JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Gongduan Fan,Rongsheng Ning,Zhongsen Yan,Jing Luo,Banghao Du,Jiajun Zhan,Lingshan Liu,Jin Zhang
Antibiotic contamination is increasing scrutinized recently. In this work, the Ag−AgCl/WO 3 /g-C 3 N 4 (AWC) nanocomposites were successfully synthesized using a two-step process involving electrostatic self-assembly and in-situ deposition for trimethoprim (TMP) degradation. The as-prepared photocatalysts were investigated and characterized by XRD, FTIR, XPS, TGA, SEM, TEM , UV–vis, PL and EIS. The experimental results indicated that 99.9% of TMP (4 mg/L) was degraded within 60 min when the concentration of AWC was 0.5 g/L. Reactive species scavenging experiments and electron spin resonance (ESR) experiments illustrated that superoxide radical (•O 2 − ) and photogenerated holes (h + ) were the main active species. The functional theory calculation and identification of intermediates via HPLC-MS revealed the possible degradation pathways of TMP. A double photoelectron-transfer mechanism in AWC photocatalyst was proposed. Five cycling photocatalytic tests and reactions under different solution matrix effects further supported that the AWC was a promising photocatalyst for the removal of TMP from the aquatic environment.
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Hongying Liu,Zhenzeng Zhou,Quan Li,Shanshan Zhan,Lihua Li,Zheng-Zhi Yin,Linan Zhang
Excessive amount of antibiotics have serious detrimental effects on the environment, making precise monitoring and removal increasingly crucial. Trimethoprim (TMP) is a typical kind of antibiotic. Herein, a novel microdetector was fabricated on the matrix of acupuncture needle (AN). The functional interface was constructed using a green electrosynthesis method, incorporating three-dimensional coral-like gold nanorods (3D-CAuNRs), polydopamine (pDA), polypyrole (pPY) and TMP molecules. Characterization was performed using electrochemistry, high-resolution SEM and elemental mapping techniques. Notably, nanocavities were formed through electropolymeric molecular imprinting, resulting in highly selective and sensitive detecting of TMP. This was attributed to the structure-complementary and configuration-suitable microenvironment, facilitating specific electron-transfer. The intrinsic properties of the microsensor were thoroughly investigated. Under optimized conditions, the sensor exhibited a wide linear range of 0.05 ∼ 50 µmol/L with a low limit detection of 0.017 µmol/L (S/N = 3) for TMP, along with high selectivity, reproducibility, and stability. Furthermore, the sensor demonstrated applicability for detecting TMP in environmental water, soil and cefalexin and trimethoprim capsules.
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Food Analytical Methods
·
2013
·Vol. 7
·期 2
·308-317
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IF 1.969
Luo Haoshi,Zhang Lifang,Xue Feiqun,Li Ying,Wang Xiaoyang,Fei Chenzhong,Zhang Chong
A sensitive liquid chromatography–tandem mass spectrometry method for simultaneous determination of trimethoprim and diaveridine in edible tissue samples (chicken and porcine muscle; liver, kidney, and fat tissues as well as fish muscle) was developed and validated in this study. Trimethoprim, diaveridine, and the internal standard trimethoprim-D 3 were extracted from samples using acetonitrile. The Oasis MCX Solid-Phase Extraction Cartridge was selected for cleaning up the extracts. Chromatographic separation was performed on a hydrophilic interaction liquid chromatography column with gradient elution. The analytes were determined using triple–quadrupole mass spectrometry in positive electrospray ionization and multiple reaction monitoring mode. The relative recoveries from spiked samples ranged from 82.5 to 117.2 %, with the relative standard deviations generally being below 15.4 %. Limits of detection and quantification for analytes were within 0.3–1 and 1–2 μg kg −1 , respectively. The proposed method was successfully applied to detect trimethoprim and diaveridine in real samples.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Manman Li,Kunlun Yang,Xin Huang,Shiguang Liu,Yifan Jia,Peng Gu,Hengfeng Miao
