ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Gaozheng Zhao,Huihui Wu,Ruilu Feng,Dongdong Wang,Pengping Xu,Peng Jiang,Kang Yang,Haibao Wang,Zhen Guo,Qianwang Chen
Phothermal therapy has received increasing attention in recent years as a potentially effective way to treat cancer. In pursuit of a more biocompatible photothermal agent, we utilize biosafe materials including ellagic acid (EA), polyvinylpyrrolidone (PVP), and iron element as building blocks, and we successfully fabricate a homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nanoagent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo. The microenvironment responsiveness to both pH and hydrogen peroxide makes the NPs biodegradable in tumor tissues, and the framework should be easily cleared by the body. Photothermal potentials of the nanoparticles are demonstrated with relevant features of strong NIR light absorption, moderately effective photothermal conversion efficiency, and good photothermal stability. The in vivo photothermal therapy also achieved effective tumor ablation with no apparent toxicity. On the other hand, it also exhibits T2 MR imaging ability originated from ferric ions. Our work highlights the promise of the Fe-EA framework for imaging-guided photothermal therapy.
研究领域:
生物医学工程
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肿瘤学
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纳米医学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2020
·
IF 2.463
Chao Li,Baoguo Li,Chuanhui Zhu,Xiang Meng
New preparation condition of magnetic microcapsule was designed and optimized by response surface methodology(RSM) in this study. The optimal formula was as follows: the concentration of chitosan(CTS), magnetofluid(MHD), calcium chloride(CaCl 2 ) and sodium alginate solution(ALG) were 10.4(g/L),4.83(g/L), 5.625(g/L), and 28(g/L),respectively. The optimized magnetic microcapsules had good slow release effect, and the release time of magnetic microcapsule was up to 100 h. The chemical structure of magnetic microcapsules was determined by Fourier transform infrared(FT-IR) spectrometer. Meanwhile, the chemical composition of the magnetic microcapsule was determined by X-ray diffraction(XRD) instrument.Thermogravimetric analysis(TGA) was used to detect the thermal properties . The properties of anti-oxidation and drug release of the magnetic microcapsules were further analyzed. Most importantly, magnetic microcapsules had superparamagnetism with extremely low magnetic retention and coercivity , which could be used as a good microcapsule embolization agent for tumor endovascular embolization therapy.
研究领域:
食品科学
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生物医学工程
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DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2022
·Vol. 43
·期 7
·2100830
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IF 5.006
Hanru Liu,Huimin Geng,Xiaohui Zhang,Xu Wang,Jingcheng Hao,Jiwei Cui
The rapid and facile synthesis of hot melt super glue (HMSG) via the formation of adhesive supramolecular networks between catechol or pyrogallol hydroxyl groups (−OH) of polyphenols and repeat units (−CH 2 CH 2 O−) of poly(ethylene glycol) (PEG) based on hydrogen bonds is reported. The adhesion strength of HMSG, processed by heating–cooling of polyphenols and PEG without additional solvents, can be tuned up to 8.8 MPa via changing the molecular weight of PEG and the ratio of hydrogen bonding donors and receptors. The advantages of the reported HMSG lie in the ease and scalability of the assembly process, rapid adhesion on various substrates with excellent processability, resistance of low temperature and organic solvents, and recyclable adhesion strength. The solvent-free HMSG represents a promising adhesive supramolecular network to expand the versatility and application of polyphenol-based materials.
