Exploration
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2026
·
IF 30.4
Yuxu Wu,Kan Jiang,Xiao Wen,Chihao Jin,Kai Zhang,Jiakai Zhang,Jiale Jin,Jiaqian Wang,Huiyu Hu,Zonghan Xu,Xianzhu Zhang,Yihe Hu
Diabetic foot ulcers (DFUs) present a persistent clinical challenge, posing a significant and ongoing threat to patient health. Current treatment strategies are failing to concurrently address the excessive oxidative stress and impaired angiogenesis during whole-course management of diabetic wounds. To overcome these limitations, this study developed an innovative microneedle (MN)-based drug delivery system incorporating cerium-based metal‒organic frameworks (MOFs) loaded with dihydrocapsaicin (DHC). Fabricated from a Gelatin Methacryloyl (GelMA) hydrogel, the resulting MN-MOF@DHC system exhibited a sustained release profile of DHC that nearly covered the whole-course management of diabetic wounds. Our results revealed that the MN-MOF@DHC system effectively reduced the levels of reactive oxygen species (ROS), promoted the transformation of macrophage phenotypes from the pro-inflammatory M1 subtype to the anti-inflammatory M2 subtype, and significantly enhanced endothelial cell angiogenesis. These combined actions markedly accelerated wound closure. Collectively, the advanced MN platform offers a highly promising strategy for the treatment of DFUs.
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DOI
高影响因子
Nanomedicine
·
2025
·
IF 3.9
Xiaolin Zeng,Baoyan Chen,Peng Qian,Dongjun Jiang,Xianwei Wu,Shiqi Wei,Yangchen Xing,Yuxin Chen,Qianyu Zhang,Huali Chen
Aim To develop an enteric sustained-release nanoparticle formulations of aspirin for applicability to a broader population.Methods Aspirin-loaded nanoparticles were prepared using poly(lactic-co-glycolic acid) (PLGA) and the enteric polymer Eudragit L100–55 through an optimized oil-in-water emulsification solvent evaporation method. The nanoparticles were subjected to comprehensive physicochemical characterization, including particle size, zeta potential, and morphological analysis. Additionally, their stability, in vitro drug release profile, cytotoxicity, intestinal absorption, and in vivo pharmacokinetics were systematically evaluated.Results The nanoparticles exhibited well-defined spherical morphology, uniform particle size, and favorable surface charge, demonstrating excellent biocompatibility. In the in vitro drug release study, AS-PLGA@NPs exhibited pronounced enterolysis effect. The morphology of the nanoparticles was confirmed by scanning electron microscopy (SEM) at different release stages. In vivo intestinal absorption and pharmacokinetic studies in rats demonstrated that AS-PLGA-EL@NPs enhanced drug absorption, prolonged drug release, and showed higher bioavailability compared to conventional enteric-coated tablets.Conclusion The development and preparation of an oral enteric sustained-release nanoparticle delivery system for aspirin has the potential to serve a broader population, with promising applications in various therapeutic contexts.
研究领域:
药剂学
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生物医学工程
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PubMed
高影响因子
MATERIALS & DESIGN
·
2025
·
IF 7.9
Hongping Ge,Jing Yu,Li Pan,Lifang Zhang,Xiaohang Yin,Jie Cai,Chenghu Wu,Chen Wang,Shisheng Chen
Oral ulcers affect more than 25 % of the global population and are driven by complex pathological mechanisms, including bacterial infection, oxidative stress, and dysregulated inflammation, all of which impede healing. To address the limitations of therapies that target only a single aspect of ulcer pathology, this study developed a multifunctional electrospun film by combining 45S5 bioactive glass (BG) with hydroxypropyl methyl cellulose (HPMC). The BG/HPMC films, fabricated by electrospinning with 5 wt% BG incorporated into HPMC matrices, were thoroughly characterized for their structural and bioactive properties. In a rat oral ulcer model, the BG/HPMC films significantly accelerated re-epithelialization and reduced ulcer size compared to both control and chitosan-treated groups. The films also exhibited strong antibacterial activity against Staphylococcus aureus. In vitro, BG extracts promoted the viability and migration of human oral epithelial cells (HOECs) and human umbilical vein endothelial cells (HUVECs), mitigated hydrogen peroxide-induced oxidative stress, and suppressed the expression of pro-inflammatory cytokines—interleukin-1 alpha (IL-1α), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)—in lipopolysaccharide-stimulated macrophages.