In this study, the flat microfiltration ceramic membrane (CM) was modified by wet impregnation method (Mn-Fe-CM) to catalyze ozone (O 3 ) for the oxidative degradation of trimethoprim (TMP). The conventional characterization test showed that the Mn-Fe binary oxides (Mn/FeO x ) with the crystal structure of FeMnO 3 were successfully loaded on the membrane and the catalytic performance of Mn-Fe-CM for O 3 was apparently enhanced as compared to CM. Consequently, compared with O 3 oxidation alone, the degradation and mineralization efficiencies of TMP in the O 3 /Mn-Fe-CM system were both improved and 98.6% of TMP could be removed within 10 min. The degradation efficiency of TMP decreased with the increasing pH and the addition of Cl - 、HCO 3 – 、PO 4 3- , while humic acid (HA) exhibited negative effect on the TMP removal. Radical scavenger experiment and electron paramagnetic resonance (EPR) analysis confirmed that direct oxidation by O 3 played an important role in the degradation of TMP, while hydroxyl radical (·OH) and 1 O 2 also participated. Fe(II) could act as an intermediate to transfer electrons and accelerate the transformation of Mn(III) to Mn(II) and Mn(IV) to Mn(III) during the ozonation process, which definitely strengthened the synergic catalytic effect of Mn-Fe-CM. The proposed degradation mechanism of TMP mainly contained hydroxylation , carbonylation , demethoxylation and deamination . Due to the strong catalytic ozonation performance for organic pollutants degradation, the O 3 /Mn-Fe-CM system revealed better anti-membrane fouling ability, strong cyclic usage performance and high applicability for the actual surface water treatment.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 47
·71766-71773
·
IF 5.19
Huo Junyu,Li Chaoyu,Hu Xiaojin,Xie Huijun,Hu Zhen,Wu Haiming,Liang Shuang,Zhang Jian
Iron ore and manganese ore were used as substrate of constructed wetlands (CWs) to enhance nitrogen (N) removal. However, the N purification performance in CWs filled with iron or manganese ore under antibiotics stress needs further study. In this study, three groups of CWs filled with river sand, limonite (a kind of iron ore), and manganese ore sand were constructed, which were named as C-CWs, Fe-CWs, and Mn-CWs, respectively. The effect and mechanism of the composite antibiotics sulfamethoxazole (SMX) and trimethoprim (TMP) on N removal in CWs were investigated. While the addition of SMX and TMP inhibited about 40% nitrification and promoted about 25% denitrification in all CWs, Fe-CWs and Mn-CWs always had better N removal performance than C-CWs. Changes in microbial community structure in CWs indicated that the better N removal performance in Fe-CWs and Mn-CWs was attributed to the presence of more abundant and diverse N-associated bacteria, especially Fe- and Mn-driven autotrophic denitrifying bacteria. What’s more, the addition of iron ore or manganese ore contributed to the better N removal performance with highest relative abundance of N-transferring bacteria under antibiotics stress.
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MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Xizhuang Yue,Zaiyu Li,Shuang Zhao
A novel electrochemical sensor based on graphene (GR) and ZnO nanorods (GR-ZnO/GCE) was developed to detect sulfamethoxazole (SMX) and trimethoprim (TMP) simultaneously. SEM image showed that ZnO had a rod shaped morphology. XRD result indicated a hexagonal wurtzite phase of ZnO nanorods. The electrochemical experiment results showed that the synergetic effect of GR and ZnO endowed the prepared sensor excellent electrocatalytic behavior towards the oxidation of SMX and TMP. SMX and TMP were detected by DPV method at 0.85 V and 1.06 V, respectively. Under the optimal conditions, the GR-ZnO/GCE showed superior wide linear responses in concentration range of 1–220 μmol/L for SMX and 1–180 μmol/L for TMP with the limit of detection (LOD) of 0.4 μmol/L and 0.3 μmol/L, respectively. In addition, the sensor has good stability, good selectivity, anti-jamming ability and reproducibility. We tested SMX and TMP in lake water, tap water, urine and serum with recovery between 93.2% and 108%. The proposed sensor has a good application prospect in biomedicine and environmental protection.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Xue Wang,Yaoli Wei,Zenan Zhang,Mengnan Cao,Bin Liang,Xiuping Yue,Aijuan Zhou
