APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Fengtao Chen,Xingxing Shi,Xiaobing Chen,Wenxing Chen
A facile strategy to improve the hydrophilicity and the antifouling properties of poly(vinylidene fluoride) (PVDF) membranes, a functional monomer of 4-methacrylamidobenzenesulfonic acid (MABS), was designed and synthesized through the amidation reaction between 2-methylacryloyl chloride and sulfanilic acid. Utilizing PVDF and the obtained MABS as reaction monomers, a novel amphiphilic copolymer was firstly prepared by radical polymerization method. The resulting PVDF-g-PMABS was used as a hydrophilic additive in the fabrication of PVDF porous membranes via immersion precipitation process. The surface chemical compositions and structure morphologies of as-prepared blend membranes (PVDF-g-PMABS/PVDF) were characterized by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM), respectively. Contact angle measurement and cross-flow permeation test were employed to evaluate the hydrophilicity and antifouling properties of the membranes. It was found that the blend membrane with 4 wt.% PVDF-g-PMABS exhibited a noticeable pure water flux (136.34 L m −2 h −1 ) and a remarkable flux recovery ratio (FRR) of 98.60% in comparison with the pristine PVDF membrane (63.37 L m −2 h −1 and 38.67%, respectively). The enhanced performance was attributed to the synergetic effects of the strong hydrogen bonding force and the electrostatic repulsion of sulfonic groups against the protein foulants.
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DOI
高影响因子
Polymer Chemistry
·
2012
·Vol. 3
·期 9
·2421-2429
·
IF 5.321
Bin Li,Gao Chen,Fanbo Meng,Taihang Li,Jun Yue,Xiabin Jing,Yubin Huang
New amphiphilic graft copolymers with hydrophilic poly(ethylene oxide-co-allyl glycidyl ether) (PEAG) as the backbone and hydrophobic poly(ε-caprolactone) (PCL) as the side chains (PEAG-g-PCL) were designed and synthesized. For this purpose, the combined techniques of anionic copolymerization, radical mediated thiol–ene reaction and ring-opening polymerization were employed. The properties of the graft copolymer were characterized by 1H NMR, 13C NMR, GPC and MALDI-TOF-MS. The self-assembly of the copolymers in aqueous solution was examined by fluorescence spectroscopy, DLS and TEM. The results showed that with a relatively low critical aggregation concentration (CAC), the graft copolymers could form different morphologies including vesicles (polymersomes). The formed polymersomes had the capacity to encapsulate protein molecules (like hemoglobin, Hb) through a modified lyophilization–rehydration method as analyzed via TEM and SDS-PAGE. Furthermore the gas-binding capacity of the encapsulated Hb was assayed via UV-vis spectroscopy. The characteristic absorption peak of the encapsulated Hb in different gas-binding states (CO, O2, N2) showed no significant change by comparison with that of free Hb. These Hb encapsulated PEAG-g-PCL polymersomes could have the potential to be applied as an artificial oxygen carrier for transfusion.
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高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 33
·4343-4353
·
IF 4.927
Yanyan Zhou,Lei Li,Wei Chen,Dian Li,Nianchen Zhou,Jinlin He,Peihong Ni,Zhengbiao Zhang,Xiulin Zhu
A tadpole-shaped amphiphilic copolymer containing cyclic hydrophobic poly(ε-caprolactone) (PCL) and two hydrophilic poly(ethylene glycol) (PEG) tails, PEG-b-(c-PCL)-b-PEG, was rationally designed and prepared by a combination of ring-opening polymerization (ROP), chain end modification and intermolecular Cu-catalyzed azide–alkyne cycloaddition (CuAAC) “click” reaction. Firstly, cyclic PCL with two pendent alkynyl groups (c-PCL-2alkynyl) was prepared via successive ROP, a bimolecular CuAAC “click” reaction and transformation of pendent hydroxyl groups to alkynyl groups. Subsequently, a tadpole-shaped amphiphilic copolymer PEG-b-(c-PCL)-b-PEG was fabricated by the CuAAC “click” reaction between c-PCL-2alkynyl and azido-terminated PEG (PEG-N3). For the comparison purpose, a linear triblock copolymer [PEG-b-(l-PCL)-b-PEG] and a 4-arm star copolymer (2PEG-b-2PCL) with comparable molecular weights and compositions were also synthesized. All these polymers were fully characterized by size exclusion chromatography (SEC), nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. In addition, the self-assembly behavior, drug loading capacity and in vitro cytotoxicity of the tadpole-shaped amphiphilic copolymer and its linear and 4-arm star analogues were preliminarily investigated. It was found that the assemblies of PEG-b-(c-PCL)-b-PEG showed a similar spherical morphology but a smaller size compared with those of PEG-b-(l-PCL)-b-PEG and 2PEG-b-2PCL. The in vitro cytotoxicities against L929 fibroblast cells and HeLa cells evaluated by MTT assays revealed that the copolymers, especially PEG-b-(c-PCL)-b-PEG and 2PEG-b-2PCL, exhibited favorable biocompatibility, which might be potentially used as nanoscale drug delivery systems.
