CERAMICS INTERNATIONAL
·
2024
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IF 5.1
Zihao Chen,Jiamei Han,Xin Gu,Kaikai Wu,Jiabin Jiang,Liming Zhao,Yixin Yan,Haitao Wang,Xiaolu Liang,Yao Wang,Zhenyu Wang,Xiaokun Zhu,Zimeng Pan,Xiang Liu
Perovskite manganese oxides are highly desirable for infrared acquisition owing to their characteristics of ferromagnetic metal-paramagnetic insulators. In this work, the sol-gel spin-coating technique was employed to prepare La 1- x Ca x MnO 3 (LCMO) films with varying Ca 2+ content ( x = 0.1, 0.2, 0.3, 0.4, 0.5) on the (l00) LaAlO 3 (LAO) substrates. In comparison to previous studies, the pre-sintering temperature, final sintering temperature, and final sintering period were modified. The crystal structure, surface topography, elemental valence states, and electrical transport performance of the LCMO films were characterized and analyzed as well. The results demonstrated that the diffraction peaks of the above films were aligned with those of the LAO single-crystal substrate. The change in Ca 2+ content caused an increase in the Mn–O bond length, the amount of Mn 4+ , and the Mn– O –Mn angle in LCMO films, promoting the double exchange effect. These modifications had a considerable impact on the resistivity of LCMO films, increasing their TCR value. The maximum TCR of 22.92% K −1 was reached at x = 0.3 and peak TCR temperature ( T k ) of 241.93 K. Therefore, the film has great application potential for infrared bolometers.
研究领域:
材料科学
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物理学
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DOI
高影响因子
Translational Cancer Research
·
2026
·Vol. 15
·期 2
·97
·
IF 2.1
Xiang Lei,Shi Jinjie,Huang Xueqing,Zhou Shi
Background Donafenib (DON) has been found to be effective in prolonging progression-free survival for advanced hepatocellular carcinoma (HCC), although it remains limited in improving long-term survival outcomes. Quercetin (QUE) has also been demonstrated to exhibit anticancer effects in various malignant tumors. The most recent research has shown that the combination therapy of QUE and conventional chemotherapy drugs can enhance its anti-cancer activity. Therefore, this study aimed to investigate whether QUE and DON in combination could synergistically suppress tumor growth in HepG2 cells. Methods In this study, the effects of QUE alone and in combination with DON were assessed on HCC HepG2 cells. Both in vitro and in vivo (subcutaneous xenograft models in nude mice) experiments were conducted. The expression of cyclic AMP-responsive element-binding protein 1 (CREB1), a putative common target, was evaluated, and its role in lipid metabolism was investigated. Results CREB1 was confirmed to be highly expressed in HepG2 cells and serves as a molecular target for both QUE and DON. Suppressing CREB1 expression significantly inhibited lipid metabolism and reduced the biological activity of HepG2 cells. Furthermore, QUE, both alone and in combination with DON, was shown to down-regulate the CREB1/dynamin-related protein 1 (DRP1)/sterol regulatory element-binding protein 1 (SREBP1) signaling axis. This inhibition significantly suppressed lipid metabolism and tumor growth in the nude mouse xenograft models. Conclusions These findings indicate that the combination of QUE and DON exerts its antitumor effects by inhibiting the CREB1/DRP1/SREBP1 axis mediated lipid metabolism pathway in HepG2 cells. This offers a novel potential approach for enhancing the therapeutic efficacy of DON in the treatment of HCC.
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DOI
PubMed
高影响因子
Translational Cancer Research
·
2026
·Vol. 15
·期 4
·238
·
IF 2.1
Lin Xiang,Tian Peng,Guo-Bin Song,Hou-Qun Ying,Xue-Xin Cheng
Background The cell division cycle-associated ( CDCA ) gene family regulates cell cycle progression and is frequently dysregulated in multiple cancers. However, its roles in tumor stemness maintenance and drug sensitivity remain unclear. This study aimed to investigate the expression of the CDCAs in cancers and their associations with tumor stemness and drug sensitivity, with a particular focus on the effects of CDCA2 on stemness and drug sensitivity in lung and colorectal cancers. Methods CDCA s expression and prognostic value were analyzed using The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) datasets, while correlations with stemness [DNA methylation-based stemness scores (DNAss) and RNA-based stemness scores (RNAss)] and drug sensitivity [Genomics of Drug Sensitivity in Cancer (GDSC)] were assessed. Functional validation was performed by knocking down CDCA2 in lung and colorectal cancer cell lines. Results Pan-cancer analysis revealed that CDCA s were broadly upregulated across tumor types and were significantly associated with poor prognosis in multiple cancers (P<0.05). Most CDCA s showed positive associations with tumor stemness based on RNAss and DNAss analyses (r>0.3, P<0.05). Drug sensitivity analysis indicated that CDCA expression was closely related to responses to various anticancer agents. Experimental validation demonstrated that CDCA2 knockdown significantly inhibited proliferation of lung and colorectal cancer cells, reduced stemness marker expression, and increased sensitivity to oxaliplatin. Conclusions CDCAs are widely upregulated in cancers and associated with poor prognosis, enhanced tumor stemness, and drug resistance. CDCA2 promotes proliferation and chemoresistance, highlighting its potential as a prognostic biomarker and therapeutic target.
