Nanomedicine
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2025
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IF 3.9
Xiaolin Zeng,Baoyan Chen,Peng Qian,Dongjun Jiang,Xianwei Wu,Shiqi Wei,Yangchen Xing,Yuxin Chen,Qianyu Zhang,Huali Chen
Aim To develop an enteric sustained-release nanoparticle formulations of aspirin for applicability to a broader population.Methods Aspirin-loaded nanoparticles were prepared using poly(lactic-co-glycolic acid) (PLGA) and the enteric polymer Eudragit L100–55 through an optimized oil-in-water emulsification solvent evaporation method. The nanoparticles were subjected to comprehensive physicochemical characterization, including particle size, zeta potential, and morphological analysis. Additionally, their stability, in vitro drug release profile, cytotoxicity, intestinal absorption, and in vivo pharmacokinetics were systematically evaluated.Results The nanoparticles exhibited well-defined spherical morphology, uniform particle size, and favorable surface charge, demonstrating excellent biocompatibility. In the in vitro drug release study, AS-PLGA@NPs exhibited pronounced enterolysis effect. The morphology of the nanoparticles was confirmed by scanning electron microscopy (SEM) at different release stages. In vivo intestinal absorption and pharmacokinetic studies in rats demonstrated that AS-PLGA-EL@NPs enhanced drug absorption, prolonged drug release, and showed higher bioavailability compared to conventional enteric-coated tablets.Conclusion The development and preparation of an oral enteric sustained-release nanoparticle delivery system for aspirin has the potential to serve a broader population, with promising applications in various therapeutic contexts.
研究领域:
药剂学
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生物医学工程
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DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 3
·882-891
·
IF 6.183
Zecong Xiao,Xinyao Zheng,Ying An,Kangning Wang,Junwen Zhang,Huacheng He,Jiang Wu
Growth factors (GFs) have been well known for their therapeutic effects on wound healing. Due to their vulnerable biostability, biomaterial carriers are usually used to deliver GFs to maintain their bioactivity. Among the carriers, PEG hydrogels are the most widely applied. But the uncontrolled release of GFs and their immunogenicity dramatically retard the application of PEG hydrogels as carriers of GFs. Herein, FGF2 loaded zwitterionic sulfobetaine methacrylate (SBMA) hydrogels were developed, and it was revealed that these hydrogels were more effective in delivering FGF2 for wound healing than were PEG hydrogels. In vitro studies demonstrated that SBMA hydrogels could successfully prolong the release of FGF2, which effectively maintained the bioactivity of FGF2. Further in vivo investigation showed that SBMA hydrogels could efficiently accelerate wound regeneration by promoting granulation tissue formation, collagen deposition, cell proliferation and migration, reepithelialization and angiogenesis. All results validated that SBMA hydrogels were promising substituents of PEG hydrogels for delivering FGF2 for wound regeneration.
研究领域:
生物材料
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组织工程
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伤口愈合
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药物递送系统
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DOI
PubMed
高影响因子
MATERIALS & DESIGN
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2025
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IF 7.9
Hongping Ge,Jing Yu,Li Pan,Lifang Zhang,Xiaohang Yin,Jie Cai,Chenghu Wu,Chen Wang,Shisheng Chen
Oral ulcers affect more than 25 % of the global population and are driven by complex pathological mechanisms, including bacterial infection, oxidative stress, and dysregulated inflammation, all of which impede healing. To address the limitations of therapies that target only a single aspect of ulcer pathology, this study developed a multifunctional electrospun film by combining 45S5 bioactive glass (BG) with hydroxypropyl methyl cellulose (HPMC). The BG/HPMC films, fabricated by electrospinning with 5 wt% BG incorporated into HPMC matrices, were thoroughly characterized for their structural and bioactive properties. In a rat oral ulcer model, the BG/HPMC films significantly accelerated re-epithelialization and reduced ulcer size compared to both control and chitosan-treated groups. The films also exhibited strong antibacterial activity against Staphylococcus aureus. In vitro, BG extracts promoted the viability and migration of human oral epithelial cells (HOECs) and human umbilical vein endothelial cells (HUVECs), mitigated hydrogen peroxide-induced oxidative stress, and suppressed the expression of pro-inflammatory cytokines—interleukin-1 alpha (IL-1α), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)—in lipopolysaccharide-stimulated macrophages.
