International Journal of Nanomedicine
·
2025
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IF 6.5
Zhiyu Zheng,Gareth R Williams,Honghua Guo,Yilu Zheng,Mengting Xiu,Yanyan Zhang,Huan Zhang,Kai Wang,Jindong Xia,Yu Wang,Li-Min Zhu
Purpose Owing to the limitations of single-mode cancer treatments, combination therapies have attracted much attention. However, constructing a platform for combination therapies in a simple and effective way and improving the overall treatment effect remains a challenge. Our aim was to combine sonodynamic therapy, radiotherapy and chemotherapy together and improve therapeutic outcomes within one nanoplatform.Methods In this work, we sought to exploit the properties of nanoscale heterojunctions to this end. A multifunctional Bi2O3-TiO2@polydopamine-doxorubicin (BTPD) nanoparticle platform was constructed as an anti-cancer theranostic. Under ultrasound irradiation, the Bi2O3-TiO2 core can generate singlet oxygen to damage tumor cells. Meanwhile, the high-Z Bi2O3 can attenuate the energy of X-rays and scatter secondary electrons to enhance radiation damage in the tumor. A thin coating of polydopamine (PDA) increases the biocompatibility but also gives the particles the ability for photoacoustic imaging. Doxorubicin, a DNA repair inhibitor which can hinder tumor recovery from radiation damage, was loaded onto the PDA.Results A comprehensive series of in vitro and in vivo assays demonstrated that the nanoparticles were effectively taken up into cancer cells, where they could induce ROS production and cause cell death. In vivo, this led to a marked reduction in tumor volume in a murine 4T1 cancer model.Conclusion The formulations developed here have significant potential for future investigation and exploration in the treatment of cancer.
研究领域:
肿瘤学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2016
·
IF 2.758
Shunqin Luo,Chao Tang,Zhaohui Huang,Chen Liu,Jiawei Chen,Minghao Fang
In this study, bismuth oxyiodide/titanium dioxide (BiOI/TiO 2 ) heterostructures with different molar ratios of Bi and Ti were synthesized by electrospinning and hydrothermal methods . The samples thus synthesized were characterized by powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy (TEM), high-resolution TEM, X-ray photoelectron spectroscopy, and ultraviolet–visible diffuse reflectance spectroscopy . The results confirmed the presence of the BiOI/TiO 2 heterojunction with Bi/Ti molar ratios of 0.20–1 by electrospinning and hydrothermal methods . Photocatalytic activity was also evaluated by the degradation of methylene blue (MB) under visible-light irradiation. The 80% BiOI/TiO 2 heterostructure exhibited the best photocatalytic activity for the degradation of MB under visible-light irradiation.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Yunfang Huang,Yuelin Wei,Jing Wang,Dan Luo,Leqing Fan,Jihuai Wu
Three-dimensional Bi 2 O 3 /TiO 2 hierarchical composites have been successfully prepared by a two-step hydrothermal method and subsequent calcination. The samples were characterized using XRD, SEM, TEM, EDS, BET and DRS. The measurement results signified that heterojunctions of various morphologies β -Bi 2 O 3 growing on the three-dimensional hierarchical anatase TiO 2 nanorods arrays on FTO glass were apparently formed. The morphology of Bi 2 O 3 changed from three-dimension flower-like microstructures to the sphere-like nanoparticles as the Li(OH) dosage increased. The photocatalytic results showed that all samples exhibited much higher photocatalytic activities than that of pure Bi 2 O 3 and TiO 2 (P25) in photocatalytic degradation of methyl blue (MB) under visible-light irradiation. Whereas BTL4 sample exhibited the highest photoactivity with increasing the dosage of Li(OH) to 2 mmol. Furthermore, the absorption edge of the Bi 2 O 3 /TiO 2 series composites displayed a broad-spectrum photoabsorption from UV to visible-light compared with the individual component. The as-synthesized Bi 2 O 3 /TiO 2 composites possessed excellent photocatalytic activity and outstanding recyclability. The enhanced photocatalytic efficiency was mainly attributed to the Bi 2 O 3 /TiO 2 p - n heterojunctions and hierarchical nanostructure. The recombination of photogenerated electron–hole pairs was efficiently suppressed by the Bi 2 O 3 /TiO 2 p - n heterojunctions.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 6
