BIOCHEMICAL PHARMACOLOGY
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2024
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IF 5.3
Yufeng Dai,Jinxiang Chen,Jialong Fang,Shuxiao Liang,Hao Zhang,Haitao Li,Wei Chen
Metabolic dysfunction-associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic disorders, including hyperglycemia, hepatic steatosis, and insulin resistance. Piperlongumine (PL), a natural amide alkaloid extracted from the fruits of Piper longum L., exhibited hepatoprotective effects in zebrafish and liver injury mice. This study aimed to investigate the therapeutic potential of PL on MAFLD and its underlying mechanisms. The findings demonstrate that PL effectively combats MAFLD induced by a high-fat diet (HFD) and improves metabolic characteristics in mice. Additionally, our results suggest that the anti-MAFLD effect of PL is attributed to the suppression of excessive hepatic gluconeogenesis, inhibition of de novo lipogenesis, and alleviation of insulin resistance. Importantly, the results indicate that, on the one hand, the hypoglycemic effect of PL is closely associated with CREB-regulated transcriptional coactivators (CRTC2)-dependent cyclic AMP response element binding protein (CREB) phosphorylation; on the other hand, the lipid-lowering effect of PL is attributed to reducing the nuclear localization of sterol regulatory element-binding proteins 1c (Srebp-1c). Mechanistically, PL could alleviate insulin resistance induced by endoplasmic reticulum stress by antagonizing the thromboxane A 2 receptor (TP)/Ca 2+ signaling, and the TP receptor serves as the potential target for PL in the treatment of MAFLD. Therefore, our results suggested PL effectively improved the major hallmarks of MAFLD induced by HFD, highlighting a potential therapeutic strategy for MAFLD.
研究领域:
药理学
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肝病学
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代谢学
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分子生物学
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DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2018
·Vol. 187
·期 4
·1488-1501
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IF 1.797
Sun Zhong-liang,Sun Li-qin,Chen Guo-zhong
This work investigated the cultivation of Chlorella vulgaris in a thin-film flat plate photobioreactor under outdoor conditions and using digested piggery wastewater as the culture medium. The algal cells were able to adapt quickly to the wastewater and outdoor conditions. A specific growth rate of 0.12 day −1 was obtained in the exponential growth phase, which was slightly higher than that during indoor cultivation using artificial culture medium. Results showed that Chlorella vulgaris effectively removed TN, TP, and COD by 72.48%, 86.93%, and 85.94%. Due to the difference in culture conditions and phosphorus availability, the biomass from outdoor cultivation contained higher lipid content and more unsaturated fatty acids compared to indoor cultures, while the amino acid composition was unaffected. Results of metallic element assay indicated that the biomass cultured with wastewater conformed to the standards required for animal feed additive production. The overall cost of the biomass production in the thin-film flat plate photobioreactor (32.94 US$/kg) was estimated to be 4.67 times lower than that of indoor cultivation (154.04 US$/kg). Together, these results provide a basis for large-scale outdoor production of microalgae and wastewater bioremediation.
研究领域:
环境工程
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生物技术
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废水处理
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藻类生物技术
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Mengxin Li,Shiyuan Fu,Yutong Han,Jingjing Zheng,Changzhi Wang,Xiangyang Xu,Liang Zhu
Aiming at the issues of high consumption of reagents and energy, and poor removal ability of carbon and phosphorus in the existing process of sewage treatment plants, a novel type of carbon & phosphorus co-trapping magnetic coagulant named as acid-modified magnetically doped biochar (A/M-BC) was prepared for sewage treatment. Results showed that the removal efficiencies of chemical oxygen demand (COD) and total phosphorus (TP) were as high as 64.4 % (±2%) and 93.7 % (±8%), respectively. A series of characterization findings indicated that the A/M-BC had a nanoscale porous structure, a surface laden with magnetic particles, and a diverse array of iron oxides, enabling the formation of phosphate complex groups and exhibiting excellent paramagnetism. The efficient co-trapping of carbon and phosphorus by A/M-BC was mediated via combined coagulation and adsorption. Where into, coagulation includes co-precipitation and bridge of phosphate-iron complexes induced by complex ferric salts and net sweep trapping with magnetic powder. The novel magnetic coagulant A/M-BC had the advantages of a better co-trapping and faster separating for carbon and phosphorus, which has great application potential in reducing carbon emissions in the sewage treatment process.