In this study, a bioelectrochemical system, with trimethoprim (TMP) as the sole carbon source, was constructed to evaluate the bioelectrogenic respiration on the acceleration of TMP degradation. The bioelectro-characterization was comprehensively optimized. The results showed that the optimal removal efficiency of TMP was achieved (99.38 %) when the external resistance, pH, and concentration of phosphate buffer solution were 1000 Ω, 7, and 25 mM, respectively. The potential TMP degradation pathways were speculated based on Liquid Chromatography-Mass Spectrometry and density functional theory calculations, including demethylation, demethoxy, hydroxylation and methylene bridge cracking. The overall biotoxicity of TMP biodegradation products after electrogenic respiration treatment was generally reduced. Electroactive bacteria (3.85 %) and potential degraders (27.18 %) were markedly increased in bioelectrogenic anaerobic treatment system, where bioelectrogenic respiration played a crucial role in promoting TMP biodegradation. However, it was observed that under long-term toxic stress of TMP, there was an enrichment of antibiotic resistance genes (ARGs) among the TMP-degrading bacteria. Furthermore, the comprehensive interaction between microbial communities and environmental variables was extensively investigated, revealing that electroactive bacteria and potential degraders were strongly positively correlated with TMP removal and biomineralization efficiency. This study provides guidance and promising strategy for the effective treatment of antibiotic-containing wastewater in practical applications.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Ying Gao,Ruibin Yang,Qinqin Chen,Xinhao Shen,Dapeng Li,Juanhong Li,Feng Liu,Jianhua Wu,Sanjian Ma,Guoliang Dai,Dongmei Wang,Lei Xie,Zixia Lin,Xin Liu
The large-scale production of iron sludge and the safety issues of H2O2 usage are two limitations in the promotion and application of the Fenton reaction. To further solve the problems, an active hydrogen reduction strategy was proposed. Herein, the reducing property of active hydrogen was utilized to simultaneously generate H2O2 in situ and accelerate the regeneration of ferric in the reaction process. The composite metal–organic frameworks (MOFs) Pd@UiO-66(Zr) and Pd@UiO-66(Zr)-2OH, which were stable under acidic conditions, were synthesized for hydrogen activation. Under the condition of only trace amounts of ferrous and hydrogen added, both catalysts showed excellent performance in the degradation experiments of trimethoprim. The kobs of the Pd@UiO(Zr)-66-mediated system is 0.0487 min–1, which is 1.67 times that of Pd@UiO-66(Zr)-2OH. In the pollutant degradation reaction system constructed by these two materials, both of the hydroxyl radicals and singlet oxygen play a dominant role. The Bader charge analysis showed that the charge transfer from Pd to the MOF host was higher on Pd@UiO-66(Zr) than Pd@UiO-66(Zr)-2OH, which could be a key factor in distinguishing the catalytic activity of the catalysts. In addition, both catalysts showed excellent stability over six cycles. Nearly 100% degradation of trimethoprim could be achieved. This study provides some reference for the control of emerging pollutants by UiO-66(Zr) series materials.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Guangyan Liu,Xilin Liang,Shili Hou,Shifeng Hou
The sensing performance of molecularly imprinted polymer (MIP) electrochemical sensors is restricted by the poor conductivity of MIP. Modifying electrodes with nanomaterials with good conductivity is a feasible method to improve the sensitivity of MIP electrochemical sensors. Herein, an MIP/TTA-TAPE-COF/MXene/GCE electrochemical sensor is constructed using novel layered pastry-like terthiophene-covalent organic frameworks (TTA-TAPE-COF) and MXene hybrids as modifying electrode materials and combined with MIP. Its outstanding electrochemical performance is demonstrated through electrochemical impedance spectroscopy (EIS) as well as cyclic voltammetry (CV). Further, the fabricated MIP/TTA-TAPE-COF/MXene/GCE sensor is applied for detecting ultra-trace trimethoprim (TMP), which has high specificity and sensitivity. The response of the differential pulse voltammetry (DPV) is linearly related to the logarithm of TMP concentration within the range of 9 × 10 −15 –9 × 10 −18 mol L −1 . The detection limit is 6.48 × 10 −18 mol L −1 . Besides, the method has an outstanding recovery in food sample analysis. The hybrid of COFs and MXene can prevent MXene from self-restacking and improve its electrical conductivity. Thus, this method markedly enhances the sensing performance, and it will provide a detection platform for ultra-trace detection of organic amine.