·4114-4120
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IF 3.201
Jiajia Li,Xiuxun Han,Min Wang,Yun Zhao,Chen Dong
Highly active and durable hydrogen evolution reaction (HER) catalysts are required for the low-cost and high-yield generation of clean energy from water splitting. Herein, a Cu3BiS3/TiO2 (C@T) heterojunction film is constructed by a facile dip-coating method for the synthesis of Cu3BiS3 nanorods on a TiO2 film. The heterojunction film is used as a catalyst in water splitting which exhibits a higher photoelectrochemical (PEC) performance and electrocatalytic activity than the respective pure Cu3BiS3 nanorods counterpart. Experimental results confirm that the PEC performance of the C@T heterojunction film displays a strong photoresponse of as high as ∼1.5 × 10−4 A cm−2 at an applied potential of −0.5 V vs. Ag/AgCl under visible light irradiation. What's more, the as-prepared C@T film shows the best electrocatalytic performance with an onset overpotential of 150 mV, a low Tafel slope of 42.67 mV dec−1, a large current density of 10.8 mA cm−2 at an overpotential of 220 mV, and a remarkable cycling stability. The enhanced PEC performance is associated with the formation of a heterojunction structure at the interface between TiO2 and Cu3BiS3, which facilitates light absorption and separation of photogenerated charge carriers. The growth of Cu3BiS3 nanorods on a TiO2 film modified the electronic structure and increased the electrochemical area, and thus is responsible for enhanced catalytic activity. Benefitting from its scalable preparation and properties, the Cu3BiS3 nanorods/TiO2 heterojunction film is indeed a promising catalyst for hydrogen evolution reaction.
研究领域:
材料科学
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能源化学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
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2016
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IF 3.15
Fengyu Tian,Dongfang Hou,Fuchao Hu,Kui Xie,Xiuqing Qiao,Dongsheng Li
1D porous CdS nanoparticles/TiO 2 nanofibers heterostructure has been fabricated via simple electrospinning and a successive ionic layer adsorption and reaction (SILAR) process. The morphology, composition, and optical properties of the resulting CdS/TiO 2 heterostructures can be rationally tailored through changing the SILAR cycles. The photocatalytic hydrogen evolution and decomposition of rhodamine B (RhB) of the as-synthesized heterostructured photocatalysts were investigated under visible light irradiation. Compared to TiO 2 nanofibers，the as-obtained CdS/TiO 2 heterostructures exhibit enhanced photocatalytic activity for hydrogen production and decomposition of RhB under visible-light irradiation. The heterojunction system performs best with H 2 generation rates of 678.61 μmol h −1 g −1 under visible light irradiation which benefits from the two effects: (a) the 1D porous nanofibrous morphology contributes to not only more active sites but also more efficient transfer of the photogenerated charges (b) the synergetic effect of heterojunction and photosensitization reducing the recombination of photogenerated electrons and holes.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2022
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IF 4.644
Honglan Huang,Shengzhe Zhao,Yi Yang,Yan Wang,Ran Lu,Yun Lu,Jinju Chen
Axially wrinkled SnO 2 /TiO 2 heteronanotubes have been successfully prepared by sacrificial template method combined with hydrothermal synthesis. The special folded morphology of SnO 2 /TiO 2 nanostructures may provide more active sites, and the S-scheme heterojunction between SnO 2 and TiO 2 enhances the separation of photogenerated electron-hole pairs, which are conducive to the improvement of photocatalytic degradation for organic pollutants. Using SnO 2 /TiO 2 nanotubes as catalyst, the removal rate of Rhodamine B (RhB), methyl orange (MO) and tetracycline hydrochloride (TCH) under the irradiation of a xenon lamp is 93%, 91% and 85%, respectively. After five cycles, the removal efficiency of organic pollutants maintains almost unchanged, indicating that the synthesized SnO 2 /TiO 2 nanotubes has good stability and reusability. In addition, trapping experiments have been carried out to investigate the major reactive oxidative species for organic pollutants photodegradation. This study provides a facile avenue to design nanotublar photocatalysts with enhanced degradation performance for organic pollutants.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
