MATERIALS CHEMISTRY AND PHYSICS
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2024
·
IF 4.3
Yikun Wang,Yuanmeng Wang,Xiangyuan Li,Jingbo Zhao
Biobased polyphenols have been widely studied for their renewable and non-toxic properties, and their thermoplastic/thermosetting materials have also been reported. However, most biobased polyphenols have high melting points and resistance to common solvents, which greatly hinder their applications in organic reactions and material synthesis. Herein, a trihydroxyethyl resveratrol (TER) with a relatively low melting point was prepared by an etherification of biobased resveratrol with ethylene carbonate, and TER trimethacrylate (TTM) was synthesized further from TER and methacryloyl chloride in the presence of triethylamine. TER and TTM were characterized by FTIR, NMR, ESI-MS, and DSC. Free radical curing reaction of TTM was conducted at different initiator dosages, and three crosslinked networks (TER-Ans) were obtained. The conversion rate, crosslinking density, T g , T α , mechanical properties, and contact angles were influenced highly by the initiator dosages. At the best initiator dosage of 1 wt% BPO, TER-A2 with the highest crosslinking density (42129.3 mol/m 3 ) and the maximum tensile strength (14.3 MPa) was obtained. Green etherification and hydroxylethylation were established to prepare sustainable crosslinked polymethacrylate materials from biobased resveratrol.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2024
·
IF 4.5
Ningning Diao,Hongwei Qu,Wenxin Wang,Min Cao,Xiaowei Liu,Weili Yang,Yuxin Cao,Tianying Sun,Huijie Pei,Chunjing Guo,Daquan Chen
Resveratrol (Res) has a variety of pharmacological activities, but it has not been widely used in clinical practice due to its poor water solubility and low bioavailability. Therefore, improving the solubility and utilization of Res is a key factor in increasing its clinical application. Microneedles (MNs) are a new type of transdermal drug delivery system, which has been widely noticed for its advantages of avoiding hepatic first-pass effect, reducing gastrointestinal side effects, and improving patient compliance. In recent years, the integration of nanomedicine with MNs has also become a novel therapy for drug delivery. In this study, a novel transdermal drug delivery system (Res NC MNs) was obtained by altering the crystalline form of resveratrol by media milling method, preparing resveratrol nanocrystals (Res NC), and loading Res NC into soluble microneedles prepared from sodium hyaluronate. Methods Res NC was prepared by media milling method, and the experimental conditions, such as the type of stabilizer, the ratio of stabilizer to the drug, the number of milling beads, and the milling time, were screened to determine the optimal preparation process, using the particle size and dispersion of nanocrystals as indicators sodium hyaluronate. Dissolvable microneedles were prepared by vacuum casting method and loaded with Res NC, and then the morphology, skin puncture performance, and skin dissolution performance of Res NC MNs were examined. Results From the in vitro release experiments, it can be seen that the resveratrol nanocrystals prepared using the optimal process had a small particle size of about 110 nm, good stability, and good release characteristics. The Res NC MNs had a good morphology, a full and uniform tip, and good skin-piercing properties and dermal solubilization properties. The Res NC MNs prepared in this study improved the drawbacks of poor water solubility and low bioavailability of resveratrol APIs, and combined with MNs, overcame the inherent defects of the traditional drug delivery methods such as oral and injection, which provided a novel idea for the integration of nanomedicine and transdermal drug delivery system.