研究领域:
材料科学
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化学工程
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生物材料
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DOI
PubMed
高影响因子
Pharmaceuticals
·
2020
·Vol. 13
·期 4
·55
·
IF 4.286
Gui-Lin Chen,Fredrick Munyao Mutie,Yong-Bing Xu,Flora Didii Saleri,Guang-Wan Hu,Ming-Quan Guo
Rhamnus prinoidesL’Herit (R. prinoides) has long been widely consumed as folk medicine in Kenya and other Africa countries. Previous studies indicated that polyphenols were abundant in genusRhamnusand exhibited outstanding antioxidant and anti-inflammatory activities. However, there are very few studies on such pharmacological activities and the polyphenol profile of this plant up to now. In the present study, the antioxidant activities of the crudeR. prinoidesextracts (CRE) and the semi-purifiedR. prinoidesextracts (SPRE) of polyphenol enriched fractions were evaluated to show the strong radical scavenging effects against 1,1-diphenyl-2- picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) (0.510 ± 0.046 and 0.204 ± 0.005, mg/mL), and 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) (0.596 ± 0.005 and 0.096 ± 0.004, mg/mL), respectively. Later, the SPRE with higher contents of polyphenols and flavonoids displayed obvious anti-inflammatory activities through reducing the NO production at the dosage of 11.11 − 100 μg/mL, and the COX-2 inhibitory activity with an IC50value at 20.61 ± 0.13 μg/mL. Meanwhile, the HPLC-UV/ESI-MS/MS analysis of polyphenol profile ofR. prinoidesrevealed that flavonoids and their glycosides were the major ingredients, and potentially responsible for its strong antioxidant and anti-inflammatory activities. For the first time, the present study comprehensively demonstrated the chemical profile ofR. prinoides, as well as noteworthy antioxidant and anti-inflammatory activities, which confirmed thatR. prinoidesis a good natural source of polyphenols and flavonoids, and provided valuable information on this medicinal plant as folk medicine and with good potential for future healthcare practice.Keywords:Rhamnus prinoides;polyphenols;antioxidant;anti-inflammatory;chemical profile
研究领域:
药理学
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植物化学
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DOI
PubMed
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
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2020
·Vol. 26
·期 66
·15159-15169
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IF 4.857
Ting Chen,Rongtao Huang,Jiawei Liang,Bo Zhou,Xiao-Lu Guo,Xing-Can Shen,Bang-Ping Jiang
Graphical Anti-cancer nanozymes : Nanozymes comprising natural polyphenol–vanadium oxide nanosheets (TA@VO x NSs) are developed. In this nanosystem, the peroxidase-like activity of VO x provides the possibility to achieve tumor-specific chemodynamic therapy (CDT). As a valid supplement to CDT, NIR absorption enables that TA@VO x NSs can realize NIR light-mediated photothermal therapy (PTT). Such combination of chemodynamic and photothermal activities means that TA@VO x NSs can be applied for effective synergistic CDT/PTT of cancers. The selection of suitable nanozymes with easy synthesis, tumor specificity, multifunction, and high therapeutics is meaningful for tumor therapy. Herein, a facile one-step assembly approach was employed to successfully prepare a novel kind of natural polyphenol tannic acid (TA) hybrid with mixed valence vanadium oxide nanosheets (TA@VO x NSs). In this system, VO x is assembled with TA through metal–phenolic coordination interaction to both introduce superior peroxidase-like activity and high near infrared (NIR) absorption owing to partial reduction of vanadium from V 5+ to V 4+ . The presence of mixed valence vanadium oxide in TA@VO x NSs is proved to be the key for the catalytic reaction of hydrogen peroxide (H 2 O 2 ) to . OH, and the corresponding catalytic mechanism of H 2 O 2 by TA@VO x NSs is proposed. Benefitting from such peroxidase-like activity of TA@VO x NSs, the overproduced H 2 O 2 of the tumor microenvironment allows the realization of tumor-specific chemodynamic therapy (CDT). As a valid supplement to CDT, the NIR absorption enables TA@VO x NSs to have NIR light-mediated conversion ability for photothermal therapy (PTT) of cancers. Furthermore, in vitro and in vivo experiments confirmed that TA@VO x NSs can effectively inhibit the growth of tumors by synergistic CDT/PTT. These results offer a promising way to develop novel vanadium oxide-based nanozymes for enhanced synergistic tumor-specific treatment.
研究领域:
纳米医学
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癌症治疗
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材料科学
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生物化学
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Min Yan,Shuli Yin,Fanqing Meng,Jianguang Qi,Xin Li,Peizhe Cui,Yinglong Wang,Liang Wang
The development of a convenient and universal strategy for the synthesis of inorganic–organic hybrid nanomaterials with phenolic coating on the surface is of special significance for the preparation of electrocatalysts . In this work, we report an environmentally friendly, practical, and convenient method for one-step reduction and generation of organically capped nanocatalysts using natural polyphenol tannic acid (TA) as reducing agents and coating agents . TA coated metal (Pd, Ag and Au) nanoparticles are prepared by this strategy, among which TA coated Pd nanoparticles (PdTA NPs) show excellent oxygen reduction reaction activity and stability under alkaline conditions. Interestingly, the TA in the outer layer makes PdTA NPs methanol resistant, and TA acts as molecular armor against CO poisoning. We propose an efficient interfacial coordination coating strategy, which opens up new way to regulate the interface engineering of electrocatalysts reasonably and has broad application prospects.
