MATERIALS LETTERS
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2017
·
IF 2.572
Yana Liu,Lu Fan,Chen Xu,Keke Sun,Zhennan Shi,Ling Li
A composite MIL-101/CDs/MIL-101 comprising MIL-101 and carbon quantum dots (CDs) was prepared and characterized. The particles were uniform in size and found to be potentially used for fluorescence imaging. Cytotoxicity assays indicated the particles were biocompatible and suitable for carrying drugs. In the drug release experiments, the MIL-101/CDs/MIL-101 demonstrated an excellent pH-triggered drug release.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 7
·4464-4470
·
IF 1.354
Ji Fan,Zhang Kun,Li Jie,Gu Yuanliang,Zhao Jinshun,Zhang Jianfeng
Cancer chemotherapy has limitations such as nonselective distribution of drugs, detrimental side effects on normal tissues; here we reported a smart pH and magnetic sensitive drug delivery system (DDS) based on PEGylated Fe3O4 superparamagnetic nanoparticles. The
citric-coated Fe3O4 (CIO) nanoparticles were firstly synthesized and further functionalized by biocompatible poly(ethylene glycol) bis(carboxymethyl ether) (COOH-PEG-COOH), thus PEGylated CIO (GCIO) nanoparticles were obtained. Doxorubicin (DOX) was conjugated as a model
drug to the nanoparticles via hydrazone bond. The roughly sphere GCIO nanoparticles were comparatively strong magnetism with high drug loading capability (~89%) in relatively uniform size. Drug release study revealed that the GCIO-DOX performed pH-responsive drug-release properties. MTT assay
demonstrated that GCIO nanoparticles possessed low cytotoxicity and good physiological stability. Further, cell viability results indicated that the GCIO-DOX showed effective cytotoxicity only a bit lower than free DOX. All obtained data indicated that the combined pH-responsive and magnetic
multifunction drug delivery system can has excellent potential applications in cancer therapy.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 37
·1800791
·
IF 13.325
Peng Long,Yiyu Feng,Chen Cao,Yu Li,Junkai Han,Shuangwen Li,Cong Peng,Zeyu Li,Wei Feng
The unstable triplet excited state is a core problem when developing self-protective room temperature phosphorescence (RTP) in carbon dots (CDs). Here, fluorine and nitrogen codoped carbon dots (FNCDs) with long-lived triplet excited states, emitting pH-stabilized blue fluorescence and pH-responsive green self-protective RTP, are reported for the first time. The self-protective RTP of FNCDs arises from n–π * electron transitions for C N/CN bonds with a small energy gap between singlet and triplet states at room temperature. Moreover, the interdot/intradot hydrogen bonds and steric protection of C F bonds reduce quenching of RTP by oxygen at room temperature. The RTP emission of FNCDs shows outstanding reversibility, while the blue fluorescence emission has good pH stability. Based on these FNCDs, a data encoding/reading strategy for advanced anticounterfeiting is proposed via time-resolved luminescence imaging techniques, as well as steganography of complex patterns.
研究领域:
材料科学
·
化学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2019
·Vol. 26
·期 24
·25107-25116
·
IF 2.914
Liu Guanghua,Lin Guanquan,Lin Xida,Zhou Hongjun,Chen Huayao,Hao Li,Zhou Xinhua
The overdosage use of pesticide was harmful to the environment and human health, which was mainly caused by the low utilization rate of the pesticide. However, the pesticide microcapsule with sustained-release and stimulating response properties could effectively solve this problem. Preparation of carboxymethyl cellulose grafting dimethyldiallylammonium chloride (CMC-g-PDMDAAC) through grafting polymerization and trapping as well as encapsulation of avermectin (AVM) via electrostatic interactions resulted in the formation of AVM/CMC-g-PDMDAAC microcapsules. The results showed that the particle size was 200~300 nm. The encapsulation efficiency was as high as 72.06%. Furthermore, the remaining rate of encapsulated AVM increased from 50.0 to 81.60% after UV irradiation for 359 min. The microcapsules exhibited significant enzyme and pH stimuli responsiveness. Finally, CMC-g-PDMDAAC had no significant difference effect on the toxicity of AVM, AVM could be found, and DMDAAC featured a synergistic effect on the toxicological effects of AVM.
