ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Ziwu Ding,Zilong Zhang,Yaqing Zou,Xiaofeng Li,Xiaolei Lin,Chunming Liu,Can Wang,Yong Chen,Xiaozhen Huang,Liangliang Zhang,Hongfang Du,Yue Wang,Mingwei An,Peng Gao,Yang Wang
Perovskite solar cells (PSCs) employing 2,2″,7,7″-tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9’-spirobifluorene (Spiro-OMeTAD) as the hole-transporting material (HTM) often suffer from dopant-induced instabilities, including lithium (Li) salt aggregation, ion migration, and the volatilization of tert-butylpyridine (tBP). Additionally, the solution processing of conventional HTMs typically relies on toxic solvents, posing environmental and industrial challenges. In this study, we introduce an “ionic lock” strategy by incorporating polyoxygenated side chains─such as crown ether and 2-methoxyethoxy groups─into the backbone of conjugated hole conductors. The resulting HTMs, MPA-NDTCE and MPA-NDTME, exhibit excellent solubility in eco-friendly solvents like 3-methylcyclohexanone (3-MC) and demonstrate favorable compatibility with Li-based dopants. Notably, MPA-NDTCE shows enhanced molecular ordering, superior hole mobility, and stronger interactions with Li+ ions, facilitating dopant immobilization and stabilizing the film morphology. Consequently, PSCs utilizing MPA-NDTCE as a green-solvent-processable HTM achieve a high power conversion efficiency of 22.6%, coupled with robust thermal stability under aging at 65 °C. These improvements are attributed to the elimination of tBP and the effective suppression of Li-ion migration.
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DOI
高影响因子
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
·
2024
·
IF 3.9
Jiawen Cui,Zhenda Liang,Yuhao Liu,Zhiyu Hao,You Tang,Li Zhou,Xiaohua Teng
Environmental endocrine disrupting chemical 4-tert-butylphenol (4-tBP), a widely-utilized surfactant in various industries, poses potential risks to aquatic organisms. Our previous sequencing results suggested that 4-tBP-induced common carp liver injury might be associated with Ca 2+ signaling and autophagy. However, the intricate involvement of these pathways in 4-tBP-induced cytotoxic mechanisms remained unexplored. To bridge these knowledge gaps, this study focused on epithelioma papulosum cyprini (EPC) cells, a significant cell type in fish biology. Initial observations showed that 4-tBP induced a dose-dependent perturbation in Ca 2+ levels. Further investigations, with siRNA and L-type Ca 2+ channel agonist (BAY K8644), identified L-type calcium channel gene CACNA1D as a critical regulator of 4-tBP-induced Ca 2+ overload. Predictive analysis using miRanda platform suggested a potential interaction between miR-363 and CACNA1D, which was subsequently verified through dual-luciferase reporter gene assays. We then established miR-363 mimic/inhibitor models, along with miR-363 and CACNA1D co-suppression models in EPC cells. Through TEM observation, immunofluorescence assay, Ca 2+ staining, and qRT-PCR analysis, we evaluated the role of miR-363/CACNA1D axis in modulating the effects of 4-tBP on Ca 2+ signaling and autophagy. Results showed that miR-363 inhibitor exacerbated 4-tBP-induced increase in CALM2, CAMKII, Calpain2, and p62 expression and also led to decrease in ATG5, ATG7, and LC3b expression. In contrast, miR-363 mimic notably alleviated these changes. Notably, siRNA CACNA1D effectively modulating miR-363 inhibitor's effect. Our study revealed that 4-tBP induced Ca 2+ overload and subsequent autophagy impairment via miR-363/CACNA1D axis. These findings illuminated a profound understanding of molecular mechanisms underlying 4-tBP-induced cytotoxicity and spotlighted a potential therapeutic target.
