INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Kedong Liu,Yun Chen,Zhaoqi Yang,Jian Jin
In recent years, zwitterionic materials have drawn great attention in oral drug delivery system due to their capacity for rapid mucus diffusion and enhanced cellular internalization. However, zwitterionic materials tend to show strong polarity that was hard to directly coat hydrophobic nanoparticles (NPs). Inspired by Pluronic coating, a simple and convenient strategy to coat NPs with zwitterionic materials using zwitterionic Pluronic analogs was developed in this investigation. Poly(carboxybetaine)-poly(propylene oxide)-Poly(carboxybetaine) (PCB-PPO-PCB, PPP), containing PPO segments with MW > 2.0 kDa, can effectively adsorb on the surface of PLGA NPs with typical core-shell spherical in shape. The [email protected] NPs were stable in gastrointestinal physiological environment and sequentially conquered mucus and epithelium barriers. Proton-assisted amine acid transporter 1 (PAT1) was verified to contribute to the enhanced internalization of [email protected] NPs, and the NPs could partially evade lysosomal degradation pathway and utilize retrograde pathway for intracellular transport. In addition, the enhanced villi absorption in situ and oral liver distribution in vivo were also observed compared to [email protected] NPs. Moreover, insulin-loaded [email protected] NPs as an oral delivery application for diabetes induce a fine hypoglycemic response in diabetic rats after oral administration. The results of this study demonstrated that zwitterionic Pluronic analogs-coated NPs might provide a new perspective for zwitterionic materials application as well as oral delivery of biotherapeutics.
研究领域:
药学
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纳米技术
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药物递送系统
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Peiang Li,Junjie Yang,Yulun He,Mingrui He,Jun Ma
Surface segregation is a practical, cost-effective technique for preparing and modifying ultrafiltration membranes, yet it often involves in the issue of insufficient stability. Due to the similar nature of surface segregation phenomena during membrane preparation and application, the majority of methods that suppress the surface segregation behavior of modifiers during membrane application for better stability also tend to inhibit that during membrane preparation, consequently compromising the initial membrane performance. In response to this issue, we tentatively introduce supramolecular assembly interactions as a means of achieving equilibrium. Specifically, β-cyclodextrin (β-CD) is employed to manipulate the surface segregation behavior of Pluronic F118, a polyethylene glycol based triblock copolymer. First of all, the hydrophily but water-insolubility of β-CD/Pluronic F118 supramolecules effectively curbs the undersegregation and oversegregation phenomenon during membrane preparation and relieves the leaching issue during application. Moreover, the supramolecular assembly of β-CD acts as a nodal role, enhancing hydrogen bonding, hydrophobic interactions, and molecular chain winding among the membrane bulk polymer (polyether sulfone), Pluronic F118, and β-CD. This effect intensifies with closer molecular chain spacing, further boosting the long-term stability of the segregation modifiers. Unlike common hydrophilic modifiers, β-CD does not need to exert its own antifouling property. Instead, it strengthens the surface enrichment and stability of Pluronic F118 through supramolecular assembly. As a result, significant effects can be achieved with minimal amounts of β-CD added. This advancement paves the way for creating highly efficient, durable, and cost-effective ultrafiltration membranes, with potential significant implications for the field of chemical engineering.
研究领域:
化学工程
·
材料科学
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产品关联
DOI
高影响因子
CYTOKINE
·
2024
·
IF 3.7
Chenggang Huang,Jiajia Teng,Wei Liu,Junzhe Wang,An Liu
Background Impaired wound healing in traumatic skin injuries remains a severe clinical challenge due to impaired re-vascularization, harmful bacteria infection, and inflammation dysregulation. Macrophages are recognized as prominent immune cells in tissue regeneration and wound healing. Consequently, the modulation of macrophages provides a promising therapeutic target for wound healing disorders. Here, we aimed to explore whether a novel constructed combination of thermosensitive hydrogel Pluronic F-127 (PF-127) and phillyrin (PH, the main active compound of forsythia suspensa) could improve skin wound healing. Methods Firstly, the biological effects of pH on the phenotype and inflammation of macrophages were assessed by flow cytometry and ELISA. The biocompatibility of the PF-127 plus PH combination was investigated on keratinocytes and red blood cells. The biological effect of PF-127/PH hydrogel on the migratory ability of keratinocytes in vitro was evaluated using the scratch and transwell migration assays. In addition, S. aureus and E. coli were employed to test the antibacterial properties of the PF-127 plus PH combination. Finally, PF-127 plus PH scaffold was applied to the full-thickness skin defect in mice. Histomorphological evaluation and immunochemistry were performed to explore the wound-healing activity of PF-127/PH hydrogel. Results PH can promote the polarization of macrophages from the M1 (pro-inflammatory) phenotype to the M2 (anti-inflammatory) phenotype. The PF-127/PH hydrogel was highly biocompatible and showed a potent stimulative effect on the migration of keratinocytes in vitro. The combination of PF-127 and PH exerted a pronounced antibacterial activity on S. aureus and E. coli in vitro. PF-127/PH hydrogel potently accelerates the healing of full-thickness skin defects by promoting skin cell proliferation, accelerating angiogenesis, and inhibiting inflammation. Conclusions Our study suggests that PF-127/PH hydrogel has excellent potential for treating traumatic skin defects.