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PubMed
高影响因子
Translational Cancer Research
·
2026
·Vol. 15
·期 3
·171
·
IF 2.1
Yan Zhang,Lu Lu,Qiuyu Zhao,Aiyu Ma,Meihua Jin,Xu Wang,Yuzhong Yang,Xuan Meng,Yiping Sun,Jinhua Zheng,Xiang Zheng
Background Lysosomal-associated protein transmembrane 5 (LAPTM5) is a transmembrane protein predominantly localized to late endosomes and lysosomes, with preferential expression in hematopoietic cells. Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death (PCD) that is driven by the lethal accumulation of lipid peroxides. Many studies have shown that ferroptosis is dependent on autophagy. Lipophagy is a selective form of autophagy by degrading lipid droplets (LDs) within autophagic vesicles to regulate lipid balance. Lipophagy can promote RAS-selective lethal 3 (RSL3)-induced ferroptosis. However, whether LAPTM5 regulates lipophagy to sensitize glioma cells to ferroptosis remains to be explored. Therefore, the objective of our study was to evaluate the potential role of LAPTM5 in ferroptosis. Methods The expression profile of LAPTM5 in human glioma tissues was analyzed by using The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases, and immunohistochemistry. Glioma cells were treated with ferroptosis inducer erastin, and then the cell viability, glutathione (GSH), and malondialdehyde (MDA) were detected. Lipophagy was tested by laser confocal microscopy and proteins expression were detected by western blot. Results Elevated expression of LAPTM5 was observed in glioma tissues compared to normal brain tissues, and its high expression level was associated with poorer patient prognosis. LAPTM5 promoted lipophagy in glioma cells. LAPTM5 enhanced the sensitivity of glioma cells to ferroptosis inducer erastin, while suppression of lipophagy inhibited LAPTM5-mediated sensitization to erastin. Conclusions The finding that glioma cells with high LAPTM5 expression were more sensitive to ferroptosis inducers suggests that glioma patients with high LAPTM5 expression may be more responsive to ferroptosis-inducing therapies.
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PubMed
高影响因子
Translational Cancer Research
·
2026
·Vol. 15
·期 5
·378
·
IF 2.1
Zhongshun He,Aiping Huang,Jing Lv,Jing Zhou,Wenrong Lou,Biao Xu,Xuesong Wu
Background Malignant melanoma is among the most aggressive and life-threatening forms of skin cancer, and effective therapeutic treatment options remain limited. Thus, there is an urgent need to develop efficient and broadly applicable anti-melanoma drugs. Growing evidence suggests that baicalin (BAI) possesses anti-cancer potential; however, its anti-tumor mechanisms in melanoma cells remain to be fully elucidated. Therefore, this study aimed to investigate whether BAI exerts anti-melanoma effects. Methods A375 melanoma cells were treated with varying concentrations of BAI to assess its effects on cell proliferation, migration, invasion, and apoptosis. Network pharmacology analysis was then employed to predict potential molecular targets of BAI in melanoma treatment. Molecular docking was used to evaluate the binding interactions between BAI and the predicted targets. Finally, in vitro experiments were performed to investigate the regulatory effects of the potential targets on A375 cell functions. Results BAI significantly inhibited A375 cell proliferation, invasion, and migration, as well as inducing apoptosis of A375 cells in a dose-dependent manner (all P<0.05). Subsequent network pharmacology analysis identified three potential therapeutic targets of BAI, among which epidermal growth factor receptor (EGFR) exhibited strong binding affinity with BAI. Further in vitro experiments demonstrated that BAI suppressed EGFR-mediated PI3K/AKT pathway activation in a dose-dependent manner. Consistent with previous findings, EGFR overexpression exerted oncogenic effects in melanoma cells by inhibiting apoptosis. Mechanistically, BAI induced apoptosis in melanoma cells by targeting the EGFR-mediated PI3K/AKT signaling pathway. Conclusions This study demonstrates that BAI exerted cytotoxic effects on melanoma cells by targeting EGFR and inhibiting the PI3K/AKT pathway, thereby inducing apoptosis. These findings suggest that BAI may serve as a promising therapeutic candidate for the treatment of malignant melanoma.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Jingling Ban,Ying Lu,Jing Lu,Kangyu Jia,Mengying Luo,Yang Zhou,Dong Wang,Longhai Piao
The real-time monitoring of human temperature can facilitate efficient family health supervision, disaster diagnosis, and treatment. To meet these requirements, there is an urgent need to develop fibre-based temperature sensors with high sensitivity, fast response rates, and excellent stability. This study investigated the positive temperature characteristics of a stretchable and strain-insensitive temperature sensor with a chemically modified silver nanowire (AgNW). The regulation of the surface polymer on the AgNWs using a conductive ligand of polyaniline-L-cysteine ethyl ester hydrochloride (PANI-LCO) improved the network conductivity by decreasing the junction resistance. In addition, the pristine flexibility and helicoid structure of a spandex polyurethane (SP) covered yarn substrate proved advantageous for the ultra-stretchability of the temperature sensor. Therefore, the synergistic effect of the PANI-LCO-AgNWs and the substrate endowed the composite fibre-based temperature sensor with a high-temperature coefficient of resistance (TCR) of 47.4%/°C and a high stretchability of up to 120%. Furthermore, this study investigated the actual characteristics of the sensor required for the high-performance monitoring of human temperatures. Moreover, theoretical calculations of the electrical distribution of the PANI-LCO ligands further confirmed the experimental chemical modification. A fibre-based temperature sensor can be integrated and woven or sewn onto a cloth or glove with high adaptability. This work provides an efficient strategy to control the surface chemical structure of metal nanomaterials as well as the design of fibre-based temperature sensors that are promising for wearable healthcare management systems, artificial intelligence, electronic skin, and smart robots.
研究领域:
材料科学
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纳米技术
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可穿戴技术
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生物医学工程
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高影响因子
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