研究领域:
口腔医学
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生物材料学
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药剂学
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组织工程
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炎症生物学
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纳米医学
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转化医学
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Pengpeng Yang,Wenbo Li,Shushu Li,Qingshi Wen,Chenglun Tang,YongLiang Yan,Fengxia Zou,Keke Zhang
Cordycepin shows anticancer activity in vitro but minimal in vivo activity due to its short plasma half-life. To address this, the cocrystallization technique was used to prolong its release and protect it from deamination by adenosine deaminase. In this study, multiple simulation methods were combined to identify potential cocrystal formers (CCFs). Based on the simulation results, one binary salt (cordycepin-oxalic acid) and two binary cocrystals (cordycepin-gallic acid and cordycepin-vanillic acid) were successfully screened by the mechanochemical method. The new multicomponents were characterized by several techniques. In vitro dissolution experiments showed that the binary salt has a significant sustained-release effect. This study proposes a strategy using binary cocrystals/salts to achieve sustained release and increase the half-life of cordycepin, offering potential for its in vivo application.
研究领域:
药学
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材料科学
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计算化学
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药物递送
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生物物理学
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Biomaterials Science
·
2020
·Vol. 9
·期 3
·882-891
·
IF 6.183
Zecong Xiao,Xinyao Zheng,Ying An,Kangning Wang,Junwen Zhang,Huacheng He,Jiang Wu
Growth factors (GFs) have been well known for their therapeutic effects on wound healing. Due to their vulnerable biostability, biomaterial carriers are usually used to deliver GFs to maintain their bioactivity. Among the carriers, PEG hydrogels are the most widely applied. But the uncontrolled release of GFs and their immunogenicity dramatically retard the application of PEG hydrogels as carriers of GFs. Herein, FGF2 loaded zwitterionic sulfobetaine methacrylate (SBMA) hydrogels were developed, and it was revealed that these hydrogels were more effective in delivering FGF2 for wound healing than were PEG hydrogels. In vitro studies demonstrated that SBMA hydrogels could successfully prolong the release of FGF2, which effectively maintained the bioactivity of FGF2. Further in vivo investigation showed that SBMA hydrogels could efficiently accelerate wound regeneration by promoting granulation tissue formation, collagen deposition, cell proliferation and migration, reepithelialization and angiogenesis. All results validated that SBMA hydrogels were promising substituents of PEG hydrogels for delivering FGF2 for wound regeneration.
研究领域:
生物材料
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组织工程
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伤口愈合
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药物递送系统
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Nano Research
·
2019
·Vol. 12
·期 12
·3129-3134
·
IF 8.515
Yang Hewei,Feng Yaqing,Tu Zhiyu,Su Kuo,Fan Xiaozhi,Liu Bingjie,Shi Zhiping,Zhang Yuzhe,Zhao Chenyang,Zhang Bao
Blue emitting perovskite ink obtained from cesium lead halide quantum dots bearing chlorine (CsPbCl x Br 3− x , 0 < x ≤ 3) suffers from the low photoluminescence quantum yield and poor stability. Cesium lead bromine (CsPbBr 3 ) quantum dots free of chlorine have more stable crystal structure and fewer crystal defects. Precise control of crystal sizes and surface passivation components of CsPbBr 3 quantum dots is crucial for the best use of quantum confinement effect and blueshift of emission wavelength to blue region. Here, by polymerizing acrylamide under UV-light irradiation to form polymer gel networks in dimethyl sulfoxide (DMSO) with CsPbBr 3 precursors and passivating agents trapped, we successfully prepared novel sustained release tablets with different shapes and sizes. Thanks to the limitation of the polymer networks on solvent releasing, the resulting CsPbBr 3 quantum dots have the average size of 1.1 ± 0.2 nm. On the basis of the excellent quantum confinement effect and optimized surface passivation, the obtained PQD ink can emit high quality blue light for more than 6 weeks. This work elucidates a new and convenient technique to prepare blue emission perovskite quantum dots ink with high stability and photoluminescence quantum yield and provides a great potential technology for the preparation of perovskite optoelectronic devices.