研究领域:
医学
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生物材料学
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免疫学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 20
·15639-15650
·
IF 4.6
Zicheng Wan,Dongyang Li,Yang Zhou,Tun Wang,Benyin Zhu,Changhai Du,Yimin Li,Chang Shu
This study presents a preliminary investigation of porous nickel-titanium (NiTi) materials with controllable porosity fabricated through metal injection molding combined with the powder space-holder method (MIM-PSH). The thermosensitive hydrogel Pluronic F-127 was utilized as a drug carrier to load the anti-proliferative drug rapamycin, resulting in porous NiTi-hydrogel composite materials for controlled drug release. By tuning the NiTi matrix porosity (0%, 20%, and 40%), the system achieved precise modulation of drug loading capacity and release kinetics. Notably, the 40% porous NiTi composite exhibited a threefold increase in the drug-loading capacity and sustained release over 17 days. This hybrid design leveraged the thermoresponsive properties of the hydrogel and the tailored pore architecture to enable spatiotemporal control of rapamycin delivery, effectively inhibiting human aortic smooth muscle cell proliferation and mitigating in vivo vascular tissue hyperplasia. This study provides a foundational framework for the development of multifunctional biomaterial systems for vascular therapy.
研究领域:
生物医学工程
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材料科学
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药理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2017
·Vol. 24
·期 6
·1605-1612
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IF 1.624
Xia Kechan,Wang Guoxu,Zhang Hongliang,Liu Lei,Yu Yifeng,Wang Lingli,Chen Aibing
Mesoporous materials with bimodal mesopores show advantages in adsorption, energy storage, and catalysis because such unique structures are beneficial to the mass transfer. Here, we describe the synthesis of bimodal mesoporous carbon nanospheres (BMCSs) by using phenolic resin as carbon precursor, triblock copolymer Pluronic F127 as the soft template, and mesoporous silica spheres as hard templates. The BMCSs with uniform spherical morphology, high specific surface area (1489 m 2 g − 1 ), large pore volume (0.92 cm 3 g − 1 ), and bimodal mesoporous structure (3.8 and 6.8 nm) exhibit promising properties for adsorption of methyl orange (MO). The maximum adsorption capacity of the BMCSs is 5.5 × 10 2 ± 0.2 × 10 2 mg g − 1 , which is higher than that of many adsorbents reported. The kinetics studies show a better fit of pseudo-second-order model. Meanwhile, fitting equilibrium data show that the Langmuir model is more suitable to describe the MO adsorption than Freundlich model.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2026
·
IF 4.4
Mingze Xu,Yanwei Yang,Gai Liu,Chunyun Wang,Xu Xu,Bohan Ye,Lei Liu,Xiaoyu Wu,Shiyong Song
Pluronic F127 is widely used in micelle formulations, yet its application is limited by its poor stability and low drug loading capacity. Structural modification of F127 is therefore necessary to overcome these drawbacks. Carrier materials with intrinsic pharmacological activity can reduce metabolism-related toxicity and exert synergistic effects with loaded drugs, offering broad application prospects. Solanesol (SOL), a long-chain unsaturated polyisoprenoid, exhibits antitumor activity and favorable lipophilicity. In this study, a solanesol derivative, monosolanesyl succinate (MSS), was synthesized and conjugated via an amide bond to Pluronic F127 as a hydrophobic segment, forming a pH-sensitive therapeutic nanocarrier. The critical micelle concentration (CMC) of F127-MSS was 10-fold lower than that of F127, indicating a significantly improved stability. The resulting doxorubicin-loaded F127-MSS micelles (F127-MSS-DOX) had an average particle size of approximately 130 nm and a drug loading capacity of ∼ 6.2%, which was about 4 times higher than those of F127-DOX micelles. The F127-MSS-DOX micelles exhibited pH-responsive drug release, promoting drug accumulation at tumor sites while reducing the toxicity in normal tissues. They also demonstrated excellent dilution, plasma, and storage stability. Blank F127-MSS micelles showed inherent inhibitory effects on HepG-2 and MCF-7 cells, attributed to the pharmacological activity of MSS. Furthermore, F127-MSS-DOX micelles displayed potent antitumor activity, comparable to that of free DOX at high concentrations. In vivo studies confirmed that blank F127-MSS micelles moderately suppressed tumor growth, while F127-MSS-DOX micelles significantly inhibited tumor progression and markedly reduced the systemic toxicity of free DOX, owing to their high drug loading, superior stability, pH sensitivity, and synergistic antitumor effect. These findings highlight the great potential of F127-MSS-DOX micelles for tumor treatment.