研究领域:
口腔医学
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生物材料学
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药剂学
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组织工程
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炎症生物学
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纳米医学
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转化医学
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2025
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IF 3.9
Pengpeng Yang,Wenbo Li,Shushu Li,Qingshi Wen,Chenglun Tang,YongLiang Yan,Fengxia Zou,Keke Zhang
Cordycepin shows anticancer activity in vitro but minimal in vivo activity due to its short plasma half-life. To address this, the cocrystallization technique was used to prolong its release and protect it from deamination by adenosine deaminase. In this study, multiple simulation methods were combined to identify potential cocrystal formers (CCFs). Based on the simulation results, one binary salt (cordycepin-oxalic acid) and two binary cocrystals (cordycepin-gallic acid and cordycepin-vanillic acid) were successfully screened by the mechanochemical method. The new multicomponents were characterized by several techniques. In vitro dissolution experiments showed that the binary salt has a significant sustained-release effect. This study proposes a strategy using binary cocrystals/salts to achieve sustained release and increase the half-life of cordycepin, offering potential for its in vivo application.
研究领域:
药学
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材料科学
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计算化学
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药物递送
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生物物理学
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产品关联
DOI
高影响因子
Analytical Methods
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2024
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IF 2.7
Xue Hua Wang,Mei Ju Luo,Xinyu Li,Qingling Yang,Zhishun Guo,Hao Lin Zou,Hong Qun Luo,Nian Bing Li,Bang Lin Li
In this work, 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (AHMT) was pre-doped into agarose hydrogels; consequently, sustained hydrogel systems with modulated release performance were constructed for simple operation and recyclability in point-of-care detection of formaldehyde (FA). With the increase in FA concentrations, the absorbance response of the supernatant solutions showed linear relationships and the color of the reaction mixtures gradually increased. The detection limit was calculated to be 0.013 μg mL−1. To verify its practical application, a simple, rapid and low-cost FA detection platform was built on the basis of the optimized conditions, and the method shows the merits of simplicity, high sensitivity and selectivity. More importantly, the developed hydrogels are recyclable and can be used at least five times without any loss in sensing performance. Significantly, the sensory hydrogels can be employed by non-skilled people for monitoring food safety and applied for the practical detection of FA in foods.
研究领域:
分析化学
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食品科学
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生物材料学
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产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
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2024
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IF 9.4
Yuanfang Huo,Yannan Cheng,Xianzhen Dong,Qiang Cheng,Xinyue Liang,Ping Duan,Yongle Yu,Lesan Yan,Tong Qiu,Zhenyu Pan,Honglian Dai
The regenerative microenvironment after peripheral nerve injury is imbalanced and difficult to rebalance, which is mainly affected by inflammation, oxidative stress, and inadequate blood supply. The difficulty in remodeling the nerve regeneration microenvironment is the main reason for slow nerve regeneration. Traditional drug treatments have certain limitations, such as difficulty in penetrating the blood-nerve barrier and lack of pleiotropic effects. Therefore, there is an urgent need to build multifunctional nerve grafts that can effectively regulate the regenerative microenvironment and promote nerve regeneration. Nitric oxide (NO), a highly effective gas transmitter with diatomic radicals, is an important regulator of axonal growth and migration, synaptic plasticity, proliferation of neural precursor cells, and neuronal survival. Moreover, NO provides potential anti-inflammation, anti-oxidation, and blood vessel promotion applications. However, excess NO may cause cell death and neuroinflammatory cell damage. The prerequisite for NO treatment of peripheral nerve injury is that it is gradually released over time. In this study, we constructed an injectable NO slow-release system with two main components, including macromolecular NO donor nanoparticles (mPEG-P(MSNO-EG) nanoparticles, NO-NPs) and a carrier for the nanoparticles, mPEG-PA-PP injectable temperature-sensitive hydrogel. Due to the multiple physiological regulation of NO and better physiological barrier penetration, the conduit effectively regulates the inflammatory response and oxidative stress of damaged peripheral nerves, promotes nerve vascularization, and nerve regeneration and docking, accelerating the nerve regeneration process. Statement of Significance The slow regeneration speed of peripheral nerves is mainly due to the destruction of the regeneration microenvironment. Neural conduits with drug delivery capabilities have the potential to improve the microenvironment of nerve regeneration. However, traditional drugs are hindered by the blood nerve barrier and cannot effectively target the injured area. NO, an endogenous gas signaling molecule, can freely cross the blood nerve barrier and act on target cells. However, excessive NO can lead to cell apoptosis. In this study, a NO sustained-release system was constructed to regulate the microenvironment of nerve regeneration through various pathways and promote nerve regeneration.