研究领域:
材料科学
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纳米技术
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光电子学
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量子点
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钙钛矿材料
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高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 2
·e03878
·
IF 2
Wenfeng Xie,Zhongxiao Li,Yuwei Hao,Shouzheng Jiao,Siqiao Zhang,Fanghua Pan,Lu Han,Ruping Liu,Zhicheng Sun
In this study, grapefruit essential oil (GEO)-loaded microcapsules encapsulated within silver/calcium alginate (Ag/CA) composite shells were successfully fabricated through an electrostatic spray technique. First, a pre-emulsion of GEO was prepared in the presence of sodium dodecyl sulfate (SDS) and sodium alginate (SA). Subsequently, the pre-emulsion was sprayed into an aqueous calcium chloride solution using electrostatic spray technique in the form of microdroplets, yielding calcium alginate (CA) gel microcapsules encapsulating GEO. Then, the previously prepared CA@GEO microcapsules were introduced into hydroxymethyl aminomethane (Tris) buffer solution, followed by the addition of dopamine hydrochloride. This enabled dopamine adsorption onto the microcapsule surface and subsequent polymerization to form a polydopamine layer. Finally, the dopamine hydrochloride-treated CA@GEO microcapsules were placed into a silver ammonia solution, where coordination interaction occurred between the polydopamine (PDA) on the microcapsule surface and silver ammonia particles. Subsequent in situ reduction, facilitated by glucose acting as a reducing agent, resulted in the formation of a silver shell on the microcapsule surface. The morphology and structure of the microcapsules were comprehensively characterized using scanning electron microscopy (SEM), particle size distribution analysis, x-ray photoelectron spectroscopy (XPS), etc. Moreover, the sustained release and antibacterial properties of Ag/CA@GEO microcapsules were investigated. Graphical A pre-emulsion of grapefruit essential oil (GEO) was prepared with sodium dodecyl sulfate and sodium alginate as stabilizers. Calcium alginate (CA) gel microcapsules encapsulating GEO were prepared by electrostatically spraying the pre-emulsion as microdroplets into an aqueous calcium chloride solution. Subsequently, a polydopamine layer was deposited onto the microsphere surfaces; this layer chelated silver ammonia ions and facilitated in-situ reduction in the presence of glucose, ultimately yielding a dense silver shell on the microspheres.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 15
·e53716
·
IF 3
Cai-xia Yang,Jun Li,Yu-qing Zhang,Chao Wu,De-qiang Li
Efficient utilization of pesticides has presented various advantages in the ecological environment, food safety, and agricultural sustainability. Pesticide microcapsule could significantly improve the pesticide utilization ratio, and thus, we prepared a sustained-release microcapsule from cellulose nanocrystal (CNCs) stabilized Pickering emulsion template. The NaCl was added to overcome the strong electrostatic repulsion among CNCs for forming a stable oil-in-water (O/W) CNCs-based Pickering emulsion template, followed by crosslinking with hexamethylene diisocyanate on the interface. UV–vis and zeta-potential were used to characterize the as-prepared Pickering emulsion, and the stability and emulsion fraction were calculated. Results indicated that NaCl contributed to the stability of Pickering emulsion, even at a low concentration. The obtained CNCs-based microcapsule was characterized by FT-IR, XRD, SEM, TG-DTG, and three-phase contact angles. The microcapsule presented an encapsulation efficiency of 96.76% and sustained release of the imidacloprid for more than 82 h. Results indicated the potential for loading and sustained release of imidacloprid, which is beneficial to the environment, food, and agriculture.
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高影响因子
AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 6
·1-10
·
IF 3.3
Tang XiaoFei,Qin Huaiying,Yang Jianhua,Zhang XiaoYun
Dissolving microneedle (DMN) has been researched as a drug delivery technology that improves drug molecule transportation through the skin with little discomfort. However, the sluggish drug absorption, poor skin dissolution, and lengthy time lags of DMN have limited its potential uses. The aim of this study was to design a novel DMN system for the administration of the poorly water-soluble drug, estradiol (E2), with fast skin penetration and a stable release rate for a long time. DMN containing E2 emulsion (E2-EM-DMN) and traditional DMN (T-DMN) were prepared. Rat skin was used for penetration test and guinea pig skin was used for skin irritation experiment. The drug release profiles and stability properties of these two kinds of DMNs were also investigated. High performance liquid chromatography was employed to determine the E2 content in DMN. The E2 concentration in rat plasma was achieved by a newly developed liquid chromatography-mass spectrometry method that was fast, reproducible, and specific. The height of E2-EM-DMN and T-DMN was 600 μm. The drug loading of the E2-EM-DMN and T-DMN was 667.30 ± 7.21 μg/patch and 672.56 ± 6.98 μg/patch. E2-EM-DMN possessed enough mechanical strength to penetrate the skin and caused no irritation to the skin. E2-EM-DMN could release the drug more rapidly and more continuously than T-DMN. E2-EM-DMN had good pharmaceutical stability. In summary, the E2-EM-DMN showed reliable quality and superior release performance. Emulsion-embedded DMN is an ideal transdermal delivery system for drugs. Graphical Abstract