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 36
·2002488
·
IF 16.836
Xuanyu Yang,Penghao Lu,Lei Yu,Panpan Pan,Ahmed A. Elzatahry,Abdulaziz Alghamdi,Wei Luo,Xiaowei Cheng,Yonghui Deng
Mesoporous carbon matrix with open pore structure, short diffusion length, and large pore size can favor the in-pore immobilization of active species and facilitate mass diffusion during catalytic reactions. However, a great difficulty still remains on controllable synthesis of uniform mesoporous carbon spheres with these structural characteristics. Herein, using amphiphilic Pluronic F127 as the surfactant, 1,3,5-trimethyl benzene (TMB) as the pore swelling and interface-adjusting agent, and dopamine as the carbon source, a robust emulsion-induced interface assembly approach for rational synthesis of mesoporous carbon spheres is demonstrated. The interface assembly process, including dopamine polymerization and fusion of TMB/F127/dopamine emulsions, can be regulated by tuning the dosage of dopamine and ammonia water, resulting in mesoporous carbon spheres with tunable pore sizes and versatile architectures, such as vesicles, walnut shapes, spheres with dendritic-like 3D radially aligned mesochannels (RA-MC), and isolated spherical mesopores. Moreover, the derived RA-MC is used as a promising matrix to immobilize ultra-small Au nanoparticles (≈3 nm). The Au/RA-MC exhibits no mass diffusion limitations in reduction of 4-nitrophenol, showing high conversion efficiency and good recyclability. This work paves a new avenue for controllable synthesis of mesoporous carbon spheres with well-developed mesoporosity and architectures and their application as novel heterogeneous catalysts.
研究领域:
材料科学
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催化化学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2018
·Vol. 135
·期 39
·46696
·
IF 1.901
Mengmeng Wang,Gang Sun,Peihui Han,Xin Su,Yujun Feng
Thermoviscosifying polymers are attractive for enhancing oil recovery owing to their exceptional thickening power as temperature increases. However, the polymers reported to date show inadequacies including obligatory high polymer concentration to get the thermothickening ability because of their low molecular weight (MW), and inconvenient post-treatment due to the high viscosity after manufacturing. To overcome these drawbacks, inverse emulsion polymerization was used here for preparing polyether-based thermoviscosifying polymers (TVP-Ps) by grafting acrylic monomers onto triblock copolymers PEO–PPO–PEO. It was found the MW of final products could reach 8 million Daltons, making them thermoviscosifying at 0.2 wt %. The viscosity of polymerized inverse emulsions was as low as 175 mPa·s, leading to direct dispersing. The TVP-Ps containing Pluronic F127, F108, F68 all exhibited significant thermothickening behaviors in both aqueous solutions and brines, and the critical thermoassociative temperature could be tuned by changing the nature or amount of Pluronics. After aging at 45 °C for 60 days with equal initial viscosity, TVP-Ps shows 21% higher viscosity retention than the reference polymer without Pluronic, PAMA, and preliminary core flooding test demonstrated TVP-Ps can get 2.1% higher incremental oil recovery than PAMA. This work paves a new avenue for scaled-up preparation and potential use of TVP-Ps. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 134 , 46696
研究领域:
石油工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Lianlong Zhan,Wei Lu,Qin Xiang,Zhiping Chen,Wenlu Luo,Cailin Xu,Renting Huang,Shuagnfei Wang,Hui He
Using biomass for the production of low-energy regenerative carbon capture materials represents an effective strategy to advance carbon dioxide capture and storage technologies. In this study, a low-energy regenerative bagasse-based CO 2 capture material is synthesized through a one-step, rapid crosslinking strategy. In this method, epichlorohydrin is used to crosslink bagasse with temperature sensitive Pluronic® F-127 and polyethyleneimine, thereby addressing the challenge of simultaneously incorporating multiple functional groups into the biomass matrix. The resulting material with abundant amino adsorption sites demonstrates a high adsorption capacity of 4.52 mmol/g. Interestingly, the temperature-sensitive response of the material facilitates the grafted amine chain segments on bagasse to stretch and shrink reversibly within a narrow temperature range of 25 °C for adsorption and 55 °C for desorption. The shrinkage state is conducive to the CO 2 desorption process, resulting in an ultralow regeneration temperature of 55 °C. Additionally, the water contained in the material enhances its cyclic stability in extreme environments, such as pure CO 2 atmosphere at high temperature. Overall, this research not only provides new ideas for enhancing the long-term stability and economic viability of CO 2 capture materials but also offers feasible solutions for combating climate change and promoting sustainable development.