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Drug Delivery and Translational Research
·
2024
·
IF 5.7
Diao Ningning,Liu Yan,Wang Wenxin,Cao Min,Liu Xiaowei,Yang Weili,Cao Yuxin,Sun Tianying,Pei Huijie,Guo Chunjing,Chen Daquan
Rheumatoid arthritis (RA) is a common immune disease characterized mainly by erosive arthritis with extensive clinical sequelae. Resveratrol (Res) has pharmacological effects in the treatment of RA, but it has not been widely used in the clinic due to its poor water solubility and low bioavailability. In this study, a drug delivery system (Res-NC MNs) of dissolved microneedles (MNs) loaded with Res nanocrystals (NC) was designed for the treatment of RA. Res-NC MNs can improve the drawbacks of long-term oral drug delivery with toxic side effects and low compliance associated with intra-articular drug delivery. In this study, Res-NC was prepared by media milling and loaded into soluble microneedles prepared from hyaluronic acid (HA) by vacuum casting for the treatment of RA. HA has high mechanical strength and can penetrate the cuticle layer of the skin for effective drug delivery. In in vivo pharmacodynamic experiments, Res-NC MNs achieved better therapeutic efficacy in the treatment of RA compared with oral Res. These findings suggest that Res-NC MNs may be an effective and promising drug delivery strategy for the treatment of RA. Graphical Abstract Schematic diagram of resveratrol nanocrystals microneedles for rheumatoid arthritis
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高影响因子
Food & Function
·
2024
·
IF 5.1
Jianjian Ji,Yingcai Xiong,Keyu Tao,Tao Li,Weiying Ou,Yinghui Zhou,Wenyang Zhang,Ruogu Qi,Shouchuan Wang
Resveratrol, renowned for its antiviral properties, exhibits significant potential in combatting severe respiratory infections, particularly the respiratory syncytial virus (RSV). Nevertheless, the specific mechanism underlying its inhibition of RSV replication remains unexplored. Heparan sulfate proteoglycans (HSPGs) play a pivotal role as attachment factors for numerous viruses, offering a promising avenue for countering viral infections. Our research has unveiled that resveratrol effectively curbs RSV infection in a dose-dependent manner. Remarkably, resveratrol disrupts the initial stages of RSV infection by engaging with HSPGs, rather than interacting with RSV surface proteins like fusion (F) protein and glycoprotein (G). Resveratrol's affinity appears to be predominantly directed towards the negatively charged sites on HSPGs, thus impeding the binding of viral receptors. In an in vivo study involving RSV-infected mice, resveratrol demonstrates its potential by ameliorating pulmonary pathology. This improvement is attributed to the inhibition of pro-inflammatory cytokine expression and a reduction in viral load within the lungs. Notably, resveratrol specifically alleviates inflammation characterized by an abundance of neutrophils in RSV-infected mice. In summation, our data firstly illuminates how resveratrol combats RSV infection through interactions with HSPGs, positioning it as a promising candidate for innovative drug development targeting RSV infections. Our study provides insight into the mechanism of resveratrol antiviral infection.
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International Journal of Endocrinology
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2022
·
IF 2.803
Zhihong Liu,Zhimei Zhang,Guangyao Song,Xing Wang,Hanying Xing,Chao Wang
Long noncoding RNA (lncRNA) is a crucial factor in the progression of insulin resistance (IR). Resveratrol (RSV) exhibits promising therapeutic potential for IR. However, there are few studies on whether RSV improves IR through lncRNA. This study aimed to determine whether RSV could influence the expression of lncRNA and to elucidate the underlying mechanism. Mice were divided into three groups: control group, high-fat diet (HFD) group, and HFD + RSV group. We conducted a high-throughput sequencing analysis to detect lncRNA and mRNA expression signatures and the ceRNA-network in the skeletal muscles of mice that were fed an HFD to induce IR. Hierarchical clustering, gene enrichment, and gene ceRNA-network analyses were subsequently conducted. Differentially expressed lncRNAs were selected and validated via reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The biological functions of the selected lncRNAs were investigated by silencing the target genes via lentivirus transfection of C2C12 mouse myotube cells. RSV treatment reversed the expression of 338 mRNAs and 629 lncRNAs in the skeletal muscles of mice with HFD-induced IR. The results of the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes database analyses indicated that the differentially expressed mRNAs modulated type II diabetes mellitus. After validating randomly selected lncRNAs via RT-qPCR, we identified a novel lncRNA, NONMMUT044897.2, which was upregulated in the HFD group and reversed with RSV treatment. Additionally, NONMMUT044897.2 was proven to function as a ceRNA of microRNA- (miR-) 7051-5p. Suppressor of Cytokine Signaling 1 (SOCS1) was confirmed as a target of miR-7051-5p. We further performed lentivirus transfection to knock down NONMMUT044897.2 in vitro and found that NONMMUT044897.2 silenced SOCS1 and potentiated the insulin signaling pathway. Hence, RSV mimicked the silencing effect of lentivirus transfection on NONMMUT044897.2. Our study revealed that RSV reduced IR in mouse skeletal muscles via the regulation of NONMMUT044897.2.