研究领域:
环境科学
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毒理学
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细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Yaxing Han,Ji Chen,Yuefeng Deng,Tianchi Liu,Hailian Li,Deqian Li
The current separation technique of ion-adsorption high yttrium (Y) rare earth ore (high-yttrium ore) using 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (P507) and naphthenic acid (NA) has been confronted with low separation efficiency and high acid consumption. This is a consequence of the low selectivity and the difficulty of complete stripping of heavy rare earths (HREEs). Therefore, an innovative separation technique of high-yttrium ore was proposed. The leachate of high-yttrium ore was firstly divided into Erbium (Er) / Thulium (Tm) groups with P507-isooctanol followed by separating Y (III) from the high Y-enrichment of Er (III) group with sec -octylphenoxy acetic acid (CA12)-tri- n -butyl phosphate (TBP). The basic thermodynamics experiments and cascade extraction simulations were conducted to verify the feasibility of this technology. The results show that P507-15vol% isooctanol is superior to P507 in both stripping ability and separation selectivity of HREEs. The first cascade extraction for Er (III) / Tm (III) grouping with P507-15vol% isooctanol was simulated successfully, reducing acid consumption but obtaining high purity products. In theory, the second cascade extraction simulation designed for separating Y (III) with CA12-TBP could not only improve the separation ability between Y (III) and light rare earths (LREEs) but also shorten the extraction stages and reduce the production costs. All these results revealed that this two-step separation process probably provided a promising application prospect for separating high-yttrium ore.
研究领域:
冶金工程
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稀土化学
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分离科学与技术
·
资源加工工程
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湿法冶金
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萃取分离
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DOI
高影响因子
HYDROMETALLURGY
·
2026
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IF 6.3
Zhengqin Zhang,Zheng Li,Longsheng Zhao,Bowen Wang,Zongyu Feng,Xiaowei Huang
Synergistic extraction mechanism in TBP system was investigated. • Synergistic extraction system performs better at low lithium concentration. • TBP-DEC system exhibits higher β Li/Mg than other synergistic systems. • Reducing O's electric potential in C O of synergistic agents enhance lithium selectivity. This study investigates the extraction and selective separation of Li from solutions with a high Mg/Li ratio based on a synergistic extractant system involving tributyl phosphate (TBP). Different synergistic agents were investigated, including ethyl acetate (EA), butyl acetate (BA), diethyl carbonate (DEC), methyl isobutyl ketone (MIBK), N,N-Diethylacetamide and N,N-di(1-methylheptyl)acetamide (N503). The result showed that TBP-DEC synergistic extraction system achieved the highest lithium extraction rate of 71.4% and lithium magnesium separation factor of 160, when the concentration of Li = 0.50 g/L and Mg/Li ratio = 200. Fourier Transform Infrared Spectroscopy (FT-IR) analysis revealed that TBP acted as the primary extraction agent for lithium extraction, while the O atom in the C O group of the synergistic agent participates in coordination with lithium. Additionally, the lithium extraction rate of the synergistic extractant system increased with the integrated peak area of the P O stretching vibration. Mechanism analysis reveals that increase of the negative charge density on the O atom in the C O group and reduction of the intermolecular steric hindrance of the synergistic agent can enhance the lithium selectivity of TBP.
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产品关联
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
·
IF 4.6
Qianqian Liu,Qi Chen,Wenhao Zhang,Ru Liu,Dingxuan Li,Qingcui Chu
In this work, the porous nanomaterial zeolite imidazolate framework-67 (ZIF-67) and tributyl phosphate (TBP) were introduced to co-modify the hollow-fiber liquid-phase microextraction (HF-LPME) for the first time. The extract of five typical flavor enhancers (vanillin, o-vanillin, ethyl vanillin, vanillinol and vanilla acetone) could be directly injected for electrophoretic separation and amperometric detection. The obtained optimum extraction conditions were as followed: supported liquid membrane, tributyl phosphate containing 0.050 mg mL -1 of ZIF-67; donor phase, 10 mL (pH 4.00 adjusted by HCl); acceptor phase, 10 μL (0.20 M NaOH); stirring rate, 500 rpm; extraction temperature, 25 °C; and extraction time, 45 min. Based on the synergistic enrichment effect of ZIF-67 and TBP, this HF-LPME could provide the enrichment factors of 207(V-OH)-890 times (EVA) for the flavor enhancers. This method has been successfully used for the analyses of milk, milk powder and milk tea samples. The limits of detection were 0.15-3.0 μg L -1 (S/N=3), and the recovery data were in the range of 80.1-115.5%. This developed method is easy to operate and has low consumption of solvents and samples, providing a green alternative method for the detection of typical flavor enhancers in dairy products. Besides, the greenness and eco-friendliness of the proposed method was assessed using the green analytical procedure index and analytical eco-scale tools.