研究领域:
材料科学
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环境科学
·
生物质工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER ENGINEERING
·
2017
·Vol. 38
·期 4
·371-379
·
IF 0.658
Wanli Ye,Lidan Zhu,Shan Xia,Xiumei Zhang
The purpose of this investigation is to develop a dual pH-/temperature-responsive and fluorescent hydrogel based on piperazine and Pluronic F127 (PF127). Firstly, polyurethane was synthesized using 1,6-hexamethylene diisocyanate, 1,4-bis(hydroxyethyl) piperazine, and PF127 by a step polymerization process. Erythrosine B (EB) is then incorporated into copolymers to offer a fluorescence property. The polyurethane-PF127-EB copolymer can spontaneously self-assemble into hydrogels with a great number of closely packed micelles, and the hydrogels also have the ability to undergo thermo-sensitive sol-gel phase transition above the critical gelation concentration. The gelation temperature can be adjusted near the physiological condition by modulating the concentration of the copolymer in an aqueous medium. The acid-titration curves indicate a good pH-responsive property, and the UV-vis and fluorescence spectra exhibit strong self-fluorescence signals for hydrogels. As a result, the hydrogels not only can serve as drug carriers but can also be utilized as fluorescence imaging probes in biomedical applications.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2020
·
IF 3.557
Guohong Ren,Xichen Zhang,Zhicheng Zhang,Ying Liang,Shishan Wu,Jian Shen
Pt-based nanomaterials have been proven to be effective catalysts for direct alcohol fuel cells (DAFCs). Specifically, the ternary nanoalloys (NAs) composed of Pt with other noble metals and transition metals can not only reduce the component of Pt but also enhance the electrocatalytic property and durability for alcohol oxidation. Herein, ternary PdPtCu NAs were synthesized through the solvothermal method using ethylene glycol as the solvent and reducing agent. The morphology and composition of PdPtCu NAs can be effectively controlled via selecting suitable surfactants and adjusting the proportion of precursors. The three-dimensional (3D) PdPtCu NAs with spiny rambutan-like morphology were obtained using the triblock copolymer Pluronic F-127 (PF-127) as the surfactant and adding three precursors with an equal molar ratio. The unique structure of PdPtCu NAs and the synergistic effect between the components significantly improved the electrocatalytic activity toward ethanol oxidation. Compared with different atomic ratio binary or ternary nanomaterials, 3D PdPtCu NAs manifested the best electrocatalytic performance.
研究领域:
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Gels
·
2025
·Vol. 11
·期 11
·878
·
IF 5.3
Shangpeng Liu,Min Sun,Zhen Fan
Effective management of multidrug-resistant cancers depends on effective, localized drug release and accumulation within the tumor microenvironment. In our work, Pluronic P105 and F127 mixed nanogels (PM) were fabricated through self-assembly to combat multidrug-resistant cancer. The approximate diameter of our prepared PM is 115.7 nm, an optimal size for tumor accumulation through the enhanced permeability and retention (EPR) effect. An in vitro drug release assay indicated that ultrasound could accelerate the drug release rate in doxorubicin-loaded Pluronic nanogels (PM/D). Additionally, the resistance reversion index (RRI) in the ultrasound-treated PM/D group was 4.55 and was two times higher than that in the free PM/D group, which represented better MDR reverse performance. Cell experiments demonstrated that, after 3 min of ultrasound, a greater amount of chemo-drug was released and absorbed by the MDR human breast cell line (MCF-7/ADR), resulting in significant cytotoxicity. Such enhanced therapeutic efficiency could be attributed to the combined effects of the two independent mechanisms: (i) ultrasound-controllable drug release realized effective release within resistant tumors with spatial and temporal precision and (ii) the contained Pluronic in the PM/D inhibited P-gp-mediated efflux activity to overcome MDR in tumors. Collectively, our findings support the feasibility of ultrasound-responsive PM as a drug-delivery platform for resistant cancers.
研究领域:
纳米医学
·
癌症治疗
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药物递送系统
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生物医学工程
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）