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Analytical Methods
·
2021
·Vol. 13
·期 42
·5075-5084
·
IF 2.896
Lu-Zhu Chen,Hai-Long Wu,Wan-Jun Long,Tong Wang,Gao-Yan Tong,Ru-Qin Yu
In this work, a simple and fast analytical method based on a self-weighted alternating trilinear decomposition (SWATLD) algorithm coupled with excitation–emission matrix (EEM) fluorescence was developed for the simultaneous determination of sulfamethoxazole (SMZ) and trimethoprim (TMP) illegally added to health products. With the second-order advantage, the proposed method obtained satisfactory results in the presence of peak overlap and unknown interferences. The analysis time for a single sample is only 0.8 minutes. The average spiked recoveries of SMZ and TMP in three health product spiked samples were in the range of 91.0–106.2% and 86.8–107.8%, respectively. The relative standard deviations (RSDs) were lower than 8.6%. In addition, verification parameters including sensitivity (SEN), selectivity (SEL), the limit of detection (LOD), the limit of quantification (LOQ), intra-day precision, and inter-day precision were calculated, and the results show that the proposed method is feasible. The quantitative results of the proposed method were further confirmed by the LC-MS/MS method, which proved that the proposed method was efficient and green for drug-abuse monitoring of SMZ and TMP in health products.
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TALANTA
·
2023
·
IF 6.1
Xiaoqin Shen,Bing Yan
The application of covalent organic frameworks (COFs) in fluorescence detection is of great interest. Herein, we have synthesized the ionic covalent organic framework TGH + ·PD: Eu(TTA) 4 with the characteristic emission of lanthanides by a straightforward ion-exchange method. This is the first time that aristolochic acid A (AA), a key biomarker for absorption and metabolism in the body for early diagnosis of diseases, has been detected by using COF as a fluorescent probe , which exhibits a good linear correlation with the AA concentration over a range from 5.0 to 1000 μM with a detection limit of 0.0808 μM. In addition, the selective response to sulfamethoxazole (SMZ)/trimethoprim (TMP) is achieved by varying the excitation wavelength with detection lines of 30.2 nM and 2.898 μM, respectively. It is worth mentioning that BNPP has been developed for the accurate determination of SMZ in uncertain samples. In a word, the prepared TGH + ·PD: Eu(TTA) 4 -based sensor can be used for the quantitative detection of AA and SMZ/TMP, separately, effectively extending the application of COFs in the field of fluorescence sensing.
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ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Wen Lu,Aimin Wang,Yanyu Zhang,Songyu Ren,Zhongguo Zhang
The widespread existence of antibiotics in the environment has attracted growing concerns regarding the potential adverse effects on aquatic organisms, ecosystems, and human health even at low concentrations. Extensive efforts have been devoted to developing new methods for effective elimination of antibiotics from wastewater. Herein, a novel process of Fe 2+ catalytically enhanced vacuum ultraviolet (VUV) irradiation was proposed as a promising approach for the removal of antibiotic trimethoprim (TMP) in water. Compared with UVC photolysis, VUV photolysis, and UVC/Fe 2+ , VUV/Fe 2+ could increase the pseudo-first-order reaction rate constant of TMP removal by 6.6–38.4 times and the mineralization rate by 36.5%–59.9%. The excellent performance might originate from the synergistic effect of VUV and Fe 2+ , i.e., VUV irradiation could effectively split water and largely accelerate the Fe 3+ /Fe 2+ cycle to generate more reactive oxygen species (ROS). EPR results indicated that • OH and O 2 •- were identified as the main ROS in the UVC/Fe 2+ and VUV/Fe 2+ processes, while • OH, O 2 •- , and 1 O 2 were involved in the VUV process. The operating parameters, such as Fe 2+ dosage and initial TMP contents, were evaluated and optimized. Up to 8 aromatic intermediates derived from hydroxylation, demethylation, carbonylation, and methylene group cleavage were identified by UPLC-QTOF-MS/MS technique, the possible pathways of TMP degradation were proposed. Finally, the acute and chronic toxicity of intermediates formed during TMP degradation in the VUV/Fe 2+ process were also evaluated.
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