Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Nini Li,Xiaohong Ji,Bulei Wang,Yanglin Guo,Changhao Wang,Yashao Chen
Living organisms tend to evolve various naturally photoprotective mechanisms to avoid photodamage. Among them, polydopamine (PDA) is an effective sunscreen, a mimic of melanin, which is the main functional component of the photoprotective system of human skin. However, the concerns of its dark color, skin penetration and photoprotective efficiency remain yet to be solved. Herein, we have constructed melanin-inspired nanocomposite hydrogels (CS-PDA h -GP-HA) for photoprotection, in which PDA was prepared as hollow nanoparticles (PDA h NPs) and entrapped in a physically cross-linked hydrogel (CS-GP-HA) formed by chitosan (CS) and hyaluronic acid (HA) using β -glycerophosphate ( β -GP) as a modulator. The CS-PDA h -GP-HA hydrogels exhibit a shear-thinning flow behavior with an elastic modulus of 300 Pa with the gel-sol transition temperature maintained at about 37 °C simply by adjusting the β -GP content in the hydrogels. The CS-PDA h -GP-HA hydrogels also possess excellent resistance toward skin penetration. The photoprotective performances of CS-PDA h -GP-HA hydrogels were evaluated by the determination of sun protection factor (SPF) and in vitro UVA protection efficacy (UVAPE) along with UV–Vis spectroscopy. Compared with the TiO 2 nanoparticles in CS-GP-HA hydrogel, the CS-PDA h -GP-HA hydrogels show stronger shielding ability in both UVA and UVB regions. When protected by the CS-PDA h -GP-HA hydrogels, the cell viability of NIH-3T3 fibroblasts increases to 96% while it was only 14% in the case of non-protecting group. These results suggest that the CS-PDA h -GP-HA hydrogels could efficiently shield the UV irradiation and protect the skin from photodamage. This work introduces PDA-based nanocomposite hydrogels with safe, biocompatible and photoprotective properties, and provides a melanin-mimicking photoprotection system for the application in sunscreens.
研究领域:
材料科学
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生物医学工程
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纳米技术
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光生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Xiangyu Chen,Juanjuan Yao,Bin Xia,Jingye Gan,Naiyun Gao,Zhi Zhang
The influence of pH and dissolved oxygen (DO) on the degradation of ofloxacin (OFX) in water by UVA-LED/TiO 2 nanotube arrays photocatalytic fuel cell (UVA-LED/TNA PFC) was investigated. The degradation pathway depended on the location of OFX frontier orbital with different ionization states and the role of reactive oxidative species (ROSs) played with varied pH and DO values. In presence of DO, the quencher tests revealed that O 2 − played a key role at pH 3.0, 7.0 and 11.0, while OH made its greatest contribution at pH 3.0 and the effect of h + was largely inhibited at pH 11.0. Hydroxylation for cationic OFX was more significant, while demethylation and piperazinyl ring oxidation for anionic OFX occurred more quickly compared to other forms. Besides, zwitterionic OFX underwent decarboxylation and combination of demethylation & hydroxylation more easily. Much higher power generation was observed in presence of DO at pH 7.0, probably due to the enhanced adsorption of OFX on the TNA, and DO could amplify the electric potential between the two electrodes. The degradation efficiencies were almost the same in presence or absence of DO, but the pathways were different and e- aq may replace O 2 - as the leading ROSs in absence of DO.
研究领域:
环境科学
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化学工程
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qian Ren,Tingting Tian,Bin Wang,Jun Pan,Yong Huang,Li Zhong,Yehong Wang,Xia Wang,Xiao Huang
Photodynamic therapy (PDT) remains underutilized as a primary cancer treatment due to the limited lethality of reactive oxygen species (ROS) and poor targeting efficiency of traditional photosensitizers. This the aim of the study is to develop a Fe₃O₄@ZnO nanoparticle photosensitizer co-loaded with anti-EGFR antibody, brusatol, and Nrf2-siRNA to improve the therapeutic effect of PDT. This system can be guided to tumors by a magnetic field and further targets cancer cells through EGFR-specific binding. Under UVA light, brusatol and Nrf2-siRNA are released, enabling combined chemo-, gene, and photodynamic therapy. With the photosensitizer treatment, ROS levels in cutaneous squamous cell carcinoma cells were elevated by 191.09 ± 10.02 % through suppression of Nrf2 and its associated antioxidant defenses, significantly enhancing cell lethality and reducing cell viability by 80.43 ± 9.37 %. In vivo studies further demonstrated a tumor suppression rate of 76.30 ± 5.12 % in nude mice, highlighting the robust anti-tumor efficacy of the photosensitizer and its potential for clinical application in targeted cancer therapy. The biocompatibility and high therapeutic efficacy of this photosensitizer highlight its promise as a safer and more effective option for treating cutaneous squamous cell carcinoma.
