Desalination and Water Treatment
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2026
·
IF 3.4
Haifeng Zhang,Bowen Tan,Zixie Zhang,Yuezhu Kong,Linna Zhang,Yingying Liu,Xinxia Tian
Reverse osmosis (RO) membrane with antifouling and antimicrobial performance was developed by incorporating iodophoric polyvinylpyrrolidone (PVP) coatings assisted with polydopamine (PDA). The membrane surface was coated with PDA layer through self-polymerization of DA, followed by the adhesion of hydrophilic PVP onto the coated surface via strong multiple hydrogen bonding facilitated by catechol in PDA. Iodine was introduced through complexation with PVP. The modified membrane demonstrated enhanced hydrophilicity and increased surface roughness, while exhibiting a reduction in surface negative charge. Water flux of the modified membrane remained unchanged, while the high NaCl rejection was successfully maintained and stabilized at above 99.0%. Meanwhile, modified membrane exhibited outstanding performance stability and satisfactory pH stability. Moreover, during fouling experiments with bovine serum albumin and lysozyme as model foulants, the membrane demonstrated a lower decline in flux rate and a higher recovery rate. Besides, modified membrane exhibited excellent anti-biofouling performance after soaking in bacterial suspension. Furthermore, after being in contact with the surface of membranes freshly prepared or soaked in deionized water for 4 months, E. coli and B. subtilis showed a mortality rate exceeding 99%. This study introduces an efficient strategy for preparing antifouling and bactericidal RO membranes without sacrificing their intrinsic desalination performance.
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EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Yaotian Peng,Xiaoyan Feng,Jianming Jiang,Li Ren
Bilirubin, a dangerous toxin may lead to serious brain injury, can be widely removed by hemoperfusion. However, the hemoperfusion adsorbents with higher removal ability, excellent hemocompatibility and biocompatibility still need to be explored. In this work, a novel functionalized polyvinylpyrrolidone (PVP) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Then PVP-modified polystyrene-divinylbenzene (PS-DVB-PVP) microspheres were prepared by a one-pot restore-click method. The results showed that the adsorption capacity and rate of microspheres for bilirubin were increased after modification with PVP. In the hemocompatibility and biocompatibility test, the modified microspheres demonstrated higher resistance to human serum albumin (HSA) and excellent hemolysis rate. In order to study the role of PVP in the bilirubin-adsorption process, isotherms were fitted by Langmuir model and Freundlich model, while kinetics data were fitted by pseudo-second-order model and intraparticle diffusion model. In addition, the modified microspheres showed no difference with unmodified microspheres in the coagulation test and exhibited no cytotoxicity to L929 cells. These results showed that our modified microspheres have both excellent hemocompatibility and outstanding biocompatibility, which will not cause hemolysis and coagulation. All these results made them possible to become a new adsorbent for efficient removing bilirubin in hemoperfusion.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2022
·
IF 6.51
Yaru Li,Lei Zhou,Mengmeng Zhang,Runzhi Li,Guohu Di,Hongyun Liu,Xianggen Wu
Purpose of this work was to determine the feasibility of a nano-ophthalmic solution consisting of the nanocarrier polyvinylpyrrolidone VA64 (VA64) and encapsulated apocynin (APO) as treatment for ocular inflammatory diseases. Results showed the solution, termed APO-VA64 ophthalmic solution, could be fabricated via a simple process. This solution was clear, colorless, and possessed valuable characteristics, such as small micelle size (14.12 ± 1.24 nm), narrow micelle size distribution, and high APO encapsulation efficiency. Encapsulated APO was also found to have high aqueous solubility and in vitro release and antioxidant activities. APO-VA64 ophthalmic solution showed good ocular tolerance and demonstrated improved corneal permeation ability in mouse eyes. In an in vivo mice model, topically administered APO-VA64 ophthalmic solution was found to be significantly more effective against benzalkonium chloride-induced ocular damage than APO, VA64, and a mix of APO and VA64. Blockage of high mobility group box 1 signaling and its related proinflammatory cytokines were involved in this therapeutic effect. In conclusion, these in vitro and in vivo findings demonstrate that VA64 micelles are a potential nanoplatform for ocular drug delivery, and that the nanoformulation APO-VA64 ophthalmic solution may be a promising candidate for the efficacious treatment of ocular inflammatory diseases.