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Food Bioscience
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2022
·
IF 5.318
Kexin Qu,Hongtu Qiu,Hua Zhang,Xingfu Yin
Oleogels, substances that have a liquid phase of continuous oil, are being explored as a potential substitute for trans fatty acids and saturated fatty acids in food. To develop more stable and nutritious alternative lipids using blueberry extract, oleogels loaded with resveratrol (R) and blueberry extract were prepared using soybean oil (SO) and peanut oil (PO) as base oils, and β-sitosterol and lecithin as low-molecular-weight complex oleogelators. Microstructural characterization of oleogels showed that R-loaded and R-enriched blueberry extracts maintained the degree of cross-linking between oleogel crystal units to a certain extent as well as maintained or improved the mouthfeel and hardness of the oleogels. Differential scanning calorimetry and rheometric results demonstrated that the R-loaded ternary oleogels had good thermal stability and strength. With prolonged storage, the physical stability of peanut oil oleogels (POO) was better than that of soybean oil oleogels (SOO). In addition, in vitro simulation experiments revealed that the oleogels could better serve as a carrier for R but could inhibit their bioavailability in R-loaded oleogels.
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Food Science & Nutrition
·
2025
·Vol. 13
·期 5
·e70254
·
IF 3.8
Yujie Pan,Mingyan Xia,Jin Luo,Shuai Lu
Diabetic wound healing critically depends on functional endothelial cells for angiogenesis, yet the hyperglycemic microenvironment induces endothelial dysfunction through oxidative stress, inflammation, and senescence. Although ferroptosis has been recognized as a critical pathological factor contributing to impaired diabetic wound healing, the therapeutic potential of resveratrol (Res), a natural polyphenol with well‐documented antioxidant and anti‐ferroptotic properties, remains underexplored in this context. This study aimed to investigate the protective effects of Res on endothelial cells and elucidate its underlying mechanisms in diabetic wound healing. In vitro experiments systematically evaluated Res's impact on cellular inflammatory responses, senescence levels, and angiogenic capacity. Subsequent in vivo studies assessed Res's therapeutic potential by monitoring diabetic wound healing progression and analyzing associated histological changes. To clarify the mechanisms underlying Res's promotion of diabetic wound healing, we conducted comprehensive analyses measuring intracellular reactive oxygen species, lipid peroxidation levels, mitochondrial membrane potential and morphology, ferroptosis‐related marker expression, and upstream signaling pathway regulation. Res significantly reduced HG‐induced inflammatory responses and cellular senescence in human umbilical vein endothelial cells while enhancing their angiogenic potential in vitro. In vivo results showed that Res not only markedly accelerated diabetic wound healing but also demonstrated multiple beneficial effects, including effective suppression of cellular senescence, decreased ferroptosis levels, and significantly promoted angiogenesis. Mechanistic investigations confirmed that Res achieves these effects by inhibiting ferroptosis through activation of the PI3K‐AKT‐Nrf2 signaling axis. Our results demonstrate that Res protects endothelial cells from HG‐induced ferroptosis by activating PI3K‐AKT‐Nrf2 signaling, thereby promoting angiogenesis and diabetic wound healing. These findings highlight Res as a promising therapeutic candidate for impaired diabetic wound repair and justify further clinical investigation. Resveratrol attenuates intracellular inflammatory responses and cellular senescence by inhibiting ferroptosis via activating the PI3K‐AKT‐Nrf2 signaling pathway, ultimately facilitating angiogenesis and healing of diabetic wounds.