研究领域:
神经科学
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药理学
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生物医学工程
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组织工程
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产品关联
DOI
PubMed
高影响因子
Exploration
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2026
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IF 30.4
Yuxu Wu,Kan Jiang,Xiao Wen,Chihao Jin,Kai Zhang,Jiakai Zhang,Jiale Jin,Jiaqian Wang,Huiyu Hu,Zonghan Xu,Xianzhu Zhang,Yihe Hu
Diabetic foot ulcers (DFUs) present a persistent clinical challenge, posing a significant and ongoing threat to patient health. Current treatment strategies are failing to concurrently address the excessive oxidative stress and impaired angiogenesis during whole-course management of diabetic wounds. To overcome these limitations, this study developed an innovative microneedle (MN)-based drug delivery system incorporating cerium-based metal‒organic frameworks (MOFs) loaded with dihydrocapsaicin (DHC). Fabricated from a Gelatin Methacryloyl (GelMA) hydrogel, the resulting MN-MOF@DHC system exhibited a sustained release profile of DHC that nearly covered the whole-course management of diabetic wounds. Our results revealed that the MN-MOF@DHC system effectively reduced the levels of reactive oxygen species (ROS), promoted the transformation of macrophage phenotypes from the pro-inflammatory M1 subtype to the anti-inflammatory M2 subtype, and significantly enhanced endothelial cell angiogenesis. These combined actions markedly accelerated wound closure. Collectively, the advanced MN platform offers a highly promising strategy for the treatment of DFUs.
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DOI
高影响因子
Journal of Advanced Research
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2020
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IF 6.992
Jinyun Li,Ming Guo,Yiping Wang,Bihuan Ye,Youwu Chen,Xuejuan Yang
Introduction Green algae seriously affect the quality and yield of Torreya grandis, it is important to explore new, environmentally friendly ways to control it. Objectives The present study aimed at preparing sustained-release algae-killing nanocapsules without pollution to the environment. Methods In this work, sodium carboxymethylcellulose (CMC), sodium alginate (SA), and chitosan (CTS) were used as raw materials in acylation reaction with the photosensitive catalytic material iron octaaminophthalocyanine (T) to generate the photoactive bio-based materials T-CMC, T-SA, and T-CMCS. Cinnamaldehyde and 2-aminobenzimidazole were combined using chemical grafting to produce a new algicide, and then formed nanocapsules by phase separation. The molecular structure of products was characterized by UV–Vis, FTIR, and NMR ( 1 H NMR, 13 C NMR). The particle size of the nanocapsules was determined by Zeta particle size analysis and TEM; DSC was used to investigate the thermal stability; The encapsulation efficiency and sustained-release performance were determined by HPLC. Then the phytotoxic of the new algicide was measured. Results The bio-based nanocapsules was successfully synthesized, which had a particle size of 10–30 nm and was stable at 40 °C. The encapsulation efficiency of the nanocapsules was 48.77%, the cumulative release rate was 83%, and the new algicide killed the green algae in a dose-dependent way. Conclusions The bio-based nano capsule is a new and valuable Sustained-release capsule, which is the method of green algae.
研究领域:
环境科学
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生物学
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
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2025
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IF 3.9
Fengrui Li,Yue Xiu,Anqi Wang,Yuhang Zhang,Xinyue Zhang,Shuang Gao,Fei Ye,Ying Fu
The development of hydrophobic pesticide formulations remains constrained by complicated manufacturing processes, excessive reliance on organic solvents, and indispensable surfactants. The practical application of dimethomorph (DIM) is hindered by its hydrophobic nature, posing risks to nontarget organisms. Inspired by the uptake of nanomaterials by plants, DIM was encapsulated in the cyclodextrin (CD) cavity to optimize its water-solubility and the sustained-release rate. The spatial confinement effect of CD could facilitate the thermostability of DIM. DIM/CD inclusion complex solutions were electrospun to fabricate nanofibers with bead-free and smooth morphology. As predicted, the release of DIM/CD inclusion complex nanofibers reached plateaus with accumulative release values of approximately 75%. The antifungal activity of DIM/CD inclusion complex nanofibers possesses much higher than DIM for controlling Rhizoctonia solani and Haematonectria hematococco, thereby enhancing its antifungal bioactivity and reducing pesticide spraying frequency. The inhibition rates of Rhizoctonia solani by DIM/HPβCD and DIM/HPγCD inclusion complex nanofibers are found to be 55.8% and 53.6% within 144 h, respectively. This work explores the feasibility of inclusion of complex nanofibers as a delivery platform for application in sustained agriculture production.