Graphical abstract
研究领域:
农药科学
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材料科学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Ying Wang,Jingwen Chen,Qianqian Han,Qiang Luo,Hongmei Zhang,Yanqing Wang
Lentinan(LNT) has many kinds of pharmacological activities such as antioxidative activities, hypoglycemic effect, anti-hyperlipidemic effect and so on. Here, LNT was used as the skeleton material to couple with doxorubicin(DOX) by forming the LNT–DOX conjugates in order to enhance anticancer effects and reduce the systemic side effects of DOX. Based on the screening results, we observed that LNT can acted as an antitumor carrier for release of DOX with pH-responsive. DOX release from conjugates was 63.1% at pH 5.0 for up to 48 h, whereas 13.6% of DOX release was observed at pH 7.4 in phosphate buffered saline . The grafting rate of LNT-DOX conjugates was 6.5±0.65 mg/100 mg DOX content. The morphology results showed that LNT-DOX conjugates were considerably more amorphous than LNT. LNT linked by DOX basically maintained the original structure and rheology in water solution. The in vitro anticancer activity of LNT–DOX conjugates was higher than that of free DOX. It is important that LNT–DOX conjugates can enhance anticancer effects in breast cancer cells and decrease the cytotoxocity effects against human normal cells. This work proved that the LNT–DOX conjugates might be suitable for building anticancer drug platform in the course of chemotherapy.
研究领域:
药学
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肿瘤学
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生物医学工程
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
·
IF 4.098
Qin Wang,Li-Bing Lü,Zhu Tao,Tao Sun,Qing Tang,Ying Huang
In the present work, we have investigated the effect of pH and mercury ions on the host–guest complex formed between cucurbit[7]uril (Q[7]) and Hoechst 33342 (H33342). 1 H NMR, UV–vis and fluorescence spectroscopy revealed that acid/base stimulation could change the binding stoichiometry between Q[7] and H33342. The results suggest that two complexation equilibria (1:1 and 2:1) may exist between H33342 and Q[7] at pH 2.0 and 4.5, respectively. However, a 1:1 host–guest complex was formed between H33342 and Q[7] at pH 7.0 and 10.0. Q[7] shows differential affinities for the protonated and neutral forms of H33342 dye. Moreover, the switching between H33342∙2H + @2Q[7](1:2) at pH 4.5 and H33342∙H + @Q[7](1:1) at pH 7.0 was reversible. Furthermore, as a metal stimulus, Hg 2+ ions could push (i) Q[7] from the piperazine ring to the benzimidazole position with a 1:1 guest–host ratio and (ii) a second Q[7] onto the ethyl position with a 1:2 guest–host stoichiometry. This stimulus response system will have potential applications in the field of molecular switch design.
研究领域:
超分子化学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2012
·
IF 1.58
Yi-Tian Tang,Xiao-Qiu Dou,Zhi-Ang Ji,Ping Li,Shen-Min Zhu,Jia-Jun Gu,Chuan-Liang Feng,Di Zhang
Dye/water separation is a worldwide challenge because of the increasing industrial dye wastewater. In this paper, a novel pH-responsive C 2 -symmetric cyclohexane based hydrogel was developed and was capable of rapidly adsorbing dye molecules in minutes. This hydrogel dye adsorbent was characterized by Fourier transform infrared (FT-IR) spectroscopy, Ultraviolet–visible (UV–vis) spectroscopy, Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). The adsorption equilibrium of the dyes is in good agreement with Langmuir adsorption isotherm model. Moreover, the hydrogel adsorbent can be recovered easily just by changing the pH of the medium, which is promising to be used an efficient dye adsorbent in water purification .