Journal of Materials Research and Technology-JMR&T
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2022
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IF 6.267
Tongle Gao,Ting-Ting Li,Xilin Liao,Jia-Horng Lin,Bing-Chiuan Shiu,Ching-Wen Lou
Photoelectrodes constructed with photoactive materials are of great significance for the performance of photoelectrochemical (PEC) sensors. In this study, a facile and efficacious non-enzymatic glucose sensor based on the Cu 2 O/TiO 2 heterojunction was successfully constructed for quantitative determination of glucose concentration. The Cu 2 O/TiO 2 heterojunction was generated by first obtaining TiO 2 nanofibers via electrostatic spinning and high-temperature calcination, and then synthesizing Cu 2 O nanoparticles via a one-step hydrothermal reaction. By introducing the narrow band gap semiconductor Cu 2 O, the defect that pure TiO 2 could not absorb visible light was improved, resulting in the improved photoelectrochemical performance of the composite material compared to the single component semiconductor. The sensor exhibited favorable PEC non-enzymatic glucose sensing performance under simulated sunlight irradiation with a wide linear response range from 1 mM to 14 mM (R 2 = 0.9991) and a low detection limit of 14.4 μM (S/N = 3), along with good selectivity, stability and reproducibility. This also provided more ideas and possibilities for preparing photoelectrode materials by constructing heterojunctions.
研究领域:
材料科学
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分析化学
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生物传感
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Ziwei Zhao,Qi Ling,Ziliang Li,Kui Yan,Chunsheng Ding,Peng Chen,Lei Yang,Zhaoqi Sun,Miao Zhang
The combination of light energy and mechanical energy is thought to be an effective way to manage environmental resources and create sustainable energy. In this study, thin-film catalysts compounded with photocatalytic material TiO 2 and piezoelectric material BaTiO 3 were successfully prepared by a simple hydrothermal method on glass sheets, avoiding the possibility of secondary contamination of powder catalysts. The synergistic effect of light and ultrasound enhanced the degradation of norfloxacin by heterojunction BaTiO 3 /TiO 2 . After 60 min, the norfloxacin degradation was 91.7 % complete, with a rate constant of 43 × 10 −3 min −1 . This rate constant was 2.69 times higher than the rate constant for TiO 2 at 16 × 10 −3 min −1 . The built-in electric field generated by ultrasound is thought to improve the catalytic and optoelectronic properties of the composite by separating photogenerated electrons and holes. In addition, the stability and general usability of the composites were investigated. The effects of norfloxacin concentration, solution pH, and anions on the experiments were also analyzed. Free radical trapping experiments were conducted on the composites to identify the active species. The results showed that h + and ·OH were the main active species. In addition, it was determined that S-Scheme heterojunctions were likely involved in the catalytic process.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Russian Journal of Physical Chemistry A
·
2023
·Vol. 97
·期 12
·2786-2791
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IF 0.7
Yu Hongchao,Zhang Mengmeng,Jin Tianxiang
Abstract A unique heterostructure of Ag/TiO 2 nanofibers (denoted as Ag/TiO 2 NFs) have been fabricated by a facile electrospinning technique with subsequent annealing. The loading amount of the Ag nanoparticles can be conveniently tailored by adjusting the concentration of the Ag precursor. The resulting samples were characterized by different techniques such as SEM, TEM, XRD, UV–Vis diffuse reflectance spectra and XPS. Photoelectrochemical performances were also tested under full spectrum light illumination and the results demonstrated that Ag nanoparticles provided efficient separation of photogenerated electron–hole pairs and made for the enhancement of photocatalytic activity in comparison with pure TiO 2 nanofibers. Furthermore, the optimum matching between the Ag and TiO 2 for the best photoelectrochemical activity was investigated and a reasonable mechanism was also proposed.