研究领域:
分析化学
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食品科学
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纳米技术
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分离科学
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电化学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2021
·
IF 7.312
Ruibing Bai,Junfeng Wang,Daoguang Wang,Yanqiang Zhang,Junjie Cui
The high acidity of stripping is one of the major problems that hinder the industrialization of the tributyl phosphate (TBP) + FeCl 3 system for lithium extraction from the salt lake brines with high Mg/Li ratio. In this study, a novel solvent extraction system, trialkylmethylammonium di(2-ethylhexyl)orthophosphinate ([N 1888 ][P 507 ]) + TBP + FeCl 3 , was developed to significantly reduce the difficulty of stripping and simplify the extraction process. The conditions of extraction and stripping were systematically studied in the present work. The results showed that Li + extraction efficiency could reach 61% under the optimal extraction parameters and Li + stripping ratio was 90% with a relative mild conditions of O/A = 10:1, [HCl] aq = 1.5 mol·L –1 . Also, combined with experimental results, FT-IR analysis, and UV analysis, the possible mechanisms of lithium extraction and stripping were put forward. Li + was extracted from the aqueous phase through the formation of [Li·2TBP][FeCl 4 ] adduct, meanwhile [N 1888 ][P 507 ] was just slightly involved in the extraction step. In the stripping procedure, the interaction between [FeCl 4 ] − and [Li·2TBP] + might be destroyed, and new possible complexes, [Li·2TBP] + , and [FeCl 4 ·TBP·P 507 ] 2− /[FeCl 4 ·P 507 ] 2− were formed in the organic phase. Additionally, the extraction efficiency of Li + remained above 70% while the organic phase was reused for six cycles. Compared with the traditional system, the addition of [N 1888 ][P 507 ] resulted in a slight decrease of Li + extraction efficiency (about 5%), the stripping acidity significantly reduced from 6 mol·L –1 HCl to 1.5 mol·L –1 HCl. This new extraction system showed a promising performance in selective extracting and easy stripping in lithium separation from the salt lake brines with high Mg/Li ratio.
研究领域:
化学工程
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材料科学
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环境化学
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无机化学
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产品关联
DOI
高影响因子
INORGANICA CHIMICA ACTA
·
2025
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IF 3.2
Xingyue Liu,Xuanhao Huang,Yiting Wang,Zhuang Wang,Qiao Yu,Hang Zhou,Rui Li,Songdong Ding
Tri- n -butyl phosphate (TBP), n -octanol and N,N -dihexyloctanamide (DHOA) are often used as phase modifiers to prevent the formation of the third phase during the extraction of trivalent lanthanides and actinides by N,N,N′,N′ -tetraoctyl diglycolamide (TODGA) in spent fuel reprocessing process. In this context, the effects of these three modifiers on the thermodynamic and kinetic behaviors of 0.20 mol·L −1 TODGA in n -dodecane toward Nd 3+ in nitric acid solution were studied and compared together for the first time. A systematic comparison of the effects of the three modifiers on the extraction distribution ratio, stripping percentage, loading capacity, aggregation and extraction kinetics was carried out with the aim of selecting a phase modifier for the TODGA-based process that would work optimally and to elucidate the impact of the modifiers in the TODGA extraction system. It is found that modifier reduces the capacity of TODGA to extract Nd 3+ in the order of DHOA > TBP > n -octanol, slightly hinders the stripping of Nd 3+ , while significantly enhancing the loading capacity of TODGA. With increasing the modifier concentration, the limiting organic phase concentration (LOC) for Nd 3+ increases. At the modifier concentration below 0.30 mol·L −1 , n -octanol has the greatest promotion effect on the LOC value, while at that above 0.50 mol·L −1 , TBP has the best effect. Meanwhile, through the dynamic light scattering analysis for the loaded organic phase, it is also found that the particle size of the aggregates in organic phase decreases significantly upon the addition of modifier. Furthermore, the extraction kinetics studies in a Lewis cell indicate that the addition of modifier can prolong the time to reach extraction equilibrium, and decrease the extraction rate. Although the modifier also exerts some influence on the reaction order and extraction rate constant to some extent, it does not alter the underlying regime of the extraction reaction.
