CARBOHYDRATE POLYMERS
·
2014
·
IF 3.916
Zhuang Li,Hongliang Kang,Ning Che,Zhijing Liu,Pingping Li,Weiwei Li,Chao Zhang,Chun Cao,Ruigang Liu,Yong Huang
Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8 h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
·
2022
·
IF 0
Haozheng Wang,Lei Cui,Ying Luo,Xiaoyong Zhou,Rui Liu,Qianbing Chen,Ying Guan,Yongjun Zhang
Single-injection vaccines may overcome issues, such as high cost and poor patient compliance, of the multi-bolus regimes dominantly used in vaccination. However no such vaccine has been commercialized because time-controlled release, an unconventional release kinetics, is difficult to achieve. Here a new time-controlled release system using dynamic layer-by-layer (LBL) film as erodible coating was used to design single-injection vaccine. Unlike commonly used degradable polymers, dynamic LBL film disintegrates at a constant rate, thus allowing distinct pulsatile release of antigen at predetermined intervals. The release pattern of the single-injection vaccine mimics closely to that of ordinary multi-dose regimes. It elicits both humoral and cellular immune responses which are comparable to or even stronger than the corresponding multi-dose regime. In addition, it inhibits tumor growth more effectively. The new vaccine will not only improve patient compliance but also therapeutic outcome.
研究领域:
药学
·
生物技术
·
免疫学
·
疫苗学
✓ 已验证
产品关联
DOI
PubMed
CONSTRUCTION AND BUILDING MATERIALS
·
2025
·
IF 8
Xiaoling Zou,Yuyang Yan,Yanqiu Bi,Ying Yuan,Bin Li
Asphalt pavements develop fatigue cracks during long-term service, while conventional rehab methods are inefficient and costly. Due to its excellent self-healing enhancement performance, microcapsule technology has become a research hotspot. However, current research lacks systematic investigation into the stability of microcapsules during construction and service phases, as well as the accuracy of their release mechanisms. This research aims to prepare self-healing microcapsules tailored for asphalt mixture. Accordingly, it systematically executed a full-process material optimization, structural regulation, and performance validation. Firstly, gel-permeation chromatography (GPC) was used to select the optimal rejuvenator as the core material. Meanwhile, the melamine-urea-formaldehyde (MUF) shell was chosen based on the asphalt mixture matrix's elastic-modulus matching criterion. Subsequently, microcapsules were synthesized via in-situ polymerization. By adjusting the core-shell ratio and particle size, microcapsules with controllable diameter (5–150 µm), adjustable shell thickness (200–500 nm), and compatible elastic modulus with asphalt were fabricated. Then, scanning electron microscope (SEM), differential scanning calorimetry (DSC), and nanoindentation test revealed that the microcapsules exhibit excellent thermal stability (decomposition temperature 240–280 °C) and mechanical compatibility with asphalt. Finally, rutting tests, pull-out tests, and fluorescence microscopy (FM) revealed that MUF microcapsules (particle size <25 µm) showed 60.23 % survival during construction (23.6 % higher than melamine formaldehyde microcapsules). The service-phase loss rate remained below 3 %, and the self-healing completion of asphalt cracks takes 15 min. This research achieves the tri-functional integration of “survivability, triggerability, and restorability” for microcapsules within asphalt mixtures. Providing a reliable technological pathway to enhance asphalt pavement life-cycle performance.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2016
·Vol. 122
·期 7
·1-8
·
IF 1.444
Sun Huanghui,Zhang Lingfan,Xia Wei,Chen Linxiao,Xu Zhizhen,Zhang Wenqing
