use of OPD-based colorimetric method for determining nanozyme activities is strongly discouraged. Furthermore, POPD is discovered as a new oxidase mimic, and this new mechanism also provides a general and robust method to coat nanomaterials with POPD polymers of enzyme-mimicking properties.
研究领域:
生物化学
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纳米生物学
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材料科学
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产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Chao Yang,Hao Chen,Yuankai Li,Zhelin Su,Yeshuang Wang,Xufei Liu,Huiling Fan
The low sulfur selectivity of Fe-based H2S-selective catalytic oxidation catalysts is still a problem, especially at a high O2 content. This is alleviated here through anchoring FeOx nanoclusters on UiO-66 via the formation of Fe–O–Zr bonds. The introduced FeOx species exist in the form of FeIII and FeII. Therein the FeIII–O species are the predominant active sites for H2S-oxidation. The formed Fe–O–Zr bonds strengthen the redox cycle of FeIII/FeII through promoting electron transfer from Fe to Zr. The FeII–O species can activate molecular oxygen to oxidize H2S into elemental S, which accelerates the formation rate of atomic S, hindering its further oxidation into SO2. The combination of these factors empowers the catalysts, enabling 100% H2S conversion and 98.2% sulfur yield. The catalyst also has satisfactory stability with the sulfur selectivity only decreasing from 98.2% to 91.3% after the reaction going on 50 h. The decreased sulfur selectivity might be caused by the deterioration of pores and the deposition of elemental S on the surface. The former hinders the diffusion of sulfur oligomers timely from pores to the gas phase, while the latter is suspected to capture electrons to promote its further reaction with molecular oxygen.
研究领域:
化学工程
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Tingyuan Zhang,Lingxiao Song,Jiahui Yang,Jiajia Wang,Dong Feng,Baojun Ma
Heteroatom doping is a promising strategy for optimizing the photocatalytic activity of semiconductors. However, relying solely on single-element doping often poses challenges in modulating the capabilities of semiconductors. Herein, we adopt a strategy of simultaneously modifying ZnIn 2 S 4 with the double non-metallic elements nitrogen (N) and oxygen (O) to form (N, O)-ZnIn 2 S 4 . Interestingly, (N, O)-ZnIn 2 S 4 exhibits significantly higher hydrophilicity and specific surface area compared to pristine ZnIn 2 S 4 . The contact angle decreases from 24° to 21°, while the specific surface area increases from 56 m 2 /g to 75 m 2 /g. The hydrogen production rate of (N, O)-ZnIn 2 S 4 reaches 400 μmol/h/g, which is 2.52 times higher than that of pristine ZnIn 2 S 4 . Photoelectrochemical characterization reveals that (N, O)-ZnIn 2 S 4 has a lower overpotential, higher photocurrent, lower resistance, reduced fluorescence intensity, and shorter fluorescence lifetime. Additionally, co-catalyst loading boosts the hydrogen production activity of ZnCo 2 S 4 /(N, O)-ZnIn 2 S 4 from 548 μmol/h/g to 810 μmol/h/g, compared to ZnCo 2 S 4 /ZnIn 2 S 4 . This study presents a dual non-metallic modification strategy to enhance semiconductor properties, achieving superior performance in photocatalytic hydrogen production.
研究领域:
材料科学
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能源科学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xinyu Wang,Rui Li,Guoqing Zhao,Xiaorong Yan,Mingsheng Yang,Bei Wang,Haiping Yu,Mengxiao Li,Yuxin Hao,Zhihui Wang,Jingru Liu,Mingjun Hu,Jun Yang
Organic electrode materials are considered as a promising alternative to conventional transition metal-based electrodes because of their low cost, adjustable structure, high specific capacity, and good sustainability. However, many organic molecule electrodes and their corresponding discharge products can be easily dissolved in liquid electrolytes, leading to severe shuttle effect and performance decay. Here, we designed a separator with double carbon layer modification. The first layer is a B 4 O 7 2− cross-linked GO layer, which serves as a barrier to prevent organic small molecules from passing through the separator attributed to physical blocking and electrostatic repulsion. The second layer is a carbon nanotube layer, which mainly acts as an absorbing layer and upper current collector attributed to porous structure and good conductivity. The synergistic effect of double carbon layer enables the GO-B 4 O 7 2− @CNT-modified separator to effectively inhibit the shuttling of small molecules while maintaining their intrinsic electrochemical performance. Three soluble organic electrode materials with different molecular sizes, including 2,3,5,6-tetraamino-benzoquinone (TABQ), 9,10-anthraquinone (AQ), and 3,4,9,10-perylenetetracarboxylic diimide (PTCDI), were used as model molecules to validate the availability of modified separator, and the results shows that their cycling stability, specific capacity and rate capability were enhanced significantly after using the separator. Such simple cost-effective separator modification method will substantially promote the battery performance and facilitate the application of organic small molecule electrodes for energy storage.
研究领域:
材料科学
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电化学
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储能
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）