研究领域:
材料科学
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环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2015
·
IF 5.75
Xu Jia,Xubo Zhao,Kun Tian,Tingting Zhou,Jiagen Li,Ruinian Zhang,Peng Liu
A novel water-soluble pH stimuli-responsive fluorescent copolymer of P(PEGMA-b-(MAH-co-Rh6GEAm)) was synthesized by two-step sequential RAFT polymerization. The prodrug with drug content of 0.1560 mg/mg was prepared by coupling doxorubicin (DOX) onto the copolymer via acid-cleavable hydrazone bond, formed between the carbonyl group of DOX and abundant hydrazide functional groups in the copolymer. The amphiphilic DOX-conjugated prodrug (P(PEGMA-b-(MAH-DOX-co-Rh6GEAm))) could easily form a micelle in water with Dh of less than 100 nm. It could be transported into HepG2 cells and release DOX without burst release, while the leakage of DOX can be avoided in the simulated normal physiological media. Furthermore, its fluorescence intensity experienced a reversible change with the transformation of the media pH. The better biocompatibility, pH stimuli-responsiveness, and the strong fluorescence at low pH media make the nanoparticles a potential platform for the controlled release of anticarcinogens and real-time fluorescent imaging of tumor tissues.
研究领域:
生物材料
·
药物递送
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2014
·Vol. 32
·期 10
·1329-1337
·
IF 1.42
Zhang Yan,Wang Xiao-ju,Guo Miao,Yan Hu-sheng,Wang Chen-hong,Liu Ke-liang
Multifunctional nanocarriers with multilayer core-shell architecture were prepared by coating superparamagnetic Fe 3 O 4 nanoparticles with diblock copolymer folate-poly(ethylene glycol)- b -poly(glycerol monomethacrylate) (FA-PEG- b -PGMA), and triblock copolymer methoxy poly(ethylene glycol)- b -poly(2-(dimethylamino) ethyl methacrylate)- b -poly(glycerol monomethacrylate) (MPEG- b -PDMA- b -PGMA). The PGMA segment was attached to the surfaces of Fe 3 O 4 nanoparticles, and the outer PEG shell imparted biocompatibility. In addition, folate was conjugated onto the surfaces of the nanocarriers. Cisplatin was then loaded into the nanocarrier by coordination between the Pt atom in cisplatin and the amine groups in the inner shell of the multilayer architecture. The loaded cisplatin showed pH-responsive release: slower release at pH 7.4 ( i.e. mimicking the blood environment) and faster release at more acidic pH ( i.e. mimicking endosome/lysosome conditions). All of the cisplatin-loaded nanoparticles showed concentration-dependent cytotoxicity in HeLa cells. However, the folate-conjugated cisplatin-loaded carriers exhibited higher cytotoxicity in HeLa cells than non-folate conjugated cisplatin-loaded carriers.
研究领域:
药学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2015
·Vol. 6
·期 11
·2098-2107
·
IF 5.52
Yang Kang,Xiao-Mei Zhang,Sheng Zhang,Li-Sheng Ding,Bang-Jing Li
Self-assembly of stimuli-responsive polymeric nanoparticles have attracted great attention in recent years due to their prospective biological applications. This paper developed a novel pH-sensitive amphiphilic dendritic polyrotaxane drug-polymer conjugate by covalently linking doxorubicin (DOX) and dendritic polyrotaxane via a pH-responsible hydrazone bond with 1.84 wt% (weight percent) of DOX. The drug-polymer conjugate was amphiphilic and could be self-assembled to micelles (PR-g-DOX micelles) in an aqueous solution. The globular morphology and compact micelles with a diameter of around 110 nm were observed by SEM and TEM. Moreover, the micelles showed a significantly faster DOX release at mildly acidic pH of 6.0 and 5.0 and almost no burst release at the physiological pH of 7.4. Notably, it was confirmed that this micelle could efficiently deliver DOX to the nuclei of the tumor cells, which led to a much greater cytotoxic effects in the A549 cancer cells than the parent DOX. In vivo results revealed better drug tolerability of PR-g-DOX micelles and a higher in vivo efficacy without any increase in the toxicity of the PR-g-DOX micelles. Furthermore, the maximum tolerated dose (MTD) results showed that PR-g-DOX micelles showed an excellent safety profile with a two-fold higher MTD (10 mg kg−1 DOX) than that of free DOX (5 mg kg−1 DOX). We are convinced that the PR-g-DOX micelle has tremendous potentials for targeted cancer therapy.