研究领域:
化学工程
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核燃料循环与材料科学
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DOI
高影响因子
Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
He Keting,Wei Dongfan,Liu Qiuhong,Liu Xiaoli,Zhou Diwenxin,Chen Shangci,Zhu Danhua,Xu Xiaowei
Acute liver injury (ALI) presents a challenging problem worldwide, prompting extensive research efforts. Cellular senescence has been found to be induced following ALI, and targeting cellular senescence has shown therapeutic potential. Therefore, understanding the expression of senescence-related genes in ALI can help to explore pathogenesis and treatment of this common disease. Carbon tetrachloride (CCl 4 ) is commonly used to study ALI. Although polymerase chain reaction (PCR) is a convenient and economical molecular biology technique widely used in basic medicine, research on selecting suitable reference genes to obtain objective and reproducible PCR data is scarce. Moreover, evidence supporting the choice of reference genes for experimental studies of CCl4-induced ALI and hepatic senescence in mice is limited. In this study, we obtained murine livers at four time points (0, 12, 24, and 48 h) following CCl4 treatment. We used five algorithms (geNorm, BestKeeper, NormFinder, delta Ct, and RefFinder) to rank 12 candidate genes in real-time reverse-transcription quantitative PCR (RT-qPCR) experiments. Focusing on cellular senescence in this model, we adopted four senescence-associated secretory phenotype (SASP) genes ( Il6 , Il1b , Ccl2 , and Ccl5 ) as target genes. Our results confirmed Gapdh and Tbp as suitable reference genes in murine CCl 4 -induced ALI models. Furthermore, we provide a table of published studies recommending reference genes for various liver disease models. This study provides a valuable reference for enhancing the reliability and reproducibility of ALI molecular findings.
研究领域:
分子生物学
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肝病学
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病理学
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基因组学
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产品关联
DOI
PubMed
高影响因子
AQUACULTURE
·
2022
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IF 5.135
Jia Liu,Hui Du,Tao Liu,Cheng Chen,Ying Yan,Tianqiang Liu,Lei Liu,Erlong Wang
Hepatopancreas as the main organ detoxifying xenobiotics with higher detoxifying and antioxidant enzymes activities , could best reflected the status of antioxidant defence against virus infection in the organisms. Catalase ( CAT ) and glutathione S-transferase ( GST ) were two important enzymes associated with hepatopancreas antioxidation and detoxification. To obtain the accurate expression levels of CAT and GST gene which reflect the status of hepatopancreas antioxidation and detoxification, two or more reference genes expressed stably under different conditions should be selected for RT-qPCR analysis. In this study, eight candidate reference genes were investigated using RefFinder program to screen the most stable reference gene during virus (white spot syndrome virus, WSSV) infection and drug (matrine) treatments in Procambarus clarkii , the relative expression levels and the activities of CAT and GST in hepatopancreas were detected and compared to verify the validity of selected reference genes. The results showed that taken different tissues together, EIF and EF1 α were the most stable and unstable reference genes respectively in P. clarkii no matter under different WSSV infection periods (0, 24, 48, 72 h) or different matrine treatment methods according to RefFinder analysis. The optimal number of reference genes in hepatopancreas was two using geNorm analysis, i.e. EIF and TBP , which were top two most stable reference genes in hepatopancreas. Moreover, based on the comparison between the relative expression levels and the activities of CAT and GST, EIF and TBP as reference genes were proved to be necessary and practicable to evaluate hepatopancreas antioxidation during WSSV infection and matrine treatments. Besides, the optimal number of reference genes in other P. clarkii tissues was also two genes, i.e. EIF and TUB in intestine, EIF and EF1α in muscle, EIF and GAPDH in gills, EIF and TBP in brain , TBP and UB in gonads . Our study was helpful to acquire the accurate data of antioxidation and detoxification-related and immune-related gene expression during virus infection and drug treatments in crayfish, especially in hepatopancreas tissues
研究领域:
水产养殖
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分子生物学
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免疫学
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兽医学
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产品关联
DOI
高影响因子
Journal of Agriculture and Food Research
·
2026
·
IF 7.2
Yizhu Chen,Yi Liu,Yurong Fang,Huixue Huang,Zhihong Long,Bomi Ryu,Haisheng Xie,Zhong-Ji Qian