研究领域:
材料科学
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电化学
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DOI
PubMed
高影响因子
Frontiers in Plant Science
·
2023
·
IF 5.6
Shengnan Zhai,Hang Liu,Xianchun Xia,Haosheng Li,Xinyou Cao,Zhonghu He,Wujun Ma,Cheng Liu,Jianmin Song,Aifeng Liu,Jingjuan Zhang,Jianjun Liu
Polyphenol oxidase (PPO) activity is a major cause of the undesirable brown color of wheat-based products. Ppo1 , a major gene for PPO activity, was cloned based on sequence homology in previous studies; however, its function and regulation mechanism remain unclear. In this study, the function and genetic regulation of Ppo1 were analyzed using RNA interference (RNAi) and Targeting Induced Local Lesions IN Genomes (TILLING) technology, and superior mutants were identified. Compared with the control, the level of Ppo1 transcript in RNAi transgenic lines was drastically decreased by 15.5%–60.9% during grain development, and PPO activity was significantly reduced by 12.9%–20.4%, confirming the role of Ppo1 in PPO activity. Thirty-two Ppo1 mutants were identified in the ethyl methanesulfonate (EMS)-mutagenized population, including eight missense mutations, 16 synonymous mutations, and eight intron mutations. The expression of Ppo1 was reduced significantly by 6.7%–37.1% and 10.1%–54.4% in mutants M092141 (G311S) and M091098 (G299R), respectively, in which PPO activity was decreased by 29.7% and 28.8%, respectively, indicating that mutation sites of two mutants have important effects on PPO1 function. Sequence and structure analysis revealed that the two sites were highly conserved among 74 plant species, where the frequency of glycine was 94.6% and 100%, respectively, and adjacent to the entrance of the hydrophobic pocket of the active site. The M092141 and M091098 mutants can be used as important germplasms to develop wheat cultivars with low grain PPO activity. This study provided important insights into the molecular mechanism of Ppo1 and the genetic improvement of wheat PPO activity.
研究领域:
植物学
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遗传学
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分子生物学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Min-Rui Tai,Hong-Wu Ji,Jian-Ping Chen,Xiao-Fei Liu,Bing-Bing Song,Sai-Yi Zhong,Aaqil Rifai,David R. Nisbet,Colin J. Barrow,Richard J. Williams,Rui Li
Self-assembled peptide and polysaccharide nanogels are excellent candidates for bioactive delivery vectors. However, there are still significant challenges in the application of nanogels as delivery tools for bioactive elements. This study aims to deliver, and control the release of a hydrophobic bioactive flavonoid hesperidin . Using the self-assembling peptide (SAP) Fmoc-FRGDF, extracellular matrix mimicking nanofibrils were fabricated, which were decorated and bolstered with immunomodulatory polysaccharide strands of fucoidan and infused with hesperidin . The mechanical properties, secondary structure , and microscopic morphologies of the composite hydrogels were characterized using rheometer, FTIR, XRD, and TEM, etc. The encapsulation efficiency (EE) and release behavior of hesperidin were determined. Coassembly of the SAP with fucoidan improved the mechanical properties (from 9.54 Pa of Fmoc-FRGDF hydrogel to 7735 Pa of coassembly hydrogel at 6 mg/mL fucoidan concentration), formed thicker nanofibril bundles at 4 and 6 mg/mL fucoidan concentration, improved the EE of hesperidin from 72.86 % of Fmoc-FRGDF hydrogel to over 90 % of coassembly hydrogels, and showed effectively controlled release of hesperidin in vitro . Intriguingly, the first order kinetic model predicted an enhanced hydrogel retention and release of hesperidin. This study revealed a new approach for bioengineered nanogels that could be used to stabilize and release hydrophobic payloads.
研究领域:
生物材料学
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药物递送系统
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食品科学
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2023
·
IF 14
Huining Wan,Yanyan Li,Yumei Qin,Yongqi An,Hui Yan,Xiyu Liu,Hao Zhang,Cheng Hu,Linhua Li,Daihua Fu,Yuan Yang,Yan Dai,Rifang Luo,Li Yang,Bo Zhang,Yunbing Wang
Drug-eluting stents have become one of the most effective methods to treat cardiovascular diseases. However, this therapeutic strategy may lead to thrombosis, stent restenosis , and intimal hyperplasia and prevent re-endothelialization. In this study, we selected 3-aminophenylboronic acid-modified hyaluronic acid and carboxylate chitosan as polyelectrolyte layers and embedded an epigallocatechin-3-gallate–tanshinone IIA sulfonic sodium (EGCG–TSS) complex to develop a sandwich-like layer-by-layer coating. The introduction of a functional molecular EGCG–TSS complex improved not only the biocompatibility of the coating but also its stability by enriching the interaction between the polyelectrolyte coatings through electrostatic interactions , hydrogen bonding , π–π stacking, and covalent bonding. We further elucidated the effectiveness of sandwich-like coatings in regulating the inflammatory response, smooth muscle cell growth behavior , stent thrombosis and restenosis suppression, and vessel re-endothelialization acceleration via in vivo and in vitro . Conclusively, we demonstrated that sandwich-like coating assisted by an EGCG–TSS complex may be an effective surface modification strategy for cardiovascular therapeutic applications.