研究领域:
药学
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生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 11
·1337-1347
·
IF 4.927
Lulu Cheng,Tingting Luan,Di Liu,Ju Cheng,Hongping Li,Hua Wei,Lifen Zhang,Jingfeng Lan,Yali Liu,Guanghui Zhao
A new type of reduction- and pH-mediated glyco-polymeric micelles was synthesized for the antitumor drug doxorubicin (DOX) delivery in this study. The micelles were constructed by a diblock copolymer (MH-S-S-AcMH) with a disulfide linkage between hydrophilic block maltoheptaose (MH) and hydrophobic block acetalated maltoheptaose (AcMH). The experimental results showed that the amphiphilic MH-S-S-AcMH with 20 nm average size could self-assemble into micelles under physiological conditions and rapidly release the conjugated drug DOX when exposed to weakly acidic (pH = 5) and reductive (10 mM DTT) environment. Fluorescence microscopy detection indicated that drug carriers can be endocytosed effectively, making the anticancer agents flow into cells and suppress the growth of HeLa tumor cells. Compared with DOX at higher dosage and MH-S-S-AcMH micelles which are non-toxic to tumor cells, cytotoxicity assays manifested that the DOX-loaded MH-S-S-AcMH micelles exhibited better toxicity to HeLa tumor cells. According to these results, the copolymer mentioned above as practically non-toxic, highly stable, novel reduction- and pH-mediated glyco-polymeric micelles could be employed in improving drug delivery efficiency and enhancing anticancer efficacy.
研究领域:
药物递送
·
肿瘤学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2017
·Vol. 27
·期 13
·1605665
·
IF 12.124
Huimin He,Xiaodong Cao,Hua Dong,Ting Ma,Gregory F. Payne
Biology uses various cross-linking mechanisms to tailor material properties, and this is inspiring technological efforts to couple independent cross-linking mechanisms to create hydrogels with complex mechanical properties. Here, it is reported that a hydrogel formed from a single polysaccharide can be triggered to reversibly switch cross-linking mechanisms and switch between elastic and viscoelastic properties. Specifically, the pH-responsive self-assembling aminopolysaccharide chitosan is used. Under acidic conditions, chitosan is polycationic and can be electrostatically cross-linked by sodium dodecyl sulfate (SDS) micelles to confer viscoelastic and self-healing properties. Under basic conditions, chitosan becomes neutral, the electrostatic SDS–chitosan interactions are no longer operative, and chitosan chains can self-assemble to form crystalline network junctions that serve as strong physical cross-links that confer elastic properties. Mechanical measurements performed in water demonstrate these different mechanical behaviors and the repeated pH-induced switching between these behaviors. Printing of SDS micelles onto a neutral chitosan film allows the cross-linking mechanisms to be spatially programed to confer anisotropic mechanical properties. The reversibility of these cross-linking mechanisms allows the patterned films to be erased and reprogramed with reconfigured mechanical properties. Potentially, the ability to reversibly program hydrogel networks enables fabrication of the dynamically reconfigurable networks required for soft machines.
研究领域:
材料科学
·
生物工程
✓ 已验证
产品关联
DOI
高影响因子
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