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Biomedical Materials
·
2022
·Vol. 17
·期 5
·055005
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IF 4.103
Ruiqiang Hang,Jiahui Wang,Xue Tian,Ruifeng Wu,Ruiyue Hang,Yuyu Zhao,Yonghua Sun,Honggang Wang
Orthopedic implants have been used clinically to restore the functions of the compromised bone tissues, but there is still a relatively high risk of failure for elderly people. A critical reason is pro-inflammatory immune microenvironment created by senescent macrophages with homeostasis imbalance impairs osteogenesis and angiogenesis, two major processes involved in implant osseointegration. The present work proposes to use resveratrol as an autophagy inducing agent to upregulate the autophagy level of senescent macrophages to restore homeostasis, consequently generating a favorable immune microenvironment. The results show 0.1–1 μM of resveratrol can induce autophagy of senescent macrophages, promote cell viability and proliferation, reduce intracellular reactive oxygen species level, and polarize the cells to pro-healing M2 phenotype. The immune microenvironment created by senescent macrophages upon resveratrol stimulation can promote osteogenesis and angiogenesis, as manifested by upregulated proliferation, alkaline phosphatase activity, type I collagen secretion, and extracellular matrix mineralization of senescent osteoblasts as well as nitric oxide production, migration, and in vitro angiogenesis of senescent endothelial cells. In addition, resveratrol-loaded silk fibroin coatings can be fabricated on titanium surface through electrophoretic co-deposition and the coatings show beneficial effects on the functions of senescent macrophages. Our results suggest resveratrol can be used as surface additive of titanium implants to promote osseointegration of elderly people though regulating immunology of senescent macrophages.
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高影响因子
Materials
·
2020
·Vol. 13
·期 7
·1624
·
IF 3.057
Lili Qin,Xinyu Zhao,Yiwei He,Hongqiang Wang,Hanjing Wei,Qiong Zhu,Ting Zhang,Yao Qin,Ai Du
Resveratrol is a natural active ingredient found in plants, which is a polyphenolic compound and has a variety of pharmaceutical uses. Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) was prepared using a freeze-drying method, employing high speed homogenization followed by rapid freezing with liquid nitrogen. RLTAs were designed at varying drug–cellulose aerogel ratios (1:2, 2:3, 3:2, and 2:1). It could be seen via scanning electron microscopy (SEM) that Res integrated into TEMPO-oxidized cellulose (TC) at different ratios, which changed its aggregation state and turned it into a short rod-like structure. Fourier transform infrared (FTIR) spectra confirmed that the RLTAs had the characteristic peaks of TC and Res. In addition, X-ray diffraction (XRD) demonstrated that the grain size of RLTA was obviously smaller than that of pure Res. RLTAs also had excellent stability in both simulated gastric fluid and phosphate buffer solution. The drug release rate was initially completed within 5 h under a loading rate of 30.7 wt%. The results of an MTT assay showed the low toxicity and good biocompatibility of the RLTAs. TC aerogel could be a promising drug carrier that may be widely used in designing and preparing novel biomedicine.Keywords:TEMPO-oxidized cellulose;aerogel;resveratrol;drug carrier
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高影响因子
POLYMER SCIENCE SERIES B
·
2025
·Vol. 67
·期 2
·15
·
IF 1
Zhijun Li,Huang Zhengyong,Xing Ruiguang
In this study, the preparation of diphenylsilylene diol (DP)-modified double-A epoxy resin (E51) with resveratrol-functionalized graphene (Res/rGO) composites and their performance characterization were investigated. Firstly, the double-A epoxy resin (EP) was modified with DP to improve its mechanical properties and thermal stability. Then, Res/rGO was introduced into the modified epoxy resin (DP/E51), and a series of modified epoxy resin/resveratrol functionalized graphene (Res/rGO-DP/E51) composites were prepared. The effects of different graphene contents on the mechanical properties of the materials were analyzed by conducting tensile property tests on the composites. The results showed that the DP-modified epoxy resin exhibited a significant improvement in tensile strength, especially after the introduction of an appropriate amount of Res/rGO, the tensile properties of the composites were further optimized. Resveratrol, as a natural antioxidant substance, significantly improved the interfacial bonding and dispersion of the composites after functionalization on the graphene surface, thus enhancing the overall performance of the composites. In addition, the Res/rGO-DP/E51 composites exhibited excellent thermal stability, which has a good application prospect.