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高影响因子
IONICS
·
2023
·
IF 2.8
Dai Jicui,Wang Kaipei,Han Xiaoyu,Yan Jiaxin,Teng Xiangguo
Amphoteric PSF(polysulfone)-g-NaPSS(sodium p-styrene sulfonate)/PVP (polyvinylpyrrolidone) blended ion exchange membranes were prepared by simple solution casting method with dimethyl sulfoxide (DMSO) as solvent. The effect of the ratio of PSF-g-NaPSS to PVP on the properties of the membranes were studied and compared to that of Nafion 115 (DuPont). The results proved that when the mass ratio of PSF-g-NaPSS to PVP was 3:7 (M 3:7 ), the prepared membrane has exhibited the highest ion selectivity. As a result, the VRB single cell with M 3:7 was superior to that of Nafion 115 under the same condition. Furthermore, after 300 charge-discharge cycles, the efficiency of the M 3:7 membrane has no obvious decrease, and the static chemical stability test reveals that the mass loss ratio and vanadium ion permeability loss ratio of the M 3:7 are only slightly higher than that of N 115 membrane. Consequently, the prepared PSF-g-NaPSS/PVP amphoteric membrane is one of promising candidates for VRB application.
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FOOD AND CHEMICAL TOXICOLOGY
·
2023
·
IF 4.3
Shilin Zhou,Yuxuan Sun,Kaidi Wang,Xintao Gao,Kehong Dong,Jing Wang,Xiaochen Wu,Chuanlong Guo
Oxaliplatin (OXL) is a first-line drug for the treatment of colon cancer , with excellent efficacy. Intestinal toxicity is a common side effect of OXL, with unclear pathogenesis and a lack of effective treatment strategies. Polydatin (PD) has anti-inflammatory and antioxidant activities and is a potential drug for treating intestinal diseases , but its poor water solubility limits its application. In this study, polyvinylpyrrolidone (PVP) was used as a carrier to prepare nanoparticles loaded with PD (PVP-PD), with a particle size of 92.42 nm and exhibiting sustained release properties. In vitro results showed that PVP-PD protected NCM460 cells from OXL induced injury, mitochondrial membrane potential (MMP) disruption, and accumulation of reactive oxygen species (ROS). The in vivo results demonstrated the protective effect of PVP-PD on intestinal toxicity induced by OXL, such as alleviating weight loss and colon length reduction induced by OXL. Both in vivo and in vitro mechanisms indicated that OXL induced DNA damage and activated the cGAS-STING pathway, further inducing the expression of inflammatory factors such as IL-1β and TNF-α. PVP-PD alleviated the aforementioned changes induced by OXL by inhibiting the DNA damage-cGAS-STING pathway. In summary, our study demonstrated that the DNA damage-cGAS-STING pathway was involved in OXL induced intestinal toxicity, and PVP-PD provided a potential strategy for treating OXL induced intestinal toxicity.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2017
·
IF 6.035
Xing Wu,Robert W. Field,Jun Jie Wu,Kaisong Zhang
Polyvinylpyrrolidone (PVP) modified graphene oxide (GO), hereinafter referred to as PVP-GO, was synthesized as a novel modifier to fabricate thin film nanocomposite forward osmosis membranes . The results indicated that by coating PVP on the surface of GO nanosheets , the dispersibility of GO was increased and the aggregation of GO was reduced. Compared with the pristine and GO modified FO membranes, the PVP-GO modified membranes enhanced the desalination performance giving both a higher water flux and lower reverse solute flux. When using 2 mol L −1 of NaCl as the draw solution and 10 mmol L −1 NaCl as the feed solution, the water flux of the FO membrane modified with 0.0175 wt% of PVP-GO reached 33.2 LMH in the ALDS mode (the active layer facing the draw solution), which was 3.3 times higher compared with the water flux of the pristine FO membranes. Improved desalination performances of PVP-GO modified FO membranes were attributed to the better dispersibility of the PVP-GO nanosheets and increased surface hydrophilicity of the modified FO membranes. This study indicated that PVP-GO is an effective modifier to enhance the performance of FO membranes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Song Chen,Like Cao,Tingting Wu,Jie Zhao,Jinfeng Liu,Meiwen An,Ren Guo,Hao Li,Weiyi Chen