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PubMed
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Yipeng Zhang,Jianping Zhang,Zechun Liu,Yanjun Huang,Xiaopeng Xiong
Beta-cyclodextrin (β-CD) has promising applications in many fields based on its hydrophobic cavity at the central of the cyclic molecule, which can form inclusion complex with specific molecule via a host-guest interaction. However, the water solubility of β-CD limits its application. Herein, attempts have been made to graft β-CD onto two kinds of solid particles while retaining the function of β-CD, so as to expand its application. First, SiO 2 nanoparticles were modified with silane coupling agent KH-560 to offer epoxy groups. Then, the epoxy groups of the modified SiO 2 and the hydroxyl groups of β-CD were simultaneously esterified by a dicarboxylic acid of succinic acid in a non-toxic solvent medium to obtain the β-CD modified SiO 2 (SiO 2 @β-CD). On the other hand, microcrystalline cellulose (MCC) particles were also modified with β-CD (MCC@β-CD) through co-esterification of their hydroxyl groups with succinic acid. The syntheses were monitored by Fourier transform infrared (FT-IR) spectroscopy, and the obtained materials were characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The degrees of β-CD modification for the particles have been measured and analyzed to optimize the synthesis conditions. The results indicate that the degree of β-CD modification for the SiO 2 @β-CD is relatively low, but the material exhibits over 60 ºC elevation of the thermal stability. In comparison, the degree of β-CD modification for MCC@β-CD reached as high as 422 mg/g. Due to the much higher content of β-CD, the synthesized MCC@β-CD was employed to load a flavor compound of D -limonene, and its sustained release was investigated to suggest the potential of the β-CD modified particles.
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高影响因子
Analytical Methods
·
2024
·
IF 2.7
Xue Hua Wang,Mei Ju Luo,Xinyu Li,Qingling Yang,Zhishun Guo,Hao Lin Zou,Hong Qun Luo,Nian Bing Li,Bang Lin Li
In this work, 4-amino-3-hydrazino-5-mercapto-1,2,4-triazole (AHMT) was pre-doped into agarose hydrogels; consequently, sustained hydrogel systems with modulated release performance were constructed for simple operation and recyclability in point-of-care detection of formaldehyde (FA). With the increase in FA concentrations, the absorbance response of the supernatant solutions showed linear relationships and the color of the reaction mixtures gradually increased. The detection limit was calculated to be 0.013 μg mL−1. To verify its practical application, a simple, rapid and low-cost FA detection platform was built on the basis of the optimized conditions, and the method shows the merits of simplicity, high sensitivity and selectivity. More importantly, the developed hydrogels are recyclable and can be used at least five times without any loss in sensing performance. Significantly, the sensory hydrogels can be employed by non-skilled people for monitoring food safety and applied for the practical detection of FA in foods.
研究领域:
分析化学
·
食品科学
·
生物材料学
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PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·
IF 3
Hudie Fu,Li Kang,Lanjun Yu,Yanping Fu,Zhijie Wen,Shengpeng Zhu,Mohan Zhao,Yuqing Wang,Qi Chen,Qinxiong Lin,Xinzhou Yang,Yan Hu
Hydrogels have been widely used in wound dressings owing to their biocompatibility and bacteriostatic properties. In this study, a chitosan-citric acid gel film was prepared using chitosan as the raw material and citric acid as the acid solvent and cross-linking agent. In addition, to increase the antibacterial effect of the gel film, ketoconazole/β-cyclodextrin inclusion complex was prepared by inclusion technology and added to the gel film to prepare a chitosan-citric acid sustained-release gel film loaded with ketoconazole/β-cyclodextrin inclusion complex for treating cutaneous candidiasis. The physical and chemical properties of the chitosan-citric acid gel films were investigated using infrared spectroscopy, x-ray diffraction, water vapor transmittance test, thermal analysis, and swelling tests. Drug release, antibacterial, and toxicity tests of the chitosan-citric acid gel film loading with ketoconazole/β-cyclodextrin inclusion complex were carried out in vitro. The composite film showed good sustained drug release behavior, antibacterial effects, and biocompatibility in vitro. These results support that the chitosan-citric acid hydrogel has great potential as a gel wound dressing for the treatment of cutaneous candidiasis.
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