Analytical Methods
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2014
·Vol. 7
·期 3
·1133-1139
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IF 1.938
Zhengyu Yan,Yan Yu,Jianqiu Chen
A novel sensing system has been designed for the detection of m-phenylenediamine based on carbon quantum dots (CQDs)-improved chemiluminescence (CL) in a luminol–potassium permanganate (KMnO4) system. The CQDs were synthesized by pyrolyzing a mixture of citric acid (CA) and glycine (Gly). Under the action of CQDs and KMnO4, the luminol can be oxidized by synergy, which significantly increases the chemiluminescence intensity. In this work, it has been demonstrated that this facile methodology can offer a rapid, sensitive and reliable detection of m-phenylenediamine with a detection limit as low as 1.02 × 10−3 g L−1 and a dynamic range from 2.0 × 10−3 to 3.0 × 10−1 g L−1, which shows a promising application prospect.
研究领域:
分析化学
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材料科学
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环境监测
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高影响因子
ZEITSCHRIFT FUR PHYSIKALISCHE CHEMIE-INTERNATIONAL JOURNAL OF RESEARCH IN PHYSICAL CHEMISTRY & CHEMICAL PHYSICS
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2021
·Vol. 235
·期 12
·1777-1790
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IF 2.408
Xuejun Liu,Xingchen Fan,Yuxing Wu,Huiting Ma,Cuiping Zhai
Cyclic voltammetry, 1 H nuclear magnetic resonance and quantum chemistry calculations were applied to explore the hydrogen bond interactions between ascorbic acid (AA) and glycine. The experimental results demonstrate the existence of hydrogen bonds in AA-glycine system, which has a significant effect on the oxidation peak potentials and currents of AA and the chemical shifts of glycine. The formation of hydrogen bonds between AA and glycine were further confirmed by the density functional theory, quantum theory of atoms in molecules and natural bond orbital analyses.
研究领域:
生物化学
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物理化学
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理论化学
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2025
·
IF 19
Xin Tan,He Wang,Kai Wang,Xiaoke Zhang,Huifen Ding,Shuhong Li,Jie Li,Jinlin Song
Glycine-based piezoelectric devices hold significant potential in implantable transient bioelectronics due to their biodegradability, easy accessibility, and high predicted piezoelectric responsiveness. However, challenges such as difficulties in large-scale crystal orientation alignment and weak piezoelectricity hinder their practical application. This paper proposes an innovative, simple one-step fabrication method using mussel-inspired dopamine (DA) molecules to synergistically prepare glycine-based devices with exceptional piezoelectric performance. It is found that DA can induce the formation of piezoelectric β-glycine crystals on various substrates via supramolecular interactions, achieving a maximum piezoelectric coefficient of 5.9 pC N −1 and piezoelectric voltage coefficient of 153 × 10 −3 V m N −1 in DA/glycine/polydimethylsiloxane films, with significantly enhanced thermal stability (≈120 °C). Furthermore, dopamine molecules can regulate the preferential crystal plane alignment of γ-glycine in polyvinyl alcohol (PVA)/glycine films, increasing their piezoelectric coefficient and voltage coefficient to 10.8 pC N −1 and 369 × 10 −3 V m N −1 , respectively. Using flexible glycine-based films, piezoelectric force biosensors are fabricated that demonstrate exceptional sensing capabilities for joint flexibility and oral occlusion contact patterns. Additionally, DA/glycine crystals and DA/PVA/glycine films exhibit excellent biocompatibility and biodegradability. This work offers a simple, efficient, and energy-saving approach for fabricating sensitive glycine-based piezoelectric devices, enhancing the application potential of high-performance piezoelectric biomaterials in sustainable bioelectronics.