In this study, hierarchical cellulose acetate/polyvinylpyrrolidone hollow microfibers (CA/PVP HMFs) were first prepared via a dip coating method using a steel wire as tubular template and then supported a sol-gel deposition of titania nanoparticles (NPs) to derive CA/PVP@titania NP HMFs. After hydrothermally treated in NaOH solution, CA/PVP@titania NP HMFs were transformed to CA/PVP@titania nanowire (NW) HMFs. SEM observation showed that CA/PVP@titania NW HMFs had a hollow structure with diameters of 450–600 μm and exhibited a hierarchical and nanofibrous structure. Their surfaces were constructed by numerous titania NWs with diameters of 10–30 nm and lengths of 1–5 μm. The incorporation of PVP not only caused a significant change in surface wettability from hydrophobic CA HMFs to hydrophilic CA/PVP HMFs, but also promoted the sol-gel deposition of titania NPs on CA/PVP HMFs. CA/PVP@titania NW HMFs exhibited the highest hydrophilicity with water contact angle of 32° and the largest specific surface area of 86.1 m 2 /g. In vitro biocompatible evaluation indicated that CA/PVP@titania NW HMFs exhibited much higher cell adhesion and proliferation than CA/PVP@titania NP HMFs and CA/PVP HMFs within 7 days due to the presence of nanofibrous surface architecture. Thus, the present CA/PVP titania NW HMFs have potential as biocompatible cell supporting matrices.
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ACS Applied Nano Materials
·
2024
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IF 5.3
Wenning Mu,Junjin Meng,Shixun Zhang,Chunmao Li,Xuefei Lei,Qing Wang,Shaohua Luo
The improvement of the morphology and structure of electrode materials is considered to be an effective way to improve their electrochemical performances. This study aims to search for resource-rich and inexpensive electrode materials that can improve specific capacity, energy density, and cycling stability. The NiCo-MOF nanocomposites are prepared by the solvothermal method with polyvinylpyrrolidone (PVP) as a regulator for the first time. The effect of PVP contents on the morphology, structure, and properties of NiCo-MOF is investigated. The prepared NiCo-MOF/Px nanocomposites are spherical in structure, formed by the accumulation of fine vertical nanosheets when the content of PVP was 40%, which has high specific capacity of 904 F g–1 at 1 A g–1 and smaller Rs (0.53 Ω) and Rct (0.89 Ω). The asymmetric supercapacitors, assembled with NiCo-MOF/P40% nanocomposites as the positive electrode and activated carbon as the negative electrode, have a high energy density and a power density, and it can retain an initial capacitance of approximately 87.36% after 10,000 charge/discharge cycles at 5 A g–1. The addition of PVP is demonstrated to effectively change the structure and morphology of the material to provide more redox active sites and convenient electrolyte ion diffusion channels, thus improving the electrochemical performance of the material.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yang Liu,Chuang Lang,Kai Zhang,Linlin Feng,Junying Li,Tingting Wang,Siyu Sun,Guangwei Sun
To develop a submucosal injection material with sustained submucosal lifting for endoscopic submucosal dissection (ESD), this study designed and prepared a novel composite thermosensitive hydrogel system with high pH chitosan-polyvinylpyrrolidone-β-glycerophosphate (HpHCS-PVP-GP). HpHCS improved the injectability of the hydrogels and retained the rapid gelation ability at low concentrations. The modification of PVP significantly improved the stability of low-temperature hydrogel precursor solutions and the integrity of hydrogels formed at 37 °C through hydrogen bonds between PVP and HpHCS. A mathematical model was established using response surface methodology (RSM) to e v aluate the synergistic effect of HpHCS, GP , and PVP concentrations on gelation time. This RSM model and submucosal lifting evaluation using in vitro pig esophageal models were used to determine the optimal formula of HpHCS-PVP-GP hydrogels. Although the higher PVP concentration (5 % ( w / v )) prolonged gelation time, it improved hydrogel mechanical strength , resulting in better submucosal lifting performance. The experiments of Bama mini pigs showed that the heights of the cushions elevated by the HpHCS-5%PVP-GP hydrogel remained about 80 % 1 h after injection. Repeated injections were avoided, and the hydrogel had no cytotoxicity after electric cutting. Therefore, the HpHCS-PVP-GP thermosensitive hydrogel might be a promising submucosal injection material for ESD.