Age related macular degeneration (AMD) is one of the main causes of blindness in. elderly patients, and its treatment methods include intraocular injection and oral. administration, requiring long-term treatment and suboptimal efficacy. Tilapia skin-derived oligopeptides, characterized by high safety and bioactivity, emerge as a promising source of functional food ingredients. Here, we investigated the protective mechanism of TBP-1 (Ser-Val-Val-Ala-Ile), a pentapeptide isolated from tilapia skin, against hypoxia-induced damage in retinal pigment epithelial (ARPE-19) cells and angiogenesis in human umbilical vein endothelial cells (HUVECs). In the functional evaluation, TBP-1 notably attenuated ROS overproduction in CoCl 2 -induced ARPE-19 cells, simultaneously suppressing the stabilization of hypoxia-inducible factor-1α (HIF-1α), which was associated with reduced vascular endothelial growth factor (VEGF) transcription, diminished inflammatory factor levels, and restoration of normal autophagic flux. To validate the ROS-dependent nature of this regulatory pathway, we performed a rescue experiment using N-acetylcysteine (NAC), a well-characterized ROS scavenger. In HUVECs activated by VEGF, TBP-1 decreased the phosphorylation of VEGFR-2 and dampened the activation of the MAPK signaling pathway, resulting in dose-dependent inhibition of cell migration, invasion, and the formation of capillary-like tubular structures. Molecular docking and quantum chemical analyses suggested that the bioactivity of TBP-1 may rely on the electron-donating property of the Ser residue and hydrophobic interactions mediated by Ile, both of which are critical for its ROS scavenging ability and predicted interaction with HIF-1α. Collectively, these findings suggest that TBP-1 is a multi-target functional food supplement for preventing AMD by targeting the ROS/HIF-1α/VEGF axis, providing a theoretical basis for the high-value utilization of tilapia skin.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qiuqi Niu,Xiyu Zhang,Yang Wu,Chuanzhi Sun,Xiong Zheng,Min Long,Yinguang Chen
The escalating global production of waste activated sludge (WAS) presents both environmental challenges and opportunities for resource recovery through anaerobic fermentation (AF) to volatile fatty acids (VFAs). However, the ubiquitous presence of emerging contaminants (ECs, e.g., tribromophenol (TBP)) in WAS, resulting from extensive industrial applications, raises critical concerns about potential impacts on fermentation process. This study systematically investigated dose-dependent effects of TBP on VFA production during WAS fermentation, focusing on organic matter (OM) transformation, microbial metabolism, and adaptive mechanisms. Results demonstrated that low-dose TBP (10 mg/g TSS) enhanced VFA yield by 30.4 % (from 1288 to 1680 mg COD/L), while high-dose TBP (100 mg/g TSS) inhibited production by 8.0 % (to 1185 mg COD/L). Spectroscopic analysis confirmed TBP addition significantly attenuated amide I/II band intensities (1656/1546 cm −1 ) in FTIR and reduced amino acid-associated organic C=O/C-O XPS peak areas in the solid phase, while proportionally increasing amino acids in the liquid phase. This dissolution of solid-phase proteins by TBP thereby enhanced substrate bioavailability for fermentation. The improved substrate availability stimulated the growth of Firmicutes (increased by 53.52 %) and protein-degrading genera (e.g., Proteocatella ), while upregulating key metabolic pathways including amino acid metabolism (e.g., hisC and maiA ), glycolysis (e.g., HK and apgM ), and pyruvate metabolism (e.g., porA and korA ). Moreover, low-dose TBP enhanced microbial adaptability through quorum sensing (e.g., lsrB increased by 43.9 %) and two-component systems (e.g., rstB increased by 14.0 %). However, these beneficial effects were reversed at high TBP concentrations, leading to decreased microbial activity and VFA production. This work provides a comprehensive insight into ECs impacts on WAS fermentation, highlighting the critical need for dose-dependent process control to ensure safe resource recovery.
研究领域:
环境科学
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生物技术
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微生物学
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化学工程
·
废弃物管理
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分析化学
·
生物化学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Rujie Li,Wanhang Wang,Yangyang Wang,Xiaoyu Wei,Ziqi Cai,Zhiyong Zhou
A novel ionic liquid named 1-butyl-3-methylimidazolium tetraphenylboron ([Bmim]Bph 4 ) containing a stereo symmetric structure of Bph 4 - was synthesized and used as co-extractants with TBP and CH 2 BrCl as extractant and diluent for selective extraction of lithium ions from salt lake brines with high molar ratio of magnesium to lithium. The effects of extraction conditions containing molar ratio of co-extractant to lithium ion, volume percentage of TBP and O/A phase ratio on extraction performance were investigated. Under the optimal extraction conditions, the maximum separation factor of lithium to magnesium reached up to 2754 after one single-stage extraction process. After four stages of counter-current extraction process, the extraction efficiency of Li + reached up to 99.47%. Then the washing and stripping conditions were optimized with the combination of LiCl and NaCl solution as the washing agent and Na 2 CO 3 solution as the stripping agent. After that, 10 cycles of the whole extraction experiments were carried out and the organic phase exhibited excellent reusability and stability. Since no acid and alkaline were used throughout the extraction process, the novel extraction process is greener and more environmentally friendly than the traditional solvent extraction process.
研究领域:
化学工程
·
材料科学
·
环境科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）