研究领域:
生物材料
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可持续电子学
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压电传感器
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仿生合成
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瞬态生物电子学
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DOI
高影响因子
Materials Today Communications
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2025
·
IF 4.5
Wenqin Cheng,Xiaolong Li,Haichao Zhao,Haiyue Wang,Liying Guo,Rongrong Zheng,Wenkai Zhao
In this study, a green catalytic strategy based on a deep eutectic solvents (DES) was developed for the efficient synthesis of urea diacetic acid. The effect of the formation of DES with different metal salts (ZnCl 2 , FeCl 3 , CuCl 2 , ZnBr 2 ) was systematically evaluated by combining experimental analysis and molecular thermodynamic simulation. The results showed that the DES (ΔG = −315.06 kJ/mol) formed in a 1:2 mol ratio between urea and ZnCl 2 showed the optimal catalytic activity at 353.15 K, with the product yield as high as 91.50 %, which was significantly better than the traditional non-catalytic system (35.59 %). IR and 1 H NMR spectroscopy confirmed the characteristic peaks of the secondary amine and the carboxylic acid group in urea diacetic acid, and the structural integrity of the product was further verified by the Hinsberg reaction. Mechanistic studies show that DES reduces the reaction activation energy through a dynamic hydrogen bonding network, while the electronic effect of metal salts regulates intermediate release. The urea-ZnCl 2 DES system has high catalytic efficiency and environmental friendliness under mild conditions (80℃), and can be recycled, which provides a new idea for the green industrial production of polyurea materials. This study provides the theoretical basis and practical reference for the multifunctional catalytic application and green chemical process design of DES in organic synthesis.
研究领域:
有机化学
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环境科学
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材料科学
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DOI
高影响因子
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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2025
·
IF 3
Yuqi Wang,Hao Wu,Xun Hu
Background The significance of serine and glycine metabolism in cancer cells is increasingly acknowledged, yet the quantification of their metabolic flux remains incomplete, impeding a comprehensive understanding. This study aimed to quantify the metabolic flux of serine and glycine in cancer cells, focusing on their inputs and outputs, by means of Combinations of C-13 Isotopes Tracing and mathematical delineation, alongside Isotopically Nonstationary Metabolic Flux Analysis. Results In HeLa cells, serine uptake, the serine synthesis pathway (SSP), and other sources (e.g., protein degradation) contribute 71.2 %, 24.0 %, and 5.7 %, respectively, to serine inputs. Conversely, glycine inputs stem from uptake (45.6 %), conversion from serine (45.1 %), and other sources (9.4 %). Serine input flux surpasses glycine by 7.3-fold. Serine predominantly directs a major fraction (94.7 %) to phospholipid, sphingolipid, and protein synthesis, with only a minor fraction (5.3 %) directing towards one-carbon unit and glycine production. Glycine mainly supports protein and nucleotide synthesis (100 %), without conversion back to serine. Serine output rate exceeds glycine output rate by 7.3-fold. Serine deprivation mainly impairs output to synthesis of phospholipid and sphingolipid, crucial for cell growth, while other outputs unaffected. AGS cells exhibit comparable serine and glycine flux to HeLa cells, albeit lacking SSP activity. Serine deprivation in AGS cells halts output flux to phospholipid, sphingolipid, protein synthesis, completely inhibiting cell growth. Conclusions By providing quantitative insights into serine and glycine metabolism, this study delineates the association of serine flux to different metabolic pathway with cancer cell growth and offers potential targets for therapeutic intervention, highlighting the importance of serine flux to pathway for the synthesis of phospholipids and sphingolipids in cancer cells growth.
研究领域:
生物化学
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肿瘤学
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代谢组学
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DOI
PubMed
高影响因子
INTERNATIONAL DAIRY JOURNAL
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2018
·
IF 2.201
Xue Han,Huiying Wu,Peng Yu,Lijuan Zhang,Sainan Zhao,Lanwei Zhang
Glycine betaine (GB) is a naturally occurring osmolyte that helps cells adapt to osmotic stress. In this study, the osmoprotective role of GB in Lactobacillus delbrueckii subsp. bulgaricus 34.5 under salt stress was investigated. A concentration of 0.2 m NaCl provided sufficient osmotic constraint while allowing the cells to survive. Under conditions of salt stress, Lactobacillus bulgaricus 34.5 continued to proliferate in the presence of GB, and the optimum growth was seen at 1.2 m m GB. The optimum culture conditions for L. bulgaricus 34.5 were 37 °C and pH 6.0 for 24 h. In addition, intracellular GB content increased in response to salt stress, and the extent of GB transport in L. bulgaricus 34.5 under high salt concentrations depended on the culture conditions. In conclusion, GB played a protective role in alleviating the detrimental effect of salt on L. bulgaricus 34.5.