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AICHE JOURNAL
·
2026
·
IF 4.4
Chen Yang,Hongyan Zhang,Wanqi Du,Zijian Zhang,Minjia Meng
The practical application of molecularly imprinted polymers (MIPs) in aqueous separations is critically hindered by an inherent trade-off between binding capacity and selectivity, stemming from non-specific hydrophobic interactions. Addressing this challenge, this work establishes a robust structure–performance relationship by precisely engineering the interfacial hydrophilicity of resveratrol-imprinted microspheres via epoxide ring-opening. Systematically varying the modification chemistry achieved wide-range tunability of surface wettability, with water contact angles (WCA) spanning 124.4°–19.9°. An optimal amphiphilic balance (WCA = 52.5°) using zwitterionic glycine delivered a high adsorption capacity of 43.14 mg g −1 and an imprinting factor of 2.08 under competitive aqueous conditions. Supported by molecular dynamics (MD) simulations, the optimized interface fosters a synergistic hydration shield, effectively repelling interfering species while facilitating targeted resveratrol capture. Our findings resolve the critical capacity-selectivity paradox, providing a generalizable paradigm for developing high-performance separation materials for complex aqueous streams in bio-processing and pharmaceutical wastewater treatment.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Xiang Che,Zena Chen,Qian Shen,Zhongxi Huang,Yao Wang,Yangyang Pu,Jiarui Shi,Zhipeng Zhang,Naidi Yang,Changmin Yu
A green strategy constructs quaternary ammonium‑functionalized, resveratrol‑loaded polydopamine nanoparticles (R@P)G . • (R@P)G exhibits antibacterial activities against MRSA by disrupting membrane integrity and inducing intracellular leakage. • The nanoplatform enables efficient ROS scavenging and protects cells against oxidative stress under inflammatory conditions. • (R@P)G suppresses pro-inflammatory cytokine, remodels the immune microenvironment and promotes MRSA-infected wound healing. • This multifunctional nanoplatform provides a biosafe and clinically translatable strategy for treating MRSA-infected wounds. Drug-resistant bacterial infection, oxidative stress, and persistent inflammation collectively hinder chronic wound healing, yet most antibacterial nanomaterials fail to address these interconnected pathological factors. Herein, we report a simple and green nanoplatform based on surface-quaternized, resveratrol-loaded polydopamine nanoparticles (denoted (R@P)G ) for the treatment of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds. Surface quaternization introduces cationic motifs that enable effective bacterial membrane disruption, achieving highly efficient killing of MRSA and effective biofilm eradication. Meanwhile, the polydopamine–resveratrol redox system provides broad-spectrum reactive oxygen species scavenging, alleviating oxidative damage and restoring fibroblast function. In addition, (R@P)G significantly accelerates wound closure, enhances collagen deposition and re-epithelialization, and suppresses inflammatory cytokines in vivo . The solvent-free synthesis and favorable biosafety further support its translational potential. This work presents a multifunctional biomaterial strategy for coordinated antibacterial and microenvironmental regulation in infected wound repair, offering a promising approach for the treatment of drug-resistant wound infections.
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