Functionalized graphene oxide with its unique physical and chemical properties is widely applied in biomaterials, especially in drug carrier materials. In the past few years, a number of different drugs have been loaded on functionalized graphene oxide via π–π stacking and hydrophobic interactions. The present report described a new approach, dexamethasone phosphate successfully loaded onto graphene oxide–chitosan nanocomposites as drug carrier materials by covalent bonding of phosphate ester linkage. Compared with the graphene oxide–chitosan nanocomposites that dexamethasone phosphate was loaded on via simple physical attachment, covalently linked composites as drug carrier materials were more biocompatible which effectively reduced the burst release of drug, and controlled the release of drug in different pH conditions.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2017
·
IF 3.756
Shuli Zhang,Xuan Meng,Zheng Wang,Aiping Fan,Guocheng Wang,Yanjun Zhao,Yu Tang
It is often challenging to precisely manipulate the release behavior of hydrophilic drugs that is believed to be crucial for a satisfactory therapeutic outcome. The aim of this work was to regulate the dissolution of hydrophilic drug from hot-melt extruded solid dispersion via rational screening of the pore-forming agents. Venlafaxine hydrochloride and Compritol® 888 ATO was selected as the model drug and carrier excipient, respectively. Hydrophilic polyethylene glycol (PEG 6000) and polyvinylpyrolidone (PVP K30) were chosen as the transient pore-forming agents. The X-ray diffraction and thermal analysis showed that both drug and carrier existed in the crystalline form. Both types of polymers could generate pores upon dissolution test and the drug release rate was proportionally correlated to the pore-forming agent content. The mathematical modelling showed that the Ritger-Peppas model gave the best fit to the release curves, which demonstrates a diffusion-dominant release mechanism. The scanning electron microscopy and mercury intrusion porosimetry analysis proved that PVP K30 could generate large pores with low porosity, but PEG 6000 produced smaller pores with relatively high porosity. The in vivo pharmacokinetics study in rat revealed that solid dispersions containing either PEG 6000 or PVP K30 (both at 2.5%, w/w) exhibited an elevated bioavailability compared to the commercial product, Effexor® XR. The current work implied that rational screening of transient pore-forming polymer in solid dispersion could be a robust approach for controlling hydrophilic drug release.
研究领域:
药剂学
·
药物释放系统
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULES
·
2019
·
IF 5.997
Desheng Wang,Tingting Zhang,Bo Wu,Chunxiao Ye,Zhengyang Wei,Ziquan Cao,Guojie Wang
Here, we report a novel polymeric nanoparticle prepared by the self-assembly of amphiphilic copolymers containing a fluorescent naphthalimide (NAPH) and a photochromic spiropyran (SP), which possesses reversibly photoswitchable dual-color fluorescence and controlled release properties. The amphiphilic copolymers were synthesized by incorporating NAPH and SP into methyl ether poly(ethylene glycol)-poly(β-amino esters) (MPEG-PAE) via quaternization. The nanoparticles would change between yellow and purple reversibly upon UV and visible light irradiation because of the photoisomerization between SP and merocyanine (MC). The corresponding fluorescence would be switched between green and orange-red reversibly upon blue light excitation through the fluorescence resonance energy transfer from the excited NAPH to the photoisomerized MC. Meanwhile, the prepared spherical nanoparticles could be swollen under UV irradiation as the hydrophobic SP isomerized to hydrophilic MC; the nanoparticles could also be swollen under acidic conditions because of the protonation of the amino groups of PAE. Upon UV light irradiation and acidic stimulation, the cargoes, hydrophobic Coumarin 102, encapsulated in the nanoparticles would be released. The prepared nanoparticles, which exhibit not only excellent reversible dual-color fluorescence properties but also prominent controlled release performance, will open up new possibilities for the combined application of fluorescence imaging and controlled release.