研究领域:
材料科学
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环境科学
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光催化技术
✓ 已验证
DOI
高影响因子
Journal of Nanomaterials
·
2020
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IF 1.98
Yan Zhang,Jiarong Li,Hongyuan Liu
The batch experiments of photocatalytic oxidation-reduction of bromate and ibuprofen (IBP) by graphene oxide (GO) and TiO2 heterostructure doped with F (FGT) particles were conducted. The performance and mechanism of synergistic removal of bromate and IBP by FGT were discussed. The results show that a demonstrable synergistic effect and excellent removal rate of bromate and IBP by FGT were exhibited. When pH is 5.2 and the dosage of FGT is 0.1 g/L, the reaction rate constants of bromate and IBP increased from 0.0584 min-1 and 0.4188 min-1 to 0.1353 min-1 and 0.4504 min-1, respectively, compared with the degradation of bromate or IBP alone. The reaction of photocatalytic synergistic degradation is appropriately fitted through Langmuir-Hinshelwood first-order kinetics. The mechanism of synergistic removal of bromate and IBP by FGT was discussed. And electrons (e-), hydroxyl radical (⋅OH), and superoxide radical (⋅O2-) are the main active species. The electrons play a main role in the bromate reduction, and bromine is the only reduction product, while the oxidation of IBP is the result of ⋅OH and ⋅O2-, and ⋅OH plays a key role. The recombination of electrons and holes is inhibited by simultaneous consumption of bromate and IBP, which makes full use of the redox properties of FGT and plays a synergistic role in the removal of pollutants. The results indicate that photocatalytic oxidation-reduction by FGT is a promising, efficient, and environmental-friendly method for synchronous removal of combined pollution in water.
研究领域:
环境科学
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化学工程
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DOI
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 8
·4975-4989
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IF 3.9
Jianrou Li,Zhuangzhuang Yin,Jun Guo,Wei Gan,Ruixin Chen,Miao Zhang,Zhaoqi Sun
In this study, Sb2S3/In2S3/TiO2 (SIT) heterojunction photocatalysts were prepared by a simple two-step hydrothermal method and applied to the photocatalytic degradation of levofloxacin (LEV). After 160 min of reaction under visible light, the SIT heterojunction photocatalyst degraded 10 mg L−1 LEV at a rate of 86.7%. The degradation of LEV follows pseudo-first-order kinetics with a rate constant 1.16 × 10−2 min−1, which is 1.42, 1.22 and 1.05 times higher than that of TiO2, SI and IT, respectively. Meanwhile, the SIT photocatalysts also showed high photocatalytic activity for other antibiotics. The enhanced photocatalytic activity of the ternary heterostructures was attributed to the full-spectrum response and the synergistic effect of the dual Z-type heterojunctions, which improved the visible light absorption and facilitated the charge separation. In addition, ˙OH and ˙O2− play a dominant role in the photodegradation process. This work contributes to the design of novel photocatalytic materials with dual Z-type heterojunctions and efficient photocatalysts for the degradation of antibiotics.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science and Engineering B-Advanced Functional Solid-State Materials
·
2020
·
IF 4.706
Hongyu Luo,Ming Yan,Yilin Wu,Xinyu Lin,Yongsheng Yan
Porous TiO 2 nanorods were synthesized by H 2 SO 4 etching method, combined with the synthesis technology of BiOBr-TiO 2 heterojunction and NCQDs to synthesis the ternary NCQDs-BiOBr-TiO 2 photocatalyst. The micromorphology and structural composition of different powder catalysts and photocatalytic composite membranes were studied by means of various characterization methods. The UV–vis DRS results indicated that the formation of BiOBr-TiO 2 heterojunction and the introduction of NCQDs extended the visible light absorption range of photocatalytic materials. The BSA adsorption performances of different composite membranes were investigated, and the results showed that 0.5-NCQDs-BiOBr-TiO 2 /PVDF composite membranes had strong antifouling properties. Moreover, it was found that the 0.5-NCQDs-BiOBr-TiO 2 /PVDF composite membranes exhibited high regeneration stability and easy separation recovery performance. The results showed that the TC degradation rate of 0.5-NCQDs-BiOBr-TiO 2 /PVDF composite membranes reached 77% within 120 min. Moreover, the pseudo first order kinetic apparent rate constant k value of the 0.5-NCQDs-BiOBr-TiO 2 /PVDF composite membranes was 0.01342 min −1 .
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）