研究领域:
微生物学
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食品科学
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应激生理学
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DOI
高影响因子
BIOMACROMOLECULES
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2021
·
IF 6.988
Botuo Zheng,Songyi Xu,Xufeng Ni,Jun Ling
Polymerization of N-substituted glycine N-thiocarboxyanhydrides (NNTAs) is a promising pathway to prepare functional polypeptoids benefiting from their tolerance to nucleophilic impurities. However, controlled NNTA polymerization is hard to achieve in amide polar solvents, including N,N-dimethylacetamide (DMAc), N,N-dimethylformamide (DMF), and N-methyl pyrrolidone (NMP), the only aprotic solvents for many biomacromolecules and polypeptoids. In the present work, we successfully achieve controlled NNTA polymerization in amide polar solvents by adding acetic acid as a promoter. The promotion is applied to the polymerization of sarcosine NTA, N-ethyl glycine NTA, and N-butyl glycine NTA. DMAc, DMF, and NMP are suitable solvents to prepare polypeptoids with designable molecular weights and low dispersities (1.06–1.21). The polysarcosines with high molecular weights are prepared up to 35.2 kg/mol. A kinetic investigation quantitatively reveals that the presence of acetic acid not only accelerates the polymerization, but also suppresses H2S-catalyzed decomposition of NNTAs by decreasing the concentration of H2S dissolved in polar solvents. Benzoic acid is also able to promote the polymerization, while trifluoroacetic acid, phosphoric acid, and phenol are not appropriate promoters. The moderate acidity of acids is essential. l-Methionine, l-tryptophan, and l-phenylalanine, which are dissolved in DMF, initiate the controlled polymerization of sarcosine-NTA in the presence of acetic acid and introduce functional end groups to polysarcosines quantitatively. In DMAc, hydrophilic vancomycin is grafted by poly(N-butyl glycine). The amphiphilic product dissolves in dichloromethane and stabilizes water-in-oil emulsion.
研究领域:
高分子化学
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材料科学
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生物技术
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DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2026
·
IF 6.6
Weilong Cheng,Yanbo Wang,Yixuan Li,Guoping Zhao
Imidacloprid, a neonicotinoid pesticide that was reported to induce intestinal damage at low doses, necessitating effective intervention strategies. As a common component in food, glycine (GLY) has the capacity to alleviate intestinal damage. However, whether it can relieve the damage caused by imidacloprid leave to be clarified. This study investigated the protective effects of GLY (2% and 5%) against imidacloprid induced (0.06 mg/kg bw/day) intestinal injury in male Wistar rats. GLY supplementation attenuated intestinal permeability and enhanced the expression of tight junction proteins. Further, the pregnane X receptor-myosin light chain 2 signaling pathway that mediating imidacloprid-induced intestinal toxicity was also found repaired. GLY intervention increased the enzyme activities of cytochrome P450 3A4 and glutathione-S-transferase, which were responding for phase I and phase Ⅱ imidacloprid metabolism. Meanwhile, reduced levels of imidacloprid and its phase I metabolites, as well as increased phase Ⅱ detoxifying glutathione conjugates, both suggesting the protective role of GLY intervention through enhancing imidacloprid detoxification metabolism. Importantly, the amino acid signaling pathway related fecal metabolic profiles and microbiota composition in imidacloprid treated rats were also modulated and improved by GLY. Totally, our findings demonstrated the protective effect of GLY on intestinal damage caused by imidacloprid exposure, which provided ideas for preventing and controlling the toxicity of food contaminants.