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PubMed
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 26
·e202401550
·
IF 1.9
Miaomiao Tian,Ya Wang,Gang Liu
Graphical The polyvinyl pyrrolidone (PVP) stabilized copper nanoclusters (PVP−Cu NCs) were successfully synthesized. Under alkaline conditions, the florescence of PVP−Cu NCs could be selectively quenched by the addition of dopamine. The established method was effectively utilized to detect dopamine in human urine samples with good accuracy. Dopamine (DA), a critical catecholamine in mammals, functions as a significant biological indicator for specific diseases. The precise and timely identification of DA is essential for disease monitoring and prevention. In this study, copper nanoclusters (Cu NCs) were synthesized using polyvinyl pyrrolidone (PVP) as the protective ligand and L-ascorbic acid (L-AA) as the reducing agent via a simple hydrothermal process. The produced PVP−Cu NCs displayed strong blue emission at 427 nm when excited at 365 nm. In alkaline conditions, DA was able to selectively inhibit the fluorescence of PVP−Cu NCs. The investigation of the mechanism revealed that dopamine self-polymerization resulted in the formation of polydopamine, which inhibited the emission of PVP−Cu NCs at 427 nm due to the inner filter effect (IFE). Based on the above phenomenon, a simple and selective analytical method for DA determination was developed. The fluorescence intensity of PVP−Cu NCs demonstrated a reliable response to DA concentrations within the range of 5 to 200 μM, with a detection limit (LOD) of 1.32 μM. The proposed method was successfully utilized for the precise detection of DA in human urine samples, indicating its potential application in biomedical dopamine detection.
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Sustainable Materials and Technologies
·
2026
·
IF 9.2
Qiuxia Guo,Peng Fan,Xinyi Liu,Cui Zeng,Shige Wang,Huadong Li
Uncontrolled hemorrhage and bacterial infection remain critical challenges in wound management, necessitating advanced dressings that integrate rapid hemostasis, antibacterial activity, and tissue regeneration. Herein, we present a multifunctional injectable hydrogel (QGHP) composed of oxidized hyaluronic acid (OHA), quaternized guar gum (QGG), and polyvinylpyrrolidone (PVP) via dual dynamic crosslinking (Schiff base bonds and hydrogen bonds). This design imparts QGHP with rapid self-healing capability, strong tissue adhesion, shear-thinning injectability, and customizable mechanical properties. The hydrogel demonstrates exceptional fluid absorption (swelling ratio: ~1148 %) and controlled degradation. Cationic groups of QGG confer intrinsic broad-spectrum antibacterial activity, achieving >95 % inhibition against Staphylococcus aureus and Escherichia coli without antibiotics. In a rat tail amputation model, QGHP achieves rapid hemostasis (~17 s) and reduces blood loss by ~84 %. For infected wounds, QGHP accelerates closure, suppresses bacterial proliferation (~3.5 % survival), and enhances collagen deposition and re-epithelialization. The dual-network hydrogel combines injectability, bio-adhesion, and antibacterial functionality, offering a promising solution for complex wound healing.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Huawei Li,Wang Yang,Ni Wu,Li Sun,Peidi Shen,Xiaobai Wang,Yongfeng Li
Hexagonal boron nitride (h-BN) has been widely investigated in the field of thermal interface materials (TIMs) due to its unique physicochemical properties, including high thermal conductivity and electrical insulation. However, poor dispersion of BN in polymers makes it difficult to form promising thermal conductive pathways, resulting in low thermal conductivity when blended with polymers. Therefore, surface modification of BN is usually required to increase its dispersibility and interfacial affinity in polymers. In our work, BN was first hydrothermally treated in alkaline solution to obtain hydroxylated BN, followed by the modification with carboxymethyl cellulose (CMC) and polyvinylpyrrolidone (PVP) by ball milling to further improve the water dispersibility and stability of BN. The prepared hydrophilic BN-OH-CMC-PVP (BOCP) was stably dispersed in water for one month at a concentration of 20 mg mL −1 . In addition, the multiple surface modifications effectively improved the dispersion and compatibility of BN in the epoxy, leading to a significant improvement of the thermal conductivity of BOCP/Epoxy composite. The thermal conductivity of BOCP/Epoxy reached 1.64 W m −1 K −1 at 30 wt% loading. The preparation of functionalized BN presents a facile and effective strategy to construct BN-based TIMs with improved dispersion and enhanced thermal conductivity.
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