研究领域:
材料科学
·
高分子化学
·
纳米技术
·
荧光成像
·
药物递送
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yubin Xiang,Jie Li,Tao Deng,Xue Lu,Yongming Guo
A pesticide carrier was fabricated via Fe 3+ -mediated co-crosslinking strategy. • Metal-polyphenol-functionalized carriers enabled pH-triggered controlled release. • The release was governed by synergistic effects of diffusion and hydrogel relaxation. • The carrier was non-toxic to murine fibroblast cells and showed good biosafety. Hydrogel-based controlled release systems are widely used in pharmaceutical and agricultural fields. To achieve controlled release of hydrophilic drugs, which otherwise release rapidly through hydrated polymer networks, we develop a facile ferric ion co-crosslinking strategy to fabricate composite hydrogel beads. The highly porous composite hydrogel beads were prepared by blending recycled household formaldehyde adsorbent (RFA) with sodium alginate (Alg) at a 1:1 ( w /w) ratio, followed by Fe 3+ -induced crosslinking and subsequent surface functionalization with tannic acid (TA). Through altering the Alg hydrogel structure, RFA enabled the hydrogel to synergistically restrict drug molecules, and coupled with the blocking function of metal-polyphenol complexes (MPC), this composite structure provided effective regulation of water-soluble drug molecule release. The carrier demonstrated pronounced swelling and disassembly of the metal-polyphenol microfilm, resulting in rapid gentian violet (GV) release under alkaline pH conditions. In acidic environments, the conversion of ternary metal-polyphenol complexes into double or single complexes weakened the “on-off” effect, thereby accelerating GV release compared with neutral conditions. The release of GV was governed by a combination of diffusion-controlled processes and progressive hydrogel bead relaxation. Additionally, the carrier exhibited no detectable toxicity in murine fibroblast cells and during rice seed germination, indicating its favorable biosafety. These findings demonstrated that the controlled-release system had the potential to be further explored for environmental protection and hazardous substances management.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PEST MANAGEMENT SCIENCE
·
2026
·
IF 4.2
Wenneng Wu,Chang Yan,Peng Geng,Peiyi Wang,Hongguo Wu
BACKGROUND Environmentally responsive microcapsules hold great promise for sustainable pest management by improving efficacy, lowering dosage and enhancing environmental compatibility. Herein, a pH-responsive pyraclostrobin (Pyr)-loaded microcapsule (Pyr@PU) with an isocyanate core and vanillin-Schiff base polyurethane shell were successfully fabricated via interfacial polymerization. RESULTS The obtained microcapsules exhibited high loading capacity (80.89%) and encapsulation efficiency (96.17%), indicating excellent drug loading and encapsulation performance. In vitro release experiments confirmed that the Pyr@PU microcapsules exhibited prominent pH-responsive release behavior, with a higher cumulative Pyr release (82.81%) at pH 4.0 after 144 h. Meanwhile, the prepared Pyr@PU microcapsules possessed excellent photostability, favorable leaf wettability and superior rainfastness. Bioactivity assays revealed that the microcapsules exerted favorable antifungal effects. At 200 μg mL −1 , Pyr@PU provided protective and curative efficacy of 79.62% and 67.59% against kiwifruit pathogens, as well as 57.90% and 37.89% on rice leaves, respectively. Biosafety evaluation showed that Pyr@PU reduced the 96-h acute toxicity to zebrafish by 2.3-fold and displayed no obvious adverse effects on rice seed germination. CONCLUSION The fabricated pH-responsive Pyr@PU microcapsule exhibits superior UV resistance, leaf adhesion, rainfastness, antifungal efficacy, and biocompatibility. As a promising intelligent controlled-release platform for pesticides, Pyr@PU provides both control efficacy and environmental compatibility, showing great potential for application in sustainable agriculture. © 2026 Society of Chemical Industry.
✓ 已验证
DOI
PubMed
高影响因子
IRANIAN POLYMER JOURNAL
·
2020
·Vol. 29
·期 10
·891-900
·
IF 1.707
Yang Mingxin,Hu Jie,Meng Jin,Shan Xiaojing
A hydrogel with dual thermo and photoresponsive characteristics was developed. Using poly( N -isopropylacrylamide) (PNIPAM) as the thermosensitive unit, the hydrogel network can undergo reversible swelling/shrinking behavior under different temperatures (20 °C and 37 °C) stimulation. A supramolecular host–guest complex composed of azobenzene (Azo) and α -cyclodextrin ( α -CD) was used as the photosensitive unit. Azo and α -CD can undergo reversible recombination/dissociation behavior under the stimulation of different wavelengths of light (365 nm and 430 nm). Methylene blue (MB) was selected as the model drug to measure the controlled release behavior of the hydrogel under different temperatures and photoirradiations. The experimental results showed that the hydrogel containing the thermosensitive component (PNIPAM) and the photosensitive component ( α -CD/Azo) released 69.3% and 47.2% of MB at 20 °C and 37 °C, respectively. Under the condition of light wavelengths at 430 nm and 365 nm, 73.2% and 65.6% of MB were released, respectively. The results showed that α -CD and Azo formed a supramolecular host–guest complex, which could undergo reversible binding/dissociation under the action of light stimulation, thereby controlling MB to enter and exit CD cavity. In addition, when the ambient temperature was lower or higher than the lower critical solution temperature of PNIPAM (LCST, 32 °C), the hydrogel underwent a responsive volume change to control the loading and release of MB molecules. So, combining the dual thermo and photoresponsibility, this smart hydrogel could be applied for multiple controlled release mechanisms.