研究领域:
农业科学
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材料科学
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植物保护
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产品关联
DOI
PubMed
高影响因子
Materials
·
2019
·Vol. 12
·期 22
·3780
·
IF 2.972
Xianfeng Yue,Rong Zhang,Huairui Li,Minglei Su,Xiaobei Jin,Daochun Qin
Benzyl ammonium chloride (BAC) is a broad-spectrum bactericide, but vulnerable to leaching by water. In this paper, halloysite nanotubes (HNT) and montmorillonite (MMT) were used as drug carriers to load BAC, in order to achieve good anti-mildew activity and long-term sustained release properties. The HNT and MMT nano-composites were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and nitrogen adsorption/desorption. XRD results showed that BAC intercalated the interlayer of MMT, and expanded the interlayer spacing from 1.15 nm to 1.75 nm. Pore analysis showed that BAC decreased the cavity of halloysite nanotubes to a certain extent, which indicated that BAC loaded inside the lumen of HNT successfully. TG analysis showed that the loading capacity of MMT to BAC was higher than HNT. The accelerated-release experiments revealed both two clays have significant sustained-release effects on BAC, and the releasing rate of HNT was relatively lower. Both HNT and MMT have promising application prospects as sustained-release carriers. The inhibition test showed that BAC in nano-clay has good anti-mildew resistance performance.Keywords:Benzyl ammonium chloride;halloysite nanotubes;montmorillonite;sustained release;anti-mildew
研究领域:
材料科学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 55
·期 4
·1702-1714
·
IF 3.442
Shao Qi,Feng Yechen,Wang Wenwu,Wang Min,Li Binbin,El Tahchi Mario,Yin Yixia
Chemotherapeutic drugs have shown some limitations in anti-tumor treatment, such as drug resistance, high toxicity and limited regime of clinical uses. Natural products have attracted extensive attention as potential source of unmodified chemical compounds for disease treatment. Withaferin A (WA) has the potential to inhibit multiple human tumors, but it is hardly available for oral administration due to its low water solubility and its side effects. We developed a methoxy poly(ethylene glycol) (mPEG) conjugated poly( d , l -lactide- co -glycolide) (PLGA) drug carrier particles to encapsulate WA for pancreatic cancer treatment. The results showed that WA does not lose its physicochemical properties after encapsulation, and our drug carriers are completely degraded within 1 month. We used the WA-loaded mPEG–PLGA particles for pancreatic cancer cell treatment where it exhibited stronger inhibition than free drug (WA) at the early treatment stage. Our formulation of the drug carriers provides an efficient encapsulation of WA that allows it bonding with heat shock proteins, thereby reducing the expression of AKT and CDK4 proteins to induce apoptosis in cancer cells. Together, our data demonstrate that mPEG–PLGA loaded with WA can achieve the design goals for cancer therapy given its advantages of sustained release and degradation property to reduce the side effect of WA, which provides a possibility for WA to be used in clinical applications.
研究领域:
药学
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肿瘤学
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生物医学工程
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产品关联
DOI
高影响因子
SAUDI PHARMACEUTICAL JOURNAL
·
2019
·
IF 3.643
Hao Liu,Wenmei Zhao,Qi Hu,Ling Zhao,Yumeng Wei,Chao Pi,Yuhan Yang,Xuerong Yang,Hang Yuan,Yuhan Zhang,Kunyan Qu,Xinyu Shi,Yao Huang,Houyin Shi
Dihydromyricetin (DHM) is a natural dihydroflavonol compound with quite a number of important pharmacological properties. However, its low solubility in water and poor stability in aqueous environment, have compromised drug efficacy of DHM, thus hindering its clinical use. The present study was to develop DHM-loaded gastric floating sustained-release tablet (DHM-GFT) to improve the bioavailability of DHM. DHM-GFT was prepared via powder direct compression. The formulation of tablet was optimized in terms of the floating ability and drug release rate. The optimized DHM-GFT exhibited short floating lag time of less than 10 s and long floating duration of over 12 h in acidic medium. It had a 12-hour sustained release of DHM, which proved its potential to develop as a twice-a-day dosing preparation. The physicochemical properties of DHM-GFT well satisfied the pharmacopoeial requirements. In addition, the results from pharmacokinetic studies demonstrated that, DHM-GFT could considerably prolong the in vivo residence time of drug and improve the bioavailability via good gastric floating ability and sustained drug release when compared to DHM powder. Therefore, DHM-GFT is promising to promote the application of DHM and merits studies for further development.
研究领域:
药剂学
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药物开发
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药代动力学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）