研究领域:
癌症治疗
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纳米技术
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药理学
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分子生物学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cosmetic Dermatology
·
2022
·Vol. 22
·期 3
·1046-1062
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IF 2.189
Shasha Wang,Yuxin Shi,Jiapeng Ma,Zhuofei Ye,Miaomiao Yao,Jing Shang,Jianping Liu
Dragon's Blood is a member of the Chinese medicinal herb, having anti-oxygen and anti-inflammatory activity for the photoprotective effect. However, the poor water solubility of raw Dragon's Blood powder has limited its intradermal delivery process. In this study, we evaluated nanosuspensions to enhance intradermal delivery of Dragon's Blood exerting a photoprotective effect. The prepared nanosuspension was added to a composite hydrogel patch matrix for better skin application. In the present research, we used biocompatible materials hyaluronic acid and amino acid surfactants as nanosuspension stabilizers and agar/gelatin/sodium polyacrylate as hydrogel patch matrix. The prepared Dragon's Blood nanosuspension had a particle size of 447.0 ± 48.6 nm. The micro-structures morphology and viscoelasticity characteristics by SEM and rheological testing confirmed a sufficient crosslinked hydrogel network. The skin retention amount of Dragon's Blood nanosuspension was 1.48 times of raw Dragon's Blood powder water suspension, and the skin penetration amount of Dragon's Blood nanosuspension was only about 1/3 of Dragon's Blood DMSO solution. In the UVB-irradiated HaCaT cell phototoxicity model, Dragon's Blood nanosuspension also significantly increased cell viability by about 1 time of the model group and decreased the production of reactive oxygen species about 1/2 times of model group. In vivo safety and efficiency evaluation experiment illustrated that DB-NS hydrogel patch processes have favorable safety and photoprotective effect with no skin irritancy and phototoxicity. Furthermore, DB-NS and DB-NS hydrogel patches could protect skin from UVA and UVB irritating skin reactions. Overall, our study of the combined use of biocompatible and biodegradable materials as excipients of nanosuspension and hydrogel patch could be used as an effective additive of Intradermal delivery and skin photoprotection.
研究领域:
药剂学
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纳米技术
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皮肤病学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2024
·
IF 1.2
Guofen Zhou,Linlin Yu,Wenlong Guo,Zhongwei Jiang,Lianzhe Hu,Min Wang
In this study, nanozyme is used for monitoring the dose of ultraviolet (UV) in sunlight for the first time. We find that nitrogen-doped carbon dots (N-doped C-dots) can effectively catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) under different UV region including UVA, UVB, and UVC. In comparison, the N-doped C-dots fail to show the catalytic activity under visible light. The finding is applied for distinguishing UV light and visible light through the color change of TMB. More importantly, the photo-oxidation TMB catalyzed by N-doped C-dots can work well in a near neutral pH, which is beneficial for its application in wearable device due to the reducing of acid corrosion. Finally, a wearable bracelet is fabricated by integrating N-doped C-dots and TMB into hydrogels. The bracelet is used for monitoring the UV exposure in sunlight. The color change of TMB in the bracelet can be clearly observed by naked eyes or quantified by a smartphone. The bracelet is also used for distinguishing different weather condition such as sunny/cloudy or different place such as indoor/outdoor during a sunny day. This study provides the first example of nanozyme in wearable UV sensor and will stimulate the applications of nanozyme in wearable device.
CAS / MDL:
研究领域:
材料科学
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纳米技术
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可穿戴技术
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环境监测
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光化学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Yiping Chen,Zhenze Lou,Zihao Chen,Shuangye Yang,Jiashuo Hu,Jie Wei
In this study, we fabricate magnetic–fluorescent responsive Janus photonic crystal beads (JPCBs) based on poly(styrene-methyl methacrylate-acrylic acid) (p(St-MMA-AA)) colloidal nanoparticles, Fe3O4, and photobase generators used for self-destructive anti-counterfeiting. We synthesize two kinds of photobase generators that can react with fluorescamine to produce various fluorescence colors. A microfluidic method is used to obtain the Janus photonic crystal beads. The upper portions of the JPCBs are photonic crystals assembled with colloidal spheres, whereas the Fe3O4 settles down to the bottom of the JPCBs due to its higher density. Photobase generators are distributed in photonic crystal gaps. Because of the magnetism of the Fe3O4, the JPCBs could be flipped from one side to the other in the presence of a magnet. After being exposed to UVC light and fluorescamine, the JPCBs can fluoresce under UVA light. Then, we create Janus microbeads arrays with various types of beads and apply them to the visitor card, bracelet, and box label to provide irreversible and self-destructive anti-counterfeiting. The JPCBs are capable of being encoded and angle-independently displayed, which are crucial to their applications in anti-counterfeiting, information coding, and array display.
研究领域:
材料科学
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纳米技术
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防伪技术
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光学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Nini Li,Xiaohong Ji,Somnath Mukherjee,Bing Yang,Yuqing Ren,Changhao Wang,Yashao Chen
In recent years, sunscreens’ adverse impacts on the environment and biology have gained wide attention. The improvement of sunscreen safety has become one of the major priorities in skin photoprotection research. It is an effective strategy to develop bionic photoprotective materials by simulating the photoprotective mechanism existing in nature. Inspired by the photoprotective mechanisms of skin and plant leaves, the bionic photoprotective material CS-SA-PDA nanosheet was developed using the free radical grafting method and Michael addition, with natural melanin analogue polydopamine (PDA) nanoparticles and plant sunscreen molecular sinapic acid (SA) as sun protection factors and natural polymer chitosan (CS) as the connecting arm. The results show that CS-SA-PDA can effectively shield UVB and UVA due to the possible synergistic effect between PDA and SA. The introduction of polymer CS significantly improved the photostability of SA and reduced the skin permeability of PDA nanoparticles. The CS-SA-PDA nanosheet can also effectively scavenge photoinduced free radicals. Furthermore, in vivo toxicity and anti-UV evaluations confirm that CS-SA-PDA has no skin irritation and is excellent against skin photodamage, which makes it an ideal skin photoprotective material.
研究领域:
材料科学
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纳米技术
·
生物医学工程
·
环境科学
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药学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）