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PubMed
高影响因子
Catalysis Science & Technology
·
2026
·
IF 4
Kaiyang Lian,Fei Li,Lijuan Ma,Ranran Wu,Zhiguang Zhu
Glycine, the simplest amino acid with versatile physiological functions, is widely used in pharmaceuticals, animal feed, and the food industry. However, conventional production methods are limited by sustainability, safety, and environmental concerns. Here, we develop an efficient and green one-pot in vitro multi-enzyme cascade that converts oxalate into glycine under mild conditions. Upon optimization of the reaction conditions and integration of a cofactor recycling system, nearly complete conversion (100%) of oxalate to glycine was achieved in a 1-mL reaction system within 7 hours. After 4 hours of reaction in a 10 mL system, the glycine yield reached 95.7%, with a corresponding synthesis rate of 179.6 mg L-1 h-1. This work demonstrates that a C2-fixing multi-enzyme cascade circumvents the inherent challenge of C-C bond formation, achieving efficient conversion of CO2-derived oxalate to glycine, and presents a practical and conceptually innovative strategy for carbon-negative chemical synthesis.
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DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Shanshan Wu,Qiumin Ye,Datong Wu,Yongxin Tao,Yong Kong
Glycine (Gly), an achiral amino acid, has never been reported for enantioselective recognition owing to the absence of chiral sites. Herein, a facile strategy of chirality transfer is proposed to endow Gly with chirality. Optically active CuO, L-CuO, is first prepared, which can be used for the decoration of Gly through the formation of the Cu(Gly)2 complex. Successful chirality transfer from L-CuO to Gly is confirmed by circular dichroism (CD) spectra. The formation of the Cu(Gly)2 complex is further confirmed by Fourier transform infrared spectra and X-ray photoelectron spectroscopy. Next, the resultant L-CuO-Gly is used for chiral analysis of the isomers of tryptophan (Trp). Because of the higher affinity of L-CuO-Gly toward L-Trp than its isomer, the Trp isomers exhibit significant differences in their oxidation peak currents at the L-CuO-Gly-modified glassy carbon electrode (GCE) (IL-Trp/ID-Trp = 5.24). Finally, the practicability of the developed L-CuO-Gly/GCE is assessed, and the results indicate that it could be a reliable chiral sensor for the quantitative analysis of Trp isomers in nonracemic mixtures.
研究领域:
生物化学
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分析化学
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2015
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IF 2.711
Fang Li,Jianfeng Ye,Linming Yang,Chunhua Deng,Qing Tian,Bo Yang
Due to the ease of processing and stability during filtration, polydopamine (PD) coatings with grafted hydrophilic polymers have recently received significant attention. In this study, glycine-functionalized PVA was synthesized and grafted to a PD-coated ultrafiltration (UF) membrane to improve its performance during wastewater filtration. The membranes were modified by grafting PD with glycine-functionalized PVA (PD-g-PVA), and the resultant materials were characterized using surface morphology analyses, contact angle measurements, flux, oil/water emulsion separation tests, and grafted layer stability tests. The performance of the PD-g-PVA membrane was compared to that of the membrane modified with PD-g-polyethylene glycol (PEG). After grafting the PD-g-PVA, the surface roughness of the membranes decreased significantly. The grafted PVA layer, which was stable under acidic and alkaline conditions, protected the PD layer. The filtration experiments with an oil/water emulsion indicated that modifying the glycine-functionalized PVA by grafting can significantly improve the antifouling ability of membranes.
研究领域:
材料科学
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环境工程
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化学工程
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2016
·
IF 2.822
Wenbin Zhang,Zhixing Xiong,Yingying Gao,Hang Gao,Ya Zhang
2,2,6,6-Tetramethyl-1-piperidine N -oxyl (TEMPO) and nickel hydroxide (Ni(OH) 2 ) mediated electrooxidation of glycine were performed and roles of bases in these two reactions were investigated by cyclic voltammetry . Trends of 2,4,6-collidine > 2,6-lutidine > 3-picoline > pyridine and KOH > NaOH > LiOH were observed in the studies of bases dependent activities on TEMPO and Ni(OH) 2 mediated glycine electrooxidation, respectively. Base effects can be rationalized by acid neutralization, base assisted deprotonation and the interaction between bases and catalysts.
研究领域:
电化学
·
催化反应
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分析化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）