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高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 6
·1739-1745
·
IF 4.58
Liu Jingcheng,Xie Yazhen,Wang Kuan,Zeng Qingtao,Liu Ren,Liu Xiaoya
The amphiphilic copolymer poly(vinylbenzyl thymine-co-styrene-co-maleic anhydride) (PSVM) was synthesized by radical copolymerization of styrene, vinylbenzyl thymine, and maleic anhydride. Its chemical structure was proven by using 1 H nuclear magnetic resonance spectroscopy. PSVM was used as a host to prepare a composite consisting of carbon nanotubes and gold nanoparticles by in-situ reduction. The morphology of the nanocomposites was studied by transmission electron microscopy. A glassy carbon electrode coated with this composite is shown to be a viable sensor for the determination of dopamine (DA), paracetamol (PAT) (both at a pH value of 7), and uric acid (UA) (at pH 6). Two linear relationships exists between amperometric current and analyte concentrations. For DA, the linear analytical ranges are from 0.1 to 200 μM and from 200 to 1000 μM. For PAT, the ranges are from 0.1 to 200 μM and from 200 to 1000 μM. For UA, the ranges are from 0.05 to 1000 μM. The respective limits of detection (for S/ N = 3) are 56, 27 and 50 nM. The sensor is highly sensitive, stable, reproducible, and selective.
A hybrid nanocomposite (CNT/PSVM/Au) of carbon nanotube (CNT) – Au nanoparticle composite based on the amphiphilic copolymer poly(vinylbenzyl thymine/styrene-co-maleic anhydride) (PSVM) was prepared through in situ reduction. This nanocomposite was immobilized on a glassy carbon electrode (GCE) to fabricate an electrochemical sensor to determine dopamine (DA), paracetamol (PAT) and uric acid (UA).
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2011
·
IF 3.673
Zhuan Yi,Li-Ping Zhu,Yi-Fan Zhao,Bao-Ku Zhu,You-Yi Xu
Polyethersulfone (PES) based amphiphilic block copolymer was designed as a hydrophilic additive for the modification of polysulfone (PSf) membranes. The block copolymer with PES as the middle block and poly(ethylene glycol) methyl ether methacrylate (POEM) as side blocks was synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization, using a PES-based macro-chain-transfer-agent (macro-CTA). The successful synthesis of the amphiphilic copolymer was confirmed by the nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). Blend membranes were prepared via the non-solvent induced separation method. The differential scanning calorimetry (DSC) spectra of blend membranes displayed single glass transition temperatures ( T g ), indicating the miscibility between the PSf and PES main chains. The melting peak at 37.4 °C presented the phase separation of POEM from hydrophobic domains in membranes. The great improvements in hydrophilicity, fouling-resistance, and water flux were found when the modifier was introduced. At last, the intact of RAFT agents from the additives were made use of to graft zwitterionic brushes on membrane surface.
研究领域:
高分子科学
·
膜技术
·
材料科学
·
表面改性
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 56
·50993-51004
·
IF 3.289
Beibei Lu,Lei Li,Lulu Wei,Xuhong Guo,Jun Hou,Zhiyong Liu
Well-defined amphiphilic β-cyclodextrin (β-CD) star-shaped copolymers with poly(ε-caprolactone)–poly(2-(2-methoxyethoxy)ethyl methacrylate)-co-poly(ethylene glycol)methacrylate) (β-CD–(PCL–P(MEO2MA-co-PEGMA))21 were synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP). These thermo-responsive copolymers exhibited a lower critical solution temperature (LCST) in water, which could be finely tuned by changing the feed ratio of PEGMA and MEO2MA. The LCST of star-shaped β-CD–(PCL–P(MEO2MA-co-PEGMA))21 increased from 26 to 62 °C with the increasing PEGMA content, the copolymers were characterized using Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR) and gel permeation chromatography (GPC). The star-shaped copolymers could self-assemble into micelles in aqueous solution due to their amphiphilic properties resulting from the hydrophobic β-CD and PCL core and the hydrophilic P(MEO2MA-co-PEGMA) segments, which was investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The in vitro DOX release studies showed that DOX released from drug-loaded micelles in a thermo-sensitive manner. CCK-8 assays demonstrated that these star-shaped copolymers could possess low cytotoxicity against HeLa cells, and the DOX-loaded micelles exhibited a higher inhibition of the proliferation of HeLa cells in comparison with free DOX. Moreover, the results from confocal laser scanning microscopy (CLSM) revealed that these polymeric micelles could efficiently deliver and release DOX into the nuclei of HeLa cells. This kind of biodegradable, biocompatible and stimuli-responsive copolymer could serve as a promising material for drug delivery.
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高影响因子
RSC Advances
·
2017
·Vol. 7
·期 41
·25694-25701
·
IF 3.108
Xiaoju Shi,Guoyue Lv,Xiaodong Sun,Dianbo Cao,Guangyi Wang,Yulei Chang
Recently, several targeted drug delivery systems have shown promising antitumor activity towards different types of cancer. However, targeting the tumor microenvironment, cellular surface and/or only one organelle may not achieve the expected therapeutic effects. Herein, a targeted drug delivery with stepwise targeting and image-guided strategy was obtained for enhancing antitumor therapy and overcoming various problems caused by the random drug distribution of traditional medicine. In this design, a multifunctional nanoplatform, TPGS/PPG2L@IONPs@DOX/TPP–DOX, based on poly(ethylene glycol)-poly(ε-caprolactone)-poly(amidoamine)-lactose acid (mPEG-PCL-G2.0 PAMAM-LA, PPG2L) copolymer and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS), as a co-carrier, incorporates iron oxide nanoparticles (IONPs) as imaging agents and loads a DOX/triphenylphosphonium (TPP)–DOX drug for chemotherapy. In this nanoplatform micelle, the LA as targeting moieties to hepatocarcinoma cells is the first targeting step. After the drug is released from the hybrid micelles, the incorporated DOX and TPP–DOX target delivery to nuclei and mitochondria for the next targeting step. Furthermore, with the help of MRI contrast agents of IONPs, the distribution of hybrid micelles was monitored. As a result, the hybrid micelles demonstrated enhanced antitumor cell activity in both HepG2 and HepG2/DOX cells. The results indicated that the multifunctional hybrid micelles showed great potential in enhancing antitumor activity under image-guided and stepwise targeted chemotherapy.
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高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Xubo Zhao,Mingzhu Qi,Shuo Liang,Kun Tian,Tingting Zhou,Xu Jia,Jiagen Li,Peng Liu
Novel photo- and pH dual-sensitive amphiphilic copolymers containing photolabile o-nitrobenzyl (NB) groups were designed via combination of ATRP, hydrolyzation, and simple esterification reaction and self-assembled into stimuli-regulated amphiphilic micelles in aqueous solution. On the basis of the optimization of the morphology and particle size of the micelles via modulating the number of the photocleavable o-nitrobenzyl acrylate (NBA) units, the unique ones assembled from PEG43-b-P(AA76-co-NBA35-co-tBA9) with an average hydrodynamic diameter (Dh) of 163 nm was selected as a potential drug delivery system (DDS) for UV-triggered delivery of doxorubicin (DOX). The micelles possessed a favorable drug-loading capacity (DLC) of 27.5%, with the hydrodynamic diameter of 213 nm after DOX-loading. Most importantly, the DOX-loaded PEG43-b-P(AA76-co-NBA35-co-tBA9) micelles exhibited a cumulative DOX release ratio of only 3.69% in the simulated physiological medium within 6 days without UV-irradiation, indicating their potential as leakage-free DDS. As in the acidic media mimicking the tumor microenvironment, a high cumulative DOX release ratio of 74.70% was achieved within 6 days after UV-irradiation for 20 min, showing a sustained release behavior. Under UV-irradiation, the photolabile o-nitrobenzyl moieties were cleaved off, the amphiphilic copolymer transformed into a water-soluble polymer, favoring the metabolism of drug carriers, and the micelles were demicellized to accelerate the drug release in a triggered or on-demand manner.
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DOI
PubMed
高影响因子
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