研究领域:
环境工程
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水处理
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材料科学
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可持续性
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2016
·Vol. 23
·期 19
·19450-19460
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IF 2.76
Zhou Qiongzhi,Li Feng,Ge Fei,Liu Na,Kuang Yangduo
Toxicants are generally harmful to biotechnology in wastewater treatment. However, trace toxicant can induce microbial hormesis, but to date, it is still unknown how this phenomenon affects nutrient removal during municipal wastewater treatment process. Therefore, this study focused on the effects of hormesis induced by cetyltrimethyl ammonium bromide (CTAB), a representative quaternary ammonium cationic surfactant, on nutrient removal by Chlorella vulgaris F1068. Results showed that when the concentration of CTAB was less than 10 ng/L, the cellular components chlorophyll a , proteins, polysaccharides, and total lipids increased by 10.11, 58.17, 38.78, and 11.87 %, respectively, and some enzymes in nutrient metabolism of algal cells, such as glutamine synthetase (GS), acid phosphatase (ACP), H + -ATPase, and esterase, were also enhanced. As a result, the removal efficiencies of ammonia nitrogen (NH 4
+ ) and total phosphorus (TP) increased by 14.66 and 8.51 %, respectively, compared to the control during a 7-day test period. The underlying mechanism was mainly due to an enhanced photosynthetic activity of C. vulgaris F1068 indicated by the increase in chlorophyll fluorescence parameters (the value of Fv / Fm , ΦII, Fv / Fo , and rETR increased by 12.99, 7.56, 25.59, and 8.11 %, respectively) and adenylate energy charge (AEC) (from 0.68 to 0.72). These results suggest that hormesis induced by trace toxicants could enhance the nutrient removal, which would be further considered in the design of municipal wastewater treatment processes.
The schematic mechanism of C. vulgaris F1068 under CTAB induced hormesis. Green arrows ( ) represent the increase and the red arrow ( ) represents the decrease.
研究领域:
环境科学
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微生物学
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生物技术
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废水处理
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
·
IF 8.128
Ruoxuan Guo,Yang Liu,Yingzhong Huo,Anrui Zhang,Jiahui Hong,Yuejie Ai
Covalent organic frameworks (COFs) are promising adsorbents for removing heavy metal ions , and have high crystallinity , a porous structure, and conjugated stability. N -containing functional groups are known to have great affinity for uranyl ions. In this work, to explore the peculiarity of the pyridine N structure as an efficient adsorbent, we chose 2,2′-dipyridine-5,5′-diamine (Bpy) and pyridine-2,5′-diamine (Py) as the core skeletons, and 1,3,5-triformylphloroglucinol (Tp) as the linker to synthesize two crystalline and stable N -containing COFs named TpBpy and TpPy, respectively, through a facile solvothermal method . Characterization results demonstrated that TpBpy and TpPy possessed regularly growing pore sizes, large specific surface areas and relatively strong thermal resistances . The results of batch experiments showed that both COF materials were capable of the effective removal of uranyl with uptake capacities of 115.45 mg g −1 and 291.79 mg g −1 , respectively. In addition, density functional theory (DFT) simulations highlighted the beneficial chelation effect of the double N structure in pyridine monomers for removing uranyl ions. Combining systematic experimental and theoretical analyses, the adsorption process and interaction mode of porous COFs and UO 2 2+ were revealed, to provide predictable support for the application of pyridine N -containing COFs in the field of environmental remediation.
研究领域:
环境科学
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材料科学
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化学工程
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理论化学
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DOI
PubMed
高影响因子
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