研究领域:
材料科学
·
药学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shiyu Chen,Xiaoe Chen,Gaofeng Yuan
Biocompatible and degradable hydrogels are extensively utilized for the delivery and controlled release of bioactive agents. Chitosan/squid ring teeth protein (SRT) hydrogels (CH/SRTs) cross-linked by genipin were fabricated, and their gel properties and structural characteristics were analyzed across varying SRT contents. Additionally, the curcumin-release behavior of curcumin-loaded CH/SRTs (Cur-CH/SRTs) was evaluated. Results indicated that increasing SRT content enhanced the elasticity, viscosity, gel strength, hardness, and thermal stability of CH/SRTs. Specifically, the hardness and gel strength of CH/SRT3 (Chitosan: SRT, 1:1) were 207.8 % and 220.9 % higher, respectively, than those of the pure chitosan hydrogel. Higher SRT content significantly increased the curcumin encapsulation efficiency of Cur-CH/SRTs while substantially reducing curcumin release in simulated gastrointestinal fluid. Compared to the curcumin-loaded pure chitosan hydrogel, the curcumin release rate of Cur-CH/SRT3 decreased by 56.12 % after 480 min of simulated gastrointestinal digestion. These findings were attributed to reduced swelling and improved gel strength of Cur-CH/SRTs with SRT addition. Consequently, CH/SRTs demonstrate potential for applications in the controlled release of drugs and bioactive agents.
研究领域:
生物材料学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yejun Zhong,Wenrong Huang,Yawen Zheng,Tingting Chen,Chengmei Liu
A novel carrier comprised of ethanol- and alkali-modified cellulosic pomelo pith matrix coated with alginate was developed to improve viability while enabling gastrointestinal release of probiotics. Scanning electron microscopy imaging revealed the agricultural byproduct had a honeycomb-structured cellulose framework, enabling high loading capacity of the probiotic Lactobacillus plantarum up to 9 log CFU/g. Ethanol treatment opened up pores with an average diameter of 97 μm, while alkali treatment increased swelling and porosity, with an average pore size of 51 μm. The survival rate through the stomach was increased from 89.76 % to 91.08 % and 91.24 % after ethanol and alkali modification, respectively. The control group displayed minimal release in the first 4 h followed by a burst release. Both ethanol modification and alkali modification resulted in constant linear release over time. The release time was prolonged when decreasing the width of the pomelo peel rolls from 10 mm to 5 mm while keeping the volume of the peel constant. After 8 weeks of refrigerated storage, the cellulose-encapsulated probiotics retained viability above 7 log CFU/g. This study demonstrates the potential of the structurally intact, sustainably-sourced cellulosic pomelo pith for probiotic encapsulation and controlled delivery.
研究领域:
食品科学与技术
·
生物工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Miaomiao Zhu,Wenxuan Xu,Duo Wu,Zhuangcheng Liu,Yuanyuan Song,Aying Zhou,Ranhua Xiong,Chaobo Huang
Design and fabrication of pH-responsive nanofibrous membranes by biomaterials is a key step for drug delivery systems. Currently, there is an increasing attention on design of biocompatible nanofibrous drug delivery systems. Here, a bio-based pH-responsive nanofibrous membranes loaded with antibiotic were fabricated for the controlled release of tetracycline hydrochloride (TH). The in vitro drug release behavior of varied pH-responsive nanofibrous with different mass ratios of poly (lactic acid) (PLA) and cellulose acetate phthalate (CAP) was investigated to clarify the release mechanism. TH initial burst release within 20 mins was large than 97.5% for PLA/CAP/TH NFM under alkaline conditions (pH = 8). The antioxidant activity of TH loaded PLA/CAP NFMs are all higher than 55% after 30 mins. The prepared fibrous membranes possess sufficient antibacterial activity against both to Gram-negative and Gram-positive bacteria. At the same time, it also has good biocompatibility. Therefore, the fabricated nanofibrous membranes was demonstrated to be a pH-responsive nanoplatform for drug delivery.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）