研究领域:
心血管疾病
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生物材料
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药学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ChemCatChem
·
2024
·
IF 3.8
Fang Liu,Yongcheng Chen,Yue Huang,Qiao Jin
The increasing severity of fungal infections globally and the limited availability of effective treatments necessitate novel therapeutic strategies. In this study, we developed a copper-polyphenol nanocomplexes (CPE NPs) through a one-step synthetic process by the coordination self-assembly of copper sulfate (CuSO4), protocatechuic acid (PA), and ε-Poly-L-lysine (EPL). CPE NPs demonstrated peroxidase-like activities, which could catalyze H2O2 to generate hydroxyl radicals (•OH) to effectively eradicate fungi. CPE NPs were stable in physiological neutral environment. However, since metal-phenolic coordination interaction was unstable in acidic pH, CPE NPs could be dissociated in acidic environments, such as fungal infection sites, leading to effective release of Cu2+ and EPL, thereby exerting antifungal effects. CPE NPs exhibited excellent fungicidal ability at both pH 7.4 and 6.0 against Candida albicans and Aspergillus flavus. More importantly, CPE NPs could effectively eradicate fungi in 20% Sabouraud dextrose broth (SDB) medium containing rich inorganic salts and proteins, in which dissociative Cu2+ completely lost its fungicidal ability. In summary, CPE NPs could effectively deliver Cu2+ to fungal surface for enhanced fungal eradication by generating •OH, highlighting their great potential as a promising nano-therapeutic agent for the treatment of fungal infections.
研究领域:
纳米技术
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药学
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微生物学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-17
·
IF 10.6
Wang Hui,Tang Cui,Xiang Yuxia,Zou Chan,Hu Jianming,Yang Guoping,Zhou Wenhu
Thrombotic diseases impose a significant global health burden, and conventional drug-based thrombolytic therapies are encumbered by the risk of bleeding complications. In this study, we introduce a novel drug-free nanomedicine founded on tea polyphenols nanoparticles (TPNs), which exhibits multifaceted capabilities for localized photothermal thrombolysis. TPNs were synthesized through a one-pot process under mild conditions, deriving from the monomeric epigallocatechin-3-gallate (EGCG). Within this process, indocyanine green (ICG) was effectively encapsulated, exploiting multiple intermolecular interactions between EGCG and ICG. While both TPNs and ICG inherently possessed photothermal potential, their synergy significantly enhanced photothermal conversion and stability. Furthermore, the nanomedicine was functionalized with cRGD for targeted delivery to activated platelets within thrombus sites, eliciting robust thrombolysis upon laser irradiation across diverse thrombus types. Importantly, the nanomedicine’s potent free radical scavenging abilities concurrently mitigated vascular inflammation, thus diminishing the risk of disease recurrence. In summary, this highly biocompatible multifunctional nanomaterial holds promise as a comprehensive approach that combines thrombolysis with anti-inflammatory actions, offering precision in thrombosis treatment.
研究领域:
纳米医学
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血栓治疗
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光热疗法
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炎症研究
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Xinyi Wang,Zezhen Zhang,Weishan Deng,Haolan Xiao,Liming Xia,Lili Wu
Carbon nanotube (CNT) is a promising raw material for membrane fabrication due to its good electrical conductivity, great specific surface area, and special piping structure. In this report, tannin (TA), CNT, and D-aspartic acid (DAS) were co -deposited on the surface of polyethersulfone (PES) ultrafiltration membrane to construct an electrically responsive coating. The membrane can maintain the high electrical conductivity while avoiding the membrane defects due to the accumulation of CNTs and the different lengths of chain segments in the process of CNT co-blending to form the membrane. The results show that the average pore size of the membrane is reduced from 19.55 nm to 8.165 nm, and the retention capacity is greatly improved, showing good separation efficiency (99.5 %) and hydrophilicity (water contact angle of 13°). Through adsorption and electric field deflection, CNT endows the membrane with the ability to selectively separate dyestuffs with different electrically charged properties. Long-term stability tests show that the modified membrane still maintains a high level of pure water flux and conductivity after seven days of operation. This paper is of exploratory significance in the field of electrically responsive smart membranes for dye separation. The membrane developed in this study exhibits unique selective separation performance and can dynamically adjust its separation efficiency by externally controlling the electric field strength. This demonstrates its excellent intelligence, making it highly promising for applications in electrically responsive intelligent separation membranes. Additionally, it offers a novel approach for treating dye-containing wastewater using electrically charged functional membranes.
研究领域:
材料科学